|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | MicroRNAs in tomato plants显示文摘MicroRNAs (miRNAs) are a specialized class of small silencing RNAs that regulate gene expression in eukaryotes.In plants,miRNAs negatively regulate target mRNAs containing a highly complementary sequence by either mRNA cleavage or translational repression.As a model plant to study fleshy fruit ripening,miRNA studies in tomato have made great progress recently.MiRNAs were predicted to be involved in nearly all biological processes in tomato,particularly development,differentiation,and biotic and abiotic stress responses.Surprisingly,several miRNAs were verified to be involved in tomato fruit ripening and senescence.Recent studies suggest that miRNAs are related to host-virus interactions,which raises the possibility that miRNAs can be used as diagnostic markers for response to virus infection in tomato plants.In this review,we summarize our current knowledge systematically and advance future directions for miRNA research in tomato. | ZUO JinHua WANG YunXiang LIU HaiPing MA YuanZheng JU Zheng ZHAI BaiQiang FU DaQi ZHU Yi LUO YunBo ZHU BenZhong | 2011 | Science China(Life Sciences)2011，54，7： | 13 |
| 2 | Virus-induced Gene Silencing in Eggplant(Solanum melongena)显示文摘Eggplant(Solanum melongena)is an economically important vegetable requiring investigation into its various genomic functions.The current limitation in the investigation of genomic function in eggplant is the lack of effective tools available for conducting functional assays.Virus-induced gene silencing(VIGS)has played a critical role in the functional genetic analyses.In this paper,TRV-mediated VIGS was successfully elicited in eggplant.We first cloned the CDS sequence of PDS(PHYTOENE DESATURASE) in eggplant and then silenced the PDS gene.Photo-bleaching was shown on the newly-developed leaves four weeks after agroinoculation,indicating that VIGS can be used to silence genes in eggplant.To further illustrate the reliability of VIGS in eggplant,we selected Chl H,Su and CLA1 as reporters to elicit VIGS using the high-pressure spray method.Suppression of Chl H and Su led to yellow leaves,while the depletion of CLA1 resulted in albino.In conclusion,four genes,PDS,Chl H,Su(Sulfur),CLA1,were down-regulated significantly by VIGS,indicating that the VIGS system can be successfully applied in eggplant and is a reliable tool for the study of gene function. | Haiping Liu Daqi Fu Benzhong Zhu Huaxue Yan Xiaoying Shen Jinhua Zuo Yi Zhu Yunbo Luo | 2012 | Journal of Integrative Plant Biology2012，54，6： | 11 |
| 3 | Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response显示文摘Personalized immunotherapy targeting tumor-specific antigens(TSAs)could generate efficient and safe antitumor immune response without damaging normal tissues.Although neoantigen vaccines have shown therapeutic effect in clinic trials,precise prediction of neoantigens from tumor mutations is still challenging.The host antitumor immune response selects and activates T cells recognizing tumor antigens.Hence,T cells engineered with T-cell receptors(TCRs)from these naturally occurring tumor antigen-specific T(Tas)cells in a patient will target personal TSAs in his/her tumor.To establish such a personalized TCR-T cell therapy,we comprehensively characterized T cells in tumor and its adjacent tissues by single-cell mRNA sequencing(scRNA-seq),TCR sequencing(TCR-seq)and in vitro neoantigen stimulation.Compared to bystander T cells circulating among tissues,Tas cells were characterized by tumor enrichment,tumor-specific clonal expansion and neoantigen specificity.We found that CXCL13 is a unique marker for both CD4^(+)and CD8^(+)Tas cells.Importantly,TCR-T cells expressing TCRs from Tas cells showed significant therapeutic effects on autologous patient-derived xenograft(PDX)tumors.Intratumoral Tas cell levels measured by CXCL13 expression precisely predicted the response to immune checkpoint blockade,indicating a critical role of Tas cells in the antitumor immunity.We further identified CD200 and ENTPD1 as surface markers for CD4^(^(+))and CD8^(^(+))Tas cells respectively,which enabled the isolation of Tas cells from tumor by Fluorescence Activating Cell Sorter(FACS)sorting.Overall,our results suggest that TCR-T cells engineered with Tas TCRs are a promising agent for personalized immunotherapy,and intratumoral Tas cell levels determine the response to immunotherapy. | Jingjing He Xinxin Xiong Han Yang Dandan Li Xuefei Liu Shuo Li Shuangye Liao Siyu Chen Xizhi Wen Kuai Yu Lingyi Fu Xingjun Dong Kaiyu Zhu Xiaojun Xia Tiebang Kang Chaochao Bian Xiang Li Haiping Liu Peirong Ding Xiaoshi Zhang Zhenjiang Liu Wende Li Zhixiang Zuo Penghui Zhou | 2022 | Cell Research2022，32，6： | 10 |
| 4 | Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity显示文摘Psoraleae Fructus(PF)is a well-known traditional herbal medicine in China,and it is widely used for osteoporosis,vitiligo,and other diseases in clinical settings.However,liver injury caused by PF and its preparations has been frequently reported in recent years.Our previous studies have demonstrated that PF could cause idiosyncratic drug-induced liver injury(IDILI),but the mechanism underlying its hepatotoxicity remains unclear.This paper reports that bavachin isolated from PF enhances the specific stimuli-induced activation of the NLRP3 inflammasome and leads to hepatotoxicity.Bavachin boosts the secretion of IL-ip and caspase-1 caused by ATP or nigericin but not those induced by poly(I:C),monosodium urate crystal,or intracellular lipopolysaccharide.Bavachin does not affect AIM2 or NLRC4 inflammasome activation.Mechanistically,bavachin specifically increases the production of nigericin-induced mitochondrial reactive oxygen species among the most important upstream events in the activation of the NLRP3 inflammasome.Bavachin increases the levels of aspartate transaminase and alanine aminotransferase in serum and hepatocyte injury accompanied by the secretion of IL-ip via a mouse model of lipopolysaccharide-mediated susceptibility to IDILI.These results suggest that bavachin specifically enhances the ATP-or nigericin-induced activation of the NLRP3 inflammasome.Bavachin also potentially contributes to PF-induced idiosyncratic hepatotoxicity.Moreover,bavachin and PF should be evaded among patients with diseases linked to the ATP-or nigericin-mediated activation of the NLRP3 inflammasome,which may be a dangerous factor for liver injury. | Nan Qin Guang Xu Yan Wang Xiaoyan Zhan Yuan Gao Zhilei Wang Shubin Fu Wei Shi Xiaorong Hou Chunyu Wang Ruisheng Li Yan Liu Jiabo Wang Haiping Zhao Xiaohe Xiao Zhaofang Bai | 2021 | Frontiers of Medicine2021，15，4： | 9 |
| 5 | Hierarchical Honeycomb-Structured Electret/Triboelectric Nanogenerator for Biomechanical and Morphing Wing Energy Harvesting显示文摘Flexible,compact,lightweight and sustainable power sources are indispensable for modern wearable and personal electronics and small-unmanned aerial vehicles(UAVs).Hierarchical honeycomb has the unique merits of compact mesostructures,excellent energy absorption properties and considerable weight to strength ratios.Herein,a honeycomb-inspired triboelectric nanogenerator(h-TENG)is proposed for biomechanical and UAV morphing wing energy harvesting based on contact triboelectrification wavy surface of cellular honeycomb structure.The wavy surface comprises a multilayered thin film structure(combining polyethylene terephthalate,silver nanowires and fluorinated ethylene propylene)fabricated through high-temperature thermoplastic molding and wafer-level bonding process.With superior synchronization of large amounts of energy generation units with honeycomb cells,the manufactured h-TENG prototype produces the maximum instantaneous open-circuit voltage,short-circuit current and output power of 1207 V,68.5μA and 12.4 mW,respectively,corresponding to a remarkable peak power density of 0.275 mW cm^(−3)(or 2.48 mW g^(−1))under hand pressing excitations.Attributed to the excellent elastic property of self-rebounding honeycomb structure,the flexible and transparent h-TENG can be easily pressed,bent and integrated into shoes for real-time insole plantar pressure mapping.The lightweight and compact h-TENG is further installed into a morphing wing of small UAVs for efficiently converting the flapping energy of ailerons into electricity for the first time.This research demonstrates this new conceptualizing single h-TENG device’s versatility and viability for broad-range real-world application scenarios. | Kai Tao Zhensheng Chen Haiping Yi Ruirong Zhang Qiang Shen Jin Wu Lihua Tang Kangqi Fan Yongqing Fu Jianmin Miao Weizheng Yuan | 2021 | Nano-Micro Letters2021，13，8： | 7 |
| 6 | Autophagy enhanced by curcumin ameliorates inflammation in atherogenesis via the TFEB-P300-BRD4 axis显示文摘Disturbance of macrophage-associated lipid metabolism plays a key role in atherosclerosis.Crosstalk between autophagy deficiency and inflammation response in foam cells(FCs) through epigenetic regulation is still poorly understood. Here, we demonstrate that in macrophages, oxidized lowdensity lipoprotein(ox-LDL) leads to abnormal crosstalk between autophagy and inflammation,thereby causing aberrant lipid metabolism mediated through a dysfunctional transcription factor EB (TFEB)-P300-bromodomain-containing protein 4(BRD4) axis. ox-LDL led to macrophage autophagy deficiency along with TFEB cytoplasmic accumulation and increased reactive oxygen species generation. This activated P300 promoted BRD4 binding on the promoter regions of inflammatory genes, consequently contributing to inflammation with atherogenesis. Particularly, ox-LDL activated BRD4-dependent super-enhancer associated with liquid-liquid phase separation(LLPS) on the regulatory regions of inflammatory genes. Curcumin(Cur) prominently restored FCs autophagy by promoting TFEB nuclear translocation, optimizing lipid catabolism, and reducing inflammation. The consequences of P300 and BRD4 on super-enhancer formation and inflammatory response in FCs could be prevented by Cur. Furthermore, the anti-atherogenesis effect of Cur was inhibited by macrophage-specific Brd4 overexpression or Tfeb knock-out in Apoe knock-out mice via bone marrow transplantation. The findings identify a novel TFEB-P300-BRD4 axis and establish a new epigenetic paradigm by which Cur regulates autophagy, inhibits inflammation, and decreases lipid content. | Xuesong Li Ruigong Zhu Hong Jiang Quanwen Yin Jiaming Gu Jiajing Chen Xian Ji Xuan Wu Haiping Fu Hui Wang Xin Tang Yuanqing Gao Bingjian Wang Yong Ji Hongshan Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 4 |
| 7 | Melatonin antagonizes ovarian aging via YTHDF2-MAPK-NF-κB pathway显示文摘Cellular senescence is closely associated with age-related diseases.Ovarian aging,a special type of organ senescence,is the pathophysiological foundation of the diseases of the reproductive system.It is characterized by the loss of integrity of the surface epithelium and a gradual decrease in the number of human ovarian surface epithelial cells(HOSEpiCs).To contribute to the research on delaying ovarian aging,we aimed to investigate the novel epigenetic mechanism of melatonin in protecting HOSEpiCs.We discovered that melatonin has antagonistic effects against the oncogene-induced senescence(OIS)of HOSEpiCs.Mechanistically,the oncogene Ras decreased the expression of YTHDF2,which is the reader of RNA-m6A,by stimulating the generation of reactive oxygen species(ROS).Moreover,we found that the suppression of YTHDF2 increased the expression of MAP2K4 and MAP4K4 by enhancing the stability of the transcription of their mRNAs,thereby upregulating the expression of the senescence-associated secretory phenotype(SASP)through the activation of the MAP2K4 and MAP4K4-dependent nuclear factor-κB(NF-κB)signaling pathways.We further determined that melatonin has antagonistic effects against the OIS of HOSEpiCs by inhibiting the ROS-YTHDF2-MAPK-NF-κB pathway.These findings provide key insights into the potential avenues for preventing and treating ovarian aging. | Ruigong Zhu Xian Ji Xuan Wu Jiajing Chen Xuesong Li Hong Jiang Haiping Fu Hui Wang Zhe Lin Xin Tang Shixiu Sun Qingguo Li Bingjian Wang Hongshan Chen | 2022 | Genes & Diseases2022，9，2： | 2 |
| 8 | Pumping-route-dependent concentration quenching and temperature effect of green up- and down-conversion luminescence in Er 3+ /Yb 3+ co-doped Gd 2 (WO 4 ) 3 phosphors显示文摘 | Jingjing Li Jiashi Sun Jutao Liu Xiangping Li Jinsu Zhang Yue Tian Shaobo Fu Lihong Cheng Haiyang Zhong Haiping Xia Baojiu Chen | 2013 | Materials Research Bulletin2013，，6： | 1 |
| 9 | Laser induced thermal effect on upconversion luminescence and temperature-dependent upconversion mechanism in Ho 3+ /Yb 3+ -codoped Gd 2 (WO 4 ) 3 phosphor显示文摘 | Wei Liu Jiashi Sun Xiangping Li Jinsu Zhang Yue Tian Shaobo Fu Hua Zhong Tianhong Liu Lihong Cheng Haiyang Zhong Haiping Xia Bin Dong Ruinian Hua Xiangqing Zhang Baojiu Chen | 2013 | Optical Materials2013，，7： | 1 |
| 10 | Smart Attendance System Based on Frequency Distribution Algorithm with Passive RFID Tags显示文摘Staff attendance information has always been an important part of corporate management.However,some opportunistic employees may consign others to punch their time cards,which hampers the authenticity of attendance and effectiveness of record keeping.Hence,it is necessary to develop an innovative anti-cheating system for office attendance.Radio-Frequency IDentification(RFID)offers new solutions to solve such problems because of its strong anti-interference capability and non-intrusiveness.In this paper,we present a smart attendance system that extracts distinguishable phase characteristics of individuals to enable recognition of various targets.A frequency distribution histogram is extracted as a fingerprint for recognition and the K-means clustering method is utilized for more fine-grained recognition of targets with similar features.Compared with traditional attendance mechanisms,RFID-based attendance systems are based on living biological characteristics,which greatly reduces the possibility of false records.To evaluate the performance of our system,we conducted extensive experiments.The results of which demonstrate the efficiency and accuracy of our system with an average accuracy of 92%.Moreover,the system evaluation shows that our design is robust against differences in the clothing worn and time of day,which further verifies the successful performance of our system. | Qianwen Miao Fu Xiao Haiping Huang Lijuan Sun Ruchuan Wang | 2020 | Tsinghua Science and Technology2020，25，2： | 1 |
| 11 | Microwave-assisted hydrothermal synthesis and temperature sensing application of Er 3+ /Yb 3+ doped NaY(WO 4 ) 2 microstructures显示文摘 | Hui Zheng Baojiu Chen Hongquan Yu Jinsu Zhang Jiashi Sun Xiangping Li Min Sun Bining Tian Shaobo Fu Hua Zhong Bin Dong Ruinian Hua Haiping Xia | 2014 | Journal of Colloid And Interface Science2014，，： | 1 |
| 12 | Pumping-route-dependent concentration quenching and temperature effect of green up- and down-conversion luminescence in Er 3+ /Yb 3+ co-doped Gd 2 (WO 4 ) 3 phosphors显示文摘 | Jingjing Li Jiashi Sun Jutao Liu Xiangping Li Jinsu Zhang Yue Tian Shaobo Fu Lihong Cheng Haiyang Zhong Haiping Xia Baojiu Chen | 2013 | Materials Research Bulletin2013，，6： | 1 |
| 13 | Rigidity Theorems of Complete Ricci Solitons under L^p显示文摘We prove rigidity results of complete Ricci soliton under some Lpconditions and some curvature assumptions. | Haiping FU Dengyun YANG | 2014 | Journal of Mathematical Research with Applications2014，34，6： | 0 |
| 14 | Growth,coalescence,and etching of two-dimensional overlayers on metals modulated by near-surface Ar nanobubbles显示文摘The synthesis of high-quality ultrathin overlayers is critically dependent on the surface structure of substrates,especially involving the overlayer–substrate interaction.By using in situ surface measurements,we demonstrate that the overlayer–substrate interaction can be tuned by doping near-surface Ar nanobubbles.The interfacial coupling strength significantly decreases with near-surface Ar nanobubbles,accompanying by an“anisotropic to isotropic”growth transformation.On the substrate containing near-surface Ar,the growth front crosses entire surface atomic steps in both uphill and downhill directions with no difference,and thus,the morphology of the two-dimensional(2D)overlayer exhibits a round-shape.Especially,the round-shaped 2D overlayers coalesce seamlessly with a growth acceleration in the approaching direction,which is barely observed in the synthesis of 2D materials.This can be attributed to the immigration lifetime and diffusion rate of growth species,which depends on the overlayer–substrate interaction and the surface catalysis.Furthermore,the“round to hexagon”morphological transition is achieved by etching-regrowth,revealing the inherent growth kinetics under quasi-freestanding conditions.These findings provide a novel promising way to modulate the growth,coalescence,and etching dynamics of 2D materials on solid surfaces by adjusting the strength of overlayer–substrate interaction,which contributes to optimization of large-scale production of 2D material crystals. | Wei Wei Jiaqi Pan Haiping Lin Chanan Euaruksakul Zhiyun Li Rong Huang Li Wang Zhujun Wang Qiang Fu Yi Cui | 2022 | Nano Research2022，15，3： | 0 |
| 15 | The finding of natural GaN crystals in sediments from the East Pacific Ocean显示文摘The first finding of natural GaN crystals is reported in sediments from the East Pacific. They are identified by multiple micro-beam techniques such as TEM, EDS and EELS. Detailed examinations show that these GaN crystals are euhedral and authigenic, and belong to the hexagonal system (space group P63mc) with cell parameters: a = b = 0.3186 nm, c = 0.5178 nm. Structure data fit closely with those of the synthetic GaN crystals obtained from high-temperature and high-pressure experi- ments. Moreover, the nearly perfect euhedral form of the sample excludes the possible synthetic origin of the GaN crystals as artifacts with long transport. The sampling localities are located between the Clarion and Clipperton Fracture Zone in the East Pacific where ongoing hydrothermal activities, deformation, and volcanic eruptions are very intensive. It is sug- gested that the natural GaN crystals may form at relatively high-temperature and high-pressure condi- tions in geologic environments that have been af- fected by intense hydrothermal activities. | CHEN Jing SHI Xuefa ZHANG Haiping LUE Huahua FU Zhendong | 2006 | Chinese Science Bulletin2006，51，9： | 0 |
| 16 | Complete Manifolds with Harmonic Curvature and Finite L^p-Norm Curvature显示文摘Let(M^n, g)(n ≥ 3) be an n-dimensional complete Riemannian manifold with harmonic curvature and positive Yamabe constant. Denote by R and R?m the scalar curvature and the trace-free Riemannian curvature tensor of M, respectively. The main result of this paper states that R?m goes to zero uniformly at infinity if for p ≥ n, the L^p-norm of R?m is finite.As applications, we prove that(M^n, g) is compact if the L^p-norm of R?m is finite and R is positive, and(M^n, g) is scalar flat if(M^n, g) is a complete noncompact manifold with nonnegative scalar curvature and finite L^p-norm of R?m. We prove that(M^n, g) is isometric to a spherical space form if for p ≥n/2, the L^p-norm of R?m is sufficiently small and R is positive.In particular, we prove that(M^n, g) is isometric to a spherical space form if for p ≥ n, R is positive and the L^p-norm of R?m is pinched in [0, C), where C is an explicit positive constant depending only on n, p, R and the Yamabe constant. | Haiping FU Pingping DAN Shulin SONG | 2017 | Journal of Mathematical Research with Applications2017，37，3： | 0 |
| 17 | Themis suppresses the effector function of CD8^(+)T cells in acute viral infection显示文摘CD8^(+)T cells play a central role in antiviral immune responses.Upon infection,naive CD8^(+)T cells differentiate into effector cells to eliminate virus-infected cells,and some of these effector cells further differentiate into memory cells to provide long-term protection after infection is resolved.Although extensively investigated,the underlying mechanisms of CD+T-cell differentiation remain incompletely understood.Themis is a T-cell-specific protein that plays critical roles in T-cell development.Recent studies using Themis T-cell conditional knockout mice also demonstrated that Themis is required to promote mature CD8^(+)T-cell homeostasis,cytokine responsiveness,and antibacterial responses.In this study,we used LCMV Armstrong infection as a probe to explore the role of Themis in viral infection.We found that preexisting CD8^(+)T-cell homeostasis defects and cytokine hyporesponsiveness do not impair viral clearance in Themis T-cell conditional knockout mice.Further analyses showed that in the primary immune response,Themis deficiency promoted the differentiation of CD8^(+)effector cells and increased their TNF and IFNy production.Moreover,Themis deficiency impaired memory precursor cell(MPEC)differentiation but promoted short-lived effector cell(SLEC)differentiation.Themis deficiency also enhanced effector cytokine production in memory CD8^(+)T cells while impairing central memory CD8^(+)T-cell formation.Mechanistically,we found that Themis mediates PD-1 expression and its signaling in effector CD8^(+)T cells,which explains the elevated cytokine production in these cells when Themis is disrupted. | Jian Tang Xian Jia Jian Li Junchen Dong Jiayu Wang Wanyun Li Yuzhen Zhu Yanyan Hu Bowen Hou Chunjie Lin Yu Cong Tong Ren Changsheng Yan Hongying Yang Qian Lai Haiping Zheng Yuzhou Bao Namrata Gautam Hong-Rui Wang Bing Xu Xiao Lei Chen Qing Li Nicholas R.J.Gascoigne Guo Fu | 2023 | Cellular & Molecular Immunology2023，20，5： | 0 |
| 18 | Performance Analysis for Intrusion Target Detection in Wireless Sensor Networks显示文摘 | FAN Gaojuan WANG Ruchuan HUANG Haiping SUN Lijuan XIAO Fu | 2011 | Chinese Journal of Electronics2011，20，4： | 0 |
| 19 | Acid-base Vapor Sensing Enabled by ESIPT-attributed Cd(II) Coordination Polymer with Switchable Luminescence显示文摘Fluorescence materials based on excited state intramolecular proton transfer(ESIPT)have attracted great attentiori due to the unique four-level energy states.Herein,we report the assembly of a Cd-LF coordination polymer from purposely designed LF(H2hpi2cf)ligand,which can present switchable luminescence behavior by gain or loss protons originated in uncoordinated ESIPT sites and serve as acid-base vapor sensors.Fabricated into in-situ grown film or transparent ink by simple methods,Cd-LF presents facile and portable amine sensor for food spoilage detection and fluorescent anti-counterfeiting ink applications. | FU Pengyan MO Junting SUN Sisi YIN Shaoyun WANG Haiping PAN Mei | 2020 | Chemical Research in Chinese Universities2020，36，5： | 0 |
| 20 | A Chemo-enzymatic Route for the Preparation of Chiral (S)-3-Hydroxy-3-phenylpropanoic Acid显示文摘 | ZHAO Ying MA Haiping FU Zhijing ZHANG Guoyan | 2014 | Chemical Research in Chinese Universities2014，30，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员