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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 3 | Dumbbell-shaped cervical spinal neurilemmoma presenting as neek mass 显示文摘 | Lu CL Chen MH Chao TK | 2005 | J Laryngol Otol2005，119，12： | 1 |
| 4 | Effects of clay on polymorphism of polypropylene in polypropylene/clay nanocomposites显示文摘 | Zheng WG Lu XH Toh CL | 2004 | J Polym Sci Part B - Polym Phys2004，42，10： | 1 |
| 5 | Inhibition of the MEK/ERK pathway reduces microglial activation and interleukin--1-beta expression in spinal cord ischemia/reperfusion injury in rats 显示文摘 | Lu K Liang CL Chen SD | 2007 | J Thorac Cardiovasc Surg2007，133，4： | 1 |
| 6 | Characteristics of small bowel motility in patients with irritable bowel syndrome and normal humans:an Oriental study显示文摘 | Lu CL Chen CY Chang FY | 1998 | Clin Sci (Lond)1998，95，2： | 1 |
| 7 | A Cross -cultural Exami- nation of Presenteeism and Supervisory Support 显示文摘 | Lu L Cooper CL Lin HY | 2003 | Career Development International2003，18，5： | 1 |
| 8 | Micro RNA-146a modulates TGF-β1-induced phenotypic differentiation in human dermal fibroblasts by targeting SMAD4显示文摘 | Liu Z Lu CL Cui LP | 2012 | Archives for Dermatol Res2012，304，3： | 1 |
| 9 | A calcineurin-dependent transcriptional pathway forcardiac hypertrophy显示文摘 | Molkentin JD Lu JR Antos CL | 1998 | Cell1998，93，： | 1 |
| 10 | Injury severity and cell death mechanisms:effects of concomitant hypovolemic hypotension on spinal cord ischemia-reperfusion in rats显示文摘 | Lu K Liang CL Chen H J | 2004 | Exp Neurol2004，185，1： | 1 |
| 11 | Enteric adenovirus infection in children in Taibei显示文摘 | Lin HC Kao CL Lu CY | 2000 | J Microbiol Immunol Infect2000，33，3： | 1 |
| 12 | Antimicrobial susceptibilities of commonly encountered bacterial isolates to Fosfomycin determined by agar dilution and disk diffusion methods显示文摘 | Lu CL Liu CY Huang YT | 2011 | Antimicrobial Agents And Hemotherapy2011，55，9： | 1 |
| 13 | Erythropoietin-induced neurovascular protection, angiogenesis, and cerebral blood flow restoration after focal ischemia in mice显示文摘 | Li Y Lu Z Keoqh CL | 2007 | J Cereb Blood Flow Metab2007，27，： | 1 |
| 14 | Incidence and case-fatality rates resulting from the 1998 enterovirus 71 outbreak in Taiwan显示文摘 | Lu CY Lee CY Kao CL | 2002 | J Med Virol2002，67，2： | 1 |
| 15 | Incidence and case - fatality rates re- sulting from the 1998 enterovims 71 outbreak in Taiwan显示文摘 | Lu CY Lee CY Kao CL | 2002 | J Med Virol2002，67，2： | 1 |
| 16 | Quantification of ligustilides in the roots of Angelica sinensis and related umbelliferous medicinal plants by high-performance liquid chromatography and liquid chromatogra- phy-mass spectrometry显示文摘 | Lu GH Chan K Chan CL | 2004 | J Chromatogram A2004，1046，： | 1 |
| 17 | Is fusion necessary for surgically treated burst fractures of the thoracolnmbar and lumbar spine?A prospective, randomized study显示文摘 | Wang ST Ma HL Lu CL | 2006 | Spine2006，31，： | 1 |
| 18 | Erythropoietin - induced neuro- vascular protection, angiogenesis, and cerebral blood flow res- toration after focal ischemia in mice 显示文摘 | Li Y Lu Z Keogh CL | 2007 | J Cereb Blood Flow Metab2007，27，5： | 1 |
| 19 | Risk factors of subsequent vertebral compression fractures after vertebroplasty显示文摘 | Lu K Liang CL Hsieh CH | 2012 | Pain Med2012，3，： | 1 |
| 20 | The expression of CXCR4 and itsrelationship with matrix metalloproteinase-9/vascularendothelial growth factor in esophageal squamous cellcancer 显示文摘 | Lu CL Ji Y Ge D | 2011 | Dis Esophagus2011，244，： | 1 |
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