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| 1 | Upper-gastrointestinal bleeding secondary to peptic ulcer disease:Incidence and outcomes显示文摘AIM:To evaluate the incidence,surgery,mortality,and readmission of upper gastrointestinal bleeding(UGIB)secondary to peptic ulcer disease(PUD).METHODS:Administrative databases identified all hospitalizations for UGIB secondary to PUD in Alberta,Canada from 2004 to 2010(n=7079)using the International Classification of Diseases Codes(ICD-10).A subset of the data was validated using endoscopy reports.Positive predictive value and sensitivity with 95%confidence intervals(CI)were calculated.Incidence of UGIB secondary to PUD was calculated.Logistic regression was used to evaluate surgery,in-hospital mortality,and 30-d readmission to hospital with recurrent UGIB secondary to PUD.Co-variants accounted for in our logistic regression model included:age,sex,area of residence(i.e.,urban vs rural),number of Charlson comorbidities,presence of perforated PUD,undergoing upper endoscopy,year of admission,and interventional radiological attempt at controlling bleeding.A subgroup analysis(n=6356)compared outcomes of patients with gastric ulcers to those with duodenal ulcers.Adjusted estimates are presented as odds ratios(OR)with95%CI.RESULTS:The positive predictive value and sensitivity of ICD-10 coding for UGIB secondary to PUD were85.2%(95%CI:80.2%-90.2%)and 77.1%(95%CI:69.1%-85.2%),respectively.The annual incidence between 2004 and 2010 ranged from 35.4 to 41.2 per100000.Overall risk of surgery,in-hospital mortality,and 30-d readmission to hospital for UGIB secondary to PUD were 4.3%,8.5%,and 4.7%,respectively.Interventional radiology to control bleeding was performed in 0.6%of patients and 76%of these patients avoided surgical intervention.Thirty-day readmission significantly increased from 3.1%in 2004 to 5.2%in 2010(OR=1.07;95%CI:1.01-1.14).Rural residents(OR rural vs urban:2.35;95%CI:1.83-3.01)and older individuals(OR≥65 vs<65:1.57;95%CI:1.21-2.04)were at higher odds of being readmitted to hospital.Patients with duodenal ulcers had higher odds of dying(OR=1.27;95%CI:1.05-1.53),requiring surgery(OR=1.73;95%CI:1.34-2.23),and being readmitted to hospital(OR=1.54;95%CI:1.19-1.99)when compared to gastric ulcers.CONCLUSION:UGIB secondary to PUD,particularly duodenal ulcers,was associated with significant morbidity and mortality.Early readmissions increased over time and occurred more commonly in rural areas. | Samuel Quan Alexandra Frolkis Kaylee Milne Natalie Molodecky Hong Yang Elijah Dixon Chad G Ball Robert P Myers Subrata Ghosh Robert Hilsden Sander Veldhuyzen van Zanten Gilaad G Kaplan | 2014 | World Journal of Gastroenterology2014，20，46： | 21 |
| 2 | Multitarget stool DNA for colorectal cancer screening:A review and commentary on the United States Preventive Services Draft Guidelines显示文摘Multitarget stool DNA(mt-sDNA) testing was approved for average risk colorectal cancer(CRC) screening by the United States Food and Drug Administration and thereafter reimbursed for use by the Medicare program(2014).The United States Preventive Services Task Force(USPSTF) October 2015 draft recommendation for CRC screening included mt-s DNA as an 'alternative' screening test that 'may be useful in select clinical circumstances',despite its very high sensitivity for early stage CRC.The evidence supporting mt-s DNA for routine screening use is robust.The clinical efficacy of mt-s DNA as measured by sensitivity,specificity,life-years gained(LYG),and CRC deaths averted is similar to or exceeds that of the other more specifically recommended screening options included in the draft document,especially those requiring annual testing adherence.In a population with primarily irregular screening participation,tests with the highest point sensitivity and reasonable specificity are more likely to favorably impact CRC related morbidity and mortality than those depending on annual adherence.This paper reviews the evidence supporting mt-s DNA for routine screening and demonstrates,using USPSTF's modeling data,that mt-s DNA at three-year intervals provides significant clinical net benefits and fewer complications per LYG than annual fecal immunochemical testing,high sensitivity guaiac based fecal occult blood testing and 10-year colonoscopy screening. | Barry M Berger Bernard Levin Robert J Hilsden | 2016 | World Journal of Gastrointestinal Oncology2016，8，5： | 3 |
| 3 | Prevalence of Adenomas and Colorectal Cancer in Average Risk Individuals: A Systematic Review and Meta-analysis显示文摘 | Steven J. Heitman Paul E. Ronksley Robert J. Hilsden Braden J. Manns Alaa Rostom Brenda R. Hemmelgarn | 2009 | Clinical Gastroenterology and Hepatology2009，，12： | 2 |
| 4 | Advanced proximalneoplasia of the colon in average-risk adults 显示文摘 | Rabeneck L Paszat LF Hilsden RJ | 2014 | GastrointestEndosc2014，80，4： | 1 |
| 5 | Intestinal permeability and postheparin plasma diamine oxidase activity in the prediction of Crohn's disease relapse显示文摘 | HILSDEN R J MEDDINGS J B HARDIN J | 1999 | Inflamm Bowel Dis1999，5，2： | 1 |
| 6 | Evaluation of a risk index for advanced proximal neoplasia of the colon显示文摘 | Arlinda Ruco David Stock Robert J. Hilsden S. Elizabeth McGregor Lawrence F. Paszat Refik Saskin Linda Rabeneck | 2014 | Gastrointestinal Endoscopy2014，，： | 1 |
| 7 | Publication bi-as in gastroenterological research-a retrospective co-hort study based on abstracts submitted to a scientific meeting显示文摘 | Hilsden JR Cole J | 2002 | BMC Medical Research Methodology2002，，2： | 1 |
| 8 | Bleeding and perforation after outpatient eolonoscopy and their risk factors in usual clinical prac- tice显示文摘 | Rabeneck L Paszat L F Hilsden R J | 2008 | Gastroenterology2008，135，6： | 1 |
| 9 | Bleeding and Perforation After Outpatient Colonoscopy and Their Risk Factors in Usual Clinical Practice显示文摘 | Linda Rabeneck Lawrence F. Paszat Robert J. Hilsden Refik Saskin Des Leddin Eva Grunfeld Elaine Wai Meredith Goldwasser Rinku Sutradhar Therese A. Stukel | 2008 | Gastroenterology2008，，6： | 1 |
| 10 | Use of complementary and alternative medicine by patients with inflammatory bowel disease 显示文摘 | HILSDEN R J VERHOEF M J RASMUSSEN H | 2011 | Inflamm Bowel Dis2011，17，2： | 1 |
| 11 | Bleeding and perfo-ration after outpatient colonoscopy and their risk factors in usualclinical practice显示文摘 | Rabeneck L Paszat LF Hilsden RJ | 2008 | Gastroenterology2008，135，6： | 1 |
| 12 | Bleeding and perforation after outpatient colonoscopy and their risk factors in usual clinical practice 显示文摘 | Rabeneck L Paszat LF Hilsden RJ | 2008 | Gastroenterology2008，135，6： | 1 |
| 13 | Management of gastrointestinal hemorrhage显示文摘 | Hilsden R J Shaffer E A | | 0，，03： | 1 |
| 14 | Complementary and alternative medicine use by Canadian patients with inflammatory bowel disease: results from a national survey显示文摘 | Robert J Hilsden Marja J Verhoef Allan Best Gaia Pocobelli | 2003 | The American Journal of Gastroenterology2003，，7： | 1 |
| 15 | Development and vali- dation of a nurse - assessed patient comfort score for colonoscopy 显示文摘 | Rostom A Ross E Hilsden R | 2013 | Gastrointestinal Endoscopy2013，77，2： | 1 |
| 16 | Prevalence of adenomas and colorectal cancer in average risk individuals: a systematic review and meta-analysis显示文摘 | Heitman S J Ronksley PE Hilsden RJ | 2009 | Clin Gastroenterol Hepatol2009，7，12： | 1 |
| 17 | Bleeding and perforation after outpatient colonoscopy and risk factors in usual clinical practice显示文摘 | Rabeneck L Paszat LF Hilsden RJ | 2008 | Gastroenterology2008，135，6： | 1 |
| 18 | Intestinal permeability is increased in a proportion of spouses of patients with Crohn's disease显示文摘 | Breslin NP Nash C Hilsden RJ | 2001 | Am J Gastroenterol2001，96，10： | 1 |
| 19 | Colorectal Cancer Screening for Average - Risk North Americans : An Eco- nomic Evaluation 显示文摘 | Heitman SJ Hilsden R J Au F | 2010 | PLoS Medicine2010，7，10： | 1 |
| 20 | Assessing efficacy of complementary medicine: Adding qualitative research methods to the 'Gold Standard' 显示文摘 | Verhoef MJ Casebeer AL Hilsden RJ | 2002 | J Ahem Complement Med2002，8，3： | 1 |
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