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| 1 | Use of percutaneous nephrostomy and ureteral stenting in management of ureteral obstruction显示文摘The management options for ureteral obstruction are diverse, including retrograde ureteral stent insertion or antegrade nephrostomy placement, with or without eventual antegrade stent insertion. There is currently no consensus on the ideal treatment or treatment pathway for ureteral obstruction owing, in part, to the varied etiologies of obstruction and diversity of institutional practices. Additionally, different clinicians such as internists, urologists, oncologists and radiologists are often involved in the care of patients with ureteral obstruction and may have differing opinions concerning the best management strategy. The purpose of this manuscript was to review available literature that compares percutaneous nephrostomy placement vs ureteral stenting in the management of ureteral obstruction from both benign and malignant etiologies. | Linda Hsu Hanhan Li Daniel Pucheril Moritz Hansen Raymond Littleton James Peabody Jesse Sammon | 2016 | World Journal of Nephrology2016，5，2： | 9 |
| 2 | Role of insulin resistance in uric acid nephrolithiasis显示文摘Metabolic syndrome has been implicated in the pathogenesis of uric acid stones.Although not completely understood,its role is supported by many studies demonstrating increased prevalence of uric acid stones in patients with metabolic syndrome and in particular insulin resistance,a major component of metabolic syndrome.This review presents epidemiologic studies demonstrating the association between metabolic syndrome and nephrolithiasis in general as well as the relationship between insulin resistance and uric acid stone formation,in particular.We also review studies that explore the pathophysiologic relationship between insulin resistance and uric acid nephrolithiasis. | Hanhan Li Dane E Klett Raymond Littleton Jack S Elder Jesse D Sammon | 2014 | World Journal of Nephrology2014，3，4： | 6 |
| 3 | Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients显示文摘Objective: Germline alterations in the breast cancer susceptibility genes type 1 and 2, BRCA1 and BRCA2, predispose individuals to hereditary cancers, including breast, ovarian, prostate, pancreatic, and stomach cancers.Accumulating evidence suggests inherited genetic susceptibility to lung cancer.The present study aimed to survey the prevalence of pathogenic germline BRCA mutations(gBRCAm) and explore the potential association between gBRCAm and disease onset in Chinese advanced non-small cell lung cancer(NSCLC) patients.Methods: A total of 6,220 NSCLC patients were screened using capture-based ultra-deep targeted sequencing to identify patients harboring germline BRCA1/2 mutations.Results: Out of the 6,220 patients screened, 1.03%(64/6,220) of the patients harbored the pathogenic gB RCAm, with BRCA2 mutations being the most predominant mutations(49/64, 76.5%).Patients who developed NSCLC before 50 years of age were more likely to carry gBRCAm(P = 0.036).Among the patients harboring classic lung cancer driver mutations, those with concurrent gBRCAm were significantly younger than those harboring the wild-type gBRCA(P = 0.029).By contrast, the age of patients with or without concurrent gBRCAm was comparable to those of patients without the driver mutations(P = 0.972).In addition, we identified EGFR-mutant patients with concurrent gBRCAm who showed comparable progression-free survival but significantly longer overall survival(P = 0.002) compared to EGFR-mutant patients with wild-type germline BRCA.Conclusions: Overall, our study is the largest survey of the prevalence of pathogenic gBRCAm in advanced Chinese NSCLC patients.Results suggested a lack of association between germline BRCA status and treatment outcome of EGFR-TKI.In addition,results showed a positive correlation between pathogenic gB RCAm and an early onset of NSCLC. | Xingsheng Hu Dongyong Yang Yalun Li Li Li Yan Wang Peng Chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru Mao Hai Huang Qian Chu Chengping Hu | 2019 | Cancer Biology & Medicine2019，16，3： | 4 |
| 4 | Erratum to Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients显示文摘In the published article1,the affiliation for the first author,Xingshcng Hu,is'Department of Medical Oncology,Cancer Hospital,Chinese Academy of Medical Sciences',we would like to update it to'Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,China'.We apologize for the errors and for any confusion it may have caused. | Xingsheng Hu Dongyong Yang Yalun Li Li Li Yan Wang Peng Chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru Mao Hai Huang Qian Chu Chengping Hu | 2020 | Cancer Biology & Medicine2020，17，2： | 1 |
| 5 | Microarraybased analysis of stress-regulated microRNAs in Arabidopsis thaliana显示文摘 | Liu Hanhan Tian Xin Li Yanjue | 2008 | RNA2008，14，： | 1 |
| 6 | 显示文摘 | Jin Dazhong Li Xinxin Bao Hanhan | 2007 | Appl Phys Lett2007，，04： | 1 |
| 7 | Constraining the crustal structure under the central and western Tian Shan based on teleseismic receiver functions and gravity anomalies显示文摘The Tian Shan is a vast range that spans several countries in Asia.Understanding its evolutionary history may provide valuable insights into intracontinental orogenic dynamics.In this study,we explored the crustal characteristics of the Tian Shan and their relationships to the tectonic evolution of the region.A new H-stacking method that combines the P receiver function and gravity anomalies was used to estimate the thickness and ratio of P-to S-wave velocities(Vp/Vs)for 91 broadband seismic stations in the central and western Tian Shan.Our results revealed significant lateral variations in crustal thickness and Vp/Vs.A—45-km-thick crust and an intermediate-high Vp/Vs(-1.74-1.84)were found in the Kazakh Shield and Tarim Basin,which we interpreted to indicate a mafic crystalline basement and lower crust.The central Tian Shan varied greatly in crustal thickness(40-64 km)and Vp/Vs ratio(1.65-2.00).which may be due to crustal shortening,mafic underplating,and crustal melting.In contrast,we observed a relatively thin crust(42-50 km)with an intermediate Vp/Vs ratio(-1.78)in the western Tian Shan.The differences in the crustal structures between the western and central Tian Shan imply that the Talas-Fergana Fault may be trans-lithospheric. | Yonghua Li Hanhan Tang Lei Shi | 2023 | Earthquake Science2023，36，1： | 1 |
| 8 | Characteristics of a Novel Tyrosinase Gene Involved in the Formation of Shell Color in Hard Clam Meretrix meretrix显示文摘Hard clam(Meretrix meretrix)has a rich shell color variation among individuals from light yellow to bluish gray,brown red,and black,which may associating with melanin.Tyrosinase(Tyr)is a key rate-limiting enzyme for the biosynthesis of melanin,which affects the dark color of animal skin,hair,fur,scales and feathers.Here,we isolated and characterized the full-length cDNA sequence of M.meretrix tyrosinase gene(MmTyr)which encodes a protein with 689 amino acids.Sequence characteristics and phylogenetic analysis showed that there are a variety of Tyr genes in mollusks,which can be divided into different categories.The abundance of MmTyr transcript was detected in six tissues including mantle,adductor muscle,digestive gland,foot,gill and siphon of adult M.meretrix with qRT-PCR.The results showed a higher expression specifically in the mantle,digestive gland and siphon,which was consistent with the phenotypic color difference.In the embryos and larvae at different developmental stages,high expression was found in the trochophore larvae and juvenile clams.Among three M.meretrix strains with different shell colors,the expression level of MmTyr and total melanin content in the mantle edge both showed significant differences,suggesting that MmTyr is involved in the formation of shell color.The results obtained in this study will improve our understanding of molluscan tyrosinase gene function and molecular mechanism of shell color pattern determination. | YAO Hanhan CUI Baoyue LI Xiaoying LIN Zhihua DONG Yinghui | 2020 | Journal of Ocean University of China2020，19，1： | 0 |
| 9 | Compositional characteristics and toxicological responses of human lung epithelial cells to inhalable particles (PM_(10)) from ten typical biomass fuel combustions显示文摘As the primary component of haze,atmospheric inhalable particulate matters(PMio)are highly detri-mental to human health.Biomass combustion is one of China's most pivotal sources to aerosols pollution,inducing non-negligible emissions and uncertain risks.PMio samples directly from 10 representative biomass fuel combustion sources(2 groups covering the reality widely:straws of rice,wheat,corn,corncob,soybean,peanut,rape,sesame;and branches of pine,peach)were collected using the dilution channel sampler and analyzed for chemical compositions and in vitro cytotoxicity to human lung epithelial cell lines A549.The components of PMio are dominated by organic carbon(OC),followed by Water-soluble K+and Cl,and rich in metals Fe,Zn,Cr,and Ni.Generally,PMio emitted from biomass fuel combustions can weaken the antioxidant capacity of cells,and straws emissions,especially rape and peanut straws,show stronger ability to further induce oxidative stress and inflammatory damage than fuelwoods,owing to the key toxic roles of Cr,Ni,and Co.Therefore,reducing the specific source emis--sions of PMio from crop straw combustions rich in heavy metals could be an effective oriented strategy to improve environmental air quality and control aerosols pollution precisely for protecting public health. | Hanhan Li Mingwei Tang Xiaosan Luo Weijun Li Yuting Pang Weijie Huang Zhen Zhao Yaqian Wei Tengda Long Tariq Mehmood | 2023 | Particuology2023，，7： | 0 |
| 10 | Effect of Conformation on UV-Vis Absorption Spectra of Disazo Reactive Red Dyes显示文摘In this study,twenty disazo reactive red dyes with J acid as coupling components were selected,and their ground state geometry were studied with BLYP functional and TZVP basis set. The UV-vis absorption spectra were calculated by time-dependent density functional theory(TDDFT) employing B3 LYP and PBE0 hybrid functionals and TZVP basis set,and the absolute mean errors are 0.094 e V and 0.133 e V for B3 LYP and PBE0,respectively. From the comparison of the calculated λ_(max) of the three conformations of disazo reactive red dye,cis-,trans-,and azo,with that of experimental one,we find out that conformation plays an important role on UV-Vis absorption. Dyes 6 and 8 exist in azo conformation rather than in cis-conformation. 'Hole-electron' distribution analysis reveals that although these λ_(max) arises from different electron transitions,these electron excitations have the same character of local excitation(LE). | XIE Xiaomei LI Xiaolei LUO Hanhan LEI Kelin LI Wei | 2016 | Wuhan University Journal of Natural Sciences2016，21，6： | 0 |
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