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| 1 | Partial Beclin 1 silencing aggravates doxorubicin-and Fasinduced apoptosis in HepG2 cells显示文摘瞄准:在 HepG2 房间的危险性上调查 Beclin 1 的角色在反船边交货抗体或 doxorubicin 治疗以后经历 apoptosis。方法:Beclin 1 silencing 用 RNA 干扰被完成。DNA 倍性, apoptotic 房间的百分比和 mitochondrial 膜电位被流动血细胞计数估计。多形核白细胞(自动数据处理核糖) 的 Beclin 1, Bcl-X (L) 和细胞色素 c,和劈开聚合酶(PARP ) 的层次是由使用西方的污点的 assayed。结果:Beclin 1 表示在 Beclin 1 siRNA transfection 以后由 75% 72 h 减少了。部分 Beclin 1 silencing 显著地增加了 subG1 房间的百分比有 doxorubicin 或反船边交货抗体的 24 和 40 h 术后疗法,分别地并且这 potentiation 被处理与一个 pan-caspase 禁止者废除。部分 Beclin 1 silencing 也增加了 PARP 劈开, mitochondrial 膜去极和 cytosolic 细胞色素 c。部分 Beclin 1 silencing 的 pro-apoptotic 后果没在 Bcl-X (L) 表示与衰落被联系。结论:部分 Beclin 1 silencing 在与反船边交货抗体或与 doxorubicin 对待的 HepG2 房间加重 mitochondrial permeabilization 和 apoptosis。 | Fanny Daniel Agnès Legrand Dominique Pessayre Nathalie Vadrot Véronique Descatoire Dominique Bernuau | 2006 | World Journal of Gastroenterology2006，12，18： | 11 |
| 2 | 垄行作物玉米方向亮温野外测量中视场角影响的简单分析显示文摘基于透视原理、地面试验中对于较高目标的观测存在着一定的偏差。这种偏差随传感器高度、观测角度、视场角大小、观测位置等多个因素改变。由于垄行作物空间结构和温度分布的复杂性 ,在采用较大视场角测量方向亮温的地面实验中 ,将不可避免地存在着误差。采用一个简化的三分量二维结构模型对这种误差进行初步的分析与估算。亮温三分量分别为植被、被阳光照到的亮土和植被阴影下的暗土。作物的结构简化为剖面为矩形的无限长平行体。通过对这三个分量在传感器视场中面积权重的计算来模拟目标结构、传感器高度、位置、视场角大小、观测角度等因素对测量结果产生的影响。模拟结果表明 ,在垂直观测中 ,视场中的植被权重往往被高估 ,偏差随传感器高度的降低急剧增加。在倾斜观测中 ,由于一种互补效应的产生 ,偏差被限制在一个较低的范围内。经过分析 ,减小误差的最有效办法是提高传感器高度。最后 ,实验数据与模拟结果进行了比较。恰当地选取模型输入 ,两种数据能非常好的吻合。 | 余涛 顾行发 田国良 Michel Legrand Jean-Franois Hanocq Roland Bosseno | 2004 | 遥感学报2004，8，5： | 10 |
| 3 | 玉米地组分亮度温度分类变化研究显示文摘以玉米整个生长期野外热红外辐射观测数据为基础,对两种组分亮温分类方法作了比较,并对玉米地组分亮温的变化特征展开了分析。结果表明,农田亮温组分的数目和数值随测量时间和日期改变。在整个测量期间,在当地时间中午前后,农田呈现出3个亮温组分植被、被阳光照到的亮土和植被阴影下的暗土。观测早期,植被亮温分布相对集中;随着农田植被覆盖率的增高,植被亮温分布逐步分散,组分间温差缩小,部分亮温值相互重叠。产生这些现象的原因将在以后的研究中加以探讨。 | 余涛 顾行发 田国良 Michel Legrand Jean Franc ois Hanocq Roland Bosseno 蔡红艳 | 2005 | 遥感学报2005，9，1： | 7 |
| 4 | AU-rich element-binding proteins in colorectal cancer显示文摘Trans-acting factors controlling mRNA fate are critical for the post-transcriptional regulation of inflammation-related genes, as well as for oncogene and tumor suppressor expression in human cancers. Among them, a group of RNA-binding proteins called 'Adenylate-Uridylate-rich elements binding proteins'(AUBPs)control mRNA stability or translation through their binding to AU-rich elements enriched in the 3'UTRs of inflammation-and cancer-associated mRNA transcripts. AUBPs play a central role in the recruitment of target mRNAs into small cytoplasmic foci called Processing-bodies and stress granules(also known as P-body/SG). Alterations in the expression and activities of AUBPs and Pbody/SG assembly have been observed to occur with colorectal cancer(CRC)progression, indicating the significant role AUBP-dependent post-transcriptional regulation plays in controlling gene expression during CRC tumorigenesis.Accordingly, these alterations contribute to the pathological expression of many early-response genes involved in prostaglandin biosynthesis and inflammation,along with key oncogenic pathways. In this review, we summarize the current role of these proteins in CRC development. CRC remains a major cause of cancer mortality worldwide and, therefore, targeting these AUBPs to restore efficient post-transcriptional regulation of gene expression may represent an appealing therapeutic strategy. | Noémie Legrand Dan A Dixon Cyril Sobolewski | 2019 | World Journal of Gastrointestinal Oncology2019，11，2： | 7 |
| 5 | c-Fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear Cyclin D1显示文摘AIM: To investigate the effect of stable c-Fos overexpression on immortalized human hepatocyte (IHH) proliferation. METHODS: IHHs stably transfected with c-Fos (IHH-Fos) or an empty vector (IHH-C) were grown in medium supplemented with 1% serum or stimulated with 10% serum. Cell proliferation was assessed by cell counts, 3H-thymidine uptake and fl ow cytometry analyses. The levels of cell cycle regulatory proteins (Cyclin D1, E, A) cyclin dependent kinases (cdk) cdk2, cdk4, cdk6, and their inhibitors p15, p16, p21, p27, to- tal and phosphorylated GSK-3β and epidermal growth factor receptor (EGF-R) were assayed by Western blot- ting. Analysis of Cyclin D1 mRNA levels was performed by reverse transcription-polymerase chain reaction and real-time polymerase chain reaction (PCR) analysis. Stability of Cyclin D1 was studied by cycloheximide blockade experiments. RESULTS: Stable c-Fos overexpression increased cell proliferation under low serum conditions and resulted in a two-fold increase in [3H]-thymidine incorpora- tion following serum addition. Cell cycle analysis by fl ow cytometry showed that c-Fos accelerated the cell cycle kinetics. Following serum stimulation, Cyclin D1 was more abundantly expressed in c-Fos overexpressing cells. Cyclin D1 accumulation did not result from increased transcriptional activation, but from nuclear stabilization. Overexpression of c-Fos correlated with higher nuclear levels of inactive phosphorylated GSK- 3β, a kinase involved in Cyclin D1 degradation and higher levels of EGF-R mRNA, and EGF-R protein compared to IHH-C both in serum starved, and in serum stimulated cells. Abrogation of EGF-R signalling in IHH- Fos by treatment with AG1478, a specif ic EGF-R tyrosine kinase inhibitor, prevented the phosphorylation of GSK-3β induced by serum stimulation and decreased Cyclin D1 stability in the nucleus. CONCLUSION: Our results clearly indicate a positive role for c-Fos in cell cycle regulation in hepatocytes. Importantly, we delineate a new mechanism by which c-Fos could contribute to hepatocarcinogenesis through stabilization of Cyclin D1 within the nucleus, evoking a new feature to c-Fos implication in hepatocellular carcinoma. | Meryem Güller Kahina Toualbi-Abed Agnès Legrand Laurence Michel Alain Mauviel Dominique Bernuau Fanny Daniel | 2008 | World Journal of Gastroenterology2008，14，41： | 6 |
| 6 | 不对称电压下基于NPC拓扑并网逆变器的模型预测控制研究显示文摘不对称电压暂降在电网实际运行中时有发生。该文在建立三相三电平中性点嵌位(neutral point clamped,NPC)并网逆变器数学模型基础上,提出一种电力系统发生不对称故障情况下的模型预测控制(model predictive control, MPC)方法。在预测控制方案中无需PI控制器的使用,没有相应的参数需要调节;通过在代价函数中引入附加控制项的权重系数,可有效保持三电平NPC逆变器中性点电压的平衡。最后在Matlab平台对所提控制策略进行验证。仿真结果表明:当系统发生不对称故障时,NPC并网逆变器能够更有效地抑制负序电流和功率震荡。相比于三相二电平逆变器,NPC并网逆变器在负载侧可以获得更好的电能质量。 | DANIEL Legrand Mon-Nzongo 沈学宇 魏海斌 金涛 | 2019 | 中国测试2019，45，2： | 4 |
| 7 | Stress granules in colorectal cancer:Current knowledge and potential therapeutic applications显示文摘Stress granules(SGs)represent important non-membrane cytoplasmic compartments,involved in cellular adaptation to various stressful conditions(e.g.,hypoxia,nutrient deprivation,oxidative stress).These granules contain several scaffold proteins and RNA-binding proteins,which bind to mRNAs and keep them translationally silent while protecting them from harmful conditions.Although the role of SGs in cancer development is still poorly known and vary between cancer types,increasing evidence indicate that the expression and/or the activity of several key SGs components are deregulated in colorectal tumors but also in pre-neoplastic conditions(e.g.,inflammatory bowel disease),thus suggesting a potential role in the onset of colorectal cancer(CRC).It is therefore believed that SGs formation importantly contributes to various steps of colorectal tumorigenesis but also in chemoresistance.As CRC is the third most frequent cancer and one of the leading causes of cancer mortality worldwide,development of new therapeutic targets is needed to offset the development of chemoresistance and formation of metastasis.Abolishing SGs assembly may therefore represent an appealing therapeutic strategy to re-sensitize colon cancer cells to anti-cancer chemotherapies.In this review,we summarize the current knowledge on SGs in colorectal cancer and the potential therapeutic strategies that could be employed to target them. | Noémie Legrand Dan A Dixon Cyril Sobolewski | 2020 | World Journal of Gastroenterology2020，26，35： | 4 |
| 8 | 微机电系统谐振器原子力显微镜探针设计与检测(英文)显示文摘为克服既有原子力显微镜(AFM)悬臂式探针的谐振频率难以超过3.5 MHz,Q值低、成像速度低及在液体中成像效果欠佳等缺点,设计并制作了一种基于微机电系统(MEMS)谐振器的I2形探针,并成功实现了成像实验。为更进一步提高I2形探针的力灵敏度,从结构设计和检测方法入手,对原有探针进行改进。设计了简单有效的电阻差分检测方法,成功去处了输入端与输出端的耦合现象;采用局部离子注入的方法,提高了压阻敏感的传输效率。实验结果显示,在输入信号相同的条件下,改进后探针的输出信号与原有探针相比,输出信号得到了明显提高。计算结果表明,采用新方法制作的探针可使力灵敏度提高10倍以上。 | 熊壮 Bernard Legrand | 2015 | 强激光与粒子束2015，27，2： | 3 |
| 9 | Pinoresinol–lariciresinol reductase gene expression and secoisolariciresinol diglucoside accumulation in developing flax ( Linum usitatissimum ) seeds显示文摘 | C. Hano I. Martin O. Fliniaux B. Legrand L. Gutierrez R. R. J. Arroo F. Mesnard F. Lamblin E. Lainé | 2006 | Planta2006，，6： | 2 |
| 10 | Experience with postmortem computed tomography in the forensic analysis of the November 2015 Paris attacks显示文摘Several reports discuss the added value of postmortem computed tomography(PMCT)in the forensic analysis of mass fatality incidents(MFIs),such as the 2009 Victorian bushfires,the Grenfell tower disaster and the MH17 plane crash[1–5].In France,the first deployment of PMCT in an MFI took place during the forensic analysis of the November 2015 Paris terrorist attacks. | Laura W.de Jong Laurence Legrand Tania Delabarde Ghazi Hmeydia Myriam Edjlali Lilia Hamza Joseph Benzakoun Catherine Oppenheim Bertrand Ludes Jean-Francois Meder | 2020 | Forensic Sciences Research2020，5，3： | 2 |
| 11 | Laparoscopic liver resection of benign liver tumors显示文摘 | B. Descottes D. Glineur F. Lachachi D. Valleix J. Paineau A. Hamy M. Morino H. Bismuth D. Castaing E. Savier P. Honore O. Detry M. Legrand J.S. Azagra M. Goergen M. Ceuterick J. Marescaux D. Mutter B. Hemptinne R. Troisi J. Weerts B. Dallemagne C. Jehaes | 2003 | Surgical Endoscopy2003，，4： | 2 |
| 12 | Karst hydrology:A review显示文摘 | Legrand HE Stringfield V T | 1973 | Journal of Hydrology1973，20，2： | 1 |
| 13 | Particle image velocimetry investigation of the flow-field of a 3D turbulent annular swirling decaying flow induced by means of a tangential inlet显示文摘 | J Pruvost J Legrand P Legentilhomme L Doubliez | 2000 | Experiment in Fluids2000，，29： | 1 |
| 14 | DNA genotyping of unbuffered formalin fixed paraffin embedded tissues显示文摘 | Legrand B Mazancourt P Durigon M | 2002 | Forensic Sci Int2002，125，23： | 1 |
| 15 | Use of solid phase microextraetion eoupled with gas ehromatography for the determination of residual solvents in pharmaeeutieal produets显示文摘 | Legrand S Dugay J Vial J | 2003 | Journal of Chromatography A2003，999，： | 1 |
| 16 | Evalua- tion and comparison of MRP1 activity with three fluorescent dyes and three modulators in leukemic cell lines 显示文摘 | Dogan AL Legrand O Faussat AM | 2004 | Leuk Res2004，28，6： | 1 |
| 17 | Thermodynamical and structural properties of fcc transition metals using a simple tight-binding model显示文摘 | Rosato V Massimo C Legrand B | 1989 | Philos Mag A1989，59，2： | 1 |
| 18 | Thrombospondin, a negative modulator of megakaryocytopoiesis显示文摘 | Chen Y Z Incardona F Legrand C Momeux L Caen J Han Z C | 1997 | J Lab Clin Med1997，129，： | 1 |
| 19 | Determination of ketamine and norketamine in plasma by micro-liquid chromatography-mass spectrometry显示文摘 | LEGRAND T ROY S MONCHAUD C | 2008 | Journal of Pharmaceutical and Biomedical Analysis2008，48，1： | 1 |
| 20 | Adult biphenotypic acute leukaemia: an entity with poor prognosis which is related to unfavourable cytogenetics and P-glycoprotein over-expression显示文摘 | Legrand O Perrot JY Simonin G | 1998 | BrJ Haematol1998，100，1： | 1 |
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