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| 1 | QTG-Seq Accelerates QTL Fine Mapping through QTL Partitioning and Whole-Genome Sequencing of Bulked Segregant Samples显示文摘Deciphering the genetic mechanisms underlying agronomic traits is of great importance for crop improvement. Most of these traits are controlled by multiple quantitative trait loci (QTLs), and identifying the underlying genes by conventional QTL fine-mapping is time-consuming and labor-intensive. Here, we devised a new method, named quantitative trait gene sequencing (QTG-seq), to accelerate QTL fine-mapping. QTGseq combines QTL partitioning to convert a quantitative trait into a near-qualitative trait, sequencing of bulked segregant pools from a large segregating population, and the use of a robust new algorithm for identifying candidate genes. Using QTG-seq, we fine-mapped a plant-height QTL in maize (Zea mays L.), qPH7, to a 300-kb genomic interval and verified that a gene encoding an NF-YC transcription factor was the functional gene. Functional analysis suggested that qPH7-encoding protein might influence plant height by interacting with a CO-like protein and an AP2 domain-containing protein. Selection footprint ana卜 ysis indicated that qPH7 was subject to strong selection during maize improvement. In summary, QTG-seq provides an efficient method for QTL fine-mapping in the era of “big data'. | Hongwei Zhang Xi Wang Qingchun Pan Pei Li Yunjun Liu Xiaoduo Lu Wanshun Zhong Minqi Li Linqian Han Juan Li Pingxi Wang Dongdong Li Yan Liu Qing Li Fang Yang Yuan-Ming Zhang Guoying Wang Lin Li | 2019 | Molecular Plant2019，12，3： | 13 |
| 2 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 3 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 4 | Spectroscopic study on transformations of dissolved organic matter in coal-to-liquids wastewater under integrated chemical oxidation and biological treatment process显示文摘A large amount of wastewater containing various toxic organic contaminants is produced during coal-to-liquids process. In this study, several spectroscopic methods were used to monitor the transformation of organic pollutants during an integrated chemical oxidation and biological process. The results showed that the hydrophobic acid fraction increased after Fenton oxidation, which was likely due to the production of small-molecule organic acids. Soluble microbial products were generated during biological treatment processes,which were degraded after ozonation; meanwhile, the hydrophilic base and acid components increased. Ultraviolet-visible spectroscopic analysis indicated that peaks at the absorption wavelengths of 280 and 254 nm, which are associated with aromatic substances, were detected in the raw water. The aromatic substances were gradually removed, becoming undetectable after biological aeration filter(BAF) treatment. Fourier transform infrared spectroscopy analysis revealed that the functional groups of phenols;benzene, toluene, ethylbenzene, and xylene(BTEX); aromatic hydrocarbons; aliphatic acids;aldehydes; and esters were present in raw wastewater. The organic substances were oxidized into small molecules after Fenton treatment. Aromatic hydrocarbons were effectively removed through bioadsorption and biodegradation after BAF process.Biodegradable organic matter was reduced and finally became undetectable after anoxic–oxic treatment in combination with a membrane bioreactor. Four fluorescent components were fractionated and obtained via excitation–emission matrix parallel factor analysis(EEM-PARAFAC). Dissolved organic matter fractionation in conjunction with EEM-PARAFAC was able to monitor more precisely the evolution of characteristic organic contaminants. | Siwei Peng Xuwen He Hongwei Pan | 2018 | Journal of Environmental Sciences2018，30，8： | 9 |
| 5 | The impact of the new cooperative medical scheme on financial burden of tuberculosis patients: evidence from six counties in China显示文摘Background:Tuberculosis(TB)patients in China encounter heavy financial burdens throughout the course of their treatment and it is unclear how China’s health insurance systems affect the alleviation of this burden under the integrated approach.This study aimed to measure reimbursement for TB services under the New Cooperative Medical Scheme(NCMS)in rural China and to evaluate changes in catastrophic health expenditure(CHE)caused by the reimbursement policies.Methods:Reimbursement data were obtained from routine data systems for the NCMS in Yichang(YC)and Hanzhong(HZ).1884 TB inpatients reimbursed by NCMS from 2010 to 2012 were included.Household surveys were conducted.A total of 494 TB patients under the NCMS were selected in this paper.12 Focus Group Discussions(FGDs)were held.We measured the impact of the NCMS by counterfactual analysis,which analyzed the financial burden alleviation.Equity was assessed by Concentration Index(CI),and disaggregated by project sites.Results:TB inpatients were reimbursed with an effective reimbursement rate of 57.3%.Average out-of-pocket(OOP)payments for outpatient and inpatient services after diagnosis were 1413 yuan and 430 yuan,and 3572 yuan and 3013 yuan in YC and HZ,respectively.The reimbursement level for TB outpatient care after diagnosis was very low due to a limited outpatient quota.TB patients in HZ incurred higher effective reimbursement rates,but the incidence of CHE remained higher.The reduction of CHE incidence after the NCMS showed no difference statistically(P>0.05).The severity of CHE was alleviated slightly.CIs after reimbursement were all below zero and their absolute values were higher than those before reimbursement.Conclusions:Low reimbursement for TB patients could lead to heavy financial burden.Poor TB patients incurred high rates of CHE.The NCMS was found to be a protective factor for CHE,but the impact was modest and the equity of CHE did not improve.The NCMS reimbursement policies should be improved in the future to include a more comprehensive coverage of care.Supplemental programs may be necessary to expand coverage for TB care. | Li Xiang Yao Pan Shuangyi Hou Hongwei Zhang Kaori DSato Qiang Li Jing Wang Shenglan Tang | 2016 | Infectious Diseases of Poverty2016，5，1： | 9 |
| 6 | Shape anisotropic Fe3O4 nanotubes for efficient microwave absorption显示文摘Although Fe3O4 particles have exhibited excellent microwave absorbing capacity and widely used in practical application due to the synergistic effect of magnetic loss and dielectric loss,their applications are still limited for the required high mass fraction in absorbers.To overcome this problem,the development of Fe3O4 materials with low dimensional structures is necessary.In this study,the shape anisotropic Fe3O4 nanotubes(NTs)with low mass ratios were applied to realize efficient microwave absorption.The NTs with different aspect ratios were prepared through facile electrospinning followed by two-step thermal treatments and mechanical shearing.The cross-linked nanotubular structure enabled the absorbers to have much higher electrical conductivity,multiple scattering,polarization relaxation and better anti-reflection surface,while the shape anisotropic NTs maintained significant multiple resonances with stronger coercivity.These all were beneficial to microwave absorption with enhanced dielectric loss,magnetic loss and sterling impedance matching.Results showed that the absorber with 33.3 wt.%of short Fe3O4 NTs had minimum reflection loss of-58.36 dB at 17.32 GHz with a thickness of 1.27 mm,and had the maximum effective absorbing bandwidth(EAB)of 5.27 GHz when the thickness was 1.53 mm.The absorber with 14.3 wt.%of long Fe3O4 NTs presented the widest EAB in certain radar band with attenuated 80.75%X band and 85%Ku band energy bellow-10 dB at the thickness of 2.65 and 1.53 mm,respectively.This study provided an approach for the development of shape anisotropic magnetic absorbing materials,and broadened their practical applications as magnetic absorbers. | Jialiang Pan Honggui Guo Min Wang Hui Yang Haowen Hu Peng Liu Hongwei Zhu | 2020 | Nano Research2020，13，3： | 8 |
| 7 | esveratrol inhibits necroptosis by mediating the TNF-α/RIP1/RIP3/MLKL pathway in myocardial hypoxia/reoxygenation injury显示文摘Resveratrol(RES)protects myocardial cells from hypoxia/reoxygenation(H/R)-caused injury.However,the mechanism of this effect has not been clarified.Thus,in this study,we aimed to determine whether RES attenuates H/R-induced cell necroptosis by inhibiting the tumor necrosis factor-alpha(TNF-α)/receptor-interacting protein kinase 1(RIP1)/RIP3/mixed-lineage kinase domain-like(MLKL)signaling pathway.Rat myocardial ischemia/reperfusion(I/R)models and H/R-injured cell models were constructed.Our study showed that myocardial H/R injury significantly increased the levels of TNF-α,RIP1,RIP3,and p-MLKL/MLKL by western blot analysis.Cell viability assay and 4,6-dianmidino-2-phenylindole(DAPI)-propidium iodide staining showed that the cell viability was decreased,and necroptosis was increased after myocardial H/R injury.The expressions of TNF-α,RIP1,RIP3,and p-MLKL/MLKL in H/R myocardial cells treated with different concentrations of RES were significantly downregulated.In addition,we also found that the cell viability was increased and necroptosis was decreased in dose-dependent manners when H/R-injured cells were treated with RES.In addition,the enhanced effect of TNF-αon necroptosis in myocardial H/R-injured cells was improved by RES,and the effect of RES was confirmed in vivo in I/R rats.This study also showed that RES suppresses necroptosis in H9c2 cells,which may occur through the inhibition of the TNF-α/RIP1/RIP3/MLKL signaling pathway.Our data suggest that necroptosis is a promising therapeutic target and may be a promising therapeutic target for the treatment of myocardial I/R injury. | Yongjun Hu Hongwei Pan Jianqiang Peng Jin He Mingxiang Tang Sulan Yan Jingjing Rong Junshan Li Zhaofen Zheng Haijun Wang Yanfu Liu Xin Zhong | 2021 | Acta Biochimica et Biophysica Sinica2021，53，4： | 6 |
| 8 | Characterization, treatment and releases of PBDEs and PAHs in a typical municipal sewage treatment plant situated beside an urban river, East China显示文摘Characterization, treatment and releases of eight polybrominated diphenyl ethers (PBDEs) congeners and sixteen polycyclic aromatic hydrocarbons (PAHs) in wastewater were evaluated along the treatment processes of a typical secondary treatment municipal sewage treatment plant (STP) (in Hefei City) situated the beside Nanfei River, East China. The findings showed that the average concentrations of the total PBDEs in raw wastewater and treated effluent were 188.578 and 36.884 ng/L respectively. Brominated diphenyl ether (BDE) 209 congener, the predominant PBDE in the STP and Nanfei River, could be related to the discharge of car-industry-derived wastes. For PAHs, the average concentrations in raw wastewater and treated effluent were 5758.8 and 2240.4 ng/L respectively, with naphthalene, benzo[a]pyrene and indeno[1,2,3-c,d]pyrene being detected at the highest concentrations. PAHs mainly originate from the combustion of biomass/coal and petroleum. The STP reduced about 80% of the PBDEs and 61% of the PAHs, which were eliminated mainly by sedimentation processes. The removal rates of PBDEs/PAHs increased with the increase of their solid-water partitioning coefficients. Accordingly, the STP's effluent, containing some PBDE congeners (e.g., BDE 47, 99 and 209, etc.) and low-molecular-weight PAHs, could be an important contributor of these contaminants' input to Nanfei River. It resulted in a significant increase of PBDE/PAH concentrations and PAH toxicological risk in the river water downstream. About 4.040 kg/yr of PBDEs and 245.324 kg/yr of PAHs could be released into the Nanfei River. The current conventional wastewater treatment processes should be improved to remove the relatively low-molecular-weight PBDEs/PAHs more effectively. | Xiaowei Wang Beidou Xi Shouliang Huo Wenjun Sun Hongwei Pan Jingtian Zhang Yuqing Ren Hongliang Liu | 2013 | Journal of Environmental Sciences2013，25，7： | 6 |
| 9 | Emplacement Mechanism of the Akebasitao Pluton:Implications for Regional Tectonic Evolution of West Junggar,NW China显示文摘Late Carboniferous to Early Permian A-type granites are extensively distributed throughout the West Junggar region,NW China,and the Akebasitao pluton is extremely distinguished among these plutons.In this paper,we reported new anisotropy of magnetic susceptible(AMS) data combine with detailed field study and audio magnetotelluric(AMT) sounding to assess the three-dimensional shape and magmatic emplacement mechanism of the Akebasitao pluton.The geological features and the AMT sounding indicate that the pluton had a slightly oblique movement of magma from northwest to southeast,which was most likely to correspond to an asymmetrical torch with a laccolith-shaped upper part,and a lower part formed by sub-vertical 'root' that was located within its northwestern part,probably controlled by the NE-trending Anqi fault.The AMS fabrics of aU the specimens reveal a low P_j value(mean of 1.02) and a low T value(mean of-0.024),suggesting that the deformation of the AMS ellipsoid is relatively weak.The specimens exhibit both oblate and prolate shapes of the AMS ellipsoid.Magnetic lineations and foliations are randomly distributed throughout the pluton without any preferred orientation.These AMS patterns indicate that the pluton formed in a relatively stable structural environment with no regional extrusion.Therefore,we propose a complex emplacement process in which the magmas reached the shallower crust levels via deep-faults and subsequently occupied the room created by doming,accompanied by sloping near the pluton roof.Additionally,the regional tectonic setting was relatively stable during the emplacement of the Akebasitao pluton,indicating the termination of compressional orogeny during the late Late Carboniferous in the West Junggar region.This conclusion perfectly coincides with the regional tectonic paleogeography,magmatic system,and paleostress field. | ZHANG Pan WANG Guocan LI Yongtao ZHANG Shengye PENG Chao ZHAO Hongwei ZHA Yanhong | 2017 | Acta Geologica Sinica(English Edition)2017，91，3： | 5 |
| 10 | Classification of four distinct osteoarthritis subtypes with a knee joint tissue transcriptome atlas显示文摘The limited molecular classifications and disease signatures of osteoarthritis(OA)impede the development of prediagnosis and targeted therapeutics for OA patients.To classify and understand the subtypes of OA,we collected three types of tissue including cartilage,subchondral bone,and synovium from multiple clinical centers and constructed an extensive transcriptome atlas of OA patients.By applying unsupervised clustering analysis to the cartilage transcriptome,OA patients were classified into four subtypes with distinct molecular signatures:a glycosaminoglycan metabolic disorder subtype(C1),a collagen metabolic disorder subtype(C2),an activated sensory neuron subtype(C3),and an inflammation subtype(C4).Through ligand-receptor crosstalk analysis of the three knee tissue types,we linked molecular functions with the clinical symptoms of different OA subtypes.For example,the Gene Ontology functional term of vasculature development was enriched in the subchondral bone-cartilage crosstalk of C2 and the cartilage-subchondral bone crosstalk of C4,which might lead to severe osteophytes in C2 patients and apparent joint space narrowing in C4 patients.Based on the marker genes of the four OA subtypes identified in this study,we modeled OA subtypes with two independent published RNA-seq datasets through random forest classification.The findings of this work contradicted traditional OA diagnosis by medical imaging and revealed distinct molecular subtypes in knee OA patients,which may allow for precise diagnosis and treatment of OA. | Chunhui Yuan Zongyou Pan Kun Zhao Jun Li Zixuan Sheng Xudong Yao Hua Liu Xiaolei Zhang Yang Yang Dongsheng Yu Yu Zhang Yuzi Xu Zhi-Yong Zhang Tianlong Huang Wanlu Liu Hongwei Ouyang | 2020 | Bone Research2020，8，4： | 4 |
| 11 | A highly efficient Fe-doped Ni_(3)S_(2) electrocatalyst for overall water splitting显示文摘The development of efficient and stable electrocatalysts with earth-abundant elements for both oxygen evolution reaction(OER)and hydrogen evolution reaction(HER)in the same electrolyte is incontrovertibly vital in water electrolysis.However,their large-scale fabrication remains a great challenge.Here,we report a self-supported electrocatalyst in the form of Fe-doped Ni_(3)S_(2) nanoparticles in-situ grown on three-dimensional(3D)conductive Fe−Ni alloy foam(Fe−Ni_(3)S_(2)/AF)by surface-assisted chemical vapor transport(SACVT)method.Homogeneous growth environment and scalability of SACVT method allow Fe−Ni3S2 nanoparticles uniformly growing on AF in large-scale.Fe−Ni_(3)S_(2)/AF exhibits high activity and durability when act as HER catalyst and OER precatalyst in alkaline media.The HER and OER overpotential at 10 mA/cm^(2) is considerably small,only 75 and 267 mV,respectively.Moreover,the electrolyzer assembled by Fe−Ni_(3)S_(2)/AF for overall water splitting exhibits a low cell voltage and high durability in long-term test.Based on experiments and theoretical calculation,the significantly enhanced activity could be originated from the incorporation of Fe,which contributed to increase the electrochemical active surface area,enhance electrical conductivity,optimize the hydrogen and H2O adsorption energy of Ni_(3)S_(2)(101)surface in HER,and form active bimetallic Ni−Fe(oxy)hydroxide in OER.The excellent durability of self-supported Fe−Ni_(3)S_(2)/AF could be benefited from the in-situ growth of Fe−Ni_(3)S_(2) nanoparticles on 3D AF,which could ensure closely mechanical adhesion between active materials and substrate,promote charge transport and increase surface area.This work provides a facile method for large-scale synthesis of electrocatalysts with high activity and long-term durability for efficient water electrolysis in alkaline media. | Min Wang Li Zhang Jialiang Pan Meirong Huang Hongwei Zhu | 2021 | Nano Research2021，14，12： | 4 |
| 12 | eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses显示文摘It has become increasingly challenging for researchers to analyze the exponentially expanding amount of multi-omic data.Here,we describe multi-functional software named evolutionary GenotypePhenotype Systems(eGPS)that enables users to perform comprehensive multiomic and evolutionary analyses.The eGPS combines the power of cloud computing and the advantage of desktop application,has a user-friendly graphic interface and is highly interactive. | Dalang Yu Lili Dong Fangqi Yan Hailong Mu Bixia Tang Xiao Yang Tao Zeng Qing Zhou Feng Gao Zhonghuang Wang Ziqian Hao Hongen Kang Yi Zheng Hongwei Huang Yuzhang Wei Wei Pan Yaochen Xu Junwei Zhu Shilei Zhao Ciran Wang Pengyu Wang Long Dai Mushan Li Li Lan Yiwei Wang Hua Chen Yi-Xue Li Yun-Xin Fu Zhen Shao Yiming Bao Fangqing Zhao Luo-Nan Chen Guo-Qing Zhang Wenming Zhao Haipeng Li | 2019 | National Science Review2019，6，5： | 4 |
| 13 | Controllable preparation and microwave absorption properties of shape anisotropic Fe_(3)O_(4) nanobelts显示文摘To substantially prevent electromagnetic threatens,microwave absorbing materials(MAMs)are required to eliminate surplus electromagnetic waves.As a typical MAM,Fe_(3)O_(4) particles with complex permittivity and permeability have been widely applied due to the coexistence of magnetic loss and dielectric loss.However,the necessary high mass fraction significantly limited its applications,thus Fe_(3)O_(4) nanostructures have been extensively investigated to overcome this problem.In this work,uniform Fe_(3)O_(4) nanobelts were prepared by electrospinning and two-step thermal treatment.By controlling the composition and viscosity of the electrospinning precursor solution,Fe_(3)O_(4) nanobelts with tunable lateral sizes(200 nme1 mm)were obtained.The samples with low content(only 16.7 wt%)Fe_(3)O_(4) exhibited wide maximum effective absorbing bandwidths(EAB)over 3 GHz,and Fe_(3)O_(4) nanobelts with smaller lateral sizes showed a maximum EAB of 4.93 GHz.Meanwhile,Fe_(3)O_(4) nanobelts with smaller lateral sizes presented superior reflection loss properties,the lowest reflection loss reached-53.93 dB at 10.10 GHz,while the maximum EAB was up to 2.98 GHz.The excellent microwave reflection loss of Fe_(3)O_(4) nanobelts was contributed to the enhanced synergistic effect of magnetic loss,dielectric loss,and impedance matching,originated from the hierarchically cross-linked networks and shape anisotropies.This study could broaden the practical applications of magnetic absorbers,and provided an approach for the development of shape anisotropic magnetic materials. | Jialiang Pan Rujing Zhang Jun Ling Min Wang Zechen Li Zhen Zhen Limin He Hongwei Zhu | 2021 | Journal of Materiomics2021，7，5： | 3 |
| 14 | Sandstone-concrete interface transition zone (ITZ) damage and debonding micromechanisms under freeze-thaw显示文摘The sufficient bond between concrete and rock is an important prerequisite to ensure the effect of shotcrete support. However, in cold regions engineering protection system, the bond condition of rock and concrete surface is easily affected by freeze-thaw cycles, resulting in interface damage, debonding and even supporting failure. Understanding the micromechanisms of the damage and debonding of the rock-concrete interface is essential for improving the interface protection.Therefore, the micromorphology, micromechanical properties, and microdebonding evolution of the sandstone-concrete interface transition zone(ITZ) under varying freeze-thaw cycles(0, 5, 10, 15, 20) were studied using scanning electron microscope, stereoscopic microscope, and nano-indentation. Furthermore, the distribution range and evolution process of ITZ affected by freeze-thaw cycles were defined. Major findings of this study are as follows:(1) The microdamage evolution law of the ITZ under increasing freeze-thaw cycles is clarified, and the relationship between the number of cracks in the ITZ and freeze-thaw cycles is established;(2) As the number of freeze-thaw cycles increases, the ITZ's micromechanical strength decreases, and its development width tends to increase;(3) The damage and debonding evolution mechanisms of sandstone-concrete ITZ under freeze-thaw cycles is revealed, and its micromechanical evolution model induced by freeze-thaw cycles is proposed. | YanJun Shen Huan Zhang JinYuan Zhang HongWei Yang Xu Wang Jia Pan | 2021 | Research in Cold and Arid Regions2021，13，2： | 3 |
| 15 | ASAF: altered spontaneous activity fingerprinting in Alzheimer’s disease based on multisite fMRI显示文摘Several monocentric studies have noted alterations in spontaneous brain activity in Alzheimer's disease (AD), although there is no consensus on the altered amplitude of low-frequency fluctuations in AD patients. The main aim of the present study was to identify a reliable and reproducible abnormal brain activity pattern in AD. The amplitude of local brain activity (AM), which can provide fast mapping of spontaneous brain activity across the whole brain, was evaluated based on multisite rs-fMRI data for 688 subjects (215 normal controls (NCs), 221 amnestic mild cognitive impairment (aMCI) 252 AD). Two-sample t-tests were used to detect group differences between AD patients and NCs from the same site. Differences in the AM maps were statistically analyzed via the Stouffer's meta-analysis. Consistent regions of lower spontaneous brain activity in the default mode network and increased activity in the bilateral hippocampus/parahippocampus, thalamus, caudate nucleus, orbital part of the middle frontal gyrus and left fusiform were observed in the AD patients compared with those in NCs. Significant correlations (P? | Jiachen Li Dan Jin Ang Li Bing Liu Chengyuan Song Pan Wang Dawei Wang Kaibin Xu Hongwei Yang Hongxiang Yao Bo Zhou Alexandre Bejanin Gael Chetelat Tong Han Jie Lu Qing Wang Chunshui Yu Xinqing Zhang Yuying Zhou Xi Zhang Tianzi Jiang Yong Liu Ying Han | 2019 | Science Bulletin2019，64，14： | 3 |
| 16 | Non-dormant Axillary Bud 1 regulates axillary bud outgrowth in sorghum显示文摘Tillering contributes to grain yield and plant architecture and therefore is an agronomically important trait in sorghum(Sorghum bicolor).Here,we identified and functionally characterized a mutant of the Nondormant Axillary Bud 1(NAB1)gene from an ethyl methanesulfonate-mutagenized sorghum population.The nab1 mutants have increased tillering and reduced plant height.Map-based cloning revealed that NAB1encodes a carotenoid-cleavage dioxygenase 7(CCD7)orthologous to rice(Oryza sativa)HIGH-TILLERING DWARF1/DWARF17 and Arabidopsis thaliana MORE AXILLARY BRANCHING 3.NAB1 is primarily expressed in axillary nodes and tiller bases and NAB1 localizes to chloroplasts.The nab1 mutation causes outgrowth of basal axillary buds;removing these non-dormant basal axillary buds restored the wild-type phenotype.The tillering of nab1 plants was completely suppressed by exogenous application of the synthetic strigolactone analog GR24.Moreover,the nab1plants had no detectable strigolactones and displayed stronger polar auxin transport than wild-type plants.Finally,RNA-seq showed that the expression of genes involved in multiple processes,including auxin-related genes,was significantly altered in nab1.These results suggest that NAB1 functions in strigolactone biosynthesis and the regulation of shoot branching via an interaction with auxin transport. | Jun Chen Limin Zhang Mengjiao Zhu Lijie Han Ya Lv Yishan Liu Pan Li Haichun Jing Hongwei Cai | 2018 | Journal of Integrative Plant Biology2018，60，10： | 3 |
| 17 | Mathematical model of flow characteristic in multi-strand continuous casting tundishes显示文摘In this paper,the subject of mathematical model is a series of math expressions,which is used to calculate different regions volume fraction and analyze flow characterization in multi-strand tundish.But research about mathematical model for multi-strand tundish is few,and so far,there has been no acknowledged math model for multi-strand tundish to describe its flow characteristic.If Sahai s model,which is originally proposed for the case of single-strand tundish(proposed in reference[10],and this model is widely used in the world),is applied to describe flow feature in multi-strand tundish,the calculation results would be unreasonable.Based on the data of water-model experiment results,the sum of each strand s dead region s volume fraction is bigger than 100%,and this obviously doesn t agree with reality;and the value of dead region s volume fraction is calculated to be minus according to mathematical simulation results data in another case.What s more,Sahai s model does not propose the standard of plotting the RTD-curve,and this makes scholars around the world can t achieve consensus of views about plotting RTD-curve.And the model doesn t consider the bypass flow and can t calculate its volume fraction,but bypass flow is critical to tundish metallurgy.And through Sahai s model,the calculation result of plug flow region s volume fraction is also not reasonable,because the model doesn t well describe the essence of plug flow.So these suggest that it is not reliable to apply Sahai s single-strand tundish model to multi-strand tundish case.Then a new model is attempted to propose in this paper for your discussion.In the new model,the standard of plotting RTD curve is definitely proposed,and relative calculation method is also proposed;and the feature of dead region is carefully studied and the model proposes a new method to calculate its volume fraction,and the calculation formula about its volume fraction can be adjustable according the actual demand;what s more,the new model considers the bypass flow and proposes a method to calculate its volume fraction for the first time,and then volume fraction of plug flow region,backmix flow region,dead region and bypass flow can be calculated and obtained at the same time;and this new model can better capture the deviation of reality flow pattern from ideal plug flow pattern,and reffects the feature of plug flow. | Hongwei PAN Shusen CHENG | 2009 | Acta Metallurgica Sinica(English Letters)2009，22，4： | 3 |
| 18 | Inducible overexpression of RUNX1b/c in human embryonic stem cells blocks early hematopoiesis from mesoderm显示文摘RUNX1 绝对为 RUNX1b/c 的权威的造血作用,而是功能被要求,人的 RUNX1 的二 isoforms,是不清楚的。我们建立了可诱导的 RUNX1b/c-overexpressing 人的胚胎的干细胞(hESC ) 线,在 RUNX1b/c, overexpression 阻止了 CD34+ 房间的出现早舞台,急速地从而减少造血的干细胞的生产。同时,造血作用相关的因素的表示是 downregulated。然而,如此的阻塞效果从在 hESC/AGM-S3 房间合作文化的白天 6 消失了,证明阻塞发生在 hemogenic endothelial 房间的产生前。这阻塞被 RepSox 部分救,转变生长因素(TGF ) 的一个禁止者 - 发信号的小径,显示在 RUNX1b/c 和 TGF- 小径之间的一种靠近的关系。我们的结果在早造血作用的开发建议 RUNX1b/c 的一个唯一的禁止的函数并且可以在正常和 diseased 模型帮助它的生物函数的进一步的理解。 | Bo Chen Jiawen Teng Hongwei Liu Xu Pan Ya Zhou Shu Huang Mowen Lai Guohui Bian Bin Mao Wencui Sun Qiongxiu Zhou Shengyong Yang Tatsutoshi Nakahata Feng Ma | 2017 | Journal of Molecular Cell Biology2017，9，4： | 3 |
| 19 | Bicontinuous porous membranes with micro-nano composite structure using a facile atomization-assisted nonsolvent induced phase separation method显示文摘The micro-nano composite structure can endow separation membranes with special surface properties,but it often has the problems of inefficient preparation process and poor structural stability.In this work,a novel atomization-assisted nonsolvent induced phase separation method,which is also highly efficient and very simple,has been developed.By using this method,a bicontinuous porous microfiltration membrane with robust micro-nano composite structure was obtained via commercially available polymers of polyacrylonitrile and polyvinylpyrrolidone.The formation mechanism of the micro-nano composite structure was proposed.The microphase separation of polyacrylonitrile and polyvinylpyrrolidone components during the atomization pretreatment process and the hydrogen bonding between polyacrylonitrile and polyvinylpyrrolidone molecules should have resulted in the nano-protrusions on the membrane skeleton.The membrane exhibits superhydrophilicity in air and superoleophobicity underwater.The membrane can separate both surfactant-free and surfactant-stabilized oil-in-water emulsions with high separation efficiency and permeation flux.With excellent antifouling property and robust microstructure,the membrane can easily be recycled for long-term separation.Furthermore,the scale-up verification from laboratory preparation to continuous production has been achieved.The simple,efficient,cost-effective preparation method and excellent membrane properties indicate the great potential of the developed membranes in practical applications. | Jing Wang Guoyuan Pan Yu Li Yang Zhang Hongwei Shi Xuanbo Liu Hao Yu Muhua Zhao Yiqun Liu Changjiang Wu | 2022 | Frontiers of Chemical Science and Engineering2022，16，8： | 2 |
| 20 | Contributions of distinct prefrontal neuron classes in reward processing显示文摘The prefrontal cortex(PFC)is thought to be involved in higher order cognitive functions,such as in working memory,abstract categorization,and reward processing.It has been reported that two distinct neuron classes(putative pyramidal cells and interneurons)in the PFC played different functional roles in neural circuits involved in forming working memory and abstract categories.However,it remains elusive how the two types of neurons process reward information in the PFC.To investigate this issue,the activity of single neurons was extracellularly recorded in the PFC of the monkey performing a reward predicting task.PFC neurons were classified into putative pyramidal cells and interneurons,respectively,based on the waveforms of action potentials.Both the two types of neurons encoded reward information and discriminated two reward conditions(the preferred reward condition vs.the nonpreferred reward condition).However,the putative pyramidal neurons had better and more reliable discriminability than the putative interneurons.Also,the pyramidal cells represented reward information in the preferred reward condition,but not in the nonpreferred reward condition by raising their firing rates relative to the baseline rates.In contrast,the interneurons encoded reward information in the nonpreferred reward condition,but not in the preferred reward condition by inhibiting their discharge rates relative to the baseline rates.These results suggested that the putative pyramidal cells and interneurons had complementary functions in reward processing.These findings may help to clarify individual functions of each type of neurons in PFC neuronal circuits involved in reward processing. | PAN XiaoChuan FAN HongWei WANG RuBin SAKAGAMI Masamichi | 2014 | Science China(Technological Sciences)2014，57，6： | 2 |
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