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| 1 | Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes显示文摘This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further research in this understudied malignancy. Pancreatic adenocarcinoma is a lethal condition with a rising incidence, predicted to become the second leading cause of cancer death in some regions. It often presents at an advanced stage, which contributes to poor five-year survival rates of 2%-9%, ranking firmly last amongst all cancer sites in terms of prognostic outcomes for patients. Better understanding of the risk factors and symptoms associated with this disease is essential to inform both health professionals and the general population of potential preventive and/or early detection measures. The identification of high-risk patients who could benefit from screening to detect pre-malignant conditions such as pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasms and mucinous cystic neoplasms is urgently required, however an acceptable screening test has yet to be identified. The management of pancreatic adenocarcinoma is evolving, with the introduction of new surgical techniques and medical therapies such as laparoscopic techniques and neo-adjuvant chemoradiotherapy, however this has only led to modest improvements in outcomes. The identification of novel biomarkers is desirable to move towards a precision medicine era, where pancreatic cancer therapy can be tailored to the individual patient, while unnecessary treatments that have negative consequences on quality of life could be prevented for others. Research efforts must also focus on the development of new agents and delivery systems. Overall, considerable progress is required to reduce the burden associated with pancreatic cancer. Recent, renewed efforts to fund large consortia and research into pancreatic adenocarcinoma are welcomed, but further streams will be necessary to facilitate the momentum needed to bring breakthroughs seen for other cancer sites. | Andrew McGuigan Paul Kelly Richard C Turkington Claire Jones Helen G Coleman R Stephen McCain | 2018 | World Journal of Gastroenterology2018，24，43： | 140 |
| 2 | Current practices and future prospects for the management of gallbladder polyps: A topical review显示文摘A gallbladder polyp is an elevation of the gallbladder mucosa that protrudes into the gallbladder lumen. Gallbladder polyps have an estimated prevalence in adults of between 0.3%-12.3%. However, only 5% of polyps are considered to be 'true' gallbladder polyps, meaning that they are malignant or have malignant potential. The main radiological modality used for diagnosing and surveilling gallbladder polyps is transabdominal ultrasonography. However, evidence shows that other modalities such as endoscopic ultrasound may improve diagnostic accuracy. These are discussed in turn during the course of this review. Current guidelines recommend cholecystectomy for gallbladder polyps sized 10 mm and greater, although this threshold is lowered when other risk factors are identified. The evidence behind this practice is relatively low quality. This review identifies current gaps in the available evidence and highlights the necessity for further research to enable better decision making regarding which patients should undergo cholecystectomy, and/or radiological follow-up. | R Stephen McCain Anna Diamond Claire Jones Helen G Coleman | 2018 | World Journal of Gastroenterology2018，24，26： | 25 |
| 3 | 缺血性间歇性阴茎异常勃起的药物治疗:当前的文献综述显示文摘阴茎异常勃起是指阴茎在没有受性刺激的情况下,发生的不自主的长时间勃起。目前,关于这种异常勃起的病理生理学信息很少,所以我们对此疾病也知之甚少。这种不可逆的勃起伤害以及导致的勃起功能障碍使这种疾病的并发症也很可怕。间歇性阴茎异常勃起尽管很少见,但在镰状细胞疾病(SCD)患者中发生率很高,而且也迫切需要制定指南来治疗这些病人的勃起功能问题。因为对这种疾病的发病机制不是很清楚,所以对泌尿外科医生来说,这种疾病的药物治疗也是一个极大的挑战。还需要更多的研究让我们可以有效确定这些病人的治疗方法,以预防作为最终目的。本综述主要介绍间歇性阴茎异常勃起疾病及其临床意义,尤其针对那些有SCD的病人。另外,还讨论该疾病可能的病理生理学机制,总结和讨论当前和将来的药物治疗策略。 | Helen R Levey Omer Kutlu Trinity J Bivalacqua | 2012 | Asian Journal of Andrology2012，14，1： | 5 |
| 4 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 5 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 6 | Regulation of cell adhesion in the testis: a new role for p73显示文摘在成年睾丸的男细菌房间在他们从 spermatogonial 干细胞转移到直的基因表示侧面和形态学经历的戏剧的变化成熟精子依赖于他们有 Sertoli 房间的协会。Sertoli 房间为男细菌房间的幸存和成熟是关键的。二份最近的报纸, Holembowski et al.1 和 Inoue et al.2 为 p53 家庭成员,描述了一个令人吃惊的角色 p73,在细菌 cell-Sertoli 的规定房间粘附。 | Helen E Abud Gary R Hime | 2014 | Asian Journal of Andrology2014，16，6： | 2 |
| 7 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 8 | Protective effect of amifostine during fractionated radiotherapy in patients with pelvic carcinomas: Results of a randomized trial显示文摘 | Helen Athanassiou Dosia Antonadou Nikos Coliarakis Athina Kouveli Maria Synodinou Michalakis Paraskevaidis George Sarris Gregory R Georgakopoulos Katerina Panousaki Pantelis Karageorgis Nicolas Throuvalas | 2003 | International Journal of Radiation Oncology, Biology, Physics2003，，4： | 2 |
| 9 | Adsorption of copper (Ⅱ) and chromium (Ⅲ) ions onto amidoximated cellulose 显示文摘 | RIMA S HELENE G MICHELE P R | 2000 | Journal of Applied Polymer Science2000，75，13： | 1 |
| 10 | Positive darwinian selection after gene duplication in primate ribonuclease genes显示文摘 | ZHANG J HELENE F R MASATOSHI N | 1998 | Proc Natl Acad Sci USA1998，95，： | 1 |
| 11 | Immunostimulatory DNA sequences necessary for effective intraderlmal gene immunization显示文摘 | Snato Y Mark R Helen T | 1996 | Science1996，273，： | 1 |
| 12 | Comparison between different LiFePO4 synthesis routes and their influence on its physico-chemical properties显示文摘 | SLVSIN F FREDEREC L C CAROLE B HELENE R | 2003 | J Power Source2003，，： | 1 |
| 13 | A new class of wine pigment generated by reaction between pyruvie acid and grape anthocyanins 显示文摘 | HELENE F CARIME B JACQUES R | 1997 | Phytochem1997，47，7： | 1 |
| 14 | Three-Dimensional Culture of Annulus Fibrosus Cells within PDLLA/Bioglass ? Composite Foam Scaffolds; Assessment of Cell Attachment, Proliferation and Extracellular Matrix Production 显示文摘 | Helen W Merry C L R Blaker J J | 2007 | Biomaterials2007，28，11： | 1 |
| 15 | Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics 显示文摘 | Scott WG Neil MRi Helen R | 2004 | Br J Clin Pharmacol2004，61，： | 1 |
| 16 | Cohesion Strategies and Genre in Expository Prose: An Analysis of the Writing of Children of Ethnolinguistic Cultural Groups 显示文摘 | Abadiano Helen R | 1995 | Pragmatics1995，53，： | 1 |
| 17 | Studies on the formation of furosine and pyridosine during acid hydrolysis of different amadori products of lysine显示文摘 | Krause R Knoll K Helen T | 2003 | European Food Research and Technology2003，216，4： | 1 |
| 18 | Somatostatin - like immunoreactivity in human sympathetic ganglia显示文摘 | Jarvi R Pelto H M Helen P | 1987 | Cell Tissue Res1987，249，1： | 1 |
| 19 | Upstream stimulatory factor-2 (USF2) activity is required for glucose stimulation of L-Pyruvate kinase promoter activity in single living islet β-cells 显示文摘 | Helen J Kennedy B V lmran R | 1997 | JBC1997，272，20： | 1 |
| 20 | The Geographic Distribution of Production Activity in the UK 显示文摘 | Devereux M P Griffith R Helen Simpson | 1999 | The Institute for Fiscal Studies1999，，26： | 1 |
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