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| 1 | MicroRNA-21 targets tumor suppressor genes in invasion and metastasis显示文摘MicroRNAs (miRNAs ) 是在 post-transcriptional 指向编码蛋白质的 mRNAs 的小非编码的 RNA 铺平的自然地发生的一个班。我们的以前的研究建议 mir-21 作为 oncogene 工作并且在 tumorigenesis 有一个角色,部分地通过肿瘤的规定压制或基因对流肌浆球蛋白 1 (TPM1 ) 。给那 TPM1 在房间移植被含有,在我们进一步调查了的这研究在房间侵略和肿瘤转移的 mir-21 的角色。我们发现在变形乳癌 MDA-MB-231 房间的 mir-21 的抑制显著地减少了侵略和肺转移。与这一致, TPM1 的宫外的表示显著地减少了房间侵略。而且,我们识别了二个另外的直接 mir-21 目标,规划房间死亡 4 (PDCD4 ) 并且妈大头针,哪个在侵略和转移被含有。象 TPM1 一样, PDCD4 和妈大头针也减少了 MDA-MB-231 房间的侵略海角。最后, PDCD4 的表示和妈大头针相反地在人的胸肿瘤标本与 mir-21 表示相关,显示由在这些肿瘤的 mir-21 的 PDCD4 和妈大头针的潜在的规定。总起来说,结果建议作为 oncogenic miRNA, mir-21 由指向多重肿瘤 / 转移不仅在肿瘤生长而且在侵略和肿瘤转移有一个角色压制或基因。因此, mir-21 的抑制可以为先进癌症的治疗提供一条新奇途径。 | Shuomin Zhu Hailong Wu Fangting Wu Daotai Nie Shijie Sheng Yin-Yuan Mo | 2008 | Cell Research2008，18，3： | 205 |
| 2 | Synthesis of novel nanomaterials and their application in efficient removal of radionuclides显示文摘With the development of nuclear energy, large amounts of radionuclides are inevitably released into the natural environment. It is necessary to eliminate radionuclides from wastewater for the protection of environment. Nanomaterials have been considered as the potential candidates for the effective and selective removal of radionuclides from aqueous solutions under complicated conditions because of their high specific surface area, large amounts of binding sites, abundant functional groups, pore-size controllable and easily surface modification. This review mainly summarized the recent studies for the synthesis, fabrication and surface modification of novel nanomaterials and their applications in the efficient elimination and solidification of radionuclides,and discussed the interaction mechanisms from batch experiments, spectroscopy analysis and theoretical calculations. The sorption capacities with other materials, advantages and disadvantages of different nanomaterials are compared, and at last the perspective of the novel nanomaterials is summarized. | Xiangxue Wang Long Chen Lin Wang Qiaohui Fan Duoqiang Pan Jiaxing Li Fangting Chi Yi Xie Shujun Yu Chengliang Xiao Feng Luo Jun Wang Xiaolin Wang Changlun Chen Wangsuo Wu Weiqun Shi Shuao Wang Xiangke Wang | 2019 | Science China Chemistry2019，62，8： | 20 |
| 3 | Adsorption behavior of uranium on polyvinyl alcohol-g-amidoxime:Physicochemical properties, kinetic and thermodynamic aspects显示文摘Amidoxime-based adsorbents are widely studied as the main adsorbent in the recovery of uranium from seawater.However,the adsorption rate and loading capacity of such adsorbents should be further improved due to the economic viability consideration.In this paper,polyvinyl alcohol functionalized with amidoxime(PVA-g-AO)has been prepared as a new adsorbent for uranium(Ⅵ)adsorption from aqueous solution.The physicochemical properties of PVA-g-AO were investigated using infrared spectroscopy(IR),scanning electron microscope(SEM),X-ray diffraction(XRD),and X-ray photoelectron spectroscopy(XPS).Results showed that the ligand monomers were successfully grafted onto the matrixes.The XRD and XPS analysis showed that uranium was adsorbed in metal ionic form rather than in crystal form.Uranyl(U(Ⅵ))adsorption properties onto PVA-g-AO were evaluated.The adsorption of U(Ⅵ)by PVA-g-AO was fast,with an equilibrium time of less than 50 min.Additionally the maximum adsorption capacity reached 42.84 mg/g at pH 4.0. | CHI FangTing HU ShengX HU Sheng XIONG Jie WANG XiaoLi | 2013 | Science China Chemistry2013，56，11： | 10 |
| 4 | Whole-cell matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for rapid identification of bacteria cultured in liquid media显示文摘Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has been used for many years to rapidly identify whole bacteria. However, no consistent methodology exists for the rapid identification of bacteria cultured in liquid media. Thus, in this study we explored the use of MALDI-TOF MS analysis for rapid identification of cells cultured in liquid media. We determined that 2,5-dihydroxybenzoic acid (50 mg mL-1, 50% acetonitrile, 0.1% trifluoroacetic acid) was the best matrix solution for MALDI-TOF MS for this type of study. Moreover, the tested strains were successfully differentiated by principal component analysis, and the main characteristics of the mass peaks for each species were found in mixed culture samples. In addition, we found that the minimum number of cells for detection was 1.8×103. In conclusion, our findings suggest that MS-based techniques can be developed as an auxiliary method for rapidly and accurately identifying bacteria cultured in liquid media. | ZHOU Na WANG Na XU Bin WANG Jie FANG JunJian DONG FangTing HE Kun YANG XiaoHong | 2011 | Science China(Life Sciences)2011，54，1： | 4 |
| 5 | Novel pathways for the preparation of silica antireflective films: Improvement in mechanical property显示文摘 | Fangting Chi Lianghong Yan Haibing Lv Bo Jiang | 2011 | Materials Letters2011，，7： | 2 |
| 6 | Analysis of uterine CD49a^(+) NK cell subsets in menstrual blood reflects endometrial status and association with recurrent spontaneous abortion显示文摘Maternal uterine immune cells,especially natural killer(NK)cells,are important for successful pregnancy,and an abnormal number or function of uterine NK cells is closely correlated with an impaired endometrial environment and miscarriage.However,there are currently no noninvasive testing methods using reliable indicators that accurately predict uterine changes leading to miscarriage.Here,we confirmed that before implantation,menstrual blood(MB)from healthy donors had 70%CD49a^(+)tissue-resident NK(trNK)cells,the majority of which were CD49a^(+)Eomes+NK cells.Importantly,MB from patients with recurrent spontaneous abortion(RSA)had many fewer CD49a^(+)trNK cells than MB from controls.Analysis of uNK cell populations in MB may better predict an abnormal endometrial environment associated with miscarriage than peripheral blood(PB)analysis.Therefore,we suggest using MB-and CD49a-related markers as a promising noninvasive way to evaluate endometrial status. | Xianhong Tong Min Gao Xianghui Du Fangting Lu Limin Wu Haiming Wei Binqing Fu | 2021 | Cellular & Molecular Immunology2021，18，7： | 2 |
| 7 | Nanomechanical of polydimethylsiloxane-filled a 显示文摘 | FANGT H WANGTH and surface behavior nanoporous anodic alumi Science 2009 44 (6) n KANG S H | 2009 | Journal of Materials2009，，： | 1 |
| 8 | Cell polarity protein Par3 complexes with DNA-PK via Ku70 and regulates DNA double-strand break repair显示文摘The author affiliations were mixed up in the previous published version. The third fund number of National NaturalScience Foundation of China in the Acknowledgments was wrong, it should be '30270335'. The Shanghai MunicipalCouncil for Science and Technology (No.06DZ22032) was missed in the Acknowledgments. There are some labelingand production errors in Figure 2A, Figure 3B and 3C, Figure 5C, Figure 6B and 6E, Figure 7B and 7D. In Figure 2A,left panel 'A431' should be 'Par3'. In Figure 3B and 3C, 'anti-Par3CT' should be 'anti-Par3LCT', 'GST-Par3CT'should be 'GST-Par3LCT'. In Figure 5C, the second arrow indicating 'Lamin B' should be '[3-tubulin'. In Figure 6Bright panel, the molecular weight for ?-actin should be '43' instead of'200'. In Figure 6E, 'Par3' should be 'Par3i'. Themolecular weight for the DNA-PKcs panel should be the same as the p-DNA-PKcs. In Figure 7B, the time point '240'in the left panel should be '120'; in the right panel of Figure 7B, the title for the y axis should be 'DNA released (%)'.In Figure 7D, the title for the y axis should be 'Survival (%)', and the scale for the y axis should be '100, 10 and 1'. These corrections do not affect the conclusions of the study. We apologize for any inconvenience this may havecaused. | Longhou Fangt YiGuo Wang Dan Dut Guang Yang Tim Tak Kwok Siu Kai Kong Benjamin Chen David J Chen Zhengjun Chen | 2007 | Cell Research2007，17，6： | 1 |
| 9 | Non- volatile resistive switching for advanced memory applica-tions 显示文摘 | ChenA Haddad S WuY C FangT N | 2005 | IEEE Electron Devices Meeting San Francisco2005，，20： | 1 |
| 10 | Genome Mining and Biosynthesis Study of a Type B Linaridin Reveals a Highly Versatileα-N-Methyltransferase显示文摘Linaridins are a small but growing family of natural products belonging to the ribosomally synthesized and post-translationally modified peptide(RiPP)superfamily.In this study,a genome mining approach led to the identification of a novel linaridin,mononaridin(MON),from Streptomyces monomycini.In-frame deletion genetic knockout studies showed that,in addition to many genes essential for MON biosynthesis,monM encodes an S-adenosyl methionine(SAM)-dependentα-N-methyltransferase that is responsible for installing two methyl groups in the MON N-terminus.Besides SAM,MonM also accepts ethyl-SAM and allyl-SAM,in which the methyl of SAM is replaced by an ethyl and an allyl,respectively.We showed that ethyl-SAM and allyl-SAM have distinct reactivities in MonM catalysis,and this observation was further investigated in detail by density functional theory(DFT)calculations.Remarkably,MonM acts efficiently on nisin,a prototypic lantibiotic that is structurally very different from the native substrate,and the ability of MonM to transfer an allyl group to the nisin N-terminus allowed production of a fluorescently labeled nisin,which can be further used in microscopic cell analysis.Our studies provide new insights into linaridin biosynthesis and demonstrate the potential of linaridin methyltransferases in bioengineering applications. | Fangting Wang Wanqing Wei Junfeng Zhao Tianlu Mo Xin Wang Xuedong Huang Suze Ma Shu Wang Zixin Deng Wei Ding Yong Liang Qi Zhang | 2021 | CCS Chemistry2021，3，3： | 1 |
| 11 | Preparation and microstructures of FeSiBNbCu thin films显示文摘 | Lin Fangting Shi Wangzhou Ma Xueming | 2005 | Physica B2005，355，14： | 1 |
| 12 | Naxi-Chinese Bilingual Corpus and Building a Bilingual Corpus Alignment显示文摘 | ZHAO Fangting YU Zhengtao | 2009 | Journal of Guangxi Normal University (natural science edition)2009，27，1： | 1 |
| 13 | D-tryptophan triggered epithelial-mesenchymal transition by activating TGF-βsignaling pathway显示文摘D-tryptophan is a special kind of nonprotein amino acid showing multiple physiological functions,but the detailed mechanisms are not fully revealed,impairing its further development and applications.This work was to investigate D-tryptophan physiological function and demonstrate the underlying mechanisms.D-tryptophan suppressed HaCaT cell proliferation but increased cell migration.Specifically,D-tryptophan decreased E-cadherin and increased Snail,Twist,and Slug expression,resulting in the development of an epithelial-mesenchymal transitions(EMT)phenomenon.Moreover,D-tryptophan promoted the expression of transforming growth factor-β(TGF-β)1,and Smad4 knockout damages D-tryptophan’s ability.These results indicated that D-tryptophan stimulated HaCaT cells to produce TGF-β1 and thus activated the TGF-β/Samd pathway,resulting in the triggering of EMT.This study revealed the molecular mechanisms of D-tryptophan activity,provided D-tryptophan as a potential approach for cancer treatment,wound healing,organ development and other relevant applications. | Chong Wang Fangting Wang Yanbo Wang Linglin Fu | 2022 | Food Science and Human Wellness2022，11，5： | 1 |
| 14 | Polycyanate esters: science and applications显示文摘 | Fangt Shimpda | 1995 | Prog Polym Sci1995，，20： | 1 |
| 15 | An integrated modeling tool for simultaneous analysis of thermal performance and indoor air quality inbuildings显示文摘 | Da Yan Fangting Song Xudong Yang | 2008 | Building and Environment2008，43，： | 1 |
| 16 | A neural network model based on the multi-stage optimization approach for short-term food price forecasting in China显示文摘 | Xia Guoping Yang Fangting | 2007 | Expert Systems with Applications2007，33，： | 1 |
| 17 | The brokenrock zone around tunnels and its support theory 显示文摘 | Fangting Dong Hongwei Song Zhihong Guo | 1998 | Proceedings of 7 th International Conference on GroundControl in Mining Morgantown WV ? USA1998，，： | 1 |
| 18 | Constructing the energy landscape for genetic switching system driven by intrinsic noise 显示文摘 | Lv Cheng Li Xiaoguang Li Fangting | 2014 | PLoS One2014，9，88： | 1 |
| 19 | Forest vegetation types in Gutianshan Nature Reserve in Zhejiang显示文摘 | YuMJ(于明坚) HuZH(胡正华) YuJP(余建平) DingBY(丁炳扬) FangT(方腾) | | 浙江大学 学报(农业和生命科学版)0，，2001： | 1 |
| 20 | Community composition and structure of Gutianshan forest dynamics plot in a mid-subtropical evergreen broad-leaved forest East China显示文摘 | ZhuY(祝燕) ZhaoGF(赵谷风) ZhangLW(张偭文) ShenGC(沈国春) MiXC(米湘成) RenHB(任海保) YuMJ(于明坚) ChenJH(陈建华) ChenSW(陈声文) FangT(方腾) MaKP(马克平) | | 植物生态学 报0，，2008： | 1 |
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