|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Survival and outcomes for co-infection of chronic hepatitis C with and without cirrhosis and COVID-19: A multicenter retrospective study显示文摘BACKGROUND Chronic liver disease,particularly cirrhosis,is associated with worse outcomes in patients infected with coronavirus disease 2019(COVID-19).AIM To assess outcomes of COVID-19 infection among patients with pre-existing hepatitis C with or without liver cirrhosis.METHODS This multicenter,retrospective cohort study included all cases of confirmed coinfection of severe acute respiratory syndrome coronavirus 2 and chronic hepatitis C with or without liver cirrhosis who were admitted to six hospitals(Al-Sahel Hospital,Al-Matareya Hospital,Al-Ahrar Hospital,Ahmed Maher Teaching Hospital,Al-Gomhoreya Hospital,and the National Hepatology and Tropical Medicine Research Institute)affiliated with the General Organization for Teaching Hospitals and Institutes in Egypt.Patients were recruited from May 1,2020,to July 31,2020.Demographic,laboratory,imaging features,and outcomes were collected.Multivariate regression analysis was performed to detect factors affecting mortality.RESULTS This retrospective cohort study included 125 patients with chronic hepatitis C and COVID-19 co-infection,of which 64(51.20%)had liver cirrhosis and 40(32.00%)died.Fever,cough,dyspnea,and fatigue were the most frequent symptoms in patients with liver cirrhosis.Cough,sore throat,fatigue,myalgia,and diarrhea were significantly more common in patients with liver cirrhosis than in noncirrhotic patients.There was no difference between patients with and without cirrhosis regarding comorbidities.Fifteen patients(23.40%)with liver cirrhosis presented with hepatic encephalopathy.Patients with liver cirrhosis were more likely than non-cirrhotic patients to have combined ground-glass opacities and consolidations in CT chest scans:28(43.75%)vs 4(6.55%),respectively(P value<0.001).These patients also were more likely to have severe COVID-19 infection,compared to patients without liver cirrhosis:29(45.31%)vs 11(18.04%),respectively(P value<0.003).Mortality was higher in patients with liver cirrhosis,compared to those with no cirrhosis:33(51.56%)vs 9(14.75%),respectively(P value<0.001).All patients in Child-Pugh class A recovered and were discharged.Cirrhotic mortality occurred among decompensated patients only.A multivariate regression analysis revealed the following independent factors affecting mortality:Male gender(OR 7.17,95%CI:2.19–23.51;P value=0.001),diabetes mellitus(OR 4.03,95%CI:1.49–10.91;P value=0.006),and liver cirrhosis(OR 1.103,95%CI:1.037–1.282;P value<0.0001).We found no differences in liver function,COVID-19 disease severity,or outcomes between patients who previously received direct-acting antiviral therapy(and achieved sustained virological response)and patients who did not receive this therapy.CONCLUSION Patients with liver cirrhosis are susceptible to higher severity and mortality if infected with COVID-19.Male gender,diabetes mellitus,and liver cirrhosis are independent factors associated with increased mortality risk. | Shimaa Afify Basem Eysa Fatma Abdel Hamid Omnia M Abo-Elazm Mohamed A Edris Rabab Maher Ahmed Abdelhalim Muhammad Mostafa Abdel Ghaffar Dalia A Omran Hend Ibrahim Shousha | 2021 | World Journal of Gastroenterology2021，27，42： | 2 |
| 2 | Efficacy and survival analysis of percutaneous radiofrequency versus microwave ablation for hepatocellular carcinoma: an egyptian multidisciplinary clinic experience显示文摘 | Ashraf Abdelaziz Tamer Elbaz Hend Ibrahim Shousha Sherif Mahmoud Mostafa Ibrahim Ahmed Abdelmaksoud Mohamed Nabeel | 2014 | Surgical Endoscopy2014，，12： | 1 |
| 3 | Microwave ablation versus transarterial chemoembolization in large hepatocellular carcinoma: prospective analysis显示文摘 | Ashraf Omar Abdelaziz Mohamed Mahmoud Nabeel Tamer Mahmoud Elbaz Hend Ibrahim Shousha Eman Medhat Hassan Sherif Hamdy Mahmoud Noha Ali Rashed Mostafa Mohamed Ibrahim Ahmed Hosni Abdelmaksoud | 2014 | Scandinavian Journal of Gastroenterology2014，，4： | 1 |
| 4 | Assessment of circulating levels of microRNA-326,microRNA-424,and microRNA-511 as biomarkers for hepatocellular carcinoma in Egyptians显示文摘BACKGROUND Hepatocellular carcinoma(HCC)is the fifth most common cancer.Differential expression of microRNAs(miRNAs)-326,miRNA-424,and miRNA-511 has been associated with the diagnosis and prognosis of HCC in different populations.However,limited information is available regarding their expression in Egyptian HCC patients.AIM To assess the role of circulating miRNAs-326,miRNA-424,and miRNA-511 in Egyptian HCC patients.METHODS This prospective observational study included 70 HCC patients and 25 healthy controls.The circulating levels of these three miRNAs were evaluated by real-time PCR.Receiver operating characteristic curve analysis was used to test the diagnostic accuracy of micro RNA expression levels.RESULTS All miRNAs were differentially expressed in HCC patients;miRNAs326 and miRNA-424 were upregulated,while miRNA-511 was downregulated.Both miRNA-326 and miRNA-424 showed sensitivity and specificity of 97%,71.4%,and 52%,60%,respectively,to differentiate HCC from controls.Moreover,miRNA-326 was associated with survival and could differentiate between Child grades(A vs B);miRNA-424 significantly differentiated early vs intermediate stages of HCC;while miRNA-511 was significantly correlated with response to modified Response Evaluation Criteria in Solid Tumors(m RECIST).CONCLUSION We conclude that miRNA-326,miRNA-424,and miRNA-511 have diagnostic and prognostic roles in Egyptian patients with hepatitis C virus-related HCC and should be considered for better disease management. | Samar Samir Youssef Asmaa Elfiky Mohamed M Nabeel Hend Ibrahim Shousha Tamer Elbaz Dalia Omran Mohammad Saeed Marie Mohammad A Elzahry Amr Abul-Fotouh Ahmed Hashem Mohamed F Guda Ashraf O Abdelaziz | 2022 | World Journal of Hepatology2022，14，8： | 1 |
| 5 | Hepatic and gastrointestinal disturbances in Egyptian patients infected with coronavirus disease 2019: A multicentre cohort study显示文摘BACKGROUND Various liver and gastrointestinal involvements occur in patients with coronavirus disease 2019(COVID-19)at variable prevalence.Most studies report mild liver function disturbances correlated with COVID-19 severity,though liver failure is unusual.AIM To study liver and gastrointestinal dysfunctions in Egyptian patients with COVID-19 and their relation to disease outcomes METHODS This multicentre cohort study was conducted on 547 Egyptian patients from April 15,2020 to July 29,2020.Consecutive polymerase chain reaction-confirmed COVID-19 cases were included from four quarantine hospitals affiliated to the Egyptian ministry of health.Demographic information,laboratory characteristics,treatments,fibrosis-4(FIB-4)index,COVID-19 severity,and outcomes were recorded and compared according to the degree of liver enzyme elevation and the presence of gastrointestinal symptoms.Follow-ups were conducted until discharge or death.Regression analyses were performed to determine the independent factors affecting mortality.RESULTS This study included 547 patients,of whom 53(9.68%)died during hospitalization and 1 was discharged upon his request.Patients’mean age was 45.04±17.61 years,and 21.98%had severe or critical COVID-19.Alanine aminotransferase(ALT)and aspartate aminotransferase(AST)were available for 430 and 428 patients,respectively.In total,26%and 32%of patients had elevated ALT and AST,respectively.Significant liver injury with ALT or AST elevation exceeding 3-fold was recorded in 21(4.91%)and 16(3.73%)patients,respectively.Male gender,smoking,hypertension,chronic hepatitis C,and lung involvement were associated with elevated AST or ALT.AST was elevated in 50%of patients over 60-years-old.FIB-4 was significantly higher in patients admitted to the intensive care unit(ICU),those with more severe COVID-19,and non-survivors.The independent variables affecting outcome were supplementary vitamin C intake(1 g daily capsules)[odds ratio(OR):0.05,95%confidence interval(CI):0.008–0.337];lung consolidation(OR:4.540,95%CI:1.155–17.840);ICU admission(OR:25.032,95%CI:7.110–88.128);and FIB-4 score>3.25(OR:10.393,95%CI:2.459-43.925).Among 60(13.98%)patients with gastrointestinal symptoms,52(86.67%)had diarrhoea.Patients with gastrointestinal symptoms were predominantly females with higher body mass index,and 50(83.40%)patients had non-severe COVID-19.CONCLUSION Few Egyptian patients with COVID-19 developed a significant liver injury.The independent variables affecting mortality were supplementary vitamin C intake,lung consolidation,ICU admission,and FIB-4 score. | Hend Ibrahim Shousha Shimaa Afify Rabab Maher Noha Asem Eman Fouad Ehab F Mostafa Mohammed A Medhat Amr Abdalazeem Hazem Elmorsy Miriam M Aziz Rateba S Mohammed Mohamed Ibrahem Hassan Elgarem Dalia Omran Mohamed Hassany Bassem Elsayed Ahmed Y Abdelaziz Mohamed El Kassas | 2021 | World Journal of Gastroenterology2021，27，40： | 1 |
| 6 | Proposed Different Signal Processing Tools for Efficient Optical Wireless Communications显示文摘Optical Wireless Communication(OWC)is a new trend in communication systems to achieve large bandwidth,high bit rate,high security,fast deployment,and low cost.The basic idea of the OWC is to transmit data on unguided media with light.This system requires multi-carrier modulation such as Orthogonal Frequency Division Multiplexing(OFDM).This paper studies optical OFDM performance based on Intensity Modulation with Direct Detection(IM/DD)system.This system requires a non-negativity constraint.The paper presents a framework for wireless optical OFDM system that comprises(IM/DD)with different forms,Direct Current biased Optical OFDM(DCO-OFDM),Asymmetrically Clipped Optical OFDM(ACO-OFDM),Asymmetrically DC-biased Optical OFDM(ADO-OFDM),and Flip-OFDM.It also considers channel coding as a tool for error control,channel equalization for reducing deterioration due to channel effects,and investigation of the turbulence effects.The evaluation results of the proposed framework reveal enhancement of performance.The performance of the IM/DD-OFDM system is investigated over different channel models such as AWGN,log-normal turbulence channel model,and ceiling bounce channel model.The simulation results show that the BER performance of the IM/DD-OFDM communication system is enhanced while the fading strength is decreased.The results reveal also that Hamming codes,BCH codes,and convolutional codes achieve better BER performance.Also,two algorithms of channel estimation and equalization are considered and compared.These algorithms include the Least Squares(LS)and the Minimum Mean Square Error(MMSE).The simulation results show that the MMSE algorithm gives better BER performance than the LS algorithm. | Hend Ibrahim Abeer D.Algarni Mahmoud Abdalla Walid El-Shafai Fathi E.Abd El-Samie Naglaa F.Soliman | 2022 | Computers, Materials & Continua2022，，5： | 0 |
| 7 | Voting Classifier and Metaheuristic Optimization for Network Intrusion Detection显示文摘Managing physical objects in the network’s periphery is made possible by the Internet of Things(IoT),revolutionizing human life.Open attacks and unauthorized access are possible with these IoT devices,which exchange data to enable remote access.These attacks are often detected using intrusion detection methodologies,although these systems’effectiveness and accuracy are subpar.This paper proposes a new voting classifier composed of an ensemble of machine learning models trained and optimized using metaheuristic optimization.The employed metaheuristic optimizer is a new version of the whale optimization algorithm(WOA),which is guided by the dipper throated optimizer(DTO)to improve the exploration process of the traditionalWOA optimizer.The proposed voting classifier categorizes the network intrusions robustly and efficiently.To assess the proposed approach,a dataset created from IoT devices is employed to record the efficiency of the proposed algorithm for binary attack categorization.The dataset records are balanced using the locality-sensitive hashing(LSH)and Synthetic Minority Oversampling Technique(SMOTE).The evaluation of the achieved results is performed in terms of statistical analysis and visual plots to prove the proposed approach’s effectiveness,stability,and significance.The achieved results confirmed the superiority of the proposed algorithm for the task of network intrusion detection. | Doaa Sami Khafaga Faten Khalid Karim Abdelaziz A.Abdelhamid El-Sayed M.El-kenawy Hend K.Alkahtani Nima Khodadadi Mohammed Hadwan Abdelhameed Ibrahim | 2023 | Computers, Materials & Continua2023，，2： | 0 |
| 8 | Patterns of liver profile disturbance in patients with COVID-19显示文摘Fever and cough are the most common clinical symptoms of coronavirus disease 2019(COVID-19),but complications(such as pneumonia,respiratory distress syndrome,and multiorgan failure)can occur in people with additional comorbidities.COVID-19 may be a new cause of liver disease,as liver profile disturbance is one of the most common findings among patients.The molecular mechanism underlying this phenomenon,however,is still unknown.In this paper,we review the most current research on the patterns of change in liver profile among patients with COVID-19,the possible explanation for these findings,and the relation to pre-existing liver disease in these patients. | Hend Ibrahim Shousha Ahmed Ramadan Rania Lithy Mohamed El-Kassas | 2022 | World Journal of Clinical Cases2022，10，7： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员