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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Transport of dicationic drugs pentami dine and furamidine by human organic cation transporters显示文摘 | Ming X Ju WJ Wu HL Tidwell RR Hall JE Thakker DR | 2009 | Drug Metab Dispos2009，37，2： | 1 |
| 3 | In vivo molecular imaging of strech-induced tissue factor in carotid arteries with nanoparticles 显示文摘 | LANZA GM ABENDSCHEIN DR HALL CS | 2000 | J Am Soc Echocardiogr2000，13，6： | 1 |
| 4 | Expectant management of early onset,severe preeclampsia:matemal outcome显示文摘 | Hall DR | 2000 | BJOG2000，107，10： | 1 |
| 5 | Early pre-eclampsia:what proportion of women qualify for expectant management and if not, why not?显示文摘 | Hall DR | 2006 | Eur J Obstet Gynecol Reprod Biol2006，128，12： | 1 |
| 6 | Prediction of cytochrome P450 3A inhibition by verapamil enantiomers and their metabolites 显示文摘 | Wang YH Jones DR Hall SD | 2004 | Drug Metab Dispos2004，32，： | 1 |
| 7 | A comparison of apicai root resorption during orthodontic treatment in endodontically treated and vital teeth 显示文摘 | Spurrier SW Hall SH Joondeph DR | 1990 | Am J Orthod Dentofac Orthop1990，97，： | 1 |
| 8 | Expectant management of early onest severe pre - eclampsia perinatal outcome 显示文摘 | Hall DR Odendaal H J Kirsten GF | 2000 | BJOG2000，107，： | 1 |
| 9 | Early pre-eclampsia:what proportion of women qualify for expectant management and if not,why not显示文摘 | Hall DR Grové D Carstens E | | 0，，1： | 1 |
| 10 | Expectant management of early onset, severe pre-eclampsia: perinatal outcome 显示文摘 | Hall DR Odendaal H J Kirsten GF | 2000 | Br J Obstet Gynaecol2000，107，： | 1 |
| 11 | Expectant man agement ofearly onest, severe pre-eclampsia: perinatal outcome 显示文摘 | Hall DR Odendaal HJ Kirsten GF | 2000 | BJOG2000，107，10： | 1 |
| 12 | Urinary protein excretion and expectant management of early onset, severe pre-eclampsia显示文摘 | Hall DR Odendaal HJ Steyn DW | 2002 | Int J Gyneeol Obstet2002，77，： | 1 |
| 13 | Follicle-stimulating hormone induces transient expressinn of the protooneogene c-fos in primary Sertoli cell cultures显示文摘 | Hall SH Joseph DR Franezh FS | 1998 | Mol Endocrinol1998，2，1： | 1 |
| 14 | Differential mechanism- based inhibition of CYP3A4 and CYP3A5 by verapamil 显示文摘 | WANG YH JONES DR HALL SD | 2005 | Drug Metab Dispos2005，33，5： | 1 |
| 15 | Expectant management of early onest,severe pre-eclampsia:perinatal outcome显示文摘 | Hall DR Odendaal HJ Kirsten GF | | 0，，10： | 1 |
| 16 | Early severe pre-eclampsia and delivery at 34 weeks' gestationor earlier显示文摘 | Hall DR | 2005 | Obstet Gynecol2005，88，1： | 1 |
| 17 | Abruptio placentae and disseminated intravascular coagulopathy显示文摘 | Hall DR | 2009 | Semin Perinatol2009，33，3： | 1 |
| 18 | Expectoont man-agement of early onset, severe pre - eclampsia : perinatal outcome显示文摘 | Hall DR Odendaal HJ Kirsten GF | 2000 | Br J Obstet Gynaecol2000，107，： | 1 |
| 19 | Expectant management of early onset severe pre-eclampsia : maternal outcome 显示文摘 | Hall DR Odendaal HJ Steyn DW | 2000 | Br J Obstet Gyneco2000，107，10： | 1 |
| 20 | Ealy pre-eclampsia what proportion of women qualify for expectant management and if not, whynot 显示文摘 | Hall DR | 2006 | Eur J Obstet Gynecol Reprod Biol2006，128，122： | 1 |
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