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| 1 | Current research on pharmacologic and regenerative therapies for osteoarthritis显示文摘Osteoarthritis(OA)is a degenerative joint disorder commonly encountered in clinical practice,and is the leading cause of disability in elderly people.Due to the poor self-healing capacity of articular cartilage and lack of specific diagnostic biomarkers,OA is a challenging disease with limited treatment options.Traditional pharmacologic therapies such as acetaminophen,non-steroidal anti-inflammatory drugs,and opioids are effective in relieving pain but are incapable of reversing cartilage damage and are frequently associated with adverse events.Current research focuses on the development of new OA drugs(such as sprifermin/recombinant human fibroblast growth factor-18,tanezumab/monoclonal antibody againstβ-nerve growth factor),which aims for more effectiveness and less incidence of adverse effects than the traditional ones.Furthermore,regenerative therapies(such as autologous chondrocyte implantation(ACI),new generation of matrix-induced ACI,cell-free scaffolds,induced pluripotent stem cells(iPS cells or iPSCs),and endogenous cell homing)are also emerging as promising alternatives as they have potential to enhance cartilage repair,and ultimately restore healthy tissue.However,despite currently available therapies and research advances,there remain unmet medical needs in the treatment of OA.This review highlights current research progress on pharmacologic and regenerative therapies for OA including key advances and potential limitations. | Wei Zhang Hongwei Ouyang Crispin R Dass Jiake Xu | 2015 | Bone Research2015，3，4： | 9 |
| 2 | The ethylene signaling pathway: new insights显示文摘 | Hongwei Guo Joseph R Ecker | 2003 | Current Opinion in Plant Biology2003，，1： | 2 |
| 3 | Cytokinin signaling regulates pavement cell morphogenesis in Arabidopsis显示文摘难题有交错的脑叶的塑造片的 Arabidopsis 叶人行道房间(PC ) 并且缩排是一个好模型系统调查在纸巾以内协调房间极性和形状形成的机制。植物生长素被显示了 GTPase 依赖的发信号由激活 ROP 协调 interdigitation 小径。识别另外的部件或机制,我们与反常 PC 形态发生为异种屏蔽了并且发现细胞激动素发信号调整 PC interdigitation 模式。在细胞激动素累积的减小和在细胞激动素发信号的缺点(例如在 ARR7-over-expressing 线, ahk3cre1 细胞激动素受体异种,和 ahp12345 细胞激动素表明异种) 提高的 PC interdigitation,而细胞激动素的生产过剩和细胞激动素在一根 ARR20 在表示上线发信号的在激活上在整个子叶推迟了或废除 PC interdigitation。基因、生物化学的分析建议表明 ROP 在上游的行为压制交错的模式的形成的那细胞激动素。我们的结果提供控制 PC 形状的小径的新奇机械学的理解并且揭开为细胞激动素在房间形态发生发信号的一个新角色。 | Hongjiang Li Tongda Xu Deshu Lin Mingzhang Wen M ingtang Xie Jērōme Duclercq Agnieszka Bielach Jungmook Kim G Venugopala Reddy Jianru Zuo Eva Benková Jiгi Friml Hongwei Guoz Zhenbiao Yang | 2013 | Cell Research2013，23，2： | 2 |
| 4 | Mechanoelectrical remodeling and arrhythmias during progression of hypertrophy 显示文摘 | Hongwei Jin ChemalyElie R Ahyoung Lee | 2010 | FASEB J2010，24，2： | 1 |
| 5 | The ethylene signaling pathway:New insights显示文摘 | GUO Hongwei Joseph R Ecker | 2004 | Plant Biology2004，，7： | 1 |
| 6 | Inductance control of the switched at low speed显示文摘 | Hongwei G model-based Salmasi F sensorless reluctance motor drive Transactions on Power 1568-1573 R Ehsani M | 2004 | IEEE Electronics2004，19，6： | 1 |
| 7 | Klotho suppresses RIG - 显示文摘 | Feng L Su W Hongwei R | 2011 | Nat Cell Biol2011，13，3： | 1 |
| 8 | Inductance model-based sensorless control of the switched reluctance motor drive at low speed显示文摘 | Gao Hongwei Salmasi F R Ehsani M | 2004 | IEEE Transactions on Power Electronics2004，19，6： | 1 |
| 9 | RDX-based nanocomposite microparticles for signifi-catly reduced shock sensitivity 显示文摘 | Qiu Hongwei Stepanov V Anthony R D S | 2011 | Journal of Hazar-dous Materials2011，185，1： | 1 |
| 10 | The ethylene signaling pathway:new insights显示文摘 | Guo Hongwei Ecker Joseph R | 2004 | Current Opinion in Plant Biology2004，7，1： | 1 |
| 11 | Electronic structure control of single-walled carbon nano- tube functionalization显示文摘 | Strano M S Dyke C A Usrey M L Barone P W Allen M J Hongwei S Carter K Hauge R H Tour J M Smalley R E | 2003 | Science2003，301，5639： | 1 |
| 12 | Role of histone deacetylase 2 in epi- genetics and cellular senescence: implications in lung in- flammaging and COPD显示文摘 | Hongwei Y Irfan R | 2012 | Am J Physiol: Lung Cell Mol Physiol2012，303，7： | 1 |
| 13 | Inductance model- based sensorless control of the switched reluctance motor drive at low speed显示文摘 | Hongwei G Salmasi F R | 2004 | IEEE Transactions on Power Electronics2004，19，6： | 1 |
| 14 | Apoptosis in the corneal epithelium显示文摘 | Hongwei R Graeme W | 1996 | Invest Ophthalmol Vis Sci1996，37，6： | 1 |
| 15 | 5-hydroxytryptamine-receptor antagonists versus prochlorperazine for control of delayed nausea caused by doxorubicin: a URCC CCOP randomised controlled trial显示文摘 | Jane T Hickok Joseph A Roscoe Gary R Morrow Christopher W Bole Hongwei Zhao Karen L Hoelzer Shaker R Dakhil Timothy Moore Tom R Fitch | 2005 | Lancet Oncology2005，，： | 1 |
| 16 | Inductance model-based sensorless control of the switched reluctance motor drive at low speed显示文摘 | Gao Hongwei Salmasi F R Ehsani M | 2004 | IEEE Transactions on Power Electronics2004，19，6： | 1 |
| 17 | Inductance model based sensorless control of the switched reluc tance motor drive at low speed显示文摘 | Gao Hongwei Salmasi F R Ehsani M | 2004 | IEEE Trans on Power Electronics2004，19，2： | 1 |
| 18 | SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice显示文摘 | Yao Hongwei Chung Sangwoon Hwang Jae-woong Rajendrasozhan Saravanan Sundar Isaac K Dean David A McBurney Michael W Guarente Leonard Gu Wei R?nty Mikko Kinnula Vuokko L Rahman Irfan | 2012 | EN2012，，6： | 1 |
| 19 | Plant Responses to Ethylene Gas Are Mediated by SCF EBF1/EBF2 -Dependent Proteolysis of EIN3 Transcription Factor显示文摘 | Hongwei Guo Joseph R Ecker | 2003 | Cell2003，，6： | 1 |
| 20 | Synthesis and properties of copolyimides derived from isometric biphenyltetracarboxylic dianhydrides(a-BPDA and i-BPDA) and oxydiphthalic dianhydride(ODPA) with 4,4'-oxydianiline(4,4'-ODA) 显示文摘 | Zhou Hongwei Chen Chunhai Kanbara R | 2005 | High Performance Polymers2005，17，2： | 1 |
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