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| 1 | Use of percutaneous nephrostomy and ureteral stenting in management of ureteral obstruction显示文摘The management options for ureteral obstruction are diverse, including retrograde ureteral stent insertion or antegrade nephrostomy placement, with or without eventual antegrade stent insertion. There is currently no consensus on the ideal treatment or treatment pathway for ureteral obstruction owing, in part, to the varied etiologies of obstruction and diversity of institutional practices. Additionally, different clinicians such as internists, urologists, oncologists and radiologists are often involved in the care of patients with ureteral obstruction and may have differing opinions concerning the best management strategy. The purpose of this manuscript was to review available literature that compares percutaneous nephrostomy placement vs ureteral stenting in the management of ureteral obstruction from both benign and malignant etiologies. | Linda Hsu Hanhan Li Daniel Pucheril Moritz Hansen Raymond Littleton James Peabody Jesse Sammon | 2016 | World Journal of Nephrology2016，5，2： | 9 |
| 2 | Role of insulin resistance in uric acid nephrolithiasis显示文摘Metabolic syndrome has been implicated in the pathogenesis of uric acid stones.Although not completely understood,its role is supported by many studies demonstrating increased prevalence of uric acid stones in patients with metabolic syndrome and in particular insulin resistance,a major component of metabolic syndrome.This review presents epidemiologic studies demonstrating the association between metabolic syndrome and nephrolithiasis in general as well as the relationship between insulin resistance and uric acid stone formation,in particular.We also review studies that explore the pathophysiologic relationship between insulin resistance and uric acid nephrolithiasis. | Hanhan Li Dane E Klett Raymond Littleton Jack S Elder Jesse D Sammon | 2014 | World Journal of Nephrology2014，3，4： | 6 |
| 3 | Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients显示文摘Objective: Germline alterations in the breast cancer susceptibility genes type 1 and 2, BRCA1 and BRCA2, predispose individuals to hereditary cancers, including breast, ovarian, prostate, pancreatic, and stomach cancers.Accumulating evidence suggests inherited genetic susceptibility to lung cancer.The present study aimed to survey the prevalence of pathogenic germline BRCA mutations(gBRCAm) and explore the potential association between gBRCAm and disease onset in Chinese advanced non-small cell lung cancer(NSCLC) patients.Methods: A total of 6,220 NSCLC patients were screened using capture-based ultra-deep targeted sequencing to identify patients harboring germline BRCA1/2 mutations.Results: Out of the 6,220 patients screened, 1.03%(64/6,220) of the patients harbored the pathogenic gB RCAm, with BRCA2 mutations being the most predominant mutations(49/64, 76.5%).Patients who developed NSCLC before 50 years of age were more likely to carry gBRCAm(P = 0.036).Among the patients harboring classic lung cancer driver mutations, those with concurrent gBRCAm were significantly younger than those harboring the wild-type gBRCA(P = 0.029).By contrast, the age of patients with or without concurrent gBRCAm was comparable to those of patients without the driver mutations(P = 0.972).In addition, we identified EGFR-mutant patients with concurrent gBRCAm who showed comparable progression-free survival but significantly longer overall survival(P = 0.002) compared to EGFR-mutant patients with wild-type germline BRCA.Conclusions: Overall, our study is the largest survey of the prevalence of pathogenic gBRCAm in advanced Chinese NSCLC patients.Results suggested a lack of association between germline BRCA status and treatment outcome of EGFR-TKI.In addition,results showed a positive correlation between pathogenic gB RCAm and an early onset of NSCLC. | Xingsheng Hu Dongyong Yang Yalun Li Li Li Yan Wang Peng Chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru Mao Hai Huang Qian Chu Chengping Hu | 2019 | Cancer Biology & Medicine2019，16，3： | 4 |
| 4 | Refractive Index Sensor Based on Fano Resonances in Plasmonic Waveguide With Dual Side-Coupled Ring Resonators显示文摘 | Xuewei ZHANG Yunping QI Peiyang ZHOU Hanhan GONG Bingbing HU Chunman YAN | 2018 | Photonic Sensors2018，8，4： | 3 |
| 5 | Proteome alterations in aqueous humour of primary open angle glaucoma patients显示文摘AIM: To unravel the primary open angle glaucoma(POAG) related proteomic changes in aqueous humour(AH).METHODS: Totally 35 patients listed for cataract surgery(controls: n=12, age: 67.4±13.6 y) or trabeculectomy for POAG(n=23, age: 72.5±8.3 y) were included. AH samples of those patients were obtained during cataract surgery or trabeculectomy. AH samples were subsequently pooled into the experimental groups under equal contribution in terms of protein amount of each individual patient. Protein samples were analyzed by a linear trap quadrupol Orbitrap Mass Spectrometry device with an upstream liquid chromatography system. The obtained raw data were analyzed using the Maxquant proteome software and compared. Proteins with a fold-change ratio higher than a cut-off of 2 were considered as noticeably altered.RESULTS: A total number of 175 proteins could be identified out of the AH from POAG and cataract by means of quantitative mass spectrometric analysis. Apolipoprotein D(fold change, 3.16 times), complement C3(2.96), pigment epithelium-derived factor(2.86), dickkopf-related protein 3(2.18) and wingless-related integration(Wnt) inhibitory factor 1(2.35) were significantly upregulated within the AH of glaucoma compared to cataract serving as controls.CONCLUSION: AH provides a tool to analyze changes in glaucoma and shows striking changes in Wnt signaling inhibitory molecules and other proteins. | Hanhan Liu Fabian Anders Sebastian Funke Karl Mercieca Franz Grus Verena Prokosch | 2020 | International Journal of Ophthalmology(English edition)2020，13，1： | 2 |
| 6 | Association of Mycoplasma pneumoniae infections with status asthmaticus显示文摘 | Hanhan U Orlowski J Fiallos M | 2008 | The Open Respiratory Medicine Journal2008，2，： | 1 |
| 7 | Patterns and emerging mechanisms of the angiogenic switch during tumor genesis显示文摘 | Hanhan D Folkman J | 1996 | Cell1996，86，3： | 1 |
| 8 | Fallopian tube malignancies: experience of Social Security Agency Aegean Maternity Hospital显示文摘 | Inal MM Hanhan M Pilanci B | 2004 | Int J Gynecol Cancer2004，14，4： | 1 |
| 9 | Fallopian tube malignancies: experience of Social Secmity Agency Aegean Maternity Hospital显示文摘 | Inal MM Hanhan M Pilanci B | 2004 | Int J Gynecol Cancer2004，14，4： | 1 |
| 10 | Fallopian tube malignancies: experience of social security agency aegean maternity hospital显示文摘 | INAL MM HANHAN M PILANCI B | 2004 | Int J Gynecol Cancer2004，14，4： | 1 |
| 11 | Primary retroperitoneal mucinous cystadenocarcinoma during pregnancy显示文摘 | Hanhan HM Gungorduk K Ozdemir A | 2014 | J Obstet Gynaecol2014，34，6： | 1 |
| 12 | Erratum to Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients显示文摘In the published article1,the affiliation for the first author,Xingshcng Hu,is'Department of Medical Oncology,Cancer Hospital,Chinese Academy of Medical Sciences',we would like to update it to'Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,China'.We apologize for the errors and for any confusion it may have caused. | Xingsheng Hu Dongyong Yang Yalun Li Li Li Yan Wang Peng Chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru Mao Hai Huang Qian Chu Chengping Hu | 2020 | Cancer Biology & Medicine2020，17，2： | 1 |
| 13 | Outcomes of Lung Transplantation in Patients with Scleroderma显示文摘 | Malek G. Massad MD Charles R. Powell MD Jacques Kpodonu MD Cimenga Tshibaka MD Ziad Hanhan MD Norman J. Snow MD Alexander S. Geha MD MS | 2005 | World Journal of Surgery2005，，11： | 1 |
| 14 | Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis 显示文摘 | Hanhan D Folkman J | 1996 | Cell1996，86，： | 1 |
| 15 | Microarraybased analysis of stress-regulated microRNAs in Arabidopsis thaliana显示文摘 | Liu Hanhan Tian Xin Li Yanjue | 2008 | RNA2008，14，： | 1 |
| 16 | An amino-biophosphage targets MMP-9 expressing macrophages and angionenesis to impair cervical carcinogenesis显示文摘 | Giraudo E Inane M Hanhan D | 2004 | J Clin Invest2004，114，5： | 1 |
| 17 | Hallmarks of cancer: the next genera- tion显示文摘 | Hanhan D Weinherg R A | 2011 | Cell2011，144，5： | 1 |
| 18 | Fallopian tube malignancies:experience of Social Security Agency Aegean Maternity Hospital显示文摘 | INAL M M HANHAN M PILANCI B | 2004 | Int J Gynecol Cancer2004，14，： | 1 |
| 19 | Fallopian tube malignancies:experience of Social Security Agency Aegean Maternity Hospital显示文摘 | Inal M M Hanhan M Pilancli B | 2004 | lnt J Gynecol Cancer2004，14，4： | 1 |
| 20 | Patterns and emerging mechanisms of the angigenic switch during tumorigenesis 显示文摘 | Hanhan D Folkman J | 1996 | Cell1996，86，3： | 1 |
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