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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Estimation of tibiofemoral static zero position during dynamic drop landing显示文摘 | Ida H Nagano Y Akai M | 2013 | The Knee2013，20，5： | 1 |
| 3 | Achyranthoside C and D, novel glucuronide saponins from Achyranthes fauriei Root 显示文摘 | IDA Y SATOH Y KATSUMATA M | 1995 | Chem Pharm Bull1995，43，5： | 1 |
| 4 | Kinetics of carbon dioxide sorption on potassium-doped lithium zirconate 显示文摘 | Xiong R T Ida J I Lin Y S | 2003 | Chem Eng Sci2003，58，19： | 1 |
| 5 | 查看详情显示文摘 | Lin Y S Yang Q Ida J | | 0，，03： | 1 |
| 6 | Linkages between phenonlogy,pollination,photosynthesis,and reproduction in deciduous forest understory plants显示文摘 | Kudo G Ida T Y Tani T | | 0，，02： | 1 |
| 7 | Cohesive force across the tip of a longitudinal shear crack and Griffith's specific surface energy显示文摘 | IDA Y | 1972 | Journal of Geophysical Research1972，77，20： | 1 |
| 8 | Synthesis and CO2 sorption properties of pure and modified lithium zireonate 显示文摘 | Ida J I Xiong R T Lin Y S | 2004 | Sepa ration and Purification Technol ogy2004，36，1： | 1 |
| 9 | On the statistical correlation of over-horizon VHF signals with meteorological radio ducting and seismicity显示文摘 | Yonaiguchi N Ida Y Hayakawa M | 2007 | Journal of Atmospheric and Solar-Terrestrial Physics2007，69，6： | 1 |
| 10 | IL-18 in pregnancy: me elevauon of IL-18 in maternal peripheral blood during labour and complicated pregnancies显示文摘 | Ida A Tsuji Y Muranaka J et at | 2000 | J Reprod Immunol2000，47，1： | 1 |
| 11 | IL-18 in pregnancy; the elevation of IL-18 in maternal peripheral blood during labour and complicated pregnancies 显示文摘 | IDA A TSUJI Y MURANAKA J | 2000 | J Reprod Immunol2000，47，1： | 1 |
| 12 | The isolation of multiple forms and product specificity of rice lipoxygenase 显示文摘 | Ida S Masaki Y Morita Y | 1983 | Agric Biol Chem1983，47，3： | 1 |
| 13 | Kinetics of carbon dioxide sorption on potassium-doped lithium zirconate显示文摘 | Xiong R Ida J Lin Y S | | 0，，19： | 1 |
| 14 | Kinetics of carbon dioxide sorption on potassium-doped lithium zirconate 显示文摘 | XIONG R IDA J I LIN Y S | 2003 | Chemical Engineering Science2003，58，19： | 1 |
| 15 | An object-oriented database system jasmine:implementation,application,and extension显示文摘 | Ishikawa H Yamame Y Izum Ida Y | 1996 | IEEE Transaction Knowledge and Data Engineering1996，8，2： | 1 |
| 16 | Synthesis and C02 sorption properties of pure and modified lithium zirconate 显示文摘 | IDA J I XIONG R LIN Y S | 2004 | Sep- aration and Purification Technology2004，36，1： | 1 |
| 17 | Catalytic activity of PAN-based active carbon fibre (PAN-ACF) activated with sulphuric acid for reduction of nitric oxide with ammonia显示文摘 | Komatsumara Y Ida S Fujitsu H | 1984 | Fuel1984，63，12： | 1 |
| 18 | Renal transport of adefovir,cidofovir,and tenofovir by SLC22 family members (hOAT1,hOAT3,and hOCT2)显示文摘 | Uwai Y Ida H Tsuji Y | | 0，，4： | 1 |
| 19 | Synthesis and CO2 sorption properties of pure and modified lithium zirconate显示文摘 | Ida J I Xiong R T Lin Y S | 2004 | Separation and Purification Technology2004，36，1： | 1 |
| 20 | Neural network approach for multicriteria solid transportation problem显示文摘 | Li Y Ida K Gen M Kobuchi R | 1977 | Computers and Industrial Engineering1977，33，： | 1 |
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