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| 1 | Improved Baseline Correction Method Based on Polynomial Fitting for Raman Spectroscopy显示文摘 | Haibing HU Jing BAI Guo XIA Wenda ZHANG Yan MA | 2018 | Photonic Sensors2018，8，4： | 6 |
| 2 | Spatial distribution patterns of Symplocos congeners in a subtropical evergreen broad-leaf forest of southern China显示文摘Studies on spatial distribution of congeneric species can supplement our understanding of species ecological processes. We analyzed population structure, spatial distribution, intra-and interspecific associations among six Symplocos tree species on a large(50 ha) plot in a subtropical, evergreen broad-leaf forest in southern China using spatial point pattern analysis methods. Our results suggested that the six Symplocos tree species were all clustered at small scales. The aggregation intensity of S. wikstroemiifolia with low abundance but relatively numerous large-diameter trees was much higher than that of the other five Symplocos species that occurred at high abundance but included few large-diameter trees. Spatial associations among the six congeners showed that 12 of 30 pairs were associated positively at small scales, and 13 of 30 pairs were unrelated. For species among different size classes, 79 of 120 pairs were not correlated, and 17 of 120 pairs were associated positively. These results showed insufficient evidence for interspecific competition and congeneric Symplocos species commonly coexist within subtropical plant communities. The spatial patterns of Symplocos species and their correlations changed with size(DBH) class and were simultaneously affected by spatial scales; the intensity of their aggregation and association decreased with increasing area of the sample plot. | Xiuqing Yang Haibing Yan Buhang Li Youzhi Han Bo Song | 2018 | Journal of Forestry Research2018，29，3： | 5 |
| 3 | Preparation, stability and pharmacokinetics evaluation of lipid microspheres loading a promising antitumor candidate, Timataxel显示文摘Timataxel(13-(N-Boc-3-i-butylisoserinoyl-4,10-β-diacetoxy-2-α-benzoyloxy-5-β-20-epoxy-1,13-α-dihydroxy-9-oxo-19-norcyclopropa[g]tax-11-ene)), used to be called TM-2, is a novel semi-synthetic promising candidate for cancer treatment. However the preformulation study showed that TM-2 was insoluble and chemically instable in water, which would limit its application. This study aimed at the preparation of Timataxel lipid microspheres(TM-2 LMs)and investigated the difference between TM-2 LMs and TM-2 solution in pharmacokinetics. In this work, the final formulation was as follows: 0.10%(w/v) TM-2;10.00%(w/v) oil phase(long chain triglyceride:media chain triglyceride = 2.50%:7.50%);1.40%(w/v) phospholipid;0.02%(w/v) NaH2 PO4;2.25%(w/v) glycerin and water to a total volume of 100 ml.The particle size distribution, content and entrapment efficacy were 205.0 ± 43.3 nm, 101.00% and 99.12%, respectively. TM-2 LMs were stable during storage at 25 °C for 3 months, even under the condition of 60 °C and 4500 lx for 10 d. Phosphatidylethanolamine(PE) in phospholipid may contribute to the stability of TM-2 LMs. The pharmacokinetic parameters for TM-2 LMs were as follows: AUC(0-∞) 3663.71 μg/l h and the clearance 2.26 l/h/kg. As for solution, these parameters were 1712.52 μg/l h and 4.77 l/h/kg, respectively. The t1/2 of TM-2 LMs was similar to TM-2 solution. The pharmacokinetic results indicated that the AUC of TM-2 LMs was larger, the clearance was smaller than that of TM-2 solution. In a word, lipid microspheres were a promising drug delivery system for TM-2. | Yan Li Haibing He Qiao Wang Xing Tang | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，6： | 4 |
| 4 | Application of the Material Balance Method in Paleoelevation Recovery: A Case Study of the Longmen Mountains Foreland Basin on the Eastern Margin of the Tibetan Plateau显示文摘We applied the material balance principle of the denudation volume and sedimentary flux to study the denudation-accumulation system between the Longmen Mountains(Mts.) and the foreland basin. The amount of sediment in each sedimentation stage of the basin was estimated to obtain the denudation volume,erosion thickness and deposit thickness since the Late Triassic Epoch,to enable us to recover the paleoelevation of the provenance and the sedimentary area. The results show the following:(1) Since the Late Triassic Epoch,the elevation of the surface of the Longmen Mts. has uplifted from 0 m to 2751 m,and the crust of the Longmen Mts. has uplifted by 9.8 km. Approximately 72% of the materials introduced have been denuded from the mountains.(2) It is difficult to recover the paleoelevation of each stage of the Longmen Mts. foreland basin quantitatively by the present-day techniques and data.(3) The formation of the Longmen Mts. foreland basin consisted of three stages of thrust belt tectonic load and three stages of thrust belt erosional unload. During tectonic loading stages(Late Triassic Epoch,Late Jurassic–Early Cretaceous,Late Cretaceous–Miocene),the average elevation of Longmen Mts. was lower(approximately 700–1700 m). During erosional unloading stages(Early and Middle Jurassic,Middle Cretaceous and Jiaguan,Late Cenozoic),the average elevation of Longmen Mts. was high at approximately 2000–2800m. | YAN Zhaokun LI Yong LI Haibing DONG Shunli ZHAO Guohua LI Jingbo LI Fensheng YAN Liang ZHENG Lilong | 2015 | Acta Geologica Sinica(English Edition)2015，89，2： | 4 |
| 5 | Novel pathways for the preparation of silica antireflective films: Improvement in mechanical property显示文摘 | Fangting Chi Lianghong Yan Haibing Lv Bo Jiang | 2011 | Materials Letters2011，，7： | 2 |
| 6 | Thermo-and pH-dual responsive inorganic-organic hybrid hydrogels with tunable luminescence显示文摘A thermo-and pH-dual responsive luminescent hydrogel was successfully constructed by coupling dysprosium-containing polyoxometalates Na_9 DyW_(10) O_(36)(DyW_(10)) with the ABA triblock copolymer, where the B block is PEO and the A block is the thermosensitive poly(methoxydi(ethylene glycol) methacrylate-co-N,N-dimethylaminoethyl methacrylate). The complex hybrid underwent a sol-gel phase transition above the lower critical solution temperature(LCST) of the A block. DyW_(10) was electrostatically encapsulated into the hydrophobic domain of the A block with enhanced photoluminescence. When temperature cooled down, the luminescence could be restored. By addition of acids to protonate the A block, and emission of DyW_(10) was simultaneously enhanced. Sensitivity of poly(N,N-dimethy laminoethyl methacrylate)(PDMAEMA) to pH also enabled the emission of DyW_(10)/copolymer hydrogel to be reversibly switched by alternating acid/base treatments. | Jinlong Zhang Haibing Wei Junyan Tan Weihong Qiao Yan Guan Jie Zhang | 2018 | Science China Chemistry2018，61，3： | 2 |
| 7 | Distribution characteristics of lipids in hadal sediment in the Yap Trench显示文摘In this study,cored sediment samples collected by the Jiaolong Submersible at 6779 m depth from the hadal zone of the Yap Trench in May 2016 were sliced in 1-cm interval from top to bottom,and lipids in each sediment layer were quantitatively and qualitatively analyzed.The vertical distribution profiles of the lipids in the sediment sample,their main existing forms,and their possible sources were investigated.The results show that the concentration of lipid in the surface sediment was the highest with the carbon number from 12 to 27,dominated by medium and short-chain lipids.The total concentration of fatty acids in surface sediment was much higher than those in the offshore and deep-sea areas,being up to 325.77μg/g due to the funnel effect caused by the“V”terrain of the trench.Fatty acid 18:0 was the most abundant lipids in the sediment sample.Abnormal high concentrations of fatty acid 18:1ω7 and alkanes indicated the existence of hydrothermal fluids in the study area.In addition,saturated fatty acids and monounsaturated fatty acids existed mainly in free form,and polyunsaturated fatty acids existed mainly in bound form.Most of the alkanes were in bound form,and their major source was autochthounous input.The carbon number of alcohols in the sediment sample ranged from 12 to 20,mainly existed in bound form.The source of fatty acids was mainly autochthonous input,and the neutral lipids had both marine and terrestrial origin.This is the first study of lipids in hadal sediment of the Yap Trench.The results will promote deeper understanding of organic carbon cycle in marine environment. | YAN Yixin SUN Chengjun HUANG Yuhuan CAO Wei JIANG Fenghua YANG Guipeng DING Haibing | 2020 | Journal of Oceanology and Limnology2020，38，3： | 2 |
| 8 | Maternal genetic history of ancient Tibetans over the past 4000 years显示文摘The settlement of the Tibetan Plateau epitomizes human adaptation to a high-altitude environment that poses great challenges to human activity.Here,we reconstruct a 4000-year maternal genetic history of Tibetans using 128 ancient mitochondrial genome data from 37 sites in Tibet.The phylogeny of haplotypes M9a1a,M9a1b,D4g2,G2a’c,and D4i show that ancient Tibetans share the most recent common ancestor with ancient Middle and Upper Yellow River populations around the Early and Middle Holocene.In addition,the connections between Tibetans and Northeastern Asians vary over the past 4000 years,with a stronger matrilineal connection between the two during 4000 BPe3000 BP,and a weakened connection after 3000 BP,that are coincident with climate change,followed by a reinforced connection after the Tubo period(1400 BPe1100 BP).Besides,an over 4000-year matrilineal continuity is observed in some of the maternal lineages.We also find the maternal genetic structure of ancient Tibetans is correlated to the geography and interactions between ancient Tibetans and ancient Nepal and Pakistan populations.Overall,the maternal genetic history of Tibetans can be characterized as a long-term matrilineal continuity with frequent internal and external population interactions that are dynamically shaped by geography,climate changes,as well as historical events. | Ganyu Zhang Can Cui Shargan Wangdue Hongliang Lu Honghai Chen Lin Xi Wei He Haibing Yuan Tinley Tsring Zujun Chen Feng Yang Tashi Tsering Shuai Li Norbu Tashi Tsho Yang Yan Tong Xiaohong Wu Linhui Li Yuanhong He Peng Cao Qingyan Dai Feng Liu Xiaotian Feng Tianyi Wang Ruowei Yang Wanjing Ping Ming Zhang Xing Gao Yichen Liu Wenjun Wang Qiaomei Fu | 2023 | Journal of Genetics and Genomics2023，50，10： | 1 |
| 9 | Oxidative Stress Upregulates PDCD4 Expression in Patients with Gastric Cancer via miR-21显示文摘 | Honglei Tu Haibing Sun Yan Lin Jie Ding Kejun Nan Zongfang Li Qiang Shen Yongchang Wei | 2014 | Current Pharmaceutical Design2014，，11： | 1 |
| 10 | Calixazrene capped quantum dots as luminescent probes for Hg^2+ ions 显示文摘 | Li Haibing Zhang Yan Wang Xiaoqiong | 2007 | Materials Letters2007，61，7： | 1 |
| 11 | A Perceptual Two-pass VBR MPEG-2 Video Encoder显示文摘 | Yin Haibing Fang Xiangzhong Cheng Yan | 2005 | IEEE Transactions on Consumer Electronics2005，51，4： | 1 |
| 12 | Hydro-oleophobic silica antireflective films with high laser-damage threshold显示文摘 | Lianghong Yan Haibing Lv Chengcheng Wang Xiaodong Yuan | 2010 | Optics and Laser Technology2010，，1： | 1 |
| 13 | Calixarene capped quantum dots as luminescent probes for Hg 2+ ions显示文摘 | Haibing Li Yan Zhang Xiaoqiong Wang Dejun Xiong Yiqiong Bai | 2006 | Materials Letters2006，，7： | 1 |
| 14 | An intravenous clarithromycin lipid emulsion with a high drug loading, H-bonding and a hydrogen-bonded ion pair complex exhibiting excellent antibacterial activity显示文摘The aim of this study was to develop an intravenous clarithromycin lipid emulsion(CLE)with good stability and excellent antibacterial activity. The CLE was prepared by the thinfilm dispersed homogenization method. The interaction between clarithromycin(CLA) and cholesteryl hemisuccinate(CHEMS) was confirmed by DSC, FT-IR and^1H NMR analysis. The interfacial drug loading, thermal sterilization, freeze–thaw stability, and in vitro and in vivo antibacterial activity were investigated systematically. DSC, FT-IR and^1H NMR spectra showed that CHEMS(CLA: CHEMS, M ratio 1:2) could interact with CLA through H-bonding and a hydrogen-bonded ion pair. The CHEMS was found necessary to maintain the stability of CLE.Ultracentrifugation showed that almost 88% CLA could be loaded into the interfacial layer.The optimized CLE formulation could withstand autoclaving at 121 °C for 10 min and remain stable after three freeze–thaw cycles. The in vitro susceptibility test revealed that the CLA–CHEMS ion-pair and CLE have similar activity to the parent drug against many different bacterial strains. The in vivo antibacterial activity showed that the ED50 of intravenous CLE was markedly lower than that of CLA solution administrated orally. CLE exhibited pronounced antibacterial activity and might be a candidate for a new nanocarrier for CLA with potential advantages over the current commercial formulation. | Haoyu Gong Sicong Geng Qi Zheng Puxiu Wang Lifeng Luo Xiuzhi Wang Yan Zhang Yu Zhang Haibing He Xing Tang | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，5： | 1 |
| 15 | Vertical variations of dissolved carbohydrates in the North Yap Trench显示文摘The concentrations of dissolved monosaccharides(MCHO),polysaccharides(PCHO),and total carbohydrates(TCHO)in the seawater samples collected from the north of the Yap Trench in the western Pacific Ocean were measured by 2,4,6-tripyridine-s-triazine(TPTZ)spectrophotometry method.The results show that the concentrations of MCHO,PCHO,and TCHO ranged from 4.6 to 22.1μmol C/L,3.5 to 27.3μmol C/L,and 13.8 to 36.3μmol C/L,respectively.In different sampling stations,the concentrations of MCHO,PCHO,and TCHO with water depth showed complex variation patterns.In the study area,the maximum concentrations of MCHO,PCHO,and TCHO occurred in the euphotic layer and the minimum concentrations occurred in mesopelagic seawater layer.Generally,the concentrations of MCHO,PCHO,and TCHO decreased with water depth from the euphotic layer to the hadal zone.The average value of PCHO/TCHO was higher than the average value of MCHO/TCHO,indicating that PCHO was the main component of TCHO in north of the Yap Trench. | GUO Chaonan SUN Chengjun YANG Guipeng ZHANG Honghai CHEN Yan YIN Xiaofei JIANG Fenghua HUANG Yuhuan NIU Jiaohong DING Haibing | 2020 | Journal of Oceanology and Limnology2020，38，3： | 1 |
| 16 | Black phosphorus quantum dots as multifunctional nanozymes for tumor photothermal/catalytic synergistic therapy显示文摘Nanozymes are nanomaterials with enzyme-like properties that have attracted significant interest owing to their high stability,easy preparation,and tunable catalytic properties,especially in the field of cancer therapy.However,the unfavorable catalytic effects of nanozymes in the acidic tumor microenvironment have limited their applications.Herein,we developed a biomimetic erythrocyte membrane-camouflaged ultrasmall black phosphorus quantum dots(BPQDs)nanozymes that simultaneously exhibited an exceptional near-infrared(NIR)photothermal property and dramatically photothermal-enhanced glucose oxidase(GOx)-like activity in the acidic tumor microenvironment.We demonstrated the engineered BPQDs gave a photothermal conversion efficiency of 28.9%that could rapidly heat the tumor up to 50℃ while effectively localized into tumors via homing peptide iRGD leading after intravenously injection.Meanwhile,the significantly enhanced GOx-like activity of BPQDs under NIR irradiation was capable of catalytical generating massive toxic reactive oxygen species via using cellular glucose.By combining the intrinsic photothermal property and the unique photothermal-enhanced GOx-like catalytic activity,the developed BPQDs were demonstrated to be an effective therapeutic strategy for inhibiting tumor growth in vivo.We believe that this work will provide a novel perspective for the development of nanozymes in tumor catalytic therapy. | Hui Ding Daji Wang Haibing Huang Xiaozhu Chen Jie Wang Jinjie Sun Jianlin Zhang Lu Lu Beiping Miao Yanjuan Cai Kelong Fan Yongtian Lu Hongsong Dong Xiyun Yan Guohui Nie Minmin Liang | 2022 | Nano Research2022，15，2： | 1 |
| 17 | 'Lone Wolf' Terror and How to Prevent It显示文摘In comparison with organized terrorist attack, 'lone wolf' attack usually takes place more unexpectedly. Currently this kind of terror is regarded as the biggest threat to homeland security by many countries in Europe and North America. It is necessary for international community to take the 'lone wolf' terrorism seriously and to cope with the threat more effectively. | Yan Shuai Xing Haibing | 2014 | Contemporary International Relations2014，24，5： | 1 |
| 18 | Snow resisting capacity of Caragana microphylla and Achnatherum splendens in a typical steppe region of Inner Mongolia,China显示文摘Snow resisting capacity of vegetation is important for secondary distribution of water resources in seasonal snow areas of grassland because it affects the regeneration,growth and nutrient circulation of vegetation in grassland.This study investigated vegetation characteristics(canopy height,canopy length and crown width)of Caragana microphylla Lam.(shrub)and Achnatherum splendens(Trin.)Nevski.(herb),and snow morphologies(snow depth,snow width and snow braid length)in a typical steppe region of Inner Mongolia,China in 2017.And the influence of vegetation characteristic on snow resisting capacity(the indices of bottom area of snow and snow volume reflect snow resisting capacity)was analyzed.The results showed that snow morphology depends on vegetation characteristics of shrub and herb.The canopy height was found to have the greatest influence on snow depth and the crown width had the greatest influence on snow width.The canopy length was found to have little influence on morphological parameters of snow.When the windward areas of C.microphylla and A.splendens were within the ranges of 0.0-0.5 m2 and 0.0-8.0 m2,respectively,the variation of snow cover was large;however,beyond these areas,the variation of snow cover became gradually stable.The potential area of snow retardation for a single plant was 1.5-2.5 m2 and the amount of snow resistance was 0.15-0.20 m3.The bottom area of snow and snow volume(i.e.,snow resisting capacity)of clumped C.microphylla and A.splendens was found to be 4 and 25 times that of individual plant,respectively.The results could provide a theoretical basis both for the estimation of snow cover and the establishment of a plant-based technical system for the control of windblown snow in the typical steppe region of Inner Mongolia. | YAN Min ZUO Hejun WANG Haibing DONG Zhi LI Gangtie | 2020 | Journal of Arid Land2020，12，2： | 1 |
| 19 | Effect of normal and strict anaerobic fermentation on physicochemical quality and metabolomics of yogurt显示文摘Generally,yogurts on the market are usually anaerobic fermentation,but oxygen can be still dissolved in the production process,which is actually not strict anaerobic.This study explored the multiple quality indicators and the metabolomic analysis of yogurts fermented by Lactobacillus bulgaricus and Streptococcus thermophilus using two fermentation methods,namely,strict anaerobic and normal fermentation.The changes in flavor substances in yogurts,including 17 free amino acids,17 fatty acids,and 7 response value,were detected using principal component and multi factor analyses.Based on the results of the comparisons between basic physical and chemical indicators,strict anaerobic fermentation increased the growth and acidification of the two bacteria,the response value of sourness,umami and richness.Strict anaerobic fermentation increased the free amino acid(Fold change=1.53)and short chain fatty acid levels(Fold change=1.73),and reduced the polyunsaturated fatty acid(Fold change=0.51)levels.Furthermore,metabolomic analysis based on UPLC-Triple TOF-MS/MS showed that 92 differential metabolites were screened;45 differential metabolites were increased and 47 were decreased.The results revealed that strict anaerobic fermentation was beneficial to metabolic changes and nutritional indicators of yogurt,which may be as indicators of valuable reference to improve dairy fermentation process. | Ruixue Ding Mohan Li Yiting Zou Yiran Wang Chunyue Yan Haibing Zhang Rina Wu Junrui Wu | 2022 | Food Bioscience2022，46，2： | 0 |
| 20 | Erratum to:Black phosphorus quantum dots as multifunctional nanozymes for tumor photothermal/catalytic synergistic therapy显示文摘Erratum to Nano Research 2022,15(2):1554–1563 http://gffzzd3cc09b8251d45dfsb0popbff6v6v6pf9.ffgz.tsg.suse.edu.cn/10.1007/s12274-021-3701-8 Figure 3(d)in the original paper contained duplicated micrographs(BPQDs+NIR)for different xenografts(B16 vs.CNE-2).This error did not affect any of the conclusions from the published paper. | Hui Ding Daji Wang Haibing Huang Xiaozhu Chen Jie Wang Jinjie Sun Jianlin Zhang Lu Lu Beiping Miao Yanjuan Cai Kelong Fan Yongtian Lu Hongsong Dong Xiyun Yan Guohui Nie Minmin Liang | 2023 | Nano Research2023，16，1： | 0 |
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