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| 1 | WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics显示文摘有干细胞特征的前列腺癌症房间被他们在非支持者文化从单个房间形成自我更新的 prostaspheres 的能力在人的前列腺癌症房间线识别。Prostaspheres 展出了增长,区别和茎的异构的表示联系房间的制造者 CD44, ABCG2 和 CD133。有 WNT 禁止者的治疗减少了 prostasphere 尺寸和自强。相反,引起的 Wnt3a 的增加增加了 prostasphere 尺寸和自强,它与原子尾 - catenin 的重要增加被联系,角质素 18, CD133 和 CD44 表示。作为 LNCaP 和 C4-2B 癌症房间快车雄激素受体的一个高比例,我们决定了雄激素受体对手 bicalutamide 的效果。雄激素受体抑制减少了 prostasphere 尺寸和 PSA 的表示,但是没禁止 prostasphere 形成。这些效果与有干细胞特征和放大房间的运输的雄激素依赖者增长的房间的雄激素无关的自强一致。作为发信号的受动器尾 - catenin 能也与雄激素受体联系的正规 WNT,我们为包含在 WNT 和雄激素受体活动之间的平衡的瘤繁殖建议一个模型。那将与干细胞特征和开车运输放大房间增长和区别影响一个癌症房间的自强。在结论,我们提供那项 WNT 活动独立于雄激素受体活动与干细胞特征调整前列腺癌症房间的自强的证据。WNT 发信号的抑制因此有潜力与干细胞特征减少前列腺癌症房间的自强并且改进治疗学的结果。 | Isabelle Bisson David M Prowse | 2009 | Cell Research2009，，6： | 37 |
| 2 | Assessment of drug-induced hepatotoxicity in clinical practice: A challenge for gastroenterologists显示文摘Currently, pharmaceutical preparations are serious contributors to liver disease; hepatotoxicity ranking as the most frequent cause for acute liver failure and post-commercialization regulatory decisions. The diagnosis of hepatotoxicity remains a difficult task because of the lack of reliable markers for use in general clinical practice. To incriminate any given drug in an episode of liver dysfunction is a step-by-step process that requires a high degree of suspicion, compatible chronology, awareness of the drug’s hepatotoxic potential, the exclusion of alternative causes of liver damage and the ability to detect the presence of subtle data that favors a toxic etiology. This process is time-consuming and the final result is frequently inaccurate. Diagnostic algorithms may add consistency to the diagnostic process by translating the suspicion into a quantitative score. Such scales are useful since they provide a framework that emphasizes the features that merit attention in cases of suspected hepatic adverse reaction as well. Current efforts in collecting bona fide cases of drug-induced hepatotoxicity will make refinements of existing scales feasible. It is now relatively easy to accommodate relevant data within the scoring system and to delete low-impact items. Efforts should also be directed toward the development of an abridged instrument for use in evaluating suspected drug-induced hepatotoxicity at the very beginning of the diagnosis and treatment process when clinical decisions need to be made. The instrument chosen would enable a confident diagnosis to be made on admission of the patient and treatment to be fine-tuned as further information is collected. | Raúl J Andrade Mercedes Robles Alejandra Fernández-Castaer Susana López-Ortega M Carmen López-Vega M Isabel Lucena | 2007 | World Journal of Gastroenterology2007，13，3： | 18 |
| 3 | drug-induced autoimmune liver disease:a diagnostic dilemma of an increasingly reported disease显示文摘The aetiology of autoimmune hepatitis(AIH) is uncer-tain but the disease can be triggered in susceptible patients by external factors such as viruses or drugs.AIH usually develops in individuals with a genetic back-ground mainly consisting of some risk alleles of the major histocompatibility complex(HLA).Many drugs have been linked to AIH phenotypes,which sometimes persist after drug discontinuation,suggesting that they awaken latent autoimmunity.At least three clini-cal scenarios have been proposed that refers to drug- induced autoimmune liver disease(DIAILD):AIH with drug-induced liver injury(DILI); drug induced-AIH(DI-AIH); and immune mediated DILI(IM-DILI).In addi-tion,there are instances showing mixed features of DI-AIH and IM-DILI,as well as DILI cases with positive autoantibodies.Histologically distinguishing DILI from AIH remains a challenge.Even more challenging is the differentiation of AIH from DI-AIH mainly relying in histological features; however,a detailed standard-ised histologic evaluation of large cohorts of AIH and DI-AIH patients would probably render more subtle features that could be of help in the differential diag-nosis between both entities.Growing information on the relationship of drugs and AIH is being available,being drugs like statins and biologic agents more fre-quently involved in cases of DIAILD.In addition,there is some evidence on the fact that patients diagnosed with DIAILD may have had a previous episode of hepa-totoxicity.Further collaborative studies in DIAILD will strengthen the knowledge and understanding of this intriguing and complex disorder which might represent different phenotypes across the spectrum of | Agustin Castiella Eva Zapata M Isabel Lucena Raúl J Andrade | 2014 | World Journal of Hepatology2014，6，4： | 13 |
| 4 | Helicobacter pylori infection- recent developments in diagnosis显示文摘Considering the recommended indications for Helicobacter pylori(H.pylori)eradication therapy and the broad spectrum of available diagnostic methods,a reliable diagnosis is mandatory both before and after eradication therapy.Only highly accurate tests should be used in clinical practice,and the sensitivity and specificity of an adequate test should exceed 90%.The choice of tests should take into account clinical circumstances,the likelihood ratio of positive and negative tests,the cost-effectiveness of the testing strategy and the availability of the tests.This review concerns some of the most recent developments in diagnostic methods of H.pylori infection,namely the contribution of novel endoscopic evaluation methodologies for the diagnosis of H.pylori infection,such as magnifying endoscopy techniques and chromoendoscopy.In addition,the diagnostic contribution of histology and the urea breath test was explored recently in specific clinical settings and patient groups.Recent studies recommend enhancing the number of biopsy fragments for the rapid urease test.Bacterial culture from the gastric biopsy is the gold standard technique,and is recommended for antibiotic susceptibility test.Serology is used for initial screening and the stool antigen test is particularly used when the urea breath test is not available,while molecular methods have gained attention mostly for detecting antibiotic resistance. | Ana Isabel Lopes Filipa F Vale Mónica Oleastro | 2014 | World Journal of Gastroenterology2014，20，28： | 12 |
| 5 | DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection显示文摘 | Oertli Mathias Sundquist Malin Hitzler Iris Engler Daniela B Arnold Isabelle C Reuter Sebastian Maxeiner Joachim Hansson Malin Taube Christian Quiding-J?rbrink Marianne Müller Anne | 2012 | EN2012，，3： | 5 |
| 6 | National natural capital accounting with the ecological footprint concept显示文摘 | Mathis Wackernagel Larry Onisto Patricia Bello Alejandro Callejas Linares Ina Susana López Falfán Jesus Méndez Garc??a Ana Isabel Suárez Guerrero Ma Guadalupe Suárez Guerrero | 1999 | Ecological Economics1999，，3： | 5 |
| 7 | Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells显示文摘 | Arnold Isabelle C Dehzad Nina Reuter Sebastian Martin Helen Becher Burkhard Taube Christian Müller Anne | 2011 | Journal of Clinical Investigation2011，，8： | 4 |
| 8 | 达比加群酯、利伐沙班或阿哌沙班与依诺肝素用于全髋关节或膝关节置换术后的血栓预防:系统综述、荟萃分析和间接治疗比较显示文摘目的 分析新型口服抗凝药预防全髋或全膝关节置换术后静脉血栓栓塞的临床转归.设计系统综述、荟萃分析以及间接治疗比较.数据来源 Medline和CENTRAL(至2011年4月为止)、临床试验注册中心、会议论文集以及药品监管机构的网站.研究选择利伐沙班、达比加群酯或阿哌沙班与依诺肝素相比,预防全髋或全膝关节置换术后静脉血栓栓塞症的随机对照试验.由两名研究者独立提取数据.采用随机效应荟萃分析估计症状性静脉血栓栓塞、临床相关出血、死亡和净临床终点(症状性静脉血栓栓塞、严重出血和死亡的复合转归)的相对危险度.分别使用RevMan和ITC软件进行直接和间接比较.结果 共纳入16项试验,共计38 747例患者.与依诺肝素组相比,利伐沙班组(RR:0.48;95%CI:0.31~0.75)和阿哌沙班组(RR:0.82;95%CI:0.41~1.64)的症状性静脉血栓栓塞发生风险较低,达比加群酯组(RR:0.71;95%CI:0.23~2.12).与依诺肝素组相比,利伐沙班组的临床相关出血相对危险度较高(RR:1.25;95%CI:1.05~1.49),达比加群酯组与依诺肝素组相似(RR:1.12;95%CI:0.94~1.35),而阿哌沙班组的相对危险度则较低(RR:0.82;95%CI:0.69~0.98).直接和间接比较的结果显示,各种治疗的净临床终点均无差异.结论新型口服抗凝药的有效性较高,同时普遍有较高的出血倾向.新型口服抗凝药之间的有效性和安全性无显著差异. | Antonio Gómez-Outes Ana Isabel Terleira-Fernández M Luisa Suárez-Gea Emilio Vargas-Castrillón | 2013 | 中华关节外科杂志(电子版)2013，7，6： | 4 |
| 9 | National natural capital accounting with the ecological footprint concept显示文摘 | Mathis Wackernagel Larry Onisto Patricia Bello Alejandro Callejas Linares Ina Susana López Falfán Jesus Méndez Garc??a Ana Isabel Suárez Guerrero Ma Guadalupe Suárez Guerrero | 1999 | Ecological Economics1999，，3： | 3 |
| 10 | Pharmacological challenges in chronic pancreatitis显示文摘Drug absorption in patients with chronic pancreatitis might be affected by the pathophysiology of the disease.The exocrine pancreatic insufficiency is associated with changes in gastrointestinal intraluminal pH,motility disorder,bacterial overgrowth and changed pancreatic gland secretion.Together these factors can result in malabsorption and may also affect the efficacy of pharmacological intervention.The lifestyle of chronic pancreatitis patients may also contribute to gastrointestinal changes.Many patients limit their food intake because of the pain caused by eating and in some cases food intake is more or less substituted with alcohol,tobacco and coffee.Alcohol and drug interaction are known to influence the pharmacokinetics by altering either drug absorption or by affecting liver metabolism.Since patients suffering from chronic pancreatitis experience severe pain,opioids are often prescribed as pain treatment.Opioids have intrinsic effects on gastrointestinal motility and hence can modify the absorption of other drugs taken at the same time.Furthermore,the increased fluid absorption caused by opioids will decrease water available for drug dissolution and may hereby affect absorption of the drug.As stated above many factors can influence drug absorption and metabolism in patients with chronic pancreatitis.The factors may not have clinical relevance,but may explain inter-individual variations in responses to a given drug,in patients with chronic pancreatitis. | Anne Estrup Olesen Anne Brokjaer Iben WD Fisher Isabelle M Larsen | 2013 | World Journal of Gastroenterology2013，19，42： | 3 |
| 11 | Survival of patients with hepatocellular carcinoma treated by transarterial chemoembolisation (TACE) using Drug Eluting Beads. Implications for clinical practice and trial design显示文摘 | Marta Burrel María Reig Alejandro Forner Marta Barrufet Carlos Rodríguez de Lope Silvia Tremosini Carmen Ayuso Josep M Llovet María Isabel Real Jordi Bruix | 2012 | Journal of Hepatology2012，，6： | 3 |
| 12 | Factors related to quality of life in patients with cirrhosis and ascites: Relevance of serum sodium concentration and leg edema显示文摘 | Elsa Solà Hugh Watson Isabel Graupera Fanny Turón Rogelio Barreto Ezequiel Rodríguez Marco Pavesi Vicente Arroyo Mónica Guevara Pere Ginès | 2012 | Journal of Hepatology2012，，6： | 3 |
| 13 | Food groups, diet quality and colorectal cancer risk in the Basque Country显示文摘BACKGROUND The results obtained to date concerning food groups,diet quality and colorectal cancer(CRC)risk vary according to criteria used and the study populations.AIM To study the relationships between food groups,diet quality and CRC risk,in an adult population of the Basque Country(North of Spain).METHODS This observational study included 308 patients diagnosed with CRC and 308 ageand sex-matched subjects as controls.During recruitment,dietary,anthropometric,lifestyle,socioeconomic,demographic and health status information was collected.Adherence to the dietary recommendations was evaluated utilizing the Healthy Eating Index for the Spanish Diet and the MedDietScore.Conditional logistic regressions were used to evaluate the associations of food group intakes,diet quality scores,categorized in tertiles,with CRC risk.RESULTS The adjusted models for potential confounding factors showed a direct association between milk and dairy products consumption,in particular high-fat cheeses[odds ratio(OR)third tertile vs first tertile=1.87,95%confidence intervals(CI):1.11-3.16],and CRC risk.While the consumption of fiber-containing foods,especially whole grains(OR third tertile vs first tertile=0.62,95%CI:0.39-0.98),and fatty fish(OR third tertile vs first tertile=0.53,95%CI:0.27-0.99)was associated with a lower risk for CRC.Moreover,higher MD adherence was associated with a reduced CRC risk in adjusted models(OR third tertile vs first tertile=0.40,95%CI:0.20-0.80).CONCLUSION Direct associations were found for high-fat cheese,whereas an inverse relation was reported for fiber-containing foods and fatty fish,as well as adherence to a Mediterranean dietary pattern. | Iker Alegria-Lertxundi Carmelo Aguirre Luis Bujanda Francisco J Fernandez Francisco Polo JoseMªOrdovas MªCarmen Etxezarraga Inaki Zabalza Mikel Larzabal Isabel Portillo Marian M de Pancorbo Koldo Garcia-Etxebarria Ana MªRocandio Marta Arroyo-Izaga | 2020 | World Journal of Gastroenterology2020，26，28： | 3 |
| 14 | A framework infrageneric classification of Carex (Cyperaceae) and its organizing principles显示文摘Phylogenetic studies of Carex L.(Cyperaceae)have consistently demonstrated that most subgenera and sections are para-or polyphyletic.Yet,taxonomists continue to use subgenera and sections in Carex classification.Why?The Global Carex Group(GCG)here takes the position that the historical and continued use of subgenera and sections serves to(i)organize our understanding of lineages in Carex,(ii)create an identification mechanism to break the~2000 species of Carex into manageable groups and stimulate its study,and(iii)provide a framework to recognize morphologically diagnosable lineages within Carex.Unfortunately,the current understanding of phylogenetic relationships in Carex is not yet sufficient for a global reclassification of the genus within a Linnean infrageneric(sectional)framework.Rather than leaving Carex classification in its current state,which is misleading and confusing,we here take the intermediate steps of implementing the recently revised subgeneric classification and using a combination of informally named clades and formally named sections to reflect the current state of our knowledge.This hybrid classification framework is presented in an order corresponding to a linear arrangement of the clades on a ladderized phylogeny,largely based on the recent phylogenies published by the GCG.It organizes Carex into six subgenera,which are,in turn,subdivided into 62 formally named Linnean sections plus 49 informal groups.This framework will serve as a roadmap for research on Carex phylogeny,enabling further development of a complete reclassification by presenting relevant morphological and geographical information on clades where possible and standardizing the use of formal sectional names. | Eric H.Roalson Pedro Jiménez-Mejías Andrew L.Hipp Carmen Benítez-Benítez Leo P.Bruederle Kyong-Sook Chung Marcial Escudero Bruce A.Ford Kerry Ford Sebastian Gebauer Berit Gehrke Marlene Hahn Muhammad Qasim Hayat Mathias H.Hoffmann Xiao-Feng Jin Sangtae Kim Isabel Larridon Étienne Léveillé-Bourret Yi-Fei Lu Modesto Luceño Enrique Maguilla Jose IgnacioMárquez-Corro Santiago Martín-Bravo Tomomi Masaki Mónica Míguez Robert F.C.Naczi Anton A.Reznicek Daniel Spalink Julian R.Starr Uzma Tamara Villaverde Marcia J.Waterway Karen L.Wilson and Shu-Ren Zhang | 2021 | Journal of Systematics and Evolution2021，59，4： | 3 |
| 15 | Direct determination of 2,4,6-tricholoroanisole in wines by single-drop ionic liquid microextraction coupled with multicapillary column separation and ion mobility spectrometry detection显示文摘 | Isabel Márquez-Sillero Soledad Cárdenas Miguel Valcárcel | 2011 | Journal of Chromatography A2011，，42： | 2 |
| 16 | Drugs Associated with Hepatotoxicity and their Reporting Frequency of Liver Adverse Events in VigiBase(TM)显示文摘 | Suzuki Ayako Andrade Raul J Bjornsson Einar Lucena M Isabel Lee William M Yuen Nancy A Hunt Christine M Freston James W | 2010 | Drug Safety2010，，6： | 2 |
| 17 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 18 | Assessing the estrogenic potency in a Portuguese wastewater treatment plant using an integrated approach显示文摘The estrogenic potency of a wastewater treatment plant(WWTP) was evaluated using chemical and biological analyses,which showed that after the station treatment processes some of the selected endocrine disruptor compounds(EDCs) were still present in the treated effuent(e.g.,bisphenol A,alkylphenols,estrone) .Thus,the most common endocrine EDCs were identified and quantified and the overall estrogenicity of the treated effuent assessed by integrating the results.Male goldfish(Carassius auratus) were used as biological indicators in a 28-day experiment.Vitellogenin(Vtg) ,gonadosomatic and hepatosomatic indices,steroids(17β-estradiol and 11-ketotestosterone) and histopathology were biomarkers used in fish to evaluate WWTP treated effuent estrogenicity,in combination with instrumental analyses.The results showed a significant increase(P<0.01) in plasma and liver Vtg,which were significantly correlated(r=0.66;P<0.01) .The gonadosmatic index was significantly(P<0.01) reduced in exposed fish.The steroid analyses revealed significant elevations in 17β-estradiol and depressed 11-ketotestosterone concentrations.The histological examinations show changes in exposed fish gonads,such as regressed testes and in some cases(43%to 75%) the development of ovo-testis in fish exposed to 50% and 100% treated effuent. | Mário S.Diniz Rita Maurício Mira Petrovic Maria J.López De Alda Leonor Amaral Isabel Peres Damiá Barceló Fernando Santana | 2010 | Journal of Environmental Sciences2010，22，10： | 2 |
| 19 | INTESTINAL CYTOSKELETON DEGRADATION PRECEDES TIGHT JUNCTION LOSS FOLLOWING HEMORRHAGIC SHOCK显示文摘 | Geertje Thuijls Jacco-Juri de Haan Joep P. M. Derikx Isabelle Daissormont M’hamed Hadfoune Erik Heineman Wim A. Buurman | 2009 | SHOCK2009，，2： | 2 |
| 20 | Adverse hepatic reactions associated with calcium carbimide and disulfiram therapy: Is there still a role for these drugs?显示文摘四乙秋兰姆化二硫和钙 carbimide 是二白酒威慑然而,广泛地在那里在酒精中毒治疗使用的狂言存在对他们的安全的大担心。hepatotoxicity 上的报告主要与四乙秋兰姆化二硫治疗有关,被出版了。钙 carbimide 的肝毒素的潜力是很好描绘的更少。这里,我们描述与被提交到 hepatotoxicity 的一张注册表并且当规定这些混合物时,指出我们面对的限制的这个治疗学的组有关的肝损坏的四个案例。对在白酒依赖的管理的这些混合物的角色的重估清楚地被需要。 | Carmen Verge M Isabel Lucena Enrique López-Torres M José Puche-García Enrique Fraga Manuel Romero-Gomez Raúl J Andrade | 2006 | World Journal of Gastroenterology2006，12，31： | 2 |
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