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| 1 | Landscape of DILI-related adverse drug reaction in China Mainland显示文摘Drug-induced liver injury(DILI)is a type of bizarre adverse drug reaction(ADR)damaging liver(L-ADR)which may lead to substantial hospitalizations and mortality.Due to the general low incidence,detection of L-ADR remains an unsolved public health challenge.Therefore,we used the data of 6.673 million of ADR reports from January 1st,2012 to December 31st,2016 in China National ADR Monitoring System to establish a new database of L-ADR reports for future investigation.Results showed that totally 114,357 ADR reports were retrieved by keywords searching of liver-related injuries from the original heterogeneous system.By cleaning and standardizing the data fields by the dictionary of synonyms and English translation,we resulted 94,593 ADR records reported to liver injury and then created a new database ready for computer mining.The reporting status of L-ADR showed a persistent 1.62-fold change over the past five years.The national population-adjusted reporting numbers of L-ADR manifested an upward trend with age increasing and more evident in men.The annual reporting rate of L-ADR in age group over 80 years old strikingly exceeded the annual DILI incidence rate in general population,despite known underreporting situation in spontaneous ADR reporting system.The percentage of herbal and traditional medicines(H/TM)L-ADR reports in the whole number was 4.5%,while 80.60%of the H/TM reports were new findings.There was great geographical disparity of reported agents,i.e.more cardiovascular and antineoplastic agents were reported in higher socio-demographic index(SDI)regions and more antimicrobials,especially antitubercular agents,were reported in lower SDI regions.In conclusion,this study presented a large-scale,unbiased,unified,and computer-minable L-ADR database for further investigation.Age-,sex-and SDI-related risks of L-ADR incidence warrant to emphasize the precise pharmacovigilance policies within China or other regions in the world. | Jiabo Wang Haibo Song Feilin Ge Peng Xiong Jing Jing Tingting He Yuming Guo Zhuo Shi Chao Zhou Zixin Han Yanzhong Han Ming Niu Zhaofang Bai Guangbin Luo Chuanyong Shen Xiaohe Xiao | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 12 |
| 2 | LEO Enhanced Global Navigation Satellite System(LeGNSS):progress,opportunities,and challenges显示文摘With the completion of Chinese BeiDou Navigation Satellite System(BDS),the world has begun to enjoy the Positioning,Navigation,and Timing(PNT)services of four Global Navigation Satellite Systems(GNSS).In order to improve the GNSS performance and expand its applications,Low Earth Orbit(LEO)Enhanced Global Navigation Satellite System(LeGNSS)is being vigorously advocated.Combined with high-,medium-,and low-earth orbit satellites,it can improve GNSS performance in terms of orbit determination,Precise Point Positioning(PPP)convergence time,etc.This paper comprehensively reviews the current status of LeGNSS,focusing on analyzing its advantages and challenges for precise orbit and clock determination,PPP convergence,earth rotation parameter estimation,and global ionosphere modeling.Thanks to the fast geometric change brought by LEO satellites,LeGNSS is expected to fundamentally solve the problem of the long convergence time of PPP without any augmentation.The convergence time can be shortened within 1 minute if appropriate LEO constellations are deployed.However,there are still some issues to overcome,such as the optimization of LEO constellation as well as the real time LEO precise orbit and clock determination. | Haibo Ge Bofeng Li Song Jia Liangwei Nie Tianhao Wu Zhe Yang Jingzhe Shang Yanning Zheng Maorong Ge | 2022 | Geo-Spatial Information Science2022，25，1： | 4 |
| 3 | Comprehensive assessment of real-time precise products from IGS analysis centers显示文摘Real-Time Precise Point Positioning(RT-PPP)has been one of the research hotspots in GNSS(Global Navigation Satellite System)community for decades.Real-time precise products of satellite orbits and clocks are the prerequisite for RT-PPP.Thus,it is of great importance to investigate the current multi-GNSS real-time precise products in State Space Representation(SSR)from diferent analysis centers.In this article,SSR products from 10 analysis centers are comprehensively evaluated by comparing them with the fnal products and performing the kinematic PPP.The results show that analysis centers CNES(Centre National D’Etudes Spatiales)and WHU(GNSS Research Center of Wuhan University)provide the most complete products with the best quality.Concerning the accuracy of real-time products for the GNSSs,the accuracies of orbit and clock products are better than 5 cm and 0.15 ns,respectively,for Global Positioning System(GPS),followed by Galileo navigation satellite system(Galileo),BeiDou-3 Navigation Satellite System(BDS-3),GLObal NAvigation Satellite System(GLONASS),and BeiDou-2 Navigation Satellite System(BDS-2).Meanwhile,the results of the RT-PPP with quad-system show that the positioning accuracies are 1.76,1.12 and 2.68 cm in east,north,and up directions,respectively,and the convergence time to 0.1,0.1,0.2 m for corresponding directions is 15.35 min. | Bofeng Li Haibo Ge Yuhang Bu Yanning Zheng Leitong Yuan | 2022 | Satellite Navigation2022，3，1： | 2 |
| 4 | Involvement of the crebellum in sequential finger movement learning:Evidence from functional magnetic resonance imaging显示文摘Whether the cerebellum is involved in volun-tary motor learning or motor performance is the subject of a new debate. Using functional magnetic resonance imaging (fMRI), we examined cerebellar activation in eight volun-teers before and after an extended period of training. Activa-tion volume on both sides of cerebellum after learning was significantly reduced compared to that before learning even under the same motor frequency. Remarkably, while motor frequency for the training sequence was significantly higher than the control sequence after 41 d of learning, activation in the cerebellum for both sequences, with respect to activation loci and volumes, was very similar. These results suggest that the cerebellum was involved in motor learning but not motor performance. Changes of cerebellar activation from training thus appear to be associated with learning but not with im-provement on task performance. | ZHU Yihong DI Haibo YUAN Yi REN Jin'ge YU Wei ZHANG Zhaoqi GAO Jiahong WENG Xuchu CHEN Yizhang | 2005 | Chinese Science Bulletin2005，50，17： | 2 |
| 5 | 显示文摘 | Ge Lei Xu Mingxia Fang Haibo | 2006 | Journal of Sol-Gel Sci- ence and Technology2006，40，1： | 1 |
| 6 | Synthesis and characterization of the Pd/In VO4-TiO2 co-doped thin films with visible light photocatalyric activities显示文摘 | GE Lei XU Mingxia FANG Haibo | 2006 | Appl Surf Sci2006，253，4： | 1 |
| 7 | Preparation and characterization of silver and indium vanadate co-doped TiO2 thin films as visible-light-activated photocatalyst显示文摘 | GE Lei XU Mingxia FANG Haibo | 2006 | J Sol Gel Sci Technol2006，40，1： | 1 |
| 8 | Synthesis and photocatalytic properties of InVO4 sol containing nanocrystals by mild hydrothermal processing显示文摘 | FANG Haibo XU Mingxia GE Lei | 2006 | Trans Nonfer Met al Soci Chin2006，16，27： | 1 |
| 9 | 显示文摘 | Ge Lei Xu Mingxia Fang Haibo | 2006 | Applied Surface Science2006，253，4： | 1 |
| 10 | Novel flame-retardant and antidripping branched polyesters prepared via-containing ionic monomer as end-capping agent 显示文摘 | Wang Junsheng Zhao Haibo Ge Xinguo | 2010 | Ind Eng Chem Res2010，49，： | 1 |
| 11 | Synthesis of Novel Photo- catalytic InVO4-TiO2 Thin Films with Visible Light Photoacti- vity显示文摘 | Ge Lei Xu Mingxia Fang Haibo | 2007 | MateLett2007，61，1： | 1 |
| 12 | Low-temperature synthesis of photocatalytic TiO2 thin film from aqueous anatase precursor sols显示文摘 | Lei Ge Mingxia Xu Ming Sun Haibo Fang | 2006 | Journal of Sol - Gel Science and Technology2006，，1： | 1 |
| 13 | Preparation of TiO2 thin films from autoclaved sol containing needle-like anatase crystals显示文摘 | Lei Ge Mingxia Xu Haibo Fang Ming Sun | 2006 | J Applied Surface Science2006，253，： | 1 |
| 14 | Novel flame-retardant and antidripping branched polyesters prepared via phosphorus-containing ionic monomer as end-capping agent显示文摘 | WANG Junsheng ZHAO Haibo GE Xinguo | | 0，，49： | 1 |
| 15 | Synthesis of novel photocatalytic InVO4-TiO2 thin films with visible light photoactivity 显示文摘 | GE Lei XU Mingxia FANG Haibo | 2007 | Mater Lett2007，61，1： | 1 |
| 16 | Phosphatase of Regenerating Liver-3 Promotes Motility and Metastasis of Mouse Melanoma Cells显示文摘 | Xiaopeng Wu Hu Zeng Xianming Zhang Ying Zhao Haibo Sha Xiaomei Ge Minyue Zhang Xiang Gao Qiang Xu | 2004 | The American Journal of Pathology2004，，6： | 1 |
| 17 | Preparation and characterization of silver and indium vanadate co-doped TiO2 thin films as visible-light-activated photocatalyst显示文摘 | Lei Ge Mingxia Xu Haibo Fang | 2006 | Journal of Sol - Gel Science and Technology2006，，1： | 1 |
| 18 | Variation of Color and Ray Pattern in Juvenile Shells in Hatchery‐produced Freshwater Triangle Pearl Mussels, Hyriopsis cumingii , in China显示文摘 | Haibo Wen Ruobo Gu Zheming Cao Xin Zhou Zhijuan Nie Xianping Ge Pao Xu Xin Zhou Zhijuan Nie Xianping Ge Pao Xu Dan Hua | 2013 | J World Aquacult Soc2013，，1： | 1 |
| 19 | Cilostazol improves long-term outcomes after coronary stent implantation显示文摘 | Yaling Han Shouli Wang Yi Li Quanmin Jing Yingyan Ma Jie Deng Guitang Yang Haibo Yu Junbo Ge | 2005 | American Heart Journal2005，，3： | 1 |
| 20 | Preparation and characterization of silver and indium vanadate co-doped TiO2 thin films as visible-light-activated photocatalyst 显示文摘 | Ge Lei Xu Mingxia Fang Haibo | 2006 | J Sol-Gel Sci Technol2006，40，1： | 1 |
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