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| 1 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 2 | Surgical intervention in histoplasmosis显示文摘 | Garrett HE Jr Roper CL | 1986 | Ann Thorae Surg1986，42，6： | 1 |
| 3 | Establishment of human prostate carcinoma skeletal metastasis models显示文摘 | Zhau HE Li CL Chung LW | 2000 | Cancer2000，88，12： | 1 |
| 4 | Dronabinol versus megestrol acetate versus combination therapy for cancer-associated anorexia:a North Central Cancer Treatment Group Study显示文摘 | Jatoi A Windschitl HE Loprinzi CL | 2002 | J Clin Oncol2002，20，2： | 1 |
| 5 | Neuropeptide- foundation and clinic显示文摘 | Lu CL Wang CH He C | 2000 | The Second Military Medical University2000，，： | 1 |
| 6 | Magnetic and conductive Fe3O4-polyaniline nanoparticles with core-shell structure 显示文摘 | Deng JG He CL Peng YX | 2003 | Synthetic: Metals2003，139，2： | 1 |
| 7 | Decreased interstitial cell of Cajal volume in patients with slow-transit constiation显示文摘 | He CL Burgart L Wang L | 2000 | Gastroenterology2000，118，1： | 1 |
| 8 | Esthetic considerations when splinting with fiber-reinforced composites显示文摘 | Strassle HE Serio CL | | 0，，02： | 1 |
| 9 | Novel pH-and Temperature-Responsive Block Copolymers with Tunable pH-Responsive Range显示文摘 | He CL Zhao CW Chen XS Guo ZJ Zhuang XL and Jing XB | | 0，，： | 1 |
| 10 | Dynamic control of a moving platform using the CAREN system to optimize walking in virtual reality environments显示文摘 | Makssoud HE Richards CL Comeau F | 2009 | Conf Proc IEEE Eng Med Biol Soc2009，2009，： | 1 |
| 11 | Diversity and origin of Desulfovibrio species: phylogenetic definition of a family显示文摘 | Devereux R He SH Doyle CL | 1990 | Journal of Baceriology1990，172，7： | 1 |
| 12 | Pan - colonic decrease in interstitial cells of cajal in patients with slow transit constipation显示文摘 | Lyford GL He CL Softer E | 2002 | Gut2002，51，： | 1 |
| 13 | Fusion of hC3d3 to hCGbeta enhances responsiveness in vitro of human peripheral immunocompetent cells upon the antigen primary challenge显示文摘 | Li HP He XJ Tang CL | 2008 | J Reprod Immunol2008，78，2： | 1 |
| 14 | Establishment of human prostate carcinoma skeletal metastasis models显示文摘 | Zhau HE Li CL Chung LW | 2000 | Cancer2000，88，12： | 1 |
| 15 | Effects of short- and long-act- ing recombinant human growth hormone(PEG-rhGH) on left v- entricular function in children with growth hormone deficiency 显示文摘 | Wang CL He Y Liang L | 2011 | Acta Paediatr2011，100，1： | 1 |
| 16 | Decreased interstitial cell of Cajalvolume in patients with slow-transit constipation 显示文摘 | He CL Burgart L Wang L | 2000 | Gastroenterology2000，118，1： | 1 |
| 17 | Decreased interstitial cells of Cajal volume in patients with slow-transit constipation 显示文摘 | He CL Burgart L Wang L | 2000 | Gastroenterology2000，118，1： | 1 |
| 18 | Differential induction of nitric oxide,degranulation, and oxidative burst activities in response to microbial agonist stimulations in monocytes and heterophils from young commercial turkeys 显示文摘 | He H Genovese KJ Swaggerty CL | 2008 | Vet Immunol Immunopathol2008，123，34： | 1 |
| 19 | Evolving of ciliary neurotrophic factor study 显示文摘 | He C Lu CL Ao SZ | 1996 | Shengli Kexue Jinzhan ( Biophisiol Sci Devel)1996，27，1： | 1 |
| 20 | Pan-colonic decrease in interstitialcells of Cajal in patients with slow transit constipation 显示文摘 | Lyford GL He CL Softer E | 2002 | Gut2002，51，： | 1 |
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