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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | Economic burden of Parkinson's disease in a developing country: A retrospective cost analysis in Shanghai, China显示文摘 | Wang G Cheng Q Zheng R Tan YY Sun XK Zhou HY Ye XL Wang Y Wang Z Sun BM Chen SD | 2006 | 中国生物学文摘2006，20，8： | 10 |
| 3 | Survival outcomes of right-lobe living donor liver transplantation for patients with high Model for End-stage Liver Disease scores显示文摘BACKGROUND: Controversy exists over whether living donor liver transplantation (LDLT) should be offered to patients with high Model for End-stage Liver Disease (MELD) scores. This study tried to determine whether a high MELD score would result in inferior outcomes of right-lobe LDLT. METHODS: Among 411 consecutive patients who received right-lobe LDLT at our center, 143 were included in this study. The patients were divided into two groups according to their MELD scores: a high-score group (MELD score ≥25; n=75) and a low-score group (MELD score <25; n=68). Their demographic data and perioperative conditions were compared. Univariable and multivariable analyses were performed to identify risk factors affecting patient survival. RESULTS: In the high-score group, more patients required preoperative intensive care unit admission (49.3% vs 2.9%; P<0.001), mechanical ventilation (21.3% vs 0%; P<0.001), or hemodialysis (13.3% vs 0%; P=0.005); the waiting time before LDLT was shorter (4 vs 66 days; P<0.001); more blood was transfused during operation (7 vs 2 units; P<0.001); patients stayed longer in the intensive care unit (6 vs 3 days; P<0.001) and hospital (21 vs 15 days; P=0.015) after transplantation;more patients developed early postoperative complications (69.3% vs 50.0%; P=0.018); and values of postoperative peak blood parameters were higher. However, the two groups had comparable hospital mortality. Graft survival and patient overall survival at one year (94.7% vs 95.6%; 95.9% vs 96.9%), three years (91.9% vs 92.6%; 93.2% vs 95.3%), and five years (90.2% vs 90.2%; 93.2% vs 95.3%) were also similar between the groups. CONCLUSIONS: Although the high-score group had signifi-cantly more early postoperative complications, the two groups had comparable hospital mortality and similar satisfactory rates of graft survival and patient overall survival. Therefore, a high MELD score should not be a contraindication to right-lobe LDLT if donor risk and recipient benefit are taken into full account. | Kenneth SH Chok See Ching Chan James YY Fung Tan To Cheung Albert CY Chan Sheung Tat Fan Chung Mau Lo | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，3： | 6 |
| 4 | Therapeutic effect of tripterine on adjuvant arthritis in rats显示文摘 | LI H ZHANG YY TAN HW | 2008 | J Ethnopharmacol2008，118，3： | 1 |
| 5 | MR imaging features of pigmented villonodular synovitis of the cervical spine显示文摘 | Parmar HA Sitoh YY Tan KK | 2004 | AJNR Am J Neuroradiol2004，25，1： | 1 |
| 6 | Schwannoma of the gastrointestinal tract : a clinicopathological, immunohistochmnical and ultrastructural study of 33 cases 显示文摘 | Hou YY Tan YS Xu JF | 2006 | Histopathology2006，48，9： | 1 |
| 7 | Interleukin-1 induce tubular epithelia-myofibroblast transdifferentiation throngh a transforming growth factor-betal dependent mechanism in vitro显示文摘 | Tan JM Huarg XR Ng YY | 2001 | Am J Kidney Dis2001，37，7： | 1 |
| 8 | Selective modified radical neck dissection for papillary thyroid cancer is level Ⅰ,Ⅱ and Ⅴ dissection always necessary显示文摘 | Caron NR Tan YY Ogilvie JB | 2006 | World J Surg2006，30，5： | 1 |
| 9 | Identification of a known mutation in Notch 3 in familiar CADASIL in China显示文摘 | Tan ZX Li FF Qu YY | 2012 | PLoS One2012，7，36： | 1 |
| 10 | BpeAB OprB, a multi- drug efflux pump in gurkholderia pseudomallei显示文摘 | Chan YY Tan TM Ong YM etal | 2004 | Antimi crob Agents Chemother2004，48，4： | 1 |
| 11 | Reproductive outcomes in women with congenital uterine anomalies : a systematic review 显示文摘 | Chan YY Jayaprakasan K Tan A | 2011 | Ultrasound Obstet Gynecol2011，38，4： | 1 |
| 12 | Impaired mobility in older persons attending a geriatric assessment clinic:Causes and management 显示文摘 | TL Tan YY Ding A Lee | 2001 | Singapore Med J2001，42，2： | 1 |
| 13 | A new strategy of minimally in- vasive surgery for cholecystolithiasis: calculi removal and gallblad- der preservation显示文摘 | Tan YY Zhao G Wang D | 2013 | Dig Surg2013，30，46： | 1 |
| 14 | Anti-fatigue activity of polysaccharides extract from Radix Rehmanniae Preparata显示文摘 | Tan W Yu KQ Liu YY | 2012 | Int J Biol Macromole2012，50，1： | 1 |
| 15 | Selective modified radical neck dissection for papillary thyroid cancer-is level I, II and V dissection always necessary?显示文摘 | Caron NR Tan YY Ogilivie JB | 2006 | World J Surg2006，30，5： | 1 |
| 16 | Anti-fatigue activity of polysaccharides extract from Radix Rehmanniae Preparata显示文摘 | Tan W Yu KQ Liu YY | 2012 | Int J Biol Macromol2012，50，1： | 1 |
| 17 | Inter levkin-1 induce tubular epithelia-myofibroblast transdifferentiation throngh a transforming growth factor-beta 1 dependent machanism in vitro 显示文摘 | Tan JM Huarg XR Ng YY | 2001 | Am J Kidney Dis2001，37，7： | 1 |
| 18 | Serum HER2 level measured by dot blot : a valid and inexpensive assay for monitoring breast cancer progression 显示文摘 | Tan LD Xu YY Yu Y | 2011 | PLoS One2011，6，4： | 1 |
| 19 | Impact of genetic and acquired alteration in cytochrome P450 sys tem on pharmacologic and clinical response to clopi dogrel显示文摘 | Ma TK Lam YY Tan VP | 2010 | PharmacolTher2010，125，2： | 1 |
| 20 | The ProSeal laryngeal mask airway size selection in male and female patients in an A- sian population 显示文摘 | Tan SM Sim YY Koay CK | 2005 | Anaesth Intensive Care2005，33，2： | 1 |
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