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| 1 | α-淀粉酶抑制剂AAI的核磁共振氢谱谱峰归属及结构分析显示文摘α -淀粉酶抑制剂AAI(α -AmylaseInhibitor)是从墨西哥苋属植物Amaranthushypochondriacus种子中提取的由32个氨基酸残基组成的多肽。它能强烈地抑制几种昆虫幼虫的α -淀粉酶活性 ,而不抑制人及哺乳类动物的α -淀粉酶活性。使用核磁共振方法收集了AAI的二维氢谱谱图 ,完成了全部主链和绝大部分侧链质子共振峰的序列归属 ,并利用X -PLOR软件计算出AAI的三维结构。AAI由三股反平行 β-折叠片与三对二硫键组成抑制剂胱氨酸结模体(inhibitorcystine -knotmotif)结构,与来自虎纹捕鸟蛛的神经毒素HWTX -I和凝集素SHL -I及其它来源的多种小分子活性多肽的结构类似 ,但它们的生物活力各不相同 ,表明该模体适用于结构功能关系的比较研究和作为蛋白质工程活力改造的结构骨架 (scaffold)。AAI对昆虫α -淀粉酶具有专一活性 ,可用于通过转基因技术来赋予植物抗虫活性。 | 邓鹏翅 吕善运 罗静初 Sandor Pongor 刘修才 曲红 梁宋平 韩汝珊 顾孝诚 | 2000 | 生物物理学报2000，16，3： | 7 |
| 2 | Protein and non-protein sulfhydryls and disulfides in gastric mucosa and liver after gastrotoxic chemicals and sucralfate: Possible new targets of pharmacologic agents显示文摘瞄准:在化学上导致的胃的出血性的粘膜损害(HML ) 和 sucralfate 的胃的保护的效果的机制调查主要非蛋白质和蛋白质 sulfhydryls 和二硫化物的角色。方法:老鼠 intragastrically 被给 75% 乙醇, 25% NaCl, 0.6 mol/L HCl, 0.2 mol/L NaOH 或 1% 氨溶液的 1 mL (i.g ) 并且牺牲了 1, 3, 6 或 12 min 以后。全部(减少并且氧化) 谷胱甘肽(GSH + GSSG ) ,谷胱甘肽二硫化物(GSSG ) ,蛋白质免费 sulfhydryls (PSH ) ,蛋白质谷胱甘肽混合了二硫化物(PSSG ) ,蛋白质胱氨酸二硫化物(PSSP ) 在胃粘膜和肝被测量。结果:当氧化谷胱甘肽(GSSG ) 集中增加了时,减少的谷胱甘肽(GSH ) 在乙醇, HCl 或 NaCl 暴露以后在胃粘膜被弄空,除了由 HCl 和 NaOH 暴露。在到乙醇的暴露以后的 PSH 的减少的层次被观察, NaCl 或 NaOH 当全部的蛋白质二硫化物被增加时。比率归结为氧化谷胱甘肽或到二硫化物的 sulfhydrils 被所有化学药品减少。在 i.g 缩写第一次应该这里被拼出以后,在巯基动态平衡的变化都没在肝被检测乙醇的管理。Sucralfate 增加了 GSH 和 PSH 的集中并且在胃的粘膜巯基集中阻止了导致乙醇的变化。结论:我们的修改方法现在在胃粘膜或肝对主要蛋白质和非蛋白质 thiols/disulfides 的直接大小合适。在化学上导致的 HML 的致病并且在胃的保护的药的机制的一个普通元素似乎是象蛋白质 sulfhydryls 和二硫化物一样的减少并且氧化的谷胱甘肽的减少的比率。 | Lajos Nagy Miki Nagata Sandor Szabo | 2007 | World Journal of Gastroenterology2007，13，14： | 6 |
| 3 | 北京地区不同大豆品种异黄酮含量比较研究显示文摘异黄酮是大豆生长过程中自然产生的化学物质,被认为可以治疗和预防一些人类依赖激素的疾病。为比较北京地区生态条件下大豆品种间异黄酮含量的差异性,对53个品种种子中3种异黄酮(大豆苷元、染料木素和黄豆黄素)进行测定和分析。结果表明,品种间异黄酮含量存在较大多样性,大豆苷元为39.21-2 363.65μg/g,染料木素为77.35-1 149.50μg/g,黄豆黄素为0.0-51.30μg/g,3种异黄酮总量为146.73-2 845.60μg/g。来自山西和山东品种的异黄酮含量显著高于其他地区的品种。异黄酮总量分别与大豆苷元和染料木素呈极显著正相关,而大豆苷元和染料木素之间没有互作。因此,可以利用高含量大豆苷元或染料木素材料选育高异黄酮品种。 | 谢皓 Gyorgy Vegvari Gergo Sandor 南张杰 陈学珍 | 2009 | 中国粮油学报2009，24，5： | 5 |
| 4 | The diagnosis and management of adult intussusception显示文摘 | Dennis G. Begos Andras Sandor Irvin M. Modlin | 1997 | The American Journal of Surgery1997，，2： | 4 |
| 5 | 右位心的心脏畸形及其结局:一项基于群体的研究显示文摘右位心的发生率及其伴随的心脏、非心脏畸形尚不清楚。目前缺乏关于右位心结局的信息,不足以对患儿双亲进行预后咨询。对1985—2001年间一所三级医院中因为胚胎发育异常而导致的所有右位心进行了回顾性研究。共确诊了81例病例(48例在产前确诊)。 | Bohun C.M. Potts J.E. Casey B.M. Sandor G.G.S. 徐永城 | 2007 | 世界核心医学期刊文摘(心脏病学分册)2007，，11： | 3 |
| 6 | Evolution of disease phenotype in adult and pediatric onset Crohn's disease in a population-based cohort显示文摘AIM:To investigate the evolution of disease phenotypein adult and pediatric onset Crohn's disease(CD) populations,diagnosed between 1977 and 2008.METHODS:Data of 506 incident CD patients were analyzed(age at diagnosis:28.5 years,interquartile range:22-38 years).Both in-and outpatient records were collected prospectively with a complete clinical follow-up and comprehensively reviewed in the population-based Veszprem province database,which included incident patients diagnosed between January 1,1977 and December 31,2008 in adult and pediatric onset CD populations.Disease phenotype according to the Montreal classification and long-term disease course was analysed according to the age at onset in time-dependent univariate and multivariate analysis.RESULTS:Among this population-based cohort,seventy-four(12.8%) pediatric-onset CD patients were identified(diagnosed ≤ 17 years of age).There was no significant difference in the distribution of disease behavior between pediatric(B1:62%,B2:15%,B3:23%) and adult-onset CD patients(B1:56%,B2:21%,B3:23%) at diagnosis,or during follow-up.Overall,the probability of developing complicated disease behaviour was 49.7% and 61.3% in the pediatric and 55.1% and 62.4% in the adult onset patients after 5-and 10-years of follow-up.Similarly,time to change in disease behaviour from non stricturing,non penetrating(B1) to complicated,stricturing or penetrating(B2/B3) disease was not significantly different between pediatric and adult onset CD in a Kaplan-Meier analysis.Calendar year of diagnosis(P = 0.04),ileal location(P < 0.001),perianal disease(P < 0.001),smoking(P = 0.038) and need for steroids(P < 0.001) were associated with presence of,or progression to,complicated disease behavior at diagnosis and during follow-up.A change in disease location was observed in 8.9% of patients and it was associated with smoking status(P = 0.01),but not with age at diagnosis.CONCLUSION:Long-term evolution of disease behavior was not different in pediatric-and adult-onset CD patients in this population-based cohort but was associated to location,perianal disease and smoking status. | Barbara Dorottya Lovasz Laszlo Lakatos Agnes Horvath Istvan Szita Tunde Pandur Michael Mandel Zsuzsanna Vegh Petra Anna Golovics Gabor Mester Mihaly Balogh Csaba Molnar Erzsebet Komaromi Lajos Sandor Kiss Peter Laszlo Lakatos | 2013 | World Journal of Gastroenterology2013，19，14： | 2 |
| 7 | Correlation of mechanical properties in bulk metallic glasses with ^(27)Al NMR characteristics显示文摘We report 27Al NMR and magnetic susceptibility measurements of Zr and ZrHf-based bulk metallic glasses (BMGs). 27Al NMR Knight shift shows that there exists a clear correlation between the local electronic properties at Al sites and mechanical properties. In addition,magnetic susceptibility measurements also provide clues on the influence of the electronic states,especially the strong influence of d-orbital characteristics on the mechanical properties of toughness and hardness. | SANDOR Magdalena T KECSKES Laszlo J HE Qiang XU Jian WU Yue | 2011 | Chinese Science Bulletin2011，56，36： | 2 |
| 8 | Mechanism of Methylene Blue adsorption on hybrid laponite-multi-walled carbon nanotube particles显示文摘The kinetics of adsorption and parameters of equilibrium adsorption of Methylene Blue(MB)on hybrid laponite-multi-walled carbon nanotube(NT)particles in aqueous suspensions were determined.The laponite platelets were used in order to facilitate disaggregation of NTs in aqueous suspensions and enhance the adsorption capacity of hybrid particles for MB.Experiments were performed at room temperature(298 K),and the laponite/NT ratio(X_l)was varied in the range of 0–0.5.For elucidation of the mechanism of MB adsorption on hybrid particles,the electrical conductivity of the system as well as the electrokinetic potential of laponite-NT hybrid particles were measured.Three different stages in the kinetics of adsorption of MB on the surface of NTs or hybrid laponite-NT particles were discovered to be a fast initial stage Ⅰ(adsorption time t=0–10 min),a slower intermediate stage Ⅱ(up to t=120 min)and a long-lasting final stage Ⅲ(up to t=24 hr).The presence of these stages was explained accounting for different types of interactions between MB and adsorbent particles,as well as for the changes in the structure of aggregates of NT particles and the long-range processes of restructuring of laponite platelets on the surface of NTs.The analysis of experimental data on specific surface area versus the value of X_l evidenced in favor of the model with linear contacts between rigid laponite platelets and NTs.It was also concluded that electrostatic interactions control the first stage of adsorption at low MB concentrations. | Maryna Manilo Nikolai Lebovka Sandor Barany | 2016 | Journal of Environmental Sciences2016，28，4： | 2 |
| 9 | mRNA expression, functional profiling and multivariate classification of colon biopsy specimen by cDNA overall glass microarray显示文摘AIM: To understand the local pathophysiological altera- tions and gene ontology-based functional classification of colonic biopsies into inflammatory and neoplastic dis- eases. METHODS: Total RNA was extracted from frozen biop- sies and amplified by T7-method. Expression profile was evaluated by Atlas Glass 1K microarrays. After microar- ray quality control, applicable data were available from 10 adenomas, 6 colorectal adenocarcinomas (CRCs), and 6 inflammatory bowel diseases (IBDs). Multivariate statistical and cell functional analyses were performed. Real-time RT-PCR and immunohistochemistry were used for validation. RESULTS: Discriminant analysis of selected genes, could correctly reclassify all 22 samples using 4 parameters (heat shock transcription factor-1, bystin-like, calgranu- lin-A, TRAIL receptor 3). IBD samples were characterized by overregulated chemokine (C-X-C motif) ligand 13, replication protein A1, E74-like factor 2 and downregu- lated TNF receptor-associated factor 6, BCL2-interacting killer genes. In adenomas upregulation of TNF receptor- associated factor 6, replication protein A1, E74-like factor 2 and underexpression of BCL2-associated X protein, cal- granulin-A genes were found. CRC cases had significantly increased epidermal growth factor receptor, topoisomer- ase-1, v-jun, TNF receptor-associated factor 6 and TRAIL receptor 3, and decreased RAD51 and RAD52 DNA repair gene, protein phosphatase-2A and BCL2-interacting killer mRNA levels. Epidermal growth factor receptor RT-PCR and immunohistochemistry, topoisomerase-1 RT-PCRconfirmed the chip results. CONCLUSION: Different histological alterations can be reclassified by functional, multivariate analysis using cDNA microarrays. Further studies with expanded sample number are needed for subclassification of pathological alterations. | Orsolya Galamb Ferenc Sipos Elek Dinya Sandor Spisak Zsolt Tulassay Bela Molnar | 2006 | World Journal of Gastroenterology2006，12，43： | 2 |
| 10 | 计算直齿轮的啮合效率显示文摘直齿轮的总效率通常是根据三种类型的功率损失:齿轮啮合、轴承和间隙或者搅拌阻力。一般计算假设外啮合的齿轮效率是E=0.98,内啮合的齿轮效率是E=0.99。但是基于这样的假设,计算功率损失会导致设计中在计算其它系数时的大错误。 | SANDOR J.BARANYI 汤伟林 | 1989 | 机械1989，16，6： | 2 |
| 11 | 应用“A”型外展支具治疗股骨头缺血性坏死疗效分析显示文摘股骨头缺血性坏死的最佳治疗方法一直存在争议。包容治疗和手术包容治疗各有利弊。近期多中心的研究结果显示对于中度的股骨头缺血性坏死病变采用股骨或骨盆截骨术其结果优于未手术的患者。但对于大龄和严重的股骨头坏死病例,其结果并不理想。 | 刘双 张立军 Sandor Kiss Tamas Terebessy Gyorgy Szoke Janos Kiss Imre Antal Miklos Szendroi | 2014 | 中国矫形外科杂志2014，22，7： | 2 |
| 12 | 抗癌药的临床前药物试验显示文摘药物筛选是肿瘤化疗的一个重要组成部份,是在50年代初由美国NCI主要依靠动物肿瘤模型发展起来的。新药筛选包括几个阶段:体外试验、体内试验和临床研究。体外试验,系使用动物或人的肿瘤细胞系,观察致死性损伤。如果药物体外有效,则转入体内筛选,主要使用小鼠肿瘤。NCI原来的筛选系统主要使用动物模型,不大依赖于体外试验。 | Sandor Kerpel- Fronius 李学汤 | 1989 | 癌症1989，8，2： | 2 |
| 13 | The diagnosis and management of adult intussusception显示文摘 | Begos DC Sandor A Modlin IM | 1997 | Am J Surg1997，173，1： | 1 |
| 14 | On certain generalizations of the Smarandache function显示文摘 | Sandor J | 1999 | Notes on Number Theory and Discrete Mathematics1999，5，2： | 1 |
| 15 | Elec trical conductivities in oil-bearing shaly sand accurately described with the SATORI saturation model显示文摘 | De Kuijper A Sandor R K J Hofman J P | 1996 | The Log Analyst1996，37，5： | 1 |
| 16 | Normobaric hypoxia and nitroglycerin as trigger factors for migraine显示文摘 | Schoonman GG Sandor PS Agosti RM | 2006 | Cephalalgia2006，26，7： | 1 |
| 17 | Molecular and cellular basis of ulcer healing 显示文摘 | SZABO S KUSSTATSCHER S SANDOR Z | | Scand J Gastroenterol0，，： | 1 |
| 18 | Clindamycin in dentistry:More than just effective prophylaxis for endocarditis显示文摘 | Brook I Lewis M A O Sandor G K B | 2005 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2005，100，： | 1 |
| 19 | An analysis of 8305 cases of carcinoid tumors显示文摘 | Modlin IM Sandor A | 1997 | Cancer1997，79，4： | 1 |
| 20 | 3D printed fiber-optic nanomechanical bioprobe显示文摘Ultrasensitive nanomechanical instruments,e.g.atomic force microscopy(AFM),can be used to perform delicate biomechanical measurements and reveal the complex mechanical environment of biological processes.However,these instruments are limited because of their size and complex feedback system.In this study,we demonstrate a miniature fiber optical nanomechanical probe(FONP)that can be used to detect the mechanical properties of single cells and in vivo tissue measurements.A FONP that can operate in air and in liquids was developed by programming a microcantilever probe on the end face of a single-mode fiber using femtosecond laser two-photon polymerization nanolithography.To realize stiffness matching of the FONP and sample,a strategy of customizing the microcantilever’s spring constant according to the sample was proposed based on structure-correlated mechanics.As a proof-of concept,three FONPs with spring constants varying from 0.421 N m^(−1)to 52.6 N m^(−1)by more than two orders of magnitude were prepared.The highest microforce sensitivity was 54.5 nmμN^(−1)and the detection limit was 2.1 nN.The Young’s modulus of heterogeneous soft materials,such as polydimethylsiloxane,muscle tissue of living mice,onion cells,and MCF-7 cells,were successfully measured,which validating the broad applicability of this method.Our strategy provides a universal protocol for directly programming fiber-optic AFMs.Moreover,this method has no special requirements for the size and shape of living biological samples,which is infeasible when using commercial AFMs.FONP has made substantial progress in realizing basic biological discoveries,which may create new biomedical applications that cannot be realized by current AFMs. | Mengqiang Zou Changrui Liao Yanping Chen Lei Xu Shuo Tang Gaixia Xu Ke Ma Jiangtao Zhou Zhihao Cai Bozhe Li Cong Zhao Zhourui Xu Yuanyuan Shen Shen Liu Ying Wang Zongsong Gan Hao Wang Xuming Zhang Sandor Kasas Yiping Wang | 2023 | International Journal of Extreme Manufacturing2023，5，1： | 1 |
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