|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | Elective colon surgery according to a 'fast-track' programme显示文摘 | Wind J Maessen J Polle SW | 2006 | Ned Tijdschr Geneeskd2006，150，6： | 1 |
| 3 | Systematic review of enhanced recovery programmes in colonic surgery显示文摘 | Wind J Polle SW Fung K | 2006 | Br J Surg2006，93，7： | 1 |
| 4 | Metallic bipolar plate for PEM fuel cells显示文摘 | WIND J SPAH R KAISER W | 2002 | J Power Sources2002，105，： | 1 |
| 5 | Customerization: the next revolution in mass customization显示文摘 | WIND J RANGASWAMY A | 2001 | Journal of Interactive Marketing2001，15，1： | 1 |
| 6 | Relaxation dynamics of CO2 diffusion, sorption, and polymer swelling for plasticized polyimide membranes显示文摘 | Wind J D Sirard S M Paul D R | 2003 | Macromolecules2003，36，17： | 1 |
| 7 | Sucrose: meta- bolite and signaling molecule 显示文摘 | WIND J SMEEKENS S HANSON J | 2010 | Phytochemistry2010，71，1415： | 1 |
| 8 | Customerization:The Next Revolution in Mass Customization显示文摘 | WIND J RANGEAWMY A | 2001 | Journal of Interactive Marketing2001，15，1： | 1 |
| 9 | Customerization: The Next Revolution in Mass Customization 显示文摘 | Wind J Pangeawamy A | 2000 | Journal of Interactive Marketing2000，15，1： | 1 |
| 10 | Laparoscopy in combination with fast track multimodal management is the best perioperative strategy in patients undergoing colonic surgery:a randomized clinical trial(LAFA-study)显示文摘 | Vlug MS Wind J Hollmann MW | | 0，，06： | 1 |
| 11 | Organizational buying be- havior in an interdependent world 显示文摘 | WIND Y THOMAS R J | 2010 | Journal of Global Academy of Marketing Science2010，20，2： | 1 |
| 12 | Comparison of the protective efficacy of recombinant pseudorabies viruses against pseudorabies and classical swine fever in pigs; influence of different promoters on gene expression and on protection显示文摘 | Hoott van Iddekinge B J L de Wind N Wensvoort G | 1996 | Vaccine1996，14，： | 1 |
| 13 | Heritability of tyrosinase activity in soft white spring wheat 显示文摘 | Windes J M Souza E | 1995 | Agronomy Abstracts1995，，： | 1 |
| 14 | High yield secretion of recombinant gelatins by Pichia Pastoris显示文摘 | Werten M W Vande Bosch T J Wind R D | 1999 | Yeast1999，15，11： | 1 |
| 15 | Carbon dioxide-induced plasticization of polyimide membranes: pseudo-equilibrium relationships of diffusion, sorption, and swelling显示文摘 | Wind J D Sirard S M Paul D R | 2003 | Macromolecules2003，36，17： | 1 |
| 16 | Systematic review of enhanced recovery programmes in colonic surgery显示文摘 | Wind J Polle SW Fung Kon Jin PH | 2006 | Br J Surg2006，93，7： | 1 |
| 17 | An isolate of Exserohilure turcicum virulent on maize inbreds with resistance gene HtN 显示文摘 | WINDES J M PEDERSON W L | 1991 | Plant Disease1991，75，7： | 1 |
| 18 | Implementation of a fast-track perioperative care program: what are the difficulties? 显示文摘 | Polle SW Wind J Fuhring JW | 2007 | Dig Surg2007，24，6： | 1 |
| 19 | Vertical scaling of carbon nanotube field-effect transistors using top gate electrodes显示文摘 | Wind S J Appenzeller J Martel R | 2002 | Applied Physics Letter2002，80，： | 1 |
| 20 | Tempora- ry closure of the open abdomen:A systematic review on delayed primary fascial closure in patients with an openabdomen显示文摘 | van Hensbroek P Wind J Dijkgraaf MG | 2009 | Worm J Surg2009，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员