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| 1 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 2 | On the accuracy of homology modeling and sequence alignment methods applied to membrane proteins显示文摘 | Forrest LR Tang CL Honig B | 2006 | Biophys J2006，91，2： | 1 |
| 3 | Meta-analysis of defunctioning stomas in low anterior resection for rectal cancer显示文摘 | Tan WS Tang CL Shi L | 2009 | Br J Surg2009，96，5： | 1 |
| 4 | Brain lesion size and location:effects on motor recovery and functional outcome in stroke patients显示文摘 | Chen CL Tang FT Chen HC | 2000 | Arch Phys Med Rehabil2000，81，： | 1 |
| 5 | Effects of withdrawal of Xuezhikang,an extract of cholestin,on lipid profile and Creactive protein:a short-term time course study in patients with coronary artery disease显示文摘 | Hu CL Li YB Tang YH | 2006 | Cardiovasc Drugs Ther2006，20，3： | 1 |
| 6 | Long-term fertilizer effects on organic carbon and total nitrogen and coupling relationships of C and N in paddy soils in subtropical China显示文摘 | Tong CL Xiao HA Tang GY Wang HQ Huang TP Xia HA Keith S J Li Y Liu SL Wu JS | 2009 | Soil and Tillage Research2009，106，1： | 1 |
| 7 | Effects of with- drawal of Xuezhikang, an extract of cholestin, on lipid profile and C-reactive protein: a short-term course study in patients with coronary artery dis- ease显示文摘 | Hu CL Li YB Tang YH | 2006 | Cardiovasc Drugs Ther2006，20，3： | 1 |
| 8 | Randomized clinical trial of the effect of open versus laparoscop ically assisted colectomy on systemic immunity in patients with colorectal cancer 显示文摘 | Tang CL Eu KW Tai BC | 2001 | Br J Surg2001，88，6： | 1 |
| 9 | Gender differences in patients presenting with first - episode psychosis in Hong Kong: a three- year follow up study显示文摘 | Chang WC Tang JY Hui CL | 2011 | Aust N Z J Psychia- try2011，45，3： | 1 |
| 10 | Meta-analysis of randomized clinical trials comparing drainage alone vs primary sphincter-cutting procedures for anorectal abscess-fistula显示文摘 | Quah HM Tang CL Eu KW | 2006 | lnt J ColorectalDis2006，21，6： | 1 |
| 11 | Membrane water permeability related to antigen-presenting function of dendritic cells 显示文摘 | Wang GF Dong CL Tang GS | 2008 | Clin Exp Immunol2008，153，3： | 1 |
| 12 | Enhanced inhibitive effects of combination of rofecoxib and octreotide on the growth of human gastric cancer显示文摘 | Tang CW Liu CL Zhou XC Wang C | 2004 | Int J Cancer2004，112，3： | 1 |
| 13 | Pathogenesis of portal hypertension in liver cirrhosis rats dealt with CCl4显示文摘 | Xu CL Cai DY Tang CS | 2005 | World Chin J Digestol2005，13，2： | 1 |
| 14 | Fusion of hC3d3 to hCGbeta enhances responsiveness in vitro of human peripheral immunocompetent cells upon the antigen primary challenge显示文摘 | Li HP He XJ Tang CL | 2008 | J Reprod Immunol2008，78，2： | 1 |
| 15 | Circular DNA molecules imaged in air by scanning force microscopy 显示文摘 | Bustamante C Vesonka J Tang CL | 1992 | Biochem1992，31，1： | 1 |
| 16 | Meta-analysis of defunctioning stomas in low anterior resection for rectal cancer 显示文摘 | Tan WS Tang CL Shi L | 2009 | Br J Surg2009，96，5： | 1 |
| 17 | Hysterosalpingography;current appncations显示文摘 | Eng CW Tang PH Ong CL | 2007 | Singapore Med J2007，48，4： | 1 |
| 18 | Advanced glycation end-products activate the reninangiotensinsystem through the RAGE/PI3-K signaling pathwayin podocytes显示文摘 | Cheng CL Tang Y Zheng Z Liu X Ye ZC Wang C Lou TQ | 2012 | Clin Invest Med2012，35，5： | 1 |
| 19 | IL-8 gene expression in cultures of human corneal epithelial cells and keratocytes显示文摘 | Cubitt CL Tang Q Monteiro CA Lausch RN Oakes JE | 1993 | Invest Ophthalmol Vis Sci1993，34，11： | 1 |
| 20 | Transanal repair of rectocele cor- rects obstructed defecation if it is not associated with anismus 显示文摘 | Tjandra JJ Ooi BS Tang CL | 1999 | Dis Colon Rectum1999，42，12： | 1 |
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