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| 1 | Peripheral corticotropin releasing hormone mediates post-inflammatory visceral hypersensitivity in rats显示文摘AIM:To investigate whether peripheral corticotropin releasing hormone (CRH), which is up-regulated in intestinal inflammation, mediates the post-inflammatory visceral hypersensitivity in a rat model of colitis. METHODS:We measured mucosal myeloperoxidase (MPO) activity as a marker of inflammation, plasma CRH level, and abdominal withdrawal reflex (AWR) to colorectal distension as a visceral nociceptive response at 2, 7 and 14 d after the induction of colitis with 4% acetic acid. RESULTS:Colonic inflammation, quantified by MPO activity, significantly increased on d 2 and subsided thereafter, which indicated a resolution of inflammation within 7 d. On the contrary, plasma CRH level and AWR score were increased on d 2, remained high on d 7, and returned to control level on d 14. Intraperitoneal injection of a CRH antagonist, astressin (30 μg/kg), significantly attenuated the post-inflammatory visceral hypersensitivity on d 7. Furthermore, intraperitoneal administration of CRH (3 and 10 μg/kg) mimicked the post-inflammatory visceral hypersensitivity in naive rats. CONCLUSION:These results suggest that increased peripheral CRH mediates the enhanced visceral nociception in rats recovered from experimental colitis. | Jun-Ho La Tae-Sik Sung Hyun-Ju Kim Tae-Wan Kim Tong Mook Kang Il-Suk Yang | 2008 | World Journal of Gastroenterology2008，14，5： | 15 |
| 2 | Addition of cerium and yttrium to ferritic steel weld metal to improve hydrogen trapping efficiency显示文摘The applicability of Ce and Y as promising candidate elements to form irreversible traps in weld metal was investigated by thermal desorption spectroscopy(TDS) with gas chromatography(GC). The precise nature of the precipitate particles newly formed in the weld metal by the addition of Ce and Y to a certain alloy system was characterized. Moreover,the hydrogen trapping efficiency expressed as the reduction of the diffusible hydrogen in the weld metal was analyzed. The results showed that the addition of Ce and/or Y to this alloy system led to the formation of a mixed type of(Ce,Ti)-based oxide,(Y,Ni)-based carbide,or(Ce,Y,Ti)-based oxide particles. Because of the high activation energy of the mixed type of particles(≥ 150 k J/mol),the trapping efficiency for hydrogen was considered to be sufficiently high to effectively reduce the diffusible hydrogen content. | Sung Jin Kim Kang Mook Ryu Min-suk Oh | 2017 | International Journal of Minerals,Metallurgy and Materials2017，24，4： | 5 |
| 3 | Correlation of fatty liver and abdominal fat distribution using a simple fat computed tomography protocol显示文摘AIM: To evaluate the relationship between hepatic fat infiltration and abdominal fat volume by using computed tomography (CT).METHODS: Three hundred and six patients who visited our obesity clinic between November 2007 and April 2008 underwent fat protocol CT scans.The age range of the patients was 19 to 79 years and the mean age was 49 years.The male to female ratio was 116:190.Liver and spleen attenuation measurements were taken with three regions of interests (ROIs) from the liver and two ROIs from the spleen.Hepatic attenuation indices (HAIs) were measured as follows: (1) hepatic parenchymal attenuation (CTLP);(2) liver to spleen attenuation ratio (LS ratio);and (3) difference between hepatic and splenic attenuation (LSdif).Abdominal fat volume was measured using a 3 mm slice CT scan starting at the level of the umbilicus and was automatically calculated by a workstation.Abdominal fat was classified into total fat (TF),visceral fat (VF),and subcutaneous fat (SF).We used a bivariate correlation method to assess the relationship between the three HAIs and TF,VF,and SF.RESULTS: There were significant negative correlations between CTLP,LS ratio,and LSdif with TF,VF,and SF,respectively.The CTLP showed a strong negative correlation with TF and VF (r = -0.415 and -0.434,respectively,P < 0.001).The correlation between CTLP and SF was less significant (r = -0.313,P < 0.001).CONCLUSION: Fatty infiltration of the liver was correlated with amount of abdominal fat and VF was more strongly associated with fatty liver than SF. | Seonah Jang Chang Hee Lee Kyung Mook Choi Jongmee Lee Jae Woong Choi Kyeong Ah Kim Cheol Min Park | 2011 | World Journal of Gastroenterology2011，17，28： | 5 |
| 4 | 加味参苓白术散对吲哚美辛所致大鼠胃粘膜损伤的保护作用显示文摘通过吲哚美辛所致大鼠胃粘膜损伤模型观察了加味参苓白术散的抗氧化作用及其可能的机制。结果表明,中药预处理可使过氧化脂质含量降低,对SOD和cAT活性均有显著影响。 | Heung Mook Shin 仝小林 王红 | 2000 | 国外医学(中医中药分册)2000，22，5： | 4 |
| 5 | Adipokines as a novel link between obesity and atherosclerosis显示文摘The traditional perception of adipose tissue as a storage organ of fatty acids has been replaced by the notion that adipose tissue is an active endocrine organ, releasing various adipokines that are involved in the pathogenesis of obesity-related metabolic disturbances. Obesity is a well-known risk factor for atherosclerosis, and accelerates atherosclerosis by many mechanisms such as increase in blood pressure and glucose level, abnormal lipid profiles, and systemic inflammation. Furthermore, growing evidence suggests that some adipokines directly mediate the process of atherosclerosis by influencing the function of endothelial cells, arterial smooth muscle cells, and macrophages in vessel walls. In obese patients, the secretion and coordination of such adipokines is abnormal, and the secretion of specific adipokines increases or decreases. Accordingly, the discovery of new adipokines and elucidation of their functions might lead to a new treatment strategy for metabolic disorders related to obesity, including cardiovascular diseases. | Hye Jin Yoo Kyung Mook Choi | 2014 | World Journal of Diabetes2014，5，3： | 3 |
| 6 | Room-temperature sputtered electrocatalyst WSe2 nanomaterials for hydrogen evolution reaction显示文摘The low-temperature physical vapor deposition process of atomically thin two-dimensional transition metal dichalcogenide(2D TMD) has been gaining attention owing to the cost-effective production of diverse electrochemical catalysts for hydrogen evolution reaction(HER) applications. We, herein, propose a simple route toward the cost-effective physical vapor deposition process of 2D WSe2 layered nanofilms as HER electrochemical catalysts using RF magnetron sputtering at room temperature(<27℃). By controlling the variable sputtering parameters, such as RF power and deposition time, the loading amount and electrochemical surface area(ECSA) of WSe2 films deposited on carbon paper can be carefully determined. The surface of the sputtered WSe2 films are partially oxidized, which may cause spherical-shaped particles. Regardless of the loading amount of WSe2, Tafel slopes of WSe2 electrodes in the HER test are narrowly distributed to be ~120–138 mV dec-1, which indicates the excellent reproducibility of intrinsic catalytic activity. By considering the trade-off between the loading amount and ECSA, the best HER performance is clearly observed in the 200 W-15 min sample with an overpotential of 220 mV at a current density of 10 mA cm-2. Such a simple sputtering method at low temperature can be easily expanded to other 2D TMD electrochemical catalysts, promising potentially practical electrocatalysts. | Jae Hyeon Nam Myeong Je Jang Hye Yeon Jang Woojin Park Xiaolei Wang Sung Mook Choi Byungjin Cho | 2020 | Journal of Energy Chemistry2020，29，8： | 3 |
| 7 | High-frequency magnetic stimulation attenuates beta-amyloid protein 1-42 neurotoxicity in organotypic hippocampal slices显示文摘Repetitive transcranial magnetic stimulation (rTMS) has been utilized as a therapeutic tool for neurodegenerative disorders including Alzheimer’s disease.However,the precise mechanisms of its clinical effects remain unknown.β-amyloid (Aβ) exhibits direct neurotoxic effects and is closely related to neuronal degeneration in Alzheimer’s disease.Therefore,it has been hypothesized that the neuroprotective effects of rTMS are related to the mechanisms of protection against Aβ neurotoxicity.Organotypic hippocampal slices were prepared from 8-day old,Sprague Dawley rats.The tissue slices were exposed to 100 μmol/L Aβ1-42 since day 12 in vitro with and without high-frequency (20 Hz) magnetic stimulation.Magnetic stimulation efficacy was evaluated by measuring neuronal nuclei (NeuN) protein expression and by observing cultures following propidium iodide fluorescence staining and bromodeoxyuridine (BrdU) immunohistochemistry.Lactate dehydrogenase activity was detected in the culture media to evaluate hippocampal neuronal damage.Our results demonstrated that high-frequency magnetic stimulation significantly reversed the reduction of NeuN protein expression because of Aβ1-42 exposure (P < 0.05) and significantly reduced the number of damaged cells in the hippocampal slices (P < 0.05).However,lactate dehydrogenase levels and anti-BrdU staining results did not reveal any statistical differences.These findings indicate that high-frequency magnetic stimulation might have protective effect on hippocampal neurons from Aβ1-42 neurotoxicity. | Don-Kyu Kim Young Chul Yoon Soo Ahn Chae Kyung Mook Seo Tai Ryoon Han Si-Hyun Kang | 2010 | Neural Regeneration Research2010，5，18： | 2 |
| 8 | Skeletal muscle mass to visceral fat area ratio is associated with metabolic syndrome and arterial stiffness: The Korean Sarcopenic Obesity Study (KSOS)显示文摘 | Tae Nyun Kim Man Sik Park Kang Il Lim Sae Jeong Yang Hye Jin Yoo Hyun Joo Kang Wook Song Ji A. Seo Sin Gon Kim Nan Hee Kim Sei Hyun Baik Dong Seop Choi Kyung Mook Choi | 2011 | Diabetes Research and Clinical Practice2011，，2： | 2 |
| 9 | Activation of mitogen-activated protein kinases and AP-1 by polysaccharide isolated from the radix of Platycodon grandiflorum in RAW 264.7 cells显示文摘 | Yeo Dae Yoon Jong Soon Kang Sang Bae Han Song-Kyu Park Hyun Sun Lee Jong Seong Kang Hwan Mook Kim | 2004 | International Immunopharmacology2004，，12： | 2 |
| 10 | Acquisition of pluripotency in the chick embryo occurs during intrauterine embryonic development via a unique transcriptional network显示文摘Background: Acquisition of pluripotency by transcriptional regulatory factors is an initial developmental event that is required for regulation of cell fate and lineage specification during early embryonic development. The evolutionarily conserved core transcriptional factors regulating the pluripotency network in fishes, amphibians, and mammals have been elucidated. There are also species-specific maternally inherited transcriptional factors and their intricate transcriptional networks important in the acquisition of pluripotency. In avian species, however, the core transcriptional network that governs the acquisition of pluripotency during early embryonic development is not well understood.Results: We found that chicken NANOG(c NANOG) was expressed in the stages between the pre-ovulatory follicle and oocyte and was continuously detected in Eyal-Giladi and Kochav stage I(EGK.I) to X. However, c POUV was not expressed during fol iculogenesis, but began to be detectable between EGK.V and VI. Unexpectedly, c SOX2 could not be detected during fol iculogenesis and intrauterine embryonic development. Instead of c SOX2, c SOX3 was maternally inherited and continuously expressed during chicken intrauterine development. In addition, we found that the pluripotency-related genes such as c ENS-1, c KIT, c LIN28 A, c MYC, c PRDM14, and c SALL4 began to be dramatical y upregulated between EGK.VI and VII.Conclusion: These results suggest that chickens have a unique pluripotent circuitry since maternally inherited c NANOG and c SOX3 may play an important role in the initial acquisition of pluripotency. Moreover, the acquisition of pluripotency in chicken embryos occurs at around EGK.VI to VI I. | Jae Yong Han Hyo Gun Lee Young Hyun Park Young Sun Hwang Sang Kyung Kim Deivendran Rengaraj Byung Wook Cho Jeong Mook Lim | 2018 | Journal of Animal Science and Biotechnology2018，9，3： | 2 |
| 11 | Optimal operation of microgrid using hybrid differential evolution and harmony search algorithm显示文摘这份报纸建议为由常规生成器组成的 microgrid 安排途径的产生,风精力生成器,太阳光电(PV ) 系统,电池存储,和电的车辆。电的车辆(EV ) 起二个不同作用:当负担在收费期间要求,并且作为到到留下的供应精力的存储单位,当他们被插进 microgrid (MG ) 时,在 MG 装载要求。风和太阳的 PV 力量在自然是断断续续的;因此由包括电池存储和 EV, MG 变得更稳定。这里,全部的费用目的就常规发电机,风发电机,太阳的 PV 系统和 EV 的费用而言被最小化。建议最佳的安排问题用混合微分进化和和谐搜索(混合 DE-HS ) 被解决包括与电池存储和 EV 一起的风精力生成器和太阳的 PV 系统的算法。而且,它要求最少的投资。 | S. SURENDER REDDY Jae Young PARK Chan Mook JUNG | 2016 | Frontiers in Energy2016，10，3： | 2 |
| 12 | The role of gelatinases in colorectal cancer progression and metastasis显示文摘 | Olaf R.F. Mook Wilma M. Frederiks Cornelis J.F. Van Noorden | 2004 | BBA - Reviews on Cancer2004，，2： | 2 |
| 13 | Ovarian function during puberty in girls with type 1 diabetes meUitus: Response to leuprolide 显示文摘 | Codner E Mook K D Bazaes R A | 2005 | J Clin Endocrinol Metab2005，90，7： | 1 |
| 14 | Chemistry of dissolved in organic carbon in estuarine and coastal brackish waters显示文摘 | Mook W G Koene B K S | 1975 | Estuarine Coastal Marine Science1975，3，： | 1 |
| 15 | Kinetic Study of 显示文摘 | Yongsok Seo Sang Mook Lee Dong Young Kim | 2005 | Macromolecules2005，21，5： | 1 |
| 16 | Concurrent conditions and human Listeriosis,England, 1999-2009显示文摘 | Mook P O Brien SJ Gillespie IA | 2011 | Emerging Infectious Diseases2011，17，1： | 1 |
| 17 | Isotopic equilibrium between shells and their environment显示文摘 | Mook W G Vogel J C | 1968 | Science1968，159，： | 1 |
| 18 | The role of gelatinases in colorectal cancer progression and metastasis 显示文摘 | Mook OR Frederiks WM Van Noorden CJ | 2004 | Biochim Biophys Acta2004，1705，2： | 1 |
| 19 | Effect of hyperglycemia on pain threshold in alloxan-diabetic rats显示文摘 | Lee JH Cox DJ Mook DC | 1990 | Pain1990，40，： | 1 |
| 20 | Feasibility Study of A Passive Smart Self-healing Cementitious Composite 显示文摘 | Victor c Li Yun Mook Lira Yin-Wen Chart | 1998 | Composites Part B1998，29，： | 1 |
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