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| 1 | Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome显示文摘Aberrant activation of NLRP3 inflammasome has been implicated in the pathogenesis of diverse inflammation-related diseases, and pharmacological molecules targeting NLRP3 inflammasome are of considerable value to identifying potential therapeutic interventions. Cardamonin(CDN), the major active ingredient of the traditional Chinese medicinal herb Alpinia katsumadai, has exerted an excellent anti-inflammatory activity, but the mechanism underlying this role is not fully understood. Here, we show that CDN blocks canonical and noncanonical NLRP3 inflammasome activation triggered by multiple stimuli. Moreover, the suppression of CDN on inflammasome activation is specific to NLRP3, not to NLRC4 or AIM2 inflammasome. Besides, the inhibitory effect is not dependent on the expression of NF-κB-mediated inflammasome precursor proteins. We also demonstrate that CDN suppresses the NLRP3 inflammasome through blocking ASC oligomerization and speckle formation in a dose-dependent manner.Importantly, CDN improves the survival of mice suffering from lethal septic shock and attenuates IL-1βproduction induced by LPS in vivo, which is shown to be NLRP3 dependent. In conclusion, our results identify CDN as a broad-spectrum and specific inhibitor of NLRP3 inflammasome and a candidate therapeutic drug for treating NLRP3 inflammasome-driven diseases. | Zhilei Wang Guang Xu Yuan Gao Xiaoyan Zhan Nan Qin Shubin Fu Ruisheng Li Ming Niu Jiabo Wang Youping Liu Xiaohe Xiao Zhaofang Bai | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 19 |
| 2 | Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity显示文摘Psoraleae Fructus(PF)is a well-known traditional herbal medicine in China,and it is widely used for osteoporosis,vitiligo,and other diseases in clinical settings.However,liver injury caused by PF and its preparations has been frequently reported in recent years.Our previous studies have demonstrated that PF could cause idiosyncratic drug-induced liver injury(IDILI),but the mechanism underlying its hepatotoxicity remains unclear.This paper reports that bavachin isolated from PF enhances the specific stimuli-induced activation of the NLRP3 inflammasome and leads to hepatotoxicity.Bavachin boosts the secretion of IL-ip and caspase-1 caused by ATP or nigericin but not those induced by poly(I:C),monosodium urate crystal,or intracellular lipopolysaccharide.Bavachin does not affect AIM2 or NLRC4 inflammasome activation.Mechanistically,bavachin specifically increases the production of nigericin-induced mitochondrial reactive oxygen species among the most important upstream events in the activation of the NLRP3 inflammasome.Bavachin increases the levels of aspartate transaminase and alanine aminotransferase in serum and hepatocyte injury accompanied by the secretion of IL-ip via a mouse model of lipopolysaccharide-mediated susceptibility to IDILI.These results suggest that bavachin specifically enhances the ATP-or nigericin-induced activation of the NLRP3 inflammasome.Bavachin also potentially contributes to PF-induced idiosyncratic hepatotoxicity.Moreover,bavachin and PF should be evaded among patients with diseases linked to the ATP-or nigericin-mediated activation of the NLRP3 inflammasome,which may be a dangerous factor for liver injury. | Nan Qin Guang Xu Yan Wang Xiaoyan Zhan Yuan Gao Zhilei Wang Shubin Fu Wei Shi Xiaorong Hou Chunyu Wang Ruisheng Li Yan Liu Jiabo Wang Haiping Zhao Xiaohe Xiao Zhaofang Bai | 2021 | Frontiers of Medicine2021，15，4： | 9 |
| 3 | A Silicon Monoxide Lithium-Ion Battery Anode with Ultrahigh Areal Capacity显示文摘Silicon monoxide(SiO)is an attractive anode material for next-generation lithium-ion batteries for its ultra-high theoretical capacity of 2680 mAh g−1.The studies to date have been limited to electrodes with a rela-tively low mass loading(<3.5 mg cm^(−2)),which has seriously restricted the areal capacity and its potential in practical devices.Maximizing areal capacity with such high-capacity materials is critical for capitalizing their potential in practi-cal technologies.Herein,we report a monolithic three-dimensional(3D)large-sheet holey gra-phene framework/SiO(LHGF/SiO)composite for high-mass-loading electrode.By specifically using large-sheet holey graphene building blocks,we construct LHGF with super-elasticity and exceptional mechanical robustness,which is essential for accommodating the large volume change of SiO and ensuring the structure integrity even at ultrahigh mass loading.Additionally,the 3D porous graphene network structure in LHGF ensures excellent electron and ion transport.By systematically tailoring microstructure design,we show the LHGF/SiO anode with a mass loading of 44 mg cm^(−2)delivers a high areal capacity of 35.4 mAh cm^(−2)at a current of 8.8 mA cm^(−2)and retains a capacity of 10.6 mAh cm^(−2)at 17.6 mA cm^(−2),greatly exceeding those of the state-of-the-art commercial or research devices.Furthermore,we show an LHGF/SiO anode with an ultra-high mass loading of 94 mg cm^(−2)delivers an unprecedented areal capacity up to 140.8 mAh cm^(−2).The achievement of such high areal capacities marks a critical step toward realizing the full potential of high-capacity alloy-type electrode materials in practical lithium-ion batteries. | Jiang Zhong Tao Wang Lei Wang Lele Peng Shubin Fu Meng Zhang Jinhui Cao Xiang Xu Junfei Liang Huilong Fei Xidong Duan Bingan Lu Yiliu Wang Jian Zhu Xiangfeng Duan | 2022 | Nano-Micro Letters2022，14，3： | 4 |
| 4 | Preparation and Characterization of Ternary Europium Complex-Doped Thin Sol-Gel Hybrid Film by Fluorescence Spectroscopy显示文摘IntroductionThelow-temperatureprocessingofthesol-gelmaterialmakesitpossibletoentraporganicspecieseasilywithinarigidglassmatri... | FU Lianshe, ZHANG Hongjie**, WANG Shubin MENG Qingguo, YANG Kuiyue and NI Jiazuan (Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022) | 1999 | Chemical Research in Chinese Universities1999，15，2： | 1 |
| 5 | Preparation and Luminescence Properties of Terbium-Sal Complex In-situ Synthesized in Silica Matrix by a Two-Step Sol-Gel Process显示文摘In-situ synthesis of terbium complex with saiicylic acid (Sal) in silica matrix was made by a two-step sol-gel process. The terbium complex with salicylic acid was formed in sol-gel derived silica gel, and confirmed by the luminescence excitation spectra and infrared(IR) spectra. As compared to the pure terbium complex powder, the silica gel containing terbium complex exhibits its characteristic emission and presents a longer fluorescence lifetime than that for the pure complex. The luminescence properties of the complex containing silica gel were investigated and compared with that of both terbium doped the silica gel and the pure complex powder. The reasons leading to the above results were also discussed. | Fu, Lianshe Zhang, Hongjie Wang, Shubin Meng, Qingguo Shao, Hua Ni,
Jiazuan
| 1999 | Journal of Materials Science & Technology1999，15，2： | 1 |
| 6 | Preparation and Luminescence Properties of the Ternary Europium Complex Incorporated into an Inorganic/Polymer Matrix by a Sol-Gel Method显示文摘 | Lianshe Fu Hongjie Zhang Shubin Wang Qingguo Meng Kuiyue Yang Jianzuan Ni | 1999 | Journal of Sol - Gel Science and Technology1999，，1： | 1 |
| 7 | Chemically bonded multi-nanolayer inorganic aerogel with a record-low thermal conductivity in a vacuum显示文摘Inorganic aerogels have exhibited many superior characteristics with extensive applications,but are still plagued by a nearly century-old tradeoff between their mechanical and thermal properties.When reducing thermal conductivity by ultralow density,inorganic aerogels generally suffer from large fragility due to their brittle nature or weak joint crosslinking,while enhancing the mechanical robustness by material design and structural engineering,they easily sacrifice thermal insulation and stability.Here,we report a chemically bonded multi-nanolayer design and synthesis of a graphene/amorphous boron nitride aerogel to address this typical tradeoff to further enhance mechanical and thermal properties.Attributed to the chemically bonded interface and coupled toughening effect,our aerogels display a low density of 0.8 mg cm-3 with ultrahigh flexibility(elastic compressive strain up to 99%and bending strain up to 90%),and exceptional thermostability(strength degradation<3%after sharp thermal shocks),as well as the lowest thermal conductivities in a vacuum(only 1.57 mW m-1 K-1 at room temperature and 10.39 mW m-1 K-1 at500℃)among solid materials to date.This unique combination of mechanical and thermal properties offers an attractive material system for thermal superinsulation at extreme conditions. | Hongxuan Yu Menglin Li Yuanpeng Deng Shubin Fu Jingran Guo Han Zhao Jianing Zhang Shixuan Dang Pengyu Zhang Jian Zhou Dizhou Liu Duola Wang Chuanwei Zhang Menglong Hao Xiang Xu | 2023 | National Science Review2023，10，10： | 0 |
| 8 | Carbonaceous ceramic nanofibrous aerogels for high-temperature thermal superinsulation显示文摘Ultralight ceramic aerogels are attractive thermal superinsulating materials,but display a formidable tradeoff between low and high temperature thermal conductivity(κ)due to their low-density features.Embedding carbon species as infrared opacifier in ultralight ceramic aerogels can substantially reduce the thermal radiation heat transfer without compromising the ultralow solid conduction.However,the oxidation resistance of embedded carbon species still remains inadequate to prevent thermal etching at high temperatures.Herein,we report a carbonaceous design and synthesis of ceramic nanofibrous aerogels with amorphous carbon embedded in the yttrium-stabilized zircon nanofibers to achieve a high-temperature thermal superinsulating performance with robust thermomechanical stability.The aerogels display one of the lowestκof 95 mW·m^(−1)·K^(-1)at 1,000℃in air among ultralight material family,as well as robust mechanical flexibility with up to 95%compressive strain,30%non-linear fracture strain,and 99%bending strain,and high thermal stability with ultralow strength degradation less than 1%after sharp thermal shocks(240℃·s^(-1))and working temperature up to 1,200℃.The combined high-temperature thermal superinsulating and thermomechanical properties offer an attractive material system for robust thermal insulation under extreme conditions. | Shubin Fu Dizhou Liu Yuanpeng Deng Jingran Guo Han Zhao Jian Zhou Pengyu Zhang Hongxuan Yu Shixuan Dang Jianing Zhang Hui Li Xiang Xu | 2023 | Nano Research2023，16，4： | 0 |
| 9 | How to Memorise Phrasal Verbs显示文摘EnglishphrasalverbsformanimportantunitinEnglishlanguage.PhrasalverbsappearveryfrequentlyinEnglisharticles.Furthermore,inmany... | Fu Shubin | 1998 | 河南教育学院学报(哲学社会科学版)1998，17，3： | 0 |
| 10 | Vocabulary Teaching by Means of Enlightenment显示文摘earsofpracticehavemadeusrealizethatweshouldfocusourefortsonbasictrainingandtheenhaucementofapplyingabilityofthestudentsinCol... | Fu Shubin | 1999 | 河南教育学院学报(哲学社会科学版)1999，18，2： | 0 |
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