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| 1 | Pain sensation in pancreatic diseases is not uniform: The different facets of pancreatic pain显示文摘AIM: To systematically characterize specific pain patterns in the most frequent pancreatic diseases.METHODS: Pain in patients with chronic pancreatitis(n = 314), pancreatic cancer(n = 469), and other pancreatic tumors(n = 249) including mucinous(n = 20) and serous cystadenoma(n = 31), invasive(n = 37) and non-invasive intraductal papillary mucinous neoplasia(IPMN; n = 48), low stage(n = 18) and high stage neuroendocrine neoplasia(n = 44), and ampullary cancer(n = 51) was registered and correlated with clinicopathological data. Survival times were estimated by the Kaplan-Meier method. Patients alive at the follow-up time were censored. Survival curves were compared statistically using the log-rank test.RESULTS: Forty-nine point one percent of pancreatic cancer patients revealed no pain, whereas in chronic pancreatitis only 18.3% were pain free. In contrary, moderate/severe pain was registered in 15.1% in pancreatic cancer patients that was increased in chronic pancreatitis with up to 34.2%. Serous cystadenoma was asymptomatic in most cases(58.1%), whereas 78.9% of all mucinous cystadenoma patients suffered pain. In neuroendocrine neoplasia pain was not a key clinical symptom since 64% of low stage neuroendocrine neoplasia and 59% of high stage neuroendocrine neoplasia patients were pain free. Cancer localization in the pancreatic body and patients with malignant pancreatic neoplasms were associated with more severe pain. Tumor grading and stage did not show any impact on pain. Only in pancreatic cancer, pain was directly associated with impaired survival.CONCLUSION: Pancreatic pain depicts different patterns of abdominal pain sensation according to the respective pancreatic disorder and does not allow a unification of the term pancreatic pain. | Jan G D'Haese Mark Hartel Ihsan Ekin Demir Ulf Hinz Frank Bergmann Markus W Büchler Helmut Friess Güralp O Ceyhan | 2014 | World Journal of Gastroenterology2014，20，27： | 8 |
| 2 | Best supportive care (BSC) versus oxaliplatin, folinic acid and 5-fluorouracil (OFF) plus BSC in patients for second-line advanced pancreatic cancer: A phase III-study from the German CONKO-study group显示文摘 | Uwe Pelzer Ingo Schwaner Jens Stieler Mathias Adler J?rg Seraphin Bernd D?rken Hanno Riess Helmut Oettle | 2011 | European Journal of Cancer2011，，11： | 2 |
| 3 | Pancreatic Enzyme Replacement Therapy in Patients With Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis: A 1-Year Disease Management Study on Symptom Control and Quality of Life显示文摘 | Jan G. D’Haese Güralp O. Ceyhan Ihsan Ekin Demir Peter Layer Waldemar Uhl Matthias L?hr Reinhard Rychlik Konstantinos Pirilis York Z?llner Birgit Gradl Douglas Foerster Julia M?bius Friederike Henniges Helmut Friess | 2014 | Pancreas2014，，： | 2 |
| 4 | Pros and cons of a pushover analysis of seismic performance evaluation显示文摘 | HELMUT KRAWINKLER SENVIRATNA G D K | 1998 | Engineering Structures1998，20，4： | 1 |
| 5 | Treatment options in painful chronic pancreatitis: a systematic review显示文摘 | Jan G. D’Haese Güralp O. Ceyhan Ihsan Ekin Demir Elke Tieftrunk Helmut Friess | 2014 | HPB2014，，6： | 1 |
| 6 | Analytical characterization and the impact of ageing on antho- cyanin composition and degradation in juices from five sour cherry cultivars European显示文摘 | Daniel B Kirsten W Helmut D | 2007 | Food Re- search and Technology2007，224，3： | 1 |
| 7 | Renin-angiotensin system and atherosclerosis显示文摘 | Karsten G Helmut D Bernhard S | 2004 | Nephrol Dial Transplant2004，19，： | 1 |
| 8 | Pros and cons analysis of seismic evaluation of a pushover performance 显示文摘 | Helmut Krawinkler Seneviratna G D P K | 1998 | Engineering Structures1998，20，46： | 1 |
| 9 | Fractalkine/CX3CR1: why a single chemokine-receptor duo bears a major and unique therapeutic potential显示文摘 | Jan G D’Haese Ihsan Ekin Demir Helmut Friess Güralp O Ceyhan | 2010 | Expert Opinion on Therapeutic Targets2010，，2： | 1 |
| 10 | Adorngs view of psychoanalysis显示文摘 | Helmut D | 2012 | The- sis Eleven2012，，： | 1 |
| 11 | An apparatus for the investigation of low temperature, highpressure, vapor-liquid and vapor-liquid-liquid equilibria显示文摘 | Wolfgang D Hermann W K Helmut K | 1983 | Fluid Phase Equilibira1983，11，1： | 1 |
| 12 | Fractalkine/CX3CR1: why a single chemokine-receptor duo bears a major and unique therapeutic potential显示文摘 | Jan G D’Haese Ihsan Ekin Demir Helmut Friess Güralp O Ceyhan | 2010 | Expert Opinion on Therapeutic Targets2010，，2： | 1 |
| 13 | Nutrient-determined dominance in multispecies chemostat cultures of diatoms 显示文摘 | MICHAEL J M HELMUT M RICHARD C D | 1979 | Limnol Oceanogr1979，24，2： | 1 |
| 14 | Chemistry of aiologically important synthetic organoselenium compounds 显示文摘 | Govindasamy M Wolf Walther D M Helmut S | 2001 | Chem Rev2001，101，7： | 1 |
| 15 | Health effects of endocrine-disrupting chemicals on wildlife,with special reference to the European situation显示文摘 | Erik D Helmut A G | 2000 | Cribical Review in Toxicology2000，30，1： | 1 |
| 16 | Synthesis and polymerization of his (hexamethylene carbonate) and his (2,2,3,3, 4,4,5 Chemistry and Physics, 1996 carbonate ) 显示文摘 | Weilandt Karl D Keul Helmut HOcker Hartwig | 1996 | Macromolecular1996，197，8： | 1 |
| 17 | Estrogen receptor-β messenger RNA expression in human breast tumor biopsies: relationship to steroid receptor status and regulation by progestins显示文摘 | Etienne L Peter HW | 1999 | Cancer Res1999，59，： | 1 |
| 18 | Ac cidental bullous phototoxic reactions to bergamot aromathera py oil 显示文摘 | Steven Kaddu M D Helmut Kerl M D Peter Wolf M D | 2001 | Journal of the American Academy of Dermatology2001，45，3： | 1 |
| 19 | Pros and cons of a pushover analysis of seismic performance evaluation显示文摘 | HELMUT KRAWINKLER SENEVIRATNA G D P K | 1998 | Engineering Structures1998，20，45： | 1 |
| 20 | Rationale and design of the SERVE-HF study: treatment of sleep-disordered breathing with predominant central sleep apnoea with adaptive servo-ventilation in patients with chronic heart failure显示文摘 | Martin R. Cowie Holger Woehrle Karl Wegscheider Christiane Angermann Marie-Pia d’Ortho Erland Erdmann Patrick Levy Anita Simonds Virend K. Somers Faiez Zannad Helmut Teschler | 2013 | European Journal of Heart Failure2013，，8： | 1 |
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