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| 1 | Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients显示文摘Human infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes coronavirus disease 2019(COVID-19)and there is no cure currently.The 3CL protease(3CLpro)is a highly conserved protease which is indispensable for CoVs replication,and is a promising target for development of broad-spectrum antiviral drugs.In this study we investigated the anti-SARS-CoV-2 potential of Shuanghuanglian preparation,a Chinese traditional patent medicine with a long history for treating respiratory tract infection in China.We showed that either the oral liquid of Shuanghuanglian,the lyophilized powder of Shuanghuanglian for injection or their bioactive components dose-dependently inhibited SARS-CoV-23CLpro as well as the replication of SARS-CoV-2 in Vero E6 cells.Baicalin and baicalein,two ingredients of Shuanghuanglian,were characterized as the first noncovalent,nonpeptidomimetic inhibitors of SARS-CoV-23CLpro and exhibited potent antiviral activities in a cell-based system.Remarkably,the binding mode of baicalein with SARS-CoV-23CLpro determined by X-ray protein crystallography was distinctly different from those of known 3CLpro inhibitors.Baicalein was productively ensconced in the core of the substrate-binding pocket by interacting with two catalytic residues,the crucial S1/S2 subsites and the oxyanion loop,acting as a“shield”in front of the catalytic dyad to effectively prevent substrate access to the catalytic dyad within the active site.Overall,this study provides an example for exploring the in vitro potency of Chinese traditional patent medicines and effectively identifying bioactive ingredients toward a specific target,and gains evidence supporting the in vivo studies of Shuanghuanglian oral liquid as well as two natural products for COVID-19 treatment. | Hai-xia Su Sheng Yao Wen-feng Zhao Min-jun Li Jia Liu Wei-juan Shang Hang Xie Chang-qiang Ke Hang-chen Hu Mei-na Gao Kun-qian Yu Hong Liu Jing-shan Shen Wei Tang Lei-ke Zhang Geng-fu Xiao Li Ni Dao-wen Wang Jian-ping Zuo Hua-liang Jiang Fang Bai Yan Wu Yang Ye Ye-chun Xu | 2020 | Acta Pharmacologica Sinica2020，41，9： | 32 |
| 2 | Magnifying narrow-band imaging endoscopy is superior in diagnosis of early gastric cancer显示文摘AIM:To evaluate the diagnostic effectiveness of white light endoscopy,magnifying endoscopy(ME),and magnifying narrow-band imaging endoscopy(ME-NBI) in detecting early gastric cancer(EGC).METHODS:From March 2010 to June 2012,a total of 3616 patients received screening for gastric cancer by magnifying endoscopy. There were 3675 focal gastric lesions detected using conventional high definition white light endoscopy(HD-WLE) in four different referentialhospitals that were recruited for further investigation using ME and ME-NBI. The images obtained from HD-WLE,ME,and ME-NBI were reviewed by four experienced endoscopists to evaluate their diagnostic effectiveness for EGC. The diagnosis of cancerous and non-cancerous lesions was conducted by evaluating the microvascular and microsurface patterns using the VS classification system. The final endoscopic diagnosis of each lesion was determined by consultation when a disagreement occurred. We used histopathological results as the gold standard for the diagnosis of EGC.RESULTS:Among the 3675 lesions found,1508 were validated by pathological findings as chronic gastritis,1279 as chronic gastritis with intestinal metaplasia,631 as low-grade neoplasia,and 257 as EGC. The sensitivity,specificity,positive predictive value,negative predictive value,and accuracy of HD-WLE for the diagnosis of EGC were 71.2%,99.1%,85.5%,97.9% and 97.1%,respectively. The results of ME for diagnosing EGC were 81.3%,98.8%,83.3%,98.6% and 97.6%,respectively. The results of ME-NBI for the diagnosis of EGC were 87.2%,98.6%,82.1%,99.0% and 97.8%,respectively. The diagnostic sensitivity and accuracy of paired ME and ME-NBI were significantly better than those of HD-WLE(P < 0.05).CONCLUSION:HD-WLE has a relatively high accuracy for diagnosing EGC and is an effective screening tool. Further investigations of ME and ME-NBI are required to achieve superior accuracy. | Hang Yu Ai-Ming Yang Xing-Hua Lu Wei-Xun Zhou Fang Yao Gui-Jun Fei Tao Guo Li-Qing Yao Li-Ping He Bang-Mao Wang | 2015 | World Journal of Gastroenterology2015，21，30： | 26 |
| 3 | Tectonic dynamics and correlation of major earthquake sequences of the Xiaojiang and Qujiang-Shiping fault systems, Yunnan, China显示文摘The N-S trending Xiaojiang fault zone and the NW-SE trending Qujiang-Shiping fault zone are adjacent active fault systems and seismogenic zones associated with strong and major earthquakes in Yunnan, China. To understand the interaction of the two fault systems, and its probable influence on earthquake occurrences, this paper conducts a synthetic study based on data of active tectonics, historical earthquakes, relocated small earthquakes, GPS station velocities and focal mechanism resolutions. The study makes several conclusions. (1) The active southward motion of the western side of the Xiaojiang fault zone (i.e. the side of the Sichuan-Yunnan block) has a persistent and intensive effect on the Qujiang-Shiping fault zone. The later fault zone has absorbed and transformed the southward motion of the western side of the former fault zone through dextral strike-slip/shearing as well as transverse shortening/thrusting. (2) Along the Xiaojiang fault zone, the present sinistral strike-slip/shearing rate decreases from 10 and 8 mm/a on the northern, central and central-southern segments to 4 mm/a on the southern segment. The decreased rate has been adjusted in the area along and surrounding the Qujiang-Shiping fault zone through reverse-dextral faulting and distributed shearing and shortening. (3) The tectonic-dynamic relation between the Xiaojiang fault zone and the Qujiang-Shiping fault zone is also manifested by a close correlation of earthquake occurrences on the two fault zones. From 1500 to 1850 a sequence of strong and major earthquakes occurred along the Xiaojiang fault zone and its northern neighbor, the Zemuhe fault zone, which was characterized by gradually accelerating strain release, gradually shortening intervals between M≥7 events, and major releases occurring in the mid to later stages of the sequence. As a response to this sequence, after an 88-year delay, another sequence of 383 years (from 1588 to 1970) of strong and major earthquakes occurred on the Qujiang-Shiping fault zone, and had the same features in accelerating strain release and its temporal course. (4) Since there has been no M≥7 event for 177 years on the Xiaojiang fault zone, the potential risk of a strong or major earthquake occurring on this fault zone in the future should be noticed and studied further. | WEN XueZe DU Fang LONG Feng FAN Jun ZHU Hang | 2011 | Science China Earth Sciences2011，54，10： | 22 |
| 4 | Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12显示文摘Increasing evidences show that aberrant subchondral bone remodeling plays an important role in the development of osteoarthritis(OA).However,how subchondral bone formation is activated and the mechanism by which increased subchondral bone turnover promotes cartilage degeneration during OA remains unclear.Here,we show that the mechanistic target of rapamycin complex 1(mTORC1)pathway is activated in subchondral bone preosteoblasts(Osterix+)from OA patients and mice.Constitutive activation of mTORC1 in preosteoblasts by deletion of the mTORC1 upstream inhibitor,tuberous sclerosis 1,induced aberrant subchondral bone formation,and sclerosis with little-to-no effects on articular cartilage integrity,but accelerated posttraumatic OA development in mice.In contrast,inhibition of mTORC1 in preosteoblasts by disruption of Raptor(mTORC1-specific component)reduced subchondral bone formation and cartilage degeneration,and attenuated post-traumatic OA in mice.Mechanistically,mTORC1 activation promoted preosteoblast expansion and Cxcl12 secretion,which induced subchondral bone remodeling and cartilage degeneration during OA.A Cxcl12-neutralizing antibody reduced cartilage degeneration and alleviated OA in mice.Altogether,these findings demonstrate that mTORC1 activation in subchondral preosteoblasts is not sufficient to induce OA,but can induce aberrant subchondral bone formation and secrete of Cxcl12 to accelerate disease progression following surgical destabilization of the joint.Pharmaceutical inhibition of the pathway presents a promising therapeutic approach for OA treatment. | Chuangxin Lin Liangliang Liu Chun Zeng Zhong-Kai Cui Yuhui Chen Pinling Lai Hong Wang Yan Shao Haiyan Zhang Rongkai Zhang Chang Zhao Hang Fang Daozhang Cai Xiaochun Bai | 2019 | Bone Research2019，7，1： | 12 |
| 5 | Major advances in studies of the physical geography and living environment of China during the past 70 years and future prospects显示文摘The natural environment provides material essentials for human survival and development. The characteristics,processes, regional differentiation and forcing mechanisms of the elements of the natural environment(e.g. geomorphology,climate, hydrology, soil, etc.) are the main objects of research in physical geography. China has a complex natural environment and huge regional differentiation and therefore it provides outstanding reserach opportunities in physical geography. This review summarizes the most important developments and the main contributions of research in the physical geography and human living environment in China during the past 70 years. The major topics addressed are the uplift of the Tibetan Plateau and the evolution of its cryosphere, the development of fluvial systems, the acidification of the vast arid region of the Asian interior, variations in the monsoon and westerly climate systems on multiple timescales, the development of lakes and wetlands, the watershed system model, soil erosion, past human-environment interactions, biogeography, and physical geographic zonality. After briefly introducing international research developments, we review the history of research in physical geography in China, focusing on the major achievements and major academic debates, and finally we summarize the status of current research and the future prospects. We propose that in the context of the national demand for the construction of an ecological civilization, we should make full use of the research findings of physical geography, and determine the patterns and mechanisms of natural environmental processes in order to continue to promote the continued contribution of physical geography to national development strategies, and to further contribute to the theory of physical geography from a global perspective. | Fahu CHEN Bojie FU Jun XIA Duo WU Shaohong WU Yili ZHANG Hang SUN Yu LIU Xiaomin FANG Boqiang QIN Xin LI Tingjun ZHANG Baoyuan LIU Zhibao DONG Shugui HOU Lide TIAN Baiqing XU Guanghui DONG Jingyun ZHENG Wei YANG Xin WANG Zaijun LI Fei Wang Zhenbo HU Jie WANG Jianbao LIU Jianhui CHEN Wei HUANG Juzhi HOU Qiufang CAI Hao LONG Ming JIANG Yaxian HU Xiaoming FENG Xingguo MO Xiaoyan YANG Dongju ZHANG Xiuhong WANG Yunhe YIN Xiaochen LIU | 2019 | Science China Earth Sciences2019，62，11： | 11 |
| 6 | Microstructure and Precipitation Behavior in HAZ of V and Ti Microalloyed Steel显示文摘Three steels containing 0.05%C-0.1%V-0.01%N (steel V-LN),0.05%C-0.1%V-0.02%N (steel V-HN),and 0.05%C-0.1%V-0.02%N-0.01%Ti (steel V-HN-Ti),which were all essentially vanadium microalloyed steels,were subjected to simulating the microstructure of a coarse grained heat affected zone (CGHAZ). The process involved reheating to 1 350 ℃,rapid cooling to room temperature,and varying the welding heat input from 15 kJ/cm to 54 kJ/cm,including four cooling rates of t8/5 equal to 7.5 s,20 s,40 s,100 s,and the relationship of heat input to t8/5 was calculated by Quiksim software. The microstructure and precipitation of vanadium and titanium carbon nitrides are studied. The results indicate that the microstructure consists of granular bainite and some side plate ferrite in the grain boundary when the steels are produced with the highest heat input. As the heat input decreased,numerous polygonal ferrites and grain boundary ferrites appeared,and the size apparently increased. When the steel contained high nitrogen,it was considerably easier to form martensite-austenite island,which was even worse for the toughness and other properties of the steel. For the limitation of cooling time,vanadium carbon nitrides could not precipitate sufficiently,but as titanium was added,the unmelted or precipitated TiN on cooling absorbed some fraction of nitrogen in the matrix and made more precipitate positions for the round V(C,N),and thus several useful round particles could be seen in titanium-contained steel,and most of them were around TiN. By this experiment,we can conclude that with the help of titanium,nitrogen-enhanced steel had a better prior austenite grain size,was considerably easier to precipitate,reduced free nitrogen in the matrix effectively,and provided a very effective mechanism for restriction grain growth in the HAZ. | FANG Fang YONG Qi-long YANG Cai-fu SU Hang | 2009 | Journal of Iron and Steel Research(International)2009，16，3： | 10 |
| 7 | Static Theory for Planar Ferromagnets and Antiferromagnets | Feng Bo HANG Fang Hua LIN Courant Institute, 251 Mercer Street. New York. NY 10012, USA Dept. of Math, Princeton University, Fine Hall. Washington Road, Princeton, NJ 08544 USA. | 2001 | Acta Mathematica Sinica,English Series2001，17，4： | 8 |
| 8 | A Model for Precipitation Kinetics in Vanadium Microalloyed Steel显示文摘Small dispersoid particles inhibit recrystallization which is critical in controlling the grain structure of many high strength low alloy steels. A general kinetic model has been developed to predict precipitation of V(C, N) in vanadium microalloyed steels with a series of carbon and nitrogen contents. The solubility product and driving force of carbonitrides precipitated in austenite as well as the interfacial energy and other parameters can be evaluated to predict Nucleation rates-Temperature (NrT) and Precipitation-Time-Temperature (PTT) diagram. By using stress relaxation tests and fitting with Avrami equation, it is possible to draw PTT diagrams. The predictions of the model coincide with results of experimental investigation on V(C, N) precipitation in austenite. The nose temperature is around 850 ℃ obtained by experiment which is different from the prediction of the model and the difference is 30 ℃, and nitrogen has more effect on the shape of 'C' curve of PTT diagram than carbon that makes 'C' curve move leftward significantly. | FANG Fang YONG Qi-long YANG Cai-fu SU Hang | 2010 | Journal of Iron and Steel Research(International)2010，17，2： | 8 |
| 9 | Synthesis of fluorescent carbon quantum dots from aqua mesophase pitch and their photocatalytic degradation activity of organic dyes显示文摘A synthesis strategy of fluorescent carbon quantum dots(CQDs) with high quantum yield(QY) using aqua mesophase pitch(AMP) as the carbon source has been developed via the hydrothermal method in this study. The hydrothermal temperature and soaking time have important effects on the morphology and QY of CQDs. As-prepared CQDs at 120℃ holding for 24 h(CQDs-120-24) have the uniform size of about 2.8 nm, and the QY can reach 27.6%. The obtained CQDs are successfully modified with ammonia and thionyl chloride, respectively, and they exhibit an excellent photocatalytic performance on degrading rhodamine B(Rh B), methyl blue(MB) and indigo carmine(IC). Importantly, the degradation percentage of N-CQDs on Rh B under natural light for 4 h reaches 97% with the degradation rate constant of 0.02463 min^(-1) and it can maintain 93% after repetitively used 5 times. The results indicate that these as-prepared CQDs have the potential application in degrading organic dyes. | Youliang Cheng Mengsha Bai Jian Su Changqing Fang Hang Li Jing Chen Jieming Jiao | 2019 | Journal of Materials Science & Technology2019，35，8： | 6 |
| 10 | Effects of angiopoietin-1 on attachment and metastasis of human gastric cancer cell line BGC-823显示文摘AIM:To evaluate the effects of angiopoietin-1(Ang-1) on adhesion of gastric cancer cell line BGC-823 and expression of integrinβ1,CD44V6,urokinase-type plasminogen activator(uPA)and matrix metalloproteinase-2(MMP-2). METHODS:BGC-823 cells were transfected transiently with adenovirus-Ang-1(Ad-Ang-1).Cells transfected transiently with adenovirus-green fluorescent protein (Ad-GFP)and untransfected cells were used as a negative and blank control group,respectively.The cell adhesion rate between cell and extracellular matrix(ECM)was determined by cell adhesion assay. To investigate whether Ang-1 could reinforce gastric carcinoma metastasis,we performed migration and invasion assays in BGC-823 cells.The mRNA and protein expression of integrinβ1,CD44V6,uPA and MMP-2 were detected by reverse transcription polymerasechain reaction and Western blotting,respectively.The expression of integrinβ1 and CD44V6 was measured by immunohistochemistry. RESULTS:BGC-823 cells were transfected successfully. The adhesion rate increased significantly in the Ad- Ang-1 group(P<0.05).The Ad-Ang-1-transfected group had a significant increase in migration and invasion compared with that of the mock-transfected and Ad-GFP groups.The mRNA and protein expression of integrinβ1,CD44V6,uPA and MMP-2 in the Ad-Ang-1 group was higher than that in the Ad-GFP and blank control groups(P<0.05).Compared with mock- transfected and Ad-GFP groups,integrinβ1 and CD44V6 expression intensity greatly increased(P<0.05). CONCLUSION:Transfection of Ang-1 into human gastric cancer cell line BGC-823 can significantly increase expression of integrinβ1 and CD44V6,by which cell adhesion and metastasis to the ECM are promoted. | Xi-Long Ou Hui-Juan Chen Wei-Hao Sun Cheng Hang Liu Yang Yun-Yan Guan Fang yan Bao-An Chen | 2009 | World Journal of Gastroenterology2009，15，43： | 6 |
| 11 | Combined amendment reduces soil Cd availability and rice Cd accumulation in three consecutive rice planting seasons显示文摘The scientific application of stabilized materials has been considered an effective method for the in situ remediation of Cd-contaminated soil.This study aimed to investigate the persistence of the effect of a combined amendment of limestone and sepiolite(LS)on soil Cd availability and accumulation in rice grown in a mildly Cd-contaminated paddy field(0.45 mg/kg of Cd)over three consecutive rice seasons.1125–4500 kg/ha of LS was applied to the soil before the first rice planting season and 562.5–2250 kg/ha of LS was supplemented before the third rice planting season.The application of LS(1125–4500 kg/ha)increased the soil p H by 0.44–1.09,0.18–0.53,and 0.42–0.68 in the first,second,and third season,respectively,and decreased the soil acid-extractable Cd content by 18.2–36.4%,17.7–33.5%,and9.6–17.6%.LS application significantly decreased the Cd contents in the rice tissues.The application of 4500 kg/ha of LS decreased the Cd content in brown rice to below the National Food Limit Standard of 0.2 mg/kg(GB 2762-2017)in the three consecutive rice seasons.However,the effect of LS on the soil-rice system was significantly weakened in the third season.The supplementary application of 562.5–2250 kg/ha of LS further decreased the Cd content in brown rice by 26.1–56.5%and decreased the health risk index by 23.7–43.8%.Therefore,it was recommended to apply 4500 kg/ha of LS in the first season and to supplement2250 kg/ha of LS in the third season to effectively guarantee the clean production of rice in three consecutive rice seasons. | Wenjun Yang Shilong Wang Hang Zhou Min Zeng Jingyi Zhang Fang Huang Shiping Shan Zhaohui Guo Hongwei Yi Zhiguang Sun Jiaofeng Gu Bohan Liao | 2022 | Journal of Environmental Sciences2022，34，1： | 4 |
| 12 | The oncoprotein HBXIP promotes human breast cancer growth through down-regulating p53 via miR-18b/MDM2 and pAKT/MDM2 pathways显示文摘 | Hang Li Zhen Wang Mian Jiang Run-ping Fang Hui Shi Yu Shen Xiao-li Cai Qian Liu Kai Ye Sai-jun Fan Wei-ying Zhang Li-hong Ye | 2018 | Acta Pharmacologica Sinica2018，39，11： | 4 |
| 13 | The outbreak of rabbit hemorrhagic virus type 2 in the interior of China may be related to imported semen显示文摘Dear Editor,Rabbit hemorrhagic disease(RHD)is a fatal infectious disease that primarily affects adult rabbits and causes great economic losses in the rabbit industry(Mitro and Krauss,1993).The causative pathogen is rabbit hemorrhagic disease virus(RHDV),which belongs to the genus Lagovirus and the family Calicivirus(Moussa et al.,1992).In 1984,RHDV was first documented in China. | Ruibin Qi Chunchun Meng Jie Zhu Hang Li Qiuhong Miao Jingyu Tang Aoxing Tang Hongyuan Guo Chuncao Liu Chuanfeng Li Zongyan Chen Fang Wang Qinwen Zhang Guangqing Liu | 2022 | Virologica Sinica2022，37，4： | 3 |
| 14 | Effect of closure of live poultry markets on poultry-to-person transmission of avian influenza A H7N9 virus: an ecological study显示文摘 | Hongjie Yu Joseph T Wu Benjamin J Cowling Qiaohong Liao Vicky J Fang Sheng Zhou Peng Wu Hang Zhou Eric H Y Lau Danhuai Guo Michael Y Ni Zhibin Peng Luzhao Feng Hui Jiang Huiming Luo Qun Li Zijian Feng Yu Wang Weizhong Yang Gabriel M Leung | 2013 | The Lancet2013，，： | 2 |
| 15 | PM_(2.5) exposure associated with microbiota gut-brain axis:Multi-omics mechanistic implications from the BAPE study显示文摘Recent studies have shown that PM_(2.5) may activate the hypothalamus-pituitary-adrenal(HPA)axis by inducing hormonal changes,potentially explaining the increase in neurological and cardiovascular risks.In addition,an association between PM_(2.5) and gut microbiota and metabolites was established.The above evidence represents crucial parts of the gut-brain axis(GBA).In view of this evidence. | Tiantian Li Jianlong Fang Song Tang Hang Du Liang Zhao Yanwen Wang Fuchang Deng Yuanyuan Liu Yanjun Du Liangliang Cui Wanying Shi Yan Wang Jiaonan Wang Yingjian Zhang Xiaoyan Dong Ying Gao Yu Shen Li Dong Huichan Zhou Qinghua Sun Haoran Dong Xiumiao Peng Yi Zhang Meng Cao Hong Zhi Jingyang Zhou Xiaoming Shi | 2022 | The Innovation2022，3，2： | 2 |
| 16 | Evaluation of effective spectral features for glacial lake mapping by using Landsat-8 OLI imagery显示文摘Glacial lake mapping provides the most feasible way for investigating the water resources and monitoring the flood outburst hazards in High Mountain Region.However,various types of glacial lakes with different properties bring a constraint to the rapid and accurate glacial lake mapping over a large scale.Existing spectral features to map glacial lakes are diverse but some are generally limited to the specific glaciated regions or lake types,some have unclear applicability,which hamper their application for the large areas.To this end,this study provides a solution for evaluating the most effective spectral features in glacial lake mapping using Landsat-8 imagery.The 23 frequently-used lake mapping spectral features,including single band reflectance features,Water Index features and image transformation features were selected,then the insignificant features were filtered out based on scoring calculated from two classical feature selection methods-random forest and decision tree algorithm.The result shows that the three most prominent spectral features(SF)with high scores are NDWI1,EWI,and NDWI3(renamed as SF8,SF19 and SF12 respectively).Accuracy assessment of glacial lake mapping results in five different test sites demonstrate that the selected features performed well and robustly in classifying different types of glacial lakes without any influence from the mountain shadows.SF8 and SF19 are superior for the detection of large amount of small glacial lakes,while some lake areas extracted by SF12 are incomplete.Moreover,SF8 achieved better accuracy than the other two features in terms of both Kappa Coefficient(0.8812)and Prediction(0.9025),which further indicates that SF8 has great potential for large scale glacial lake mapping in high mountainous area. | ZHANG Mei-mei ZHAO Hang CHEN Fang ZENG Jiang-yuan | 2020 | Journal of Mountain Science2020，17，11： | 2 |
| 17 | Comparison of prognostic outcome between left circumflex artery-related and right coronary artery-related acute inferior wall myocardial infarction undergoing primary percutaneous coronary intervention显示文摘 | Chen YL Hang CL Fang HY | | 0，，： | 1 |
| 18 | Converting Thiophene in Simulated Coking Crude Benzene to N,N-Dimethyl-2-thiophenecarboxamide by Dimethylcarbamyl Chloride Under Mild Conditions显示文摘Since the content of thiophene in coking crude benzene is high, it is necessary to remove it from coking crude benzene for efficient utilization. In this study, an important intermediate, N,N-dimethyl-2-thiophenecarboxamide, was synthesized from thiophene and dimethylcarbamyl chloride. The influences of the dosages of dimethylcarbamyl chloride and ZnCl2 catalyst, reaction temperature and time on the removal rate were further explored based on the reaction kinetics.The structure of the target product was characterized by means of MS,NMR and 13C NMR.The removal rate of thiophene was 98.14% after the reaction for 2 h and thiophene was almost removed after the reaction for 3 h under the optimal reaction conditions [a molar ratio of n(thiophene):n(dimethylcarbamyl chioride):w(ZnCl2)=1:12:10,300 r/min, 318 K and 101.325 kPa].The acylation of thiophene with dimethylcarbamyl chloride was approximately in accord with the first order kinetic equation at 303-323K.The activation energy was 53.9850 kJ/mol and the pre-exponential factor was 1.4521×10^9 h^-1. | SHEN Xizhou SONG Hao FANG Liuya DENG Hang GAN Feng SHEN Zhi | 2019 | Chemical Research in Chinese Universities2019，35，4： | 1 |
| 19 | Stability of delayed neural networks with time-varying impulses 显示文摘 | Z HANG Wenbing TANG Yang FANG Jianan | 2012 | Neural Networks2012，36，8： | 1 |
| 20 | Angiographic morphologic features of infarct-related arteries and timely reperfusion in acute myocardial infarction:predictors of slow-flow and no-reflow phenomenon显示文摘 | Yip HK Chen MC Chang HW Hang CL Hsieh YK Fang CY | 2002 | Chest2002，122，4： | 1 |
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