|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Identification of serum proteins discriminating colorectal cancer patients and healthy controls using surface-enhanced laser desorption ionisation-time of flight mass spectrometry显示文摘瞄准:为颜色检测新浆液简历标记由浆液蛋白质与提高表面的激光解吸附作用 ionisation 介绍的表面的癌症(CRC )-- 飞行团分光术(SELDI-TOF MS ) 的时间。方法:二个独立浆液样品集合与 ProteinChip 技术独立被分析(集合 A:40 CRC+49 健康控制;集合 B:37 CRC+31 健康控制) ,有一个弱阳离子的使用的芯片交换一半和缓冲区 pH 5。差别的歧视的力量表示了蛋白质与一个分类树算法被估计。产生分类树的敏感和特性被盲目地从集合 B 并且反过来也如此从集合 A 把数据用于产生的树获得。CRC 浆液蛋白质侧面也与从胸的那些相比,卵巢,前列腺,和非小的房间肺癌症。结果:Mass-to-charge 比率(m/z ) 3.1x10 (3 ) , 3.3x10 (3 ) , 4.5x10 (3 ) , 6.6x10 (3 ) 和 28x10 (3 ) 在最好执行的分类树上被用作分类器。树敏感和特性在 65% 和 90% 之间。大多数这些歧视的 m/z 价值在调查的另外的瘤类型也是不同的。M/z 3.3x10 (3 ) ,在大多数树上的主要分类器,是 6.6x10 (3 ) 的一种二倍地控告的形式 -Da 蛋白质。后者作为 apolipoprotein C-I 被识别。M/z 3.1x10 (3 ) 作为 apolipoprotein A-I 作为白朊,和 m/z 28x10 (3 ) 的 N 终端碎片被识别。结论:分类树模式分析跟随的 SELDI-TOF MS 是为为 CRC 发现新浆液标记的一种合适的技术。Biomarkers 能与高敏感和特性在独立样品集合被识别并且 reproducibly 检测了。尽管为 CRC 不特定,这些简历标记在监视的疾病和治疗有一个潜在的角色。 | Judith YMN Engwegen Helgi H Helgason Annemieke Cats Nathan Harris Johannes MG Bonfrer Jan HM Schellens Jos H Beijnen | 2006 | World Journal of Gastroenterology2006，12，10： | 45 |
| 2 | Incidence, Presentation, and Outcomes in Patients With Drug-Induced Liver Injury in the General Population of Iceland显示文摘 | Einar S. Bj?rnsson Ottar M. Bergmann Helgi K. Bj?rnsson Runar B. Kvaran Sigurdur Olafsson | 2013 | Gastroenterology2013，，7： | 4 |
| 3 | The anti-microbial peptide LL-37 modulates immune responses in the palatine tonsils where it is exclusively expressed by neutrophils and a subset of dendritic cells显示文摘 | Sigrun L. Sigurdardottir Ragna H. Thorleifsdottir Andrew M. Guzman Gudmundur H. Gudmundsson Helgi Valdimarsson Andrew Johnston | 2011 | Clinical Immunology2011，，2： | 2 |
| 4 | Advances in the development of new biomarkers for Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is a complex,heterogeneous,progressive disease and is the most common type of neurodegenerative dementia.The prevalence of AD is expected to increase as the population ages,placing an additional burden on national healthcare systems.There is a large need for new diagnostic tests that can detect AD at an early stage with high specificity at relatively low cost.The development of modern analytical diagnostic tools has made it possible to determine several biomarkers of AD with high specificity,including pathogenic proteins,markers of synaptic dysfunction,and markers of inflammation in the blood.There is a considerable potential in using microRNA(miRNA)as markers of AD,and diagnostic studies based on miRNA panels suggest that AD could potentially be determined with high accuracy for individual patients.Studies of the retina with improved methods of visualization of the fundus are also showing promising results for the potential diagnosis of the disease.This review focuses on the recent developments of blood,plasma,and ocular biomarkers for the diagnosis of AD. | Timofey O.Klyucherev Pawel Olszewski Alena A.Shalimova Vladimir N.Chubarev Vadim V.Tarasov Misty M.Attwood Stina Syvänen Helgi B.Schiöth | 2022 | Translational Neurodegeneration2022，11，1： | 2 |
| 5 | The acid and alkaline solubilization process for the isolation of muscle proteins : state of the art 显示文摘 | Helgi N Ingrid U | 2009 | Food Bioprocess Technology2009，2，1： | 1 |
| 6 | Epidemiology of kidney stones in Iceland A population-based study1显示文摘 | Olafur S. Indridason Sigurjon Birgisson Vidar O. Edvardsson Helgi Sigvaldason Nikulas Sigfusson Runolfur Palsson | 2006 | Scandinavian Journal of Urology and Nephrology2006，，3： | 1 |
| 7 | Seasonal effects on the physicochemical characteristics of fish sauce made from caplin (MaUotus villosus) 显示文摘 | Hjalmarsson Gustaf Helgi Park Jac W Kristbergsson Kristberg | 2007 | Food Chemistry2007，103，： | 1 |
| 8 | Narrowband–UVB irradiation decreases the production of pro-inflammatory cytokines by stimulated T cells显示文摘 | Hekla Sigmundsdottir Andrew Johnston Johann Eli Gudjonsson Helgi Valdimarsson | 2005 | Archives of Dermatological Research2005，，1： | 1 |
| 9 | Seasonal effects on the physicochemical characteristics of fish sauce made from capelin ( Mallotus villosus )显示文摘 | Gustaf Helgi Hjalmarsson Jae W. Park Kristberg Kristbergsson | 2006 | Food Chemistry2006，，2： | 1 |
| 10 | Exposure to Bisphenol A Affects Lipid Metabolism in Drosophila melanogaster显示文摘 | Michael J. Williams Yi Wang Anica Klockars P. Monica Lind Robert Fredriksson Helgi B. Schi?th | 2014 | Basic Clin Pharmacol Toxicol2014，，5： | 1 |
| 11 | There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini显示文摘 | Robert Fredriksson David E.I. Gloriam P?r J. H?glund Malin C. Lagerstr?m Helgi B. Schi?th | 2003 | Biochemical and Biophysical Research Communications2003，，3： | 1 |
| 12 | The relative impact of chronic food restriction and acute food deprivation on plasma hormone levels and hypothalamic neuropeptide expression显示文摘 | Andreas Johansson Robert Fredriksson Sonja Winnergren Anna-Lena Hulting Helgi B. Schi?th Jonas Lindblom | 2008 | Peptides2008，，9： | 1 |
| 13 | Seasonal effects on the physicochemical characteristics of fish sauce made from capelin (Mallotus villosus) 显示文摘 | Gustaf Helgi Hjalmarsson Jae W Park Kristberg Kristbergsson | 2007 | Food Chemistry2007，103，： | 1 |
| 14 | A straightforward and efficient synthesis of praziquantel enantiomers and their 4′-hydroxy derivatives显示文摘 | Alberto Cedillo-Cruz María Isabel Aguilar Marcos Flores-Alamo Francisca Palomares-Alonso Helgi Jung-Cook | 2013 | Tetrahedron: Asymmetry2013，，： | 1 |
| 15 | In vitro characterization of some biopharmaceutical properties of praziquantel显示文摘 | González-Esquivel Dinora Rivera Julio Castro Nelly Yepez-Mulia Lilian Helgi Jung Cook | 2005 | International Journal of Pharmaceutics2005，，1： | 1 |
| 16 | Swedish Rectal Cancer Trial: Long lasting benefits from radiotherapy on survival and local recurrent rate 显示文摘 | Joakim F Helgi B Lars P | 2005 | Clin Oncol2005，23，24： | 1 |
| 17 | Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives显示文摘 | Fredriksson R Helgi B Schioth | 2003 | FEBS Lett2003，554，3： | 1 |
| 18 | Allowing Normal Food at Will After Major Upper Gastrointestinal Surgery Does Not Increase Morbidity: A Randomized Multicenter Trial显示文摘 | Kristoffer Lassen J?rn Kj?ve Torunn Fetveit Gerd Tran? Helgi Kjartan Sigurdsson Arild Horn Arthur Revhaug | 2008 | Annals of Surgery2008，，5： | 1 |
| 19 | Adverse effects of preoperative radiation therapy for rectal cancer: long-term follow-up of the Swedish Rectal Cancer Trial显示文摘 | Helgi B Lars P Bengt G | 2005 | Clin Oncol2005，23，34： | 1 |
| 20 | Occurrence of second cancers in patients treated with radiotherapy for rectal cancer显示文摘 | Helgi B Lars P Ulf G | 2005 | Clin Oncol2005，23，25： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员