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| 1 | A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers显示文摘Kr 眉 p 像像素的因素 8 (KLF8 ) 抄写因素在房间周期前进起一个关键作用, oncogenic 转变,对间充质的转变和侵略上皮。然而,它的原子本地化信号(NLS ) 没被识别。有另外的 KLF monopartite NLS (mNLS ) 和 C2H2 锌手指(ZF ) 的 KLF8 份额,哪个被显示了是为一些另外的 KLF 的 NLS。在这份报告,用指导 PCR 的 mutagenesis 和 immunofluorescent 显微镜学,我们显示出 mNLSs,任何单个 ZF 的删除,或变化的那混乱 Zn2+ 有约束力或联系 DNA 主题没影响 KLF8 的原子本地化。删除 > 然而,从 C 终点的 1.5 ZF 引起了 KLF8 的细胞质的累积。令人惊讶地,氨基酸(aa ) 的删除 151-200 区域几乎从原子核消除了 KLF8。有 PKC 禁止者的 S165A, K171E 或 K171R 变化,或处理导致了部分细胞质的累积。Co-immunoprecipitation 证明 KLF8 与 importin- 交往了,这个相互作用要求了 ZF 主题。aa 1-150 或 201-261 区域的删除独自没改变原子本地化。BrdU 加入和 cyclin D1 倡导者酶试金作为野类型的 KLF8 证明在原子本地化的 KLF8 异种有缺陷者不能支持 DNA 合成或 cyclin D1 倡导者激活。一起拿,这些结果建议 KLF8 有二 NLS,一包围 S165 和 K171 并且另外的是二双人脚踏车 ZF,它为 KLF8 原子本地化和它的细胞的功能的规定是批评的。 | Tina S Mehta Heng Lu Xianhui Wang Alison M Urvalek Kim-Hang H Nguyen Farah Monzur Jojo D Hammond Jameson Q Ma Jihe Zhao | 2009 | Cell Research2009，19，9： | 10 |
| 2 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 3 | Use of the FAO CROPWAT model in deficit irrigation studies显示文摘 | Smith M Kivumbi D Heng L K | | Defieit Irrigation Practices0，22，： | 1 |
| 4 | Pure drug nanoparticles in tablets: what are the dissolution limitations 显示文摘 | Heng D Ogawa K Cutler D J | 2010 | J Nanopart Res2010，12，5： | 1 |
| 5 | Anti-angiogenic targets in the treatment of advanced renal cell carcinoma显示文摘 | Heng D Y Bukowski R M | 2008 | Curr Cancer Drug Targets2008，8，8： | 1 |
| 6 | Reliable GPS-based timing for power systems显示文摘 | Heng L Chou D Gao G X | 2014 | Inside GNSS2014，，6： | 1 |
| 7 | Cooperative GNSS authentication: reliability from unreliable peers 显示文摘 | Heng L Work D B Gao G X | 2013 | Inside GNSS2013，，5： | 1 |
| 8 | Nano spray drying: a novel method for preparing protein nanoparticles for protein therapy 显示文摘 | Lee SH Heng D Ng WK | 2011 | IntJPharm2011，403，12： | 1 |
| 9 | Accurate and direct characterization of high-Q microwave resonators using one-port measurement显示文摘 | Lye Heng Chua Mirshekar-Syahkal D | 2003 | IEEE Transactions on Microwave Theory and Techniques2003，51，3： | 1 |
| 10 | Establishment of critical success factors for construction partnering显示文摘 | Cheng Eddie W L Li Heng love P E D | 2000 | Journal of Management in Engineering2000，16，2： | 1 |
| 11 | prognostic factors in 677 pa tients in Singapore with nondisseminated nasopharyngeal carcinoma显示文摘 | Heng D M Wee J Fong K W | 1999 | Cancer1999，86，19： | 1 |
| 12 | Rice-based ingredients in cereals and snacks显示文摘 | Heng D Y | 1995 | Cereal Foods World1995，40，： | 1 |
| 13 | ERK1/2participates in regulating the expression and distribution of tight junction proteins in the process of reflux esophagitis显示文摘 | Tan JC Cui WX Heng D | 2014 | Journal of digestive diseases2014，15，8： | 1 |
| 14 | Effects of castration on thymocyte development in two different models of thymic involution显示文摘 | Heng T S Goldberg G L Gray D H | 2005 | Immunology2005，175，5： | 1 |
| 15 | Synergistic combination dry powders for inhaled antimicrobial therapy: Formulation, characterization and in vitro evaluation显示文摘 | Lee SH Teo J Heng D | 2013 | ? EUR J PHARM BIOPHARM2013，83，： | 1 |
| 16 | The Transcription Factor PU.1 Controls Dendritic Cell Development and Flt3 Cytokine Receptor Expression in a Dose-Dependent Manner显示文摘 | Sebastian Carotta Aleksandar Dakic Angela D’Amico Swee Heng Milon Pang Kylie T. Greig Stephen L. Nutt Li Wu | 2010 | Immunity2010，，5： | 1 |
| 17 | The HECT-domain ubiquitin ligase Huwel controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein 显示文摘 | Zhao X Heng JI Guardavaccaro D | 2008 | Nat Cell Biol2008，10，： | 1 |
| 18 | Predictors of axillary lymph node metastases in women with early breast cancer in Singapore 显示文摘 | Tan LG Tan YY Heng D | 2006 | Singapore Medical Journal2006，46，12： | 1 |
| 19 | Current management and future perspectives of metastatic renal cell carcinoma显示文摘 | Lee-Ying R Lester R Heng D | 2014 | IntJ Urol2014，21，9： | 1 |
| 20 | Maximum-Likelihood Analysis of Molecular Adaptation in Abalone Sperm Lysin Reveals Variable Selective Pressures Among Lineages and Sites显示文摘 | YANG Zi heng Willie J Swanson Victor D Vacquier | 2000 | Mol Biol Evol2000，17，10： | 1 |
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