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| 1 | Primary prevention and treatment of venous thromboembolic events in patients with gastrointestinal cancers- Review显示文摘Venous thromboembolism event(VTE) is a common and morbid complication in cancer patients. Patients with gastrointestinal cancers often suffer from symptomatic or incidental splanchnic vein thrombosis, impaired liver function and/or thrombocytopenia. These characteristics require a thorough risk/benefit evaluation for individual patients. Considering the risk factors for the development of VTE and bleeding events in addition to recent study results may be helpful for correct initiation of primary pharmacological prevention and treatment of cancer-associated thrombosis(CAT), preferably with low molecular weight heparins(LMWH). Whereas thromboprophylaxis is most often recommended in hospitalized surgical and non-surgical patients with malignancy, there is less agreement as to its duration. With regard to ambulatory cancer patients, the lack of robust data results in low grade recommendations against routine use of anticoagulant drugs. Anticoagulation with LMWH for the first months is the evidence-based treatment for acute CAT, but duration of secondary prevention and the drug of choice are unclear. Based on published guidelines and literature, this review will focus on prevention and treatment strategies of VTE in patients with gastrointestinal cancers. | Hanno Riess Piet Habbel Anja Jühling Marianne Sinn Uwe Pelzer | 2016 | World Journal of Gastrointestinal Oncology2016，8，3： | 9 |
| 2 | Perioperative treatment options in resectable pancreatic cancer-how to improve long-term survival显示文摘Surgery remains the only chance of cure for pancreatic cancer, but only 15%-25% of patients present with resectable disease at the time of primary diagnosis. Important goals in clinical research must therefore be to allow early detection with suitable diagnostic procedures, to further broaden operation techniques and to determine the most effective perioperative treatment of either chemotherapy and/or radiation therapy. More extensive operations involving extended pancreatectomy, portal vein resection and pancreatic resection in resectable pancreatic cancer with limited liver metastasis, performed in specialized centers seem to be the surgical procedures with a possible impact on survival. After many years of stagnation in pharmacological clinical research on advanced pancreatic ductal adenocarcinomas(PDAC)- since the approval of gemcitabine in 1997- more effective cytotoxic substances(nab-paclitaxel) and combinations(FOLFIRINOX) are now available for perioperative treatment. Additionally, therapies with a broader mechanism of action are emerging(stroma depletion, immunotherapy, antiinflammation), raising hopes for more effective adjuvant and neoadjuvant treatment concepts, especially in the context of 'borderline resectability'. Only multidisciplinary approaches including radiology, surgery, medical and radiation oncology as the backbones of the treatment of potentially resectable PDAC may be able to further improve the rate of cure in the future. | Marianne Sinn Marcus Bahra Timm Denecke Sue Travis Uwe Pelzer Hanno Riess | 2016 | World Journal of Gastrointestinal Oncology2016，8，3： | 3 |
| 3 | Best supportive care (BSC) versus oxaliplatin, folinic acid and 5-fluorouracil (OFF) plus BSC in patients for second-line advanced pancreatic cancer: A phase III-study from the German CONKO-study group显示文摘 | Uwe Pelzer Ingo Schwaner Jens Stieler Mathias Adler J?rg Seraphin Bernd D?rken Hanno Riess Helmut Oettle | 2011 | European Journal of Cancer2011，，11： | 2 |
| 4 | Estrogen and estrogen receptors in cardiovascular oxidative stress显示文摘 | ARIAS LOZA P A MUEHLFELDER M PELZER T | 2013 | Pflugers Arch2013，465，5： | 1 |
| 5 | Ultrasound of prostate cancer:recent advances显示文摘 | Pallwein L Mitterberger M Pelzer A | 2008 | Eur Radiol2008，18，4： | 1 |
| 6 | Vascularized bone allotransplantation: current state and implications for future reconstructive surgery显示文摘 | Bishop AT Pelzer MV | 2007 | Orthop Clin North Am2007，38，1： | 1 |
| 7 | Elevated serum markers of collagen degradation in patients with mild to moderate dilated cardiomyopathy显示文摘 | Schwartzkopff B fassbach M Pelzer B | 2002 | Eur J Heart2002，4，4： | 1 |
| 8 | Advances in surgical management of malignancies of the cranial base: the extended transbasal approach显示文摘 | Chandler JP Pelzer HJ Bendok BB | 2005 | J Neurooncol2005，73，2： | 1 |
| 9 | Transcardiopulmonary vs pulmonary arterial thermodilution methods for hemodynamic monitoring of burned patients 显示文摘 | Kuntscher MV Blome - Eberwein S Pelzer M | 2002 | J Burn Care Rehabil2002，23，1： | 1 |
| 10 | 17β-estradiol prevents programmed cell death in cardiac myocytes显示文摘 | Pelzer T Schumann M Nenmann M | 2000 | Biochem and Biophys Res Commun2000，268，1： | 1 |
| 11 | Relation- ship between severity of blackleg (Leptosphaeria macu- lans/L, biglobosa species complex) and subsequent pri- mary inoculum production on oilseed rape stubble 显示文摘 | Lo -Pelzer E Aubertot J N David O | 2009 | Plant Pathology2009，58，1： | 1 |
| 12 | Some Criteria for the Accuracy and Reliability of Networks显示文摘 | Pelzer H | 1980 | DGK1980，25，2： | 1 |
| 13 | Two novel SCN1A mutations identified in families with familial hemiplegic migraine显示文摘 | Weller CM Pelzer N de Vries B | 2014 | Cephalalgia2014，34，13： | 1 |
| 14 | Gas phase catalysis by metal nanopartieles in nanoporous alumina membranes显示文摘 | KORMANN H P SCHMID G PELZER K | 2004 | Z Anorg Allg2004，630，12： | 1 |
| 15 | Association of classical semen parameters,sperm DNA fragmentation index,lipid peroxidation and antioxidant enzymatic activity of semen in ram-lambs显示文摘 | Kasimanickam R Pelzer K D Kasimanickam V | 2006 | Theriogenology2006，65，7： | 1 |
| 16 | Rationale and design of PROS- PECT- CONKO 004:a prospective, randomized trial of simultane- otis pancreatic cancer treatment with enoxaparin and chemothera py显示文摘 | Riess H Pelzer U Hilbig A | 2008 | BMC Cancer2008，8，： | 1 |
| 17 | The estrogen receptor-a agonist 16a-LE2 inhibits cardiac hypertrophy and improves hemodynamic function in estrogen-deficient spontaneously hypertensive rats显示文摘 | Pelzer T Jazbutyte V Muck J | 2005 | Cardiovas Res2005，67，4： | 1 |
| 18 | Rationale and design of PROSPECT-CONKO 004: a prospective, randomized trial of simultaneous pancreatic cancer treatment with enoxaparin and chemotherapy 显示文摘 | RIESS H PELZER U HILBIG A | 2008 | BMC Cancer2008，，8： | 1 |
| 19 | A prospective randomized trial comparing contrast-enhaneed targeted versus sys- tematic uhrasound guided biopsies:impact on prostate cancer de- tection 显示文摘 | Mitterberger M Horninger W Pelzer A | 2007 | Prostate2007，67，： | 1 |
| 20 | Phytochemical study and anti-inflammatory properties of Lampaya hieronymi Schum ex Moldenke显示文摘 | E Alvarez A E Rotelli L E Pelzer | | 0，，05： | 1 |
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