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| 1 | 美国临床肿瘤学会IV期非小细胞肺癌化疗的临床实践指南更新显示文摘本文旨在为IV期非小细胞肺癌患者的治疗提供更新版推荐。本文资料检索源自2002年以来公布的相关随机试验文献。此指南范围限于化疗与生物治疗。更新委员会对这些文献进行了总结并提供了推荐更新。162篇文献符合标准被纳入参考。本推荐基于可改善总生存期的治疗方法。仅改善无进展生存期的治疗方法推动了对毒性及生存质量的监测。对于体力状态评分为0分或1分患者的一线治疗,可推荐以铂类为基础的细胞毒性药物的两药联用。对铂类治疗有禁忌的患者,可采用非铂类细胞毒性两药联合。对于体力状态评分为2分的患者,单一细胞毒性药物即可。对于疾病进展或经过4个周期的治疗仍对治疗无反应的患者,应停止一线细胞毒性化疗。即使在6个周期后患者对治疗仍有反应,亦应停止两药细胞毒性化疗。对于伴有明确的表皮生长因子受体(epidermal growth factor receptor,EGFR)突变的患者,可推荐一线采用吉非替尼治疗;对于EGFR突变为阴性或不明确的患者,细胞毒性化疗更佳。除具有特定临床特征的患者外,可推荐贝伐单抗与卡铂-紫杉醇联用。对于通过免疫组化证实EGFR阳性的肿瘤患者,可推荐西妥昔单抗与顺铂-长春瑞滨联用。多西紫杉醇、厄洛替尼、吉非替尼或培美曲塞被推荐作为二线治疗。对于未曾接受过厄洛替尼或吉非替尼治疗的患者,可推荐厄洛替尼作为三线治疗。现有数据不足以推荐常规三线采用细胞毒性药物。已有的证据也不足以推荐常规应用分子标记物选择化疗。 | Christopher G. AZZOLI Sherman Baker JR Sarah TEMIN William PAO Timothy ALIFF Julie BRAHMER David H. JOHNSON Janessa L. LASKIN Gregory MASTERS Daniel MILTON Luke NORDQUIST David G. PFISTER Steven PIANTADOSI Joan H. SCHILLER Reily SMITH Thomas J. SMITH John R. STRAWN David TRENT Giuseppe GIACCONE 丁燕(翻译) 南娟(翻译) 刘谦(翻译) 周清华(校对) 陈军(校对) | 2010 | 中国肺癌杂志2010，13，3： | 43 |
| 2 | Optimization of phenol degradation by Candida tropicalis Z-04 using Plackett-Burman design and response surface methodology显示文摘Statistical experimental designs were used to optimize the process of phenol degradation by Candida tropicalis Z-04,isolated from phenol-degrading aerobic granules.The most important factors influencing phenol degradation (p<0.05),as identified by a two-level Plackett-Burman design with 11 variables,were yeast extract,phenol,inoculum size,and temperature.Steepest ascent method was undertaken to determine the optimal regions of these four significant factors.Central composite design (CCD) and response surface analysis were adopted to further investigate the mutual interactions between these variables and to identify their optimal values that would generate maximum phenol degradation.The analysis results indicated that interactions between yeast extract and temperature,phenol and temperature,inoculum size and temperature affected the response variable (phenol degradation) significantly.The predicted results showed that the maximum removal efficiency of phenol (99.10%) could be obtained under the optimum conditions of yeast extract 0.41 g/L,phenol 1.03 g/L,inoculum size 1.43% (V/V) and temperature 30.04°C.These predicted values were further verified by validation experiments.The excellent correlation between predicted and experimental values confirmed the validity and practicability of this statistical optimum strategy.This study indicated the excellent ability of C.tropicalis Z-04 in degrading high-strength phenol.Optimal conditions obtained in this experiment laid a solid foundation for further use of this microorganism in the treatment of highstrength phenol effluents. | Jiangya Zhou Xiaojuan Yu Cong Ding Zhiping Wang Qianqian Zhou Hao Pao Weimin Ca | 2011 | Journal of Environmental Sciences2011，23，1： | 48 |
| 3 | Comparable rate of EGFR kinase domain mutation in lung adenocarcinomas from Chinese male and female never-smokers显示文摘 | Yi-hua SUN Rong FANG Bin GAO Xiang-kun HAN Jun-hua ZHANG William PAO Hai-quan CHEN Hong-bin JI | 2010 | Acta Pharmacologica Sinica2010，31，5： | 5 |
| 4 | 中国杂交水稻在柬埔寨马德望省的生长及产量表现(英文)显示文摘【目的】研究中国杂交水稻品种在柬埔寨马德望省的种植长势和产量表现,为中国杂交水稻在柬埔寨马德望省的推广应用提供参考。【方法]2012年旱季(1~4月),将3个中国杂交水稻品种(早优362、特优362和桂源优362)与当地水稻品种(Senpidao)种植于柬埔寨马德望省,测定比较不同品种农艺性状和产量。【结果】不同水稻品种株高间差异显著。中国杂交水稻品种株高均显著高于当地对照品种(Senpidao),但分蘖数较低。中国杂交水稻品种的每穗粒数和穗长也显著高于当地对照品种,其中特优362的每穗粒数最多,桂源优362的穗最长。早优362的千粒重均高于其他3个品种,而特优362和桂源优362的产量显著高于其他两个品种。此外,每穗粒数、穗长和产量间表现出极显著的相关性。【结论】中国杂交水稻适合在柬埔寨种植,旱季在马德望省的Toul Sammng±壤种植可比当地品种增产23%。38%。 | SREAN Pao HOUM Savy TOUCH Bunna 周行 王威豪 石瑜敏 韦善富 刘百龙 | 2012 | 南方农业学报2012，43，8： | 4 |
| 5 | INFLUENCE OF THE ANTARCTIC SEA-ICE ON THE NORTH-WEST PACIFIC SUBTROPICAL HIGH AND ITS BACKGROUND OF OCEANATMOSPHERIC CIRCULATION显示文摘In view of the importance of the North-west Pacific subtropical high to weather-climate conditions in large areas of the Chinese territory, we have devoted our attention mainly to analyzing the relationship between the subtropical high and the Antarctic sea-ice. We have found that the high and the sea-ice are closely related to each other in our | 彭公炳 PAO K.WANG | 1989 | Chinese Science Bulletin1989，34，17： | 4 |
| 6 | Effects of GS3 and GL3.1 for Grain Size Editing by CRISPR/Cas9 in Rice显示文摘Grain size is one of key agronomic traits associated with grain yield and grain quality. Both major quantitative trait loci GS3 and GL3.1 play a predominant role in negative regulation of grain size. In this study, a CRISPR/Cas9-mediated multiplex genome editing system was used to simultaneously edit GS3 and GL3.1 in a typical japonica rice Nipponbare. In T1 generation, we found that gs3 formed slender grain with lower chalkiness percentage, while gs3gl3.1 produced larger grain with higher chalkiness percentage. In terms of other agronomic traits, flag leaf size, grain number and grain yield of both gs3 and gs3gl3.1 mutants were affected. It is noteworthy that gs3 and gs3gl3.1 mutants both led to dramatical reduction of grain number, thereby decreased grain yield. In conclusion, these results indicated that knockout of GS3 and GL3.1 could rapidly improve grain size, but probably have some negative influences on grain quality and grain yield. | Chen Yuyu Zhu Aike Xue Pao Wen Xiaoxia Cao Yongrun Wang Beifang Zhang Yue Shah Liaqat Cheng Shihua Cao Liyong Zhang Yingxin | 2020 | Rice science2020，27，5： | 4 |
| 7 | Characterization of high-yield performance as affected by genotype and environment in rice显示文摘We characterized yield-relevant characters and their variations over genotypes and environments(locations and years) by examining two rice varieties(9746 and Jinfeng) with high yield potential. 9746 and Jinfeng were planted in two locations of Shanghai,China,during 2005 and 2006. The results show that there was a large variation in grain yield between locations and years. The realization of high yield potential for the two types of rice was closely related to the improved sink size,such as more panicles per square meter or grains per panicle. Stem and leaf biomasses were mainly accumulated from tillering stage to heading stage,and showed slow decline during grain filling. Meanwhile,some photosynthetic characters including net photosynthesis rate(Pn),leaf area index(LAI),specific leaf area(SLA),fluorescence parameter(maximum quantum yield of PSII,Fv/Fm),chlorophyll content(expressed as SPAD value),as well as nutrient(N,P,K) uptake were also measured to determine their variations over genotypes and environments and their relationships with grain yield. Although there were significant differences between years or locations for most measurements,SLA at tillering and heading stages,Fv/Fm and LAI at heading stage,stem biomass at heading and maturity stages,and leaf nitrogen concentration at tillering and heading stages remained little changed,indicating their pos-sible applications as selectable characters in breeding programs. It was also found that stem nitrogen accumulation at tillering stage is one of the most important and stable traits for high yield formation. | Song CHEN Fang-rong ZENG Zong-zhi PAO Guo-ping ZHANG | 2008 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008，9，5： | 3 |
| 8 | Ray-normal mode and hybrid analysis of transient waves in a finite beam显示文摘 | Su X Y Pao Y H | 1992 | Journal of Sound and Vibration1992，151，2： | 2 |
| 9 | Assessing the genetic diversity of the critically endangered Chinese sturgeon Acipenser sinensis using mitochondrial markers and genome-wide single-nucleotide polymorphisms from RAD-seq显示文摘As a living fossil, the endangered Chinese sturgeon(Acipenser sinensis) has been considered a national treasure in China. Here,the famous Gezhouba Dam and Three Gorges Dam on the Yangtze River were built in 1988 and 2006, for economic purposes.The natural population of Chinese sturgeon has declined since then, as these dams block its migratory route to the original spawning grounds in the middle reaches of the Yangtze River. In 2013 and 2014, there was an absence of spawning where it typically happened near the Gezhouba Dam. Nevertheless, from April to June in 2015, over 1,000 larvae with different body lengths(10–35 cm) were detected along the Shanghai Yangtze Estuary; but only little is currently known about the population genetic structure of the Chinese sturgeon. Herein, we inferred population genetic parameters from 462 available Chinese sturgeon specimens based on a 421-bp fragment of the mitochondrial DNA(mtDNA) D-loop region and 1,481,620 SNPs(singlenucleotide polymorphisms) generated by restriction site-associated DNA sequencing(RAD-seq). For the D-loop dataset, 15 haplotypes were determined. Randomly picked 23 individuals, representing the 15 D-loop haplotype groups, were subsequently used for further RAD-seq validation. The average nucleotide diversity calculated from the mtDNA and RAD datasets was 0.0086 and 0.000478, respectively. The overall effective female population size was calculated to be 1,255 to 2,607, and the long-term effective population size was estimated to range from 11,950 to 119,500. We observed that the genetic variability and the effective female population size of the current population in the Yangtze River are severely low, which are similar to the data reported over 10 years ago. The deduced relatively small effective population of female fish, limiting the genetic connectivity among Chinese sturgeon, should be considered a serious threat to this endangered species. | Jian Liu Xinxin You Pao Xu Ping Zhuang Yueping Zheng Kai Zhang Min Wang Yunyun Lv Gangchun Xu Feng Zhao Jianhui Wu Houyong Fan Jianan Xu Zhiqiang Ruan Chao Bian Kai Liu Dongpo Xu Jinhui Chen Junmin Xu Qiong Shi | 2018 | Science China(Life Sciences)2018，61，9： | 2 |
| 10 | Atomically isolated Pd sites within Pd-S nanocrystals enable trifunctional catalysis for direct,electrocatalytic and photocatalytic syntheses of H_(2)O_(2)显示文摘Although high-efficiency production of hydrogen peroxide(H_(2)O_(2))can be realized separately by means of direct,electrochemical,and photocatalytic synthesis,developing versatile catalysts is particularly challenging yet desirable.Herein,for the first time we reported that palladium-sulphur nanocrystals(Pd-S NCs)can be adopted as robust and universal catalysts,which can realize the efficient O_(2) conversion by three methods.As a result,Pd-S NCs exhibit an excellent selectivity(89.5%)to H_(2)O_(2)with high productivity(133.6 mol·kgcat^(−1)·h^(−1))in the direct synthesis,along with the significantly enhanced H_(2)O_(2)production activity and stability via electrocatalytic and photocatalytic syntheses.It is demonstrated that the isolated Pd sites can enhance the adsorption of O_(2) and inhibit its O–O bond dissociation,improving H_(2)O_(2)selectivity and reducing H_(2)O_(2)degradation.Further study confirms that the difference in surface atom composition and arrangement is the key factor for different ORR mechanisms on Pd NCs and Pd-S NCs. | Tang Yang Chengyong Yang Jiabo Le Zhiyong Yu Lingzheng Bu Leigang Li Shuxing Bai Qi Shao Zhiwei Hu Chih-Wen Pao Jun Cheng Yonggang Feng Xiaoqing Huang | 2022 | Nano Research2022，15，3： | 2 |
| 11 | Forecast of electricity consumption and economic growth in Taiwan by state space modeling显示文摘 | Hsiao-Tien Pao | 2009 | Energy2009，，11： | 2 |
| 12 | Combinatorial optimization with use of guided evolutionary simulated annealing显示文摘 | PERCY P C Yip PAO Yoh-han | 1996 | IEEE Transactions on Neulral Network1996，，2： | 2 |
| 13 | Principle of Embedded Ethernet Sever and Its Application显示文摘Based on Supervisory & control system of Ethernet and traditional internet, the article puts forward a special embedded Ethernet sever which can contact PCs and internet console and supply electricity for internet console. It also offers detailed design and specific work process and finally explains its practical application in communication between home and school. | TAN Hai ZHOU Xin-qin TANG Bin PAO Shao-ming(East China Institute of Technology (Nanchang Campus), Nachang 330013, China)(Guangxi Institute of Technology, Liuzhou 545006, China) | 2008 | 微计算机信息2008，24，11： | 1 |
| 14 | Dynamics of nonlinear parabolic systems with time delays显示文摘 | | 1996 | J Math Appl1996，198，： | 1 |
| 15 | Low temperature growth of ultrananocry stalline diamond film and its field emission properties显示文摘 | Pradhan D Lee Y C Pao C W | 2006 | Diamond Related Mater2006，15，1112： | 1 |
| 16 | Finding The Niche Position: Competition strategy of Taiwan's IC Design Industry 显示文摘 | Pao - Long Chang Chien - Tzu Tsai | 2002 | Technovation2002，22，2： | 1 |
| 17 | Design optimization of shell- and-tube heat exchanger using particle swarm optimization technique 显示文摘 | PATEL V K PAO R V | 2010 | Applied Thermal Engineering2010，30，11： | 1 |
| 18 | Dynamics of reaction-diffusion equations with nonlocal boundary conditions 显示文摘 | Pao C V | 1995 | Quart Appl Math1995，53，： | 1 |
| 19 | Applied mechanics in science and engineering显示文摘 | PAO Y H | 1998 | Applied Mechanics Review1998，51，2： | 1 |
| 20 | Robust Input Shaper Control Design for Parameter Variations in Flexible Structures显示文摘 | Pao L Y Lau M A | 2000 | Journal of Dynamic Systems Measurement and Control2000，122，1： | 1 |
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