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| 1 | Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”显示文摘Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, S.aureus intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure. | Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan | 2019 | Bone Research2019，7，3： | 19 |
| 2 | Sex differences in cognitive impairment in Alzheimer's disease显示文摘Sex differences in neurocognitive abilities have been extensively explored both in the healthy population andin many disorders. Until recently, however, little work has examined such differences in people with Alzheimer's disease(AD). This is despite clear evidence that AD is more prevalent in women, and converging lines of evidence from brain imaging, post-mortem analyses, hormone therapy and genetics suggesting that AD affects men and women differently. We provide an overview of evidence attesting to the poorer cognitive profiles in women than in men at the same stage of AD. Indeed, men significantly outperform women in several cognitive domains, including: Language and semantic abilities, visuospatial abilities and episodic memory. These differences do not appear to be attributable to any differences in age, education, or dementia severity. Reasons posited for this female disadvantage include a reduction of estrogen in postmenopausal women, greater cognitive reserve in men, and the influence of the apolipoprotein E ε4 allele. Assessment of cognitive abilities contributes to the diagnosis of the condition and thus, it is crucial to identify the role of sex differences if potentially more accurate diagnoses and treatments are to emerge. | Keith R Laws Karen Irvine Tim M Gale | 2016 | World Journal of Psychiatry2016，6，1： | 18 |
| 3 | Phosphorylcholine polymer nanocapsules prolong the circulation time and reduce the immunogenicity of therapeutic proteins显示文摘蛋白质治疗,治疗学的蛋白质在那里被交付对待混乱,为治疗疾病被认为最安全、很直接的途径。然而,它的应用被有效策略的少量高度为在他们的管理以后在 vivo 交付蛋白质和治疗学的蛋白质的快速的清理限制。这里,我们表明能显著地延长治疗学的蛋白质的发行量时间以及最小化他们的 immunogenicity 的新奇策略。这被与抵抗蛋白质吸附的 crosslinked phosphorylcholine 聚合物的薄层包含单个蛋白质分子完成。通过广泛的细胞的研究,我们证明 crosslinked phosphorylcholine 聚合物壳有效地阻止包含的蛋白质是由巨噬细胞的 phagocytosed,它在 vivo 在 nanoparticles 的清理起一个必要作用。而且,聚合物壳阻止包含的蛋白质被有免疫力的房间识别。作为结果,对治疗学的蛋白质的有免疫力的回答有效地被压制。这个工作描述一个可行方法延长循环时间并且减少治疗学的蛋白质的 immunogenicity,它可以在多样的疾病的治疗支持新奇蛋白质治疗的发展和申请。 | Sheng Liang Yang Liu Xin Jin Gan Liu Jing Wen Linlin Zhang Jie Li Xubo Yuan Irvin S.Y. Chen Wei Chen Hui Wang Linqi Shi Xinyuan Zhu Yunfeng Lu | 2016 | Nano Research2016，9，4： | 11 |
| 4 | Interleukin-7 Receptor Signaling Network:An Integrated Systems Perspective显示文摘Interleukin-7 (IL-7) is an essential cytokine for the development and homeostatic maintenance of T and B lymphocytes. Binding of IL-7 to its cognate receptor,the IL-7 receptor (IL-7R),activates multiple pathways that regulate lymphocyte survival,glucose uptake,proliferation and differentiation. There has been much interest in understanding how IL-7 receptor signaling is modulated at multiple interconnected network levels. This review examines how the strength of the signal through the IL-7 receptor is modulated in T and B cells,including the use of shared receptor components,signaling crosstalk,shared interaction domains,feedback loops,integrated gene regulation,multimerization and ligand competition. We discuss how these network control mechanisms could integrate to govern the properties of IL-7R signaling in lymphocytes in health and disease. Analysis of IL-7 receptor signaling at a network level in a systematic manner will allow for a comprehensive approach to understanding the impact of multiple signaling pathways on lymphocyte biology. | Megan J. Palmer Vinay S. Mahajan Lily C. Trajman Darrell J. Irvine Douglas A.Lauffenburger Jianzhu Chen | 2008 | Cellular & Molecular Immunology2008，5，2： | 8 |
| 5 | Gastroenteropancreatic neuroendocrine tumours显示文摘 | Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin | 2008 | Lancet Oncology2008，，1： | 8 |
| 6 | 太阳能发电面临的挑战与机遇(英文)显示文摘在所有可再生能源中,光伏太阳能只占一小部分,然而在早期采用它的国家中,如日本和德国,却对全球工业体系起到了促进作用,对未来能源需求产生了意义深远的影响。讨论了光伏模块的当前成本和计划中的成本以及为了拓宽光伏太阳能的应用,材料科学能够为降低此成本壁垒而作出贡献的途径。文章对当前统辖市场的相对成熟的单晶硅光伏电池和有可能降低光伏模块成本的薄膜光伏电池进行了比较,指出薄膜光伏电池的转换效率需要提高而且应该能够进行大规模生产。文中给出了当前碲化镉光伏电池材料研究的一些实例,并对它们应如何在将来进行改进提出了建议。 | Stuart James Curzon Irvine Anne Stafford | 2007 | 电网技术2007，31，20： | 6 |
| 7 | A 5‐decade analysis of 13,715 carcinoid tumors显示文摘 | Irvin M.Modlin Kevin D.Lye MarkKidd | 2003 | Cancer2003，，4： | 6 |
| 8 | The Epidemiology of Gastroenteropancreatic Neuroendocrine Tumors显示文摘 | Ben Lawrence Bjorn I. Gustafsson Anthony Chan Bernhard Svejda Mark Kidd Irvin M. Modlin | 2011 | Endocrinology and Metabolism Clinics of North America2011，，1： | 6 |
| 9 | The diagnosis and management of adult intussusception显示文摘 | Dennis G. Begos Andras Sandor Irvin M. Modlin | 1997 | The American Journal of Surgery1997，，2： | 4 |
| 10 | 产业集群协同创新赋能企业核心竞争力研究——以绿色食品产业集群为例显示文摘本研究在构建企业核心竞争力与外部可观测特征关系模型的基础上,基于淮安、宿迁、徐州地区880家绿色食品产业集群成员企业的调查数据,评价绿色食品产业集群协同创新对成员企业核心竞争力的赋能效应,诊断制约绿色食品产业集群协同创新的主要因素。研究发现:企业深度参与产业集群协同创新,核心竞争力显著增强,赋能效果好;企业不具备协同创新条件,无协同创新实质活动,赋能效果差。在制约企业参与协同创新的主要因素中,资金最为关键。在技术层面需要加快推动绿色食品技术研发,在机制层面上需要以企业为创新主体,“产—学—研”“校—政—企”深度融合,完善成果转化、攻坚激励、要素保障等机制。 | 黄妍 Mark Irvin C.Celis 王国栋 | 2022 | 江苏大学学报(社会科学版)2022，24，4： | 4 |
| 11 | Neuroendocrine tumor epidemiology显示文摘 | OyvindHauso Bjorn I.Gustafsson MarkKidd Helge L.Waldum IgnatDrozdov Anthony K. C.Chan Irvin M.Modlin | 2008 | Cancer2008，，10： | 3 |
| 12 | Editor’s note显示文摘In recent years, driven by ever-increasing market demand in computing, communication, and multimedia applications, the microelectronics industry has undergone rapid development. Because of technical innovation and advances in almost all aspects of materials, processes, equipment, devices, circuits and systems, siliconbased logic and memory IC technologies using nano-scaling continue to be the industry's major R&D focus. This maintains microelectronics industry adherence to the traditional 'Moore's Law', increasing the | HUANG Ru, Guest Editor Peking University Beijing 100871, China ZHAO Bin, Guest Editor Fairchild Semiconductor 32 Discovery, Irvine, CA 92618, USA WANG RunSheng, Guest Editor Assistant CAI YiMao, Guest Editor Assistant Peking University Beijing 100871, China | 2011 | Science China(Information Sciences)2011，54，5： | 3 |
| 13 | B/N掺杂富含{001}晶面锐钛矿TiO_2的最佳可见光光电催化水氧化活性研究(英文)显示文摘本文以锐钛矿TiO_2微米球光催化材料为研究对象,其表面主要由{001}晶面组成,间隙掺杂硼原子在微米球中呈浓度梯度分布,浓度最高点位于表面.通过对其在氨气气氛、不同温度下(440–560℃)进行热处理,可实现氮替代晶格氧的掺杂,氮原子掺杂的浓度随着热处理温度的增加,由7.03增加到15.47 at%.随着掺杂氮浓度的增加,所得掺杂TiO_2微米球的可见光吸收强度相应提高.进一步研究所得掺杂TiO_2微米球的可见光光吸收、原子和电子结构与可见光光电催化水氧化活性的关联特性,发现在520℃下所得氮掺杂TiO_2的可见光光电催化水氧化活性最大,该样品吸收光谱的显著特征是在可见光区吸光率高,且没有与缺陷相关联的背底吸收. | 洪星星 康宇阳 甄超 康向东 尹利长 John TS Irvine 王连洲 刘岗 成会明 | 2018 | Science China Materials2018，61，6： | 2 |
| 14 | Endoscopic ultrasound sedation in the United Kingdom: Is life without propofol tolerable?显示文摘There is compelling evidence to support the quality,cost effectiveness and safety profile of non-anesthesiologist-administered propofol for endoscopic ultrasound (EUS). However in the United Kingdom, it is recommended that the administration and monitoring of propofol sedation for endoscopic procedures should be the responsibility of a dedicated and appropriately trained anaesthetist only. The majority of United Kingdom EUS procedures are performed with opiate and benzodiazepine sedation rather than anaesthetist led propofol lists due to anaesthetist resource availability. We sought to prospectively determine the tolerability and safety of EUS with benzodiazepine and opiate sedation in single United Kingdom centre. Two hundred consecutive patients undergoing either EUS or oesophago-gastroduodenoscopy (OGD) with conscious sedation were prospectively recruited with a 1:1 enrolment ratio. Patients completed questionnaires pre and post procedure detailing anticipated and actual pain experienced on a 1-10 visual analogue scale. Demographics, procedure duration, sedation doses and willingness to repeat the procedure were also recorded. EUS procedures lasted significantly longer than OGDs(15 min vs 6 min, P < 0.0001), however, there was no difference in anticipated pain scores between the groups(EUS 3.37/10 vs OGD 3.47/10, P = 0.46). Pain scores indicated EUS was better tolerated than OGD(1.16/10 vs 1.88/10, P = 0.03) although higher doses of sedation were used for EUS procedures. There were no complications identified in either group. We feel our study demonstrates that the tolerability of EUS with opiate and benzodiazepine sedation is acceptable. | Jennifer Anne Campbell Andrew James Irvine Andrew Derek Hopper | 2017 | World Journal of Gastroenterology2017，23，3： | 2 |
| 15 | <ce:link locator='fx1'/> A Review of Activity Indices and Efficacy End Points for Clinical Trials of Medical Therapy in Adults With Ulcerative Colitis显示文摘 | Geert D’Haens William J. Sandborn Brian G. Feagan Karel Geboes Stephen B. Hanauer E. Jan Irvine Marc Lémann Philippe Marteau Paul Rutgeerts Jurgen Sch?lmerich Lloyd R. Sutherland | 2007 | Gastroenterology2007，，2： | 2 |
| 16 | Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration显示文摘AIM:To develop a model of stress-induced senescence to study the hepatocyte senescence associated secretory phenotype(SASP).METHODS:Hydrogen peroxide treatment was used to induce senescence in the human Hep G2 hepatocyte cell line.Senescence was confirmed by cytochemical staining for a panel of markers including Ki67,p21,heterochromatin protein 1β,and senescence-associated-β-galactosidase activity.Senescent hepatocytes were characterised by gene expression arrays and quantitative polymerase chain reaction(q PCR),and conditioned media was used in proteomic analyses,a human chemokine protein array,and cell migration assays to characterise the composition and function of the hepatocyte SASP.RESULTS:Senescent hepatocytes induced classical markers of senescence(p21,heterochromatin protein1β,and senescence-associated-β-galactosidase activity);and downregulated the proliferation marker,Ki67.Hepatocyte senescence induced a 4.6-fold increase in total secreted protein(P=0.06)without major alterations in the protein profile.Senescence-induced genes were identified by microarray(Benjamini Hochbergcorrected P<0.05);and,consistent with the increase in secreted protein,gene ontology analysis revealed a significant enrichment of secreted proteins among inducible genes.The hepatocyte SASP included characteristic factors such as interleukin(IL)-8 and IL-6,as well as novel components such as SAA4,IL-32and Fibrinogen,which were validated by q PCR and/or chemokine protein array.Senescent hepatocyteconditioned medium elicited migration of inflammatory(granulocyte-macrophage colony stimulating factor,GM-CSF-derived),but not non-inflammatory(CSF-1-derived)human macrophages(P=0.022),which could contribute to a pro-inflammatory microenvironment in vivo,or facilitate the clearance of senescent cells.CONCLUSION:Our novel model of hepatocyte senescence provides insights into mechanisms by which senescent hepatocytes may promote chronic liver disease pathogenesis. | Katharine M Irvine Richard Skoien Nilesh J Bokil Michelle Melino Gethin P Thomas Dorothy Loo Brian Gabrielli Michelle M Hill Matthew J Sweet Andrew D Clouston Elizabeth E Powell | 2014 | World Journal of Gastroenterology2014，20，47： | 2 |
| 17 | On the Dynamic Response of a Suspended Cable显示文摘 | H M Irvine J H Griffin | 1974 | Earthquake Engineering and Structural Dynamics1974，4，： | 2 |
| 18 | 前蛋白转化酶枯草溶菌素9变异、低密度脂蛋白胆固醇与神经认知功能损害的关系显示文摘尽管之前的研究引发了对抑制前蛋白转化酶枯草溶菌素9(proprotein convertase subtilisin/kexintype9,PCSK9)造成神经认知功能损害事件的关注,但近期一个第3期随机试验并没有发现药物性PCSK9抑制与神经认知损害有关。 | 黄洁 叶鹏 Mefford MT Rosenson RS Cushman M Farkouh ME McClure LA Wadley VG Irvin MR Bittner VA Safford MM Somaratne R Monda KL Muntner P Levitan EB | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 19 | Standardized measurement of the future liver remnant prior to extended liver resection: Methodology and clinical associations显示文摘 | Jean-Nicolas Vauthey Amin Chaoui Kim-Anh Do Malcolm M Bilimoria Marc J Fenstermacher Chuslip Charnsangavej Marshall Hicks Guido Alsfasser Gregory Lauwers Irvin F Hawkins James Caridi | 2000 | Surgery2000，，5： | 2 |
| 20 | A Critical Review of Epidemiological Studies in Inflammatory Bowel Disease显示文摘 | F. Farrokhyar E. T. Swarbrick E. Jan Irvine | 2001 | Scandinavian Journal of Gastroenterology2001，，1： | 2 |
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