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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 3 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 4 | Acupuncture Treatment for Idiopathic Trigeminal Neuralgia:A Longitudinal Case-Control Double Blinded Study显示文摘Objective: To evaluate the treatment effect of acupuncture on patients with idiopathic trigeminal neuralgia(ITN) by case-control longitudinal blinded study. Methods: Sixty ITN patients and 30 healthy subjects were included. The ITN patients were randomly assigned to acupuncture group(15 cases), sham-acupuncture group(15 cases) and carbamazepine group(30 cases), respectively. Clinical orofacial evaluation(including pain intensity and medication doses), research diagnostic criteria for temporomandibular disorders(RDC/TMD) and Helkimo indexes(for functional evaluation of the masticatory system), and quantitative sensory testing for sensory thresholds(gustative, olfactory, cold, warm, touch, vibration and superficial and deep pain) were evaluated before treatment, immediately after treatment, and 6 months after treatment. Results: The mean pain intensity by the Visual Analogue Scale only decreased in the acupuncture group at the last evaluation(P=0.012). Patients in the sham-acupuncture group had an increase in carbamazepine doses according to the prescriptions(P<0.01). There was a reduction in secondary myofascial pain and mandibular limitations at the acupuncture and sham-acupuncture groups, however only the acupuncture group kept the changes after 6 months(P<0.01, P=0.023). There was a decrease in mechanical thresholds in the acupuncture group(tactile, P<0.01; vibration, P=0.027) and an increase in deep pain thresholds in both acupuncture and sham-acupuncture groups(P=0.013). Conclusion: Acupuncture can be an option in the treatment of ITN due to its analgesic effect in both ITN and secondary myofascial pain associated with it. | Michelle Cristina Ichida Mariana Zemuner Jorge Hosomi Hong Jin Pai Manoel Jacobsen Teixeira JoséTadeu Tesseroli de Siqueira Silvia R D T de Siqueira | 2017 | Chinese Journal of Integrative Medicine2017，23，11： | 6 |
| 5 | 多肽和蛋白质的反相高效液相色谱研究——色谱行为的多样性显示文摘以C8 柱为固定相 ,研究了微管结合蛋白2中两段重要肽段(肽1 ,肽2)和猪胰岛素在反相色谱上的保留行为。当以甲醇溶液为流动相时 ,猪胰岛素保留因子的对数值(lnK′)随流动相有机溶剂体积分数(φ)的变化呈现很好的线性关系。当以乙腈为流动相测定肽1的lnK′随 φ变化关系时 ,所得结果显示lnK′与 φ呈现良好的二次曲线关系。以乙腈为流动相测定肽1和肽2的Van'tHoff曲线(lnK′与1/T的关系图)时 ,发现两种多肽的Van'tHoff曲线分别呈二次和三次方曲线。所有这些结果说明多肽和蛋白质在反相色谱中保留行为的复杂性。 | 郭敏亮 Milton T W HEARN Hooi Hong KEAH | 2000 | 分析测试学报2000，19，4： | 4 |
| 6 | Performance of rotating drum biofilter for volatile organic compound removal at high organic loading rates显示文摘不稳定的有机化合物(VOC ) 和生物资源的不平的分发,和在一些简历过滤器的过量生物资源累积妨碍简历过滤技术的申请。一个创新的多层的旋转鼓简历过滤器(RDB ) 被开发改正这些问题。RDB 在 30 s 的一空床接触时间(EBCT ) 和 1.0 r/min 的旋转的率被操作。Diethyl 醚被选择为模型 VOC。RDB 的性能以 32.1, 64.2, 128,和 256 g ether/(m3 · h ) 的器官的装载的率被评估(16.06 g ether/(m3 · h ) ≈ 1.0 kg 化学药品氧需求(货到付款)/(m3 · d )) 。EBCT 和器官的装载率根据中等体积被记录。结果证明醚移动效率与装载率的增加的 VOC 减少了。没有生物资源控制,超过 99% 的醚移动效率甚至在装载 128 g ether/(m3 · h ) 的率的高 VOC 被完成。然而,当装载率的 VOC 被增加到 256 g ether/(m3 · h ) 时,平均移动效率落下到 43% 。滋养的限制可能在醚移动效率贡献了落下。高生物资源累积率也在装载率的二更高的醚在媒介被观察,并且在媒介的过量生物资源的移动是必要的维持稳定的性能。这个工作证明 RDB 甚至以高器官的装载率在来自废气溪流的 diethyl 醚的移动是有效的。结果可能帮助为设计并且操作 RDB 建立标准。 | YANG Chunping CHEN Hong ZENG Guangming ZHU Xueqing SUIDAN Makram T | 2008 | Journal of Environmental Sciences2008，20，3： | 3 |
| 7 | Oxygen Atom Exchange Mechanism in Reaction of OH Radical with AsO显示文摘Oxygen atom exchange reaction mechanism in the reaction of OH radicals with AsO was investigated by means of the density functional theory (DFT) with 6 311++G( 3df,3pd ) and 6 311++G( d,p ) basis sets. The calculated results suggest that the reaction between OH and AsO should make the oxygen atoms exchange rapidly because the barrier to isomerization is significantly less than the HO-AsO bond dissociation energy. | CHI Yu-juan 1, YU Hai tao 1,2** , FU Hong gang 1,2 HUANG Xu ri 2, LI Ze sheng 2 and SUN Chia chung 21. College of Chemistry and Chemical Engineering, Heilongjiang University, Harbin 150080, P. R. China 2. State Key Laboratory of T | 2002 | Chemical Research in Chinese Universities2002，18，3： | 3 |
| 8 | On compression characteristics of Ariake clays显示文摘 | Hong Z Tsuchida T | 1999 | Canadian Geotechnical Journal1999，36，5： | 2 |
| 9 | Characterization of inhibitor and corrosion product film using electrochemical impedance spectroscopy(EIS) 显示文摘 | Wang H B Hong T Jepson W P | 2001 | Corrosion2001，，： | 2 |
| 10 | 生物炭在柑橘皮厌氧发酵中作用机理研究显示文摘该研究主要调查柑橘皮废料厌氧消化能力在不同类型的生物炭和不同比率下的影响。柑橘皮对厌氧消化有抑制作用。生物炭的存在有两种影响:相对于只有柑橘皮废料的培养来说,它减少了迟滞期的长度,并且使甲烷的产量更高。微生物迟滞期随着柑橘皮与生物炭比例的增加而降低,在比例为2∶1时停滞期最长,为9.4 d,在比例为1∶3时迟滞期最短,为7.5 d。生物炭和柑橘皮培养中累积的甲烷产量在163.9到186.8 mLCH4 ·g^-1VS之间变动,而只有柑橘皮培养中的甲烷产量只有165.9 mLCH4 ·g^-1VS。在检测生物炭材料时发现了推测的产甲烷菌群。D-柠檬烯吸附和微生物固定化的协同作用在生物炭的影响下会提高厌氧消化的性能。 | Michael O Fagbohungbe Ben M J Herbert Lois Hurst Hong Li Shams Q Usmani Kirk T Semple 张冀川(译) | 2019 | 中国沼气2019，37，5： | 2 |
| 11 | Contrasting seed storage behaviour among different species of Meliaceae 显示文摘 | Hong T D Ellis R H | 1998 | Seed science and technology1998，26，1： | 1 |
| 12 | Characterization of UV-cured polyester acrylate films containing acrylate functional polydimethylsiloxane显示文摘 | Kim H K Ju H T Hong J W | 2003 | European Polymer Journal2003，39，11： | 1 |
| 13 | Study of the enhanced thermal conductivity of Fe nanofluids显示文摘 | Hong T K Yang H S Choi C J | 2005 | Journal of Applied Physics2005，97，6： | 1 |
| 14 | ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression显示文摘 | HONG T WALTER K L | 2006 | Nature2006，442，： | 1 |
| 15 | Discrete discrepancy in factorial designs显示文摘 | Fang K T | 2004 | Metrika2004，60，： | 1 |
| 16 | A study of the shelf- life of cold- stored longan fruit显示文摘 | Chen S J Hong Q Z | 2001 | Acta Hort2001，558，： | 1 |
| 17 | Corrosion control methods in supercritical water oxidation and gasification processes显示文摘 | Marronea P A Hong G T | 2009 | Supercritical Fluids2009，，51： | 1 |
| 18 | Development of the High Concentration Ⅲ-Ⅴ Photovoltaic System at INER, Taiwan 显示文摘 | Kuo C T Shin H Y Hong H F | 2009 | Renewable Energy2009，34，8： | 1 |
| 19 | Numerical simulation to relate the shot peening parameters to the induced residual stresses显示文摘 | HONG T OOI J Y SHAW B | 2008 | Engineering Failure Analysis2008，，15： | 1 |
| 20 | Antibacterial roperties,corrosion resistance and mechanical properties of Cu-modified SUS 304stainless steel显示文摘 | Hong I T Koo C H | 2005 | Materials Science and Engineering A2005，393，： | 1 |
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