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| 1 | Forming limits under multi-index constraints in NC bending of aluminum alloy thin-walled tubes with large diameters显示文摘With increasing diameters of aluminum alloy thin-walled tubes (AATTs), the tube forming limits, i.e. the minimum bending factors, and their predictions under multi-index constraints including wrinkling, thinning and flattening have been being a key problem to be urgently solved for improving tube forming potential in numerical control (NC) bending processes of AATTs with large diameters. Thus in this paper, a search algorithm of the forming limits is put forward based on a 3D elastic-plastic finite element (FE) model and a wrinkling energy prediction model for the bending processes under axial compression loading (ACL) or not. This algorithm enables to be considered the effects of process parameter combinations including die, friction parameters on the multi-indices. Based on this algorithm, the forming limits of the different size tubes are obtained, and the roles of the process parameter combinations in enabling the limit bending processes are also revealed. The followings are found: the first, within the appropriate ranges of friction and clearances between the different dies and the tubes enabling the bending processes with smaller bending factors, the ACL enables the tube limit bending processes after a decrease of the mandrel ball thickness and diameters; then, without considering the effects of the tube geometry sizes on the tube constitutive equations, the forming limits will be decided by the limit thinning values for the tubes with diameters smaller than 80 mm, while the wrinkling for the tubes with diameters no less than 80 mm. The forming limits obtained from this algorithm are smaller than the analytical results, and reduced by 57.39%; the last, the roles of the process parameter combinations in enabling the limit bending processes are verified by experimental results. | YAN Jing, YANG He, ZHAN Mei & LI Heng College of Materials Science and Engineering, State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi’an 710072, China | 2010 | Science China(Technological Sciences)2010，53，2： | 21 |
| 2 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 3 | Effects of 1-MCP on Ethylene Synthesis and Metabolismof Apple During Storage显示文摘Red Fuji apple (Malus domestica Borkh var. Red Fuji) fruits were used to study the effect of 1-MCP on ethylene biosynthesis metabolism during storage. The results showed that 1-MCP maintained the firmness and inhibited the respiration rate, LOX activity and ethylene production rate of fruits. Further study indicated that 1-MCP inhibited ACS (ACC synthase) activity from the 15th day, increased ACC accumulation,and delayed the appearance of ACO (ACC oxidase) activity peak. The increase of protein kinase activity was also inhibited by 1-MCP during fruit ethylene climacteric time. | LI Fu-jun, ZHAI Heng, YANG Hong-qiang, ZHANG Xin-hua, SHU Huai-rui and ZHOU Jie(Horticultural College , Shandong Agricultural University, Tai’an 271018 , P.R. China) | 2003 | Agricultural Sciences in China2003，2，11： | 4 |
| 4 | TWO NEW SESQUITERPENES FROM CELASTRUS ORBICULATUS显示文摘TWO NEW SESQUITERPENES FROM CELASTRUS ORBICULATUS￥MingAnWang;FuHengCHEN(DepartmentofAppliedChemistry.BeijingAgriculturalUnive... | Ming An Wang Fu Heng CHEN(Department of Applied Chemistry.Beijing Agricultural University.Beijing,100094) | 1995 | Chinese Chemical Letters1995，6，3： | 4 |
| 5 | Co-application of energy uncoupling and ultrafiltration in sludge treatment:Evaluations of sludge reduction,supernatant recovery and membrane fouling control显示文摘Energy uncoupling is often used for sludge reduction because it is easy to operate and does not require a significant amount of extra equipments(i.e.no additional tank required).However,over time the supernatant extracted using this method can deteriorate,ultimately requiring further treatment.The purpose of this study was to determine the effect of using a low-pressure ultrafiltration membrane process for sludge water recovery after the sludge had undergone an energy uncoupling treatment(using 3,3’,4’,5-tetrachlorosalicylanilide(TCS)).Energy uncoupling was found to break apart sludge floe by reducing extracellular polymeric substances(EPS)and adenosine triphosphate(ATP)content.Analysis of supernatant indicated that when energy uncoupling and membrane filtration were coapplied and the TCS dosage was below 30 mg/L,there was no significant deterioration in organic component removal.However,ammonia and phosphate concentrations were found to increase as the concentration of TCS added increased.Additionally,due to low sludge concentrations and EPS contents,addition of 30-60 mg/L TCS during sludge reduction increased the permeate flux(two times higher than the control)and decreased the hydraulic reversible and cake layer resistances.In contrast,high dosage of TCS aggravated membrane fouling by forming compact fouling layers.In general,this study found that the co-application of energy uncoupling and membrane filtration processes represents an effective alternative method for simultaneous sludge reduction and sludge supernatant recovery. | An Ding Yingxue Zhao Zhongsen Yan Langming Bai Haiyang Yang Heng Liang Guibai Li Nanqi Ren | 2020 | Frontiers of Environmental Science & Engineering2020，14，4： | 3 |
| 6 | Multi-omics approaches identify SF3B3 and SIRT3 as candidate autophagic regulators and druggable targets in invasive breast carcinoma显示文摘Autophagy is a critical cellular homeostatic mechanism,and its dysfunction is linked to invasive breast carcinoma(BRCA).Recently,several omics methods have been applied to explore autophagic regulators in BRCA;however,more reliable and robust approaches for identifying crucial regulators and druggable targets remain to be discovered.Thus,we report here the results of multi-omics approaches to identify potential autophagic regulators in BRCA,including gene expression(EXP),DNA methylation(MET)and copy number alterations(CNAs)from The Cancer Genome Atlas(TCGA).Newly identified candidate genes,such as SF3 B3,TRAPPC10,SIRT3,MTERFD1,and FBXO5,were confirmed to be involved in the positive or negative regulation of autophagy in BRCA.SF3 B3 was identified firstly as a negative autophagic regulator,and siRNA/shRNA-SF3 B3 were shown to induce autophagyassociated cell death in in vitro and in vivo breast cancer models.Moreover,a novel small-molecule activator of SIRT3,1-methylbenzylamino amiodarone,was discovered to induce autophagy in vitro and in vivo.Together,these results provide multi-omics approaches to identify some key candidate autophagic regulators,such as the negative regulator SF3 B3 and positive regulator SIRT3 in BRCA,and highlight SF3 B3 and SIRT3 as new druggable targets that could be used to fill the gap between autophagy and cancer drug development. | Shouyue Zhang Jin Zhang Yang An Xiaoxi Zeng Ziyi Qin Yuqian Zhao Heng Xu Bo Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 3 |
| 7 | Electrical breakdown characteristic of a Ce-doped W-Cu contact material显示文摘W-Cu composite powder doped with Ce (1.5 wt.%) was prepared by mechanical alloying (MA),and the W-Cu contact material was fabricated by hot pressing sintering in an electrical vacuum furnace.The microstructure,electric conductivity,hardness,and breakdown voltage of the Ce-doped W-Cu alloy were measured and compared with a conventional W-Cu alloy prepared by powder metallurgy.The results show that microstructural refinement and uniformity can improve the breakdown behavior and the electric arc stability of the Ce-doped W-Cu contact material.Also,the Ce-doped W-Cu contact material shows the characteristic of spreading electric arc,which is beneficial to electric arc erosion. | HU Kewen,CHEN Mianzhi,and YE Heng School of Materials Science and Engineering,Xi’an University of Technology,Xi’an 710048,China | 2010 | Rare Metals2010，29，3： | 2 |
| 8 | Feasibility study of creep feed grinding of 300M steel with zirconium corundum wheel显示文摘The ultrahigh strength 300M steel has been commonly used in the manufacture of aircraft landing gear and rotor shaft parts due to its excellent mechanical properties.Creep feed grinding is one of the essential operations during the whole component manufacturing processes.In this work,the feasibility of creep feed grinding of 300M steel by using the hard zirconium corundum wheel was theoretically and experimentally evaluated.A variety of responses including grinding forces,temperature fields,specific grinding energy,surface integrity and chip modes were carefully recorded.Besides,the mechanism of ground surface profile generation and the spatial frequency spectrum of the surface profile were tentatively analyzed.It was found that the wheel speed has a relative influence on the grinding forces and temperatures of which the work hardening effect dominates the material removal with lower wheel speed while the thermal softening becomes crucial as the wheel speed exceeds the critical value for the studied 300M steel.Furthermore,a scattered spatial frequency spectrum for the generated surface profile was noticed with lower wheel speed while the spectrum gathers towards the lower frequency values with higher amplitude as the wheel speed increases.The shearing chip and flowing chip dominates the main chip type,indicating the excellent abrasive sharpness during the grinding process.In general,the used zirconium corundum wheel presents feasibility for the creep feed grinding of 300M steel because of the high material removal rate,absence of surface burn,low wheel wear and higher compressive residual stresses. | Jiaqiang DANG Heng ZANG Qinglong AN Weiwei MING Ming CHEN | 2022 | Chinese Journal of Aeronautics2022，35，3： | 2 |
| 9 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 10 | Chronic Lymphocytic Leukemia Prognostic Index: A New Inteorated Scorino System to Predict the Time to First Treatment in Chinese Patients with Chronic Lymphocytic Leukemia显示文摘 | Heng Li Shu-Hua Yi Wen-Jie Xiong Hui-Min Liu Rui Lyu Ting-Yu Wang Wei Liu Shi-Zhen Zhong Zhen Yu De-Hui Zou Yan Xu Gang An Zeng-Jun Li Lu-Gui Qiu | 2017 | Chinese Medical Journal2017，，2： | 2 |
| 11 | An ultrathin and continuous Li_4Ti_5O_(12) coated carbon nanofiber interlayer for high rate lithium sulfur battery显示文摘Severe capacity fading and poor high rate performance of lithium sulfur(Li–S) battery caused by 'shuttle effect' and low conductivity of sulfur hampers its further developments and applications. Li_4Ti_5O_(12) (LTO)possesses high lithium ion conductivity, and it is also can be used as an active adsorbent for polysulfide. Herein, fine LTO particle coated carbon nanofibers(CNF) were prepared and a conductive network both for electron and lithium ion was built, which can greatly promote the electrochemical conversion of polysulfide and improve the rate performance of Li–S batteries. Meanwhile, a quantity of adsorption sites is constructed by defects of the surface of LTO-CNF membrane to effectively immobilize polysulfide. The multifunctional LTO-CNF interlayer could impede the shuttle effect and enhance comprehensive electrochemical performance of Li–S batteries, especially high rate performance. With such LTO-CNF interlayer,the Li–S battery presents a specific capacity of 641.9 mAh/g at 5 C rate. After 400 cycles at 1 C, a capacity of 618.0 mAh/g is retained. This work provides a feasible strategy to achieve high performance of Li–S battery for practical utilization. | Decheng An Lu Shen Danni Lei Lehong Wang Heng Ye Baohua Li Feiyu Kang Yan-Bing He | 2019 | Journal of Energy Chemistry2019，28，4： | 2 |
| 12 | Online identifi- cation of the antioxidant constituents of traditional Chinese medi- cine formula Chaihu-Shu-Gan-San by LC-LTQ-Orbitrap mass spectrometry and microplate spectrophotometer 显示文摘 | Su Zhi Heng Zou Guo An Alfred Preiss | 2010 | J Pharma- ceut Biomed2010，53，3： | 1 |
| 13 | Resveratrol modulates adipokine expression and improves insulin sensitivity in adipocytes:Relative to inhibition of in ammatory responses显示文摘 | Liu Kang Wang Heng An Yuan | 2010 | Biochimie2010，92，7： | 1 |
| 14 | THE STRUCTURE OF CEUSTRINE B FROM CELASTRUS FLAGELLARIS显示文摘THE STRUCTURE OF CEUSTRINE B FROM CELASTRUS FLAGELLARISMingAnWANG;MinWANG;FuHengCHEN(DepartmentofAppliedChemistryBeijingAgric... | Ming An WANG Min WANG Fu Heng CHEN (Department of Applied Chemistry Beijing Agricultural University Beijing 100094) | 1995 | Chinese Chemical Letters1995，6，12： | 1 |
| 15 | Comparison of two in vitro angiogenesis assays for evaluating the effects of netrin-1 on tube formation显示文摘Netrin-1 是也调整脉管的开发的神经指导暗示。然而,争论结果在 vivo 并且在 vitro 在脉管的开发有关 netrin-1 的角色被获得了。在现在的学习,二在 vitro angiogenesis 试金与相比评估藏匿由的 netrin-1 的效果 retrovirally 试管形成上的 transduced 黑瘤房间(Mel2a-netrin1 ) 。结果证明在调节媒介(厘米) 在 matrigel 试金从控制, Mel2a-netrin1 和 Mel2a 房间导致的试管形成没有明显的差别。在哪个 endothelial 房间然而与人的成纤维细胞是 co 有教养的,在 vitro 试金的另外一个的结果证明那 Mel2a-netrin1 厘米禁止了试管形成,据说通过堵住人的脐的静脉 endothelial 房间(HUVEC ) 的延伸和结合。这些结果证实 matrigel 试金不能表明 netrin-1 的 anti-angiogenic 角色。 | Hui Guo Yin Jia Min Shang Yuan Zhang Fu'an Xie Heng Wang Mingjing Yuan Li Yuan Jura Ye | 2014 | Acta Biochimica et Biophysica Sinica2014，46，9： | 1 |
| 16 | Carbohydrate-based drugs launched during 2000-2021显示文摘Carbohydrates are fundamental molecules involved in nearly all aspects of lives,such as being involved in formating the genetic and energy materials,supporting the structure of organisms,constituting invasion and host defense systems,and forming antibiotics secondary metabolites.The naturally occurring carbohydrates and their derivatives have been extensively studied as therapeutic agents for the treatment of various diseases.During 2000 to 2021,totally 54 carbohydrate-based drugs which contain carbohydrate moities as the major structural units have been approved as drugs or diagnostic agents.Here we provide a comprehensive review on the chemical structures,activities,and clinical trial results of these carbohydrate-based drugs,which are categorized by their indications into antiviral drugs,antibacterial/antiparasitic drugs,anticancer drugs,antidiabetics drugs,cardiovascular drugs,nervous system drugs,and other agents. | Xin Cao Xiaojing Du Heng Jiao Quanlin An Ruoxue Chen Pengfei Fang Jing Wang Biao Yu | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 1 |
| 17 | Investigation on the Cu–Cr–RE alloys by rapid solidification显示文摘 | Ming Xie Jianliang Liu Xianyong Lu An Shi Zhongmin Den Heng Jang Fuqian Zheng | 2001 | Materials Science & Engineering A2001，，： | 1 |
| 18 | Stock price synchronicity, crash risk and institutional investors 显示文摘 | An Heng Zhang Ting | 2013 | Journal of Corporate Fi- nance2013，21，6： | 1 |
| 19 | Design of readout electronics based on peak-holding circuit and multiplexer for a fast neutron spectrometer显示文摘Background Fast neutron detection is meaningful in many research fields such as space environment monitoring.A scintillating fiber array model for fast neutron detection was proposed and developed in 1980s.Aerospace applications of the model require electronics in small size.Purpose To design a dedicated electronic system to readout and process the 384-channel signals from scintillating fiber array,and to use the designed system to fabricate a neutron detector for aerospace applications.Methods With the method of nuclear recoil,fast neutron is detected by tracking recoil proton of n–p scatter in scintillating plastic fibers.Using the peak-holding circuits and multiplexers,the system size and power consumption were reduced.Results The detector fabricated with the designed system,had 34 cm×34 cm×27 cm mechanical size,20.4 kg weight,and 30.05W power consumption.Comparing to traditional waveform sampling electronics,the designed electronics was highly integrated and had a small size.The readout electronics also gave a better energy resolution of 39%in neutron detection,while the energy resolution was 43%in previous version.Conclusion In this study,a highly integrated readout electronic system was designed and verified.The detector using the system gave good performance.The designed electronics had potential development in fast neutron detection and other high energy physics detection system. | Liyang Sun Kai Zhuang Xiaoming Wang Fanjian Zeng Heng An Daowu Li Yuxiong Xue Zhiming Zhang Wei Zhou Yingjie Wang Baotong Feng Peilin Wang Xiaohui Li Jiale Cai Teng Tong Fanhui Meng Junguang Zhou Huan Huang Xuanhou Hu Xiubo Qin | 2018 | Radiation Detection Technology and Methods2018，2，1： | 1 |
| 20 | Synthesis and in vitro biological evaluation of farnesylthiosalicylic acid derivatives as anti-tumor carcinoma agents显示文摘Novel farnesylthiosahcylic acid(FTA) derivatives 5a-m with different substituted 1,3,4-thiadiazoles were synthesized. Compounds 5b,5c,5e and 5f displayed anti-tumor activities superior to FTA in most cancer cells tested.Furthermore,5e induced tumor cell apoptosis,which was accompanied by lower Bcl-2 expression,but with higher Bax and caspase 3 expression activities in cancer cells. | Yong Ling You An Xiao Guang Tong Chen Dong Geng Wang Yu Qin Li Xin Yang Wang Heng Zheng | 2012 | Chinese Chemical Letters2012，23，10： | 1 |
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