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22篇 您的检索式:作者名="Haibing He"
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1Preparation, stability and pharmacokinetics evaluation of lipid microspheres loading a promising antitumor candidate, Timataxel显示文摘Timataxel(13-(N-Boc-3-i-butylisoserinoyl-4,10-β-diacetoxy-2-α-benzoyloxy-5-β-20-epoxy-1,13-α-dihydroxy-9-oxo-19-norcyclopropa[g]tax-11-ene)), used to be called TM-2, is a novel semi-synthetic promising candidate for cancer treatment. However the preformulation study showed that TM-2 was insoluble and chemically instable in water, which would limit its application. This study aimed at the preparation of Timataxel lipid microspheres(TM-2 LMs)and investigated the difference between TM-2 LMs and TM-2 solution in pharmacokinetics. In this work, the final formulation was as follows: 0.10%(w/v) TM-2;10.00%(w/v) oil phase(long chain triglyceride:media chain triglyceride = 2.50%:7.50%);1.40%(w/v) phospholipid;0.02%(w/v) NaH2 PO4;2.25%(w/v) glycerin and water to a total volume of 100 ml.The particle size distribution, content and entrapment efficacy were 205.0 ± 43.3 nm, 101.00% and 99.12%, respectively. TM-2 LMs were stable during storage at 25 °C for 3 months, even under the condition of 60 °C and 4500 lx for 10 d. Phosphatidylethanolamine(PE) in phospholipid may contribute to the stability of TM-2 LMs. The pharmacokinetic parameters for TM-2 LMs were as follows: AUC(0-∞) 3663.71 μg/l h and the clearance 2.26 l/h/kg. As for solution, these parameters were 1712.52 μg/l h and 4.77 l/h/kg, respectively. The t1/2 of TM-2 LMs was similar to TM-2 solution. The pharmacokinetic results indicated that the AUC of TM-2 LMs was larger, the clearance was smaller than that of TM-2 solution. In a word, lipid microspheres were a promising drug delivery system for TM-2.Yan Li Haibing He Qiao Wang Xing Tang 2016Asian Journal of Pharmaceutical Sciences2016,11,6:4
2A New Insight into the Influence of Composition of Fault Rocks on Aseismic and Seismic Fault Slip显示文摘Active faults can slip either slowly and continuously by aseismic creep, or abruptly by a seismic event. Both slip modes of faults are closely related to the composition of fault rocks. However, the actual materials resulting in differences of slip behavior remain uncertain. The Guanxian-Anxian fault (GAF) characterized by long-term aseismic creep and the Yingxiu-Beichuan fault (YBF) slipping by large earthquakes in the Longmen Shan fault zone (LSFZ) are ideal examples for exploring the above issues. Here, in the light of observation and component analyses, we find that the distribution of carbonate minerals in both faults is distinct.HE Xiangli LI Haibing WANG Huan SI Jialiang ZHANG Lei XU Zhiqin SUN Zhiming 2019Acta Geologica Sinica(English Edition)2019,93,3:3
3Supersaturation induced by Itraconazole/Soluplus micelles provided high GI absorption in vivo显示文摘To investigate the effect of supersaturation induced by micelle formation during dissolution on the bioavailability of itraconazole(ITZ)/Soluplus~? solid dispersion. Solid dispersions prepared by hot melt extrusion (HME) were compressed into tablets directly with other excipients. Dissolution behavior of ITZ tablets was studied by dissolution testing and the morphology of micelles in dissolution media was studied using transmission electron microscopy (TEM). Drug transferring from stomach into intestine was simulated to obtain a supersaturated drug solution. Bioavailability studies were performed on the ITZ tablets and Sporanox~? in beagle dogs. The morphology of micelles in the dissolution media was observed to be spherical in shape, with an average size smaller than 100 nm. The supersaturated solutions formed by Soluplus~? micelles were stable and no precipitation took place over a period of 180 min. Compared with Sporanox~?, ITZ tablets exhibited a 2.50-fold increase in the AUC (0–96) of ITZ and a 1.95-fold increase in its active metabolite hydroxyitraconazole (OHITZ) in the plasma of beagle dogs. The results obtained provided clear evidence that not only the increase in the dissolution rate in the stomach, but also the supersaturation produced by micelles in the small intestine may be of great assistance in the successful development of poorly water-soluble drugs. The micelles formed by Soluplus~? enwrapped the molecular ITZ inside the core which promoted the amount of free drug in the intestinal cavity and carried ITZ through the aqueous boundary layer(ABL), resulting in high absorption by passive transportation across biological membranes. The uptake of intact micelles through pinocytosis together with the inhibition of P-glycoprotein-mediated drug efflux in intestinal epithelia contributed to the absorption of ITZ in the gastrointestinal tract. These results indicate that HME with Soluplus~?, which can induce supersaturation by micelleformation, may be of great assistance to the successful development of poorly watersoluble drugs.Yue Zhong Guanghui Jing Bin Tian Hao Huang Yuanyuan Zhang Jingxin Gou Xing Tang Haibing He Yanjiao Wang 2016Asian Journal of Pharmaceutical Sciences2016,11,2:3
4Underground water Cherenkov muon detector array with the Tibet air shower array for gamma-ray astronomy in the 100 TeV region显示文摘M. Amenomori S. Ayabe X. J. Bi D. Chen S. W. Cui Danzengluobu L. K. Ding X. H. Ding C. F. Feng Zhaoyang Feng Z. Y. Feng X. Y. Gao Q. X. Geng H. W. Guo H. H. He M. He K. Hibino N. Hotta Haibing Hu H. B. Hu J. Huang Q. Huang H. Y. Jia F. Kajino K. Kasahara 2007Astrophysics and Space Science (-)2007,,1:1
5Organic-inorganic hybrid hole transport layers with SnS doping boost the performance of perovskite solar cells显示文摘Perovskite solar cells(PSCs) have demonstrated excellent photovoltaic performance which currently rival the long-standing silicon solar cells’ efficiency. However, the relatively poor device operational stability of PSCs still limits their future commercialization. Binary sulfide is a category of materials with promising optoelectrical properties, which shows the potential to improve both the efficiency and stability of PSCs.Here we demonstrate that the inorganic tin monosulfide(Sn S) can be an efficient dopant in 2,2’,7,7’-tet rakis(N,N-di-p-methoxy-phenylamine)-9,9’-spirobifluorene(spiro-OMe TAD) to form a composite hole transport layer(HTL) for PSCs. Sn S nanoparticles(NPs) synthesized through a simple chemical precipitation method exhibit good crystallization and suitable band matching with the perovskites. The introduction of Sn S NPs in Spiro-OMTAD HTLs enhanced charge extraction, reduced trap state density, and shallowed trap state energy level of the devices based on the composite HTLs. Therefore, the resulting solar cells employing Sn S-doped spiro-OMe TAD HTLs delivered an improved stabilized power output efficiency of 21.75% as well as enhanced long-term stability and operational stability. Our results provide a simple method to modify the conventional spiro-OMe TAD and obtain PSCs with both high efficiency and good stability.Xiaolu Zheng Haibing Wang Feihong Ye Cong Chen Weijun Ke Wenjing Zhang Chuanxin He Yanlong Tai Guojia Fang 2022Journal of Energy Chemistry2022,31,5:1
6Tablets of paliperidone using compression-coated technology for controlled ascending release显示文摘The aim of this work was to prepare ascending release compression-coated(CC) tablets with paliperidone(PAL) using a simple manufacturing technique and short manufacturing process.The release behavior and mechanisms in vitro of the final tablets was investigated and evaluated. The PAL CC tablets were comprised of a core layer of high viscosity hydroxypropyl cellulose(HPC-H) and a coating layer of high viscosity hydroxypropyl methylcellulose(HPMCK100 M). Several factors such as materials and core tablet compositions were studied for their influence in the formulation procedure. The drug release mechanism was studied using gravimetric analysis. The data could be fitted to the Peppas model. The ascending drug release results were expressed in terms of the slope of the release curve at different time points.Results showed that the formulation could achieve a good ascending drug release when the weight ratio of PAL was 5:1(core:layer). The fraction of HPC and HPMC was 33 %, and the combination of Eudragit RL-PO was 10%. The ascending release mechanism was due to solvent penetration into the PAL CC tablets, and subsequent drug dissolution from the gelatinous HPC and HPMC matrix erosion. The release mechanism was therefore a combination of diffusion and erosion. This work demonstrated that the compression-coated tablets could achieve controlled ascending release over 24 h for the oral administration systems.Yingying Tang Huan Teng Yanan Shi Haibing He Yu Zhang Tian Yin Cuifang Cai Xing Tang 2018Asian Journal of Pharmaceutical Sciences2018,13,2:1
7Maternal genetic history of ancient Tibetans over the past 4000 years显示文摘The settlement of the Tibetan Plateau epitomizes human adaptation to a high-altitude environment that poses great challenges to human activity.Here,we reconstruct a 4000-year maternal genetic history of Tibetans using 128 ancient mitochondrial genome data from 37 sites in Tibet.The phylogeny of haplotypes M9a1a,M9a1b,D4g2,G2a’c,and D4i show that ancient Tibetans share the most recent common ancestor with ancient Middle and Upper Yellow River populations around the Early and Middle Holocene.In addition,the connections between Tibetans and Northeastern Asians vary over the past 4000 years,with a stronger matrilineal connection between the two during 4000 BPe3000 BP,and a weakened connection after 3000 BP,that are coincident with climate change,followed by a reinforced connection after the Tubo period(1400 BPe1100 BP).Besides,an over 4000-year matrilineal continuity is observed in some of the maternal lineages.We also find the maternal genetic structure of ancient Tibetans is correlated to the geography and interactions between ancient Tibetans and ancient Nepal and Pakistan populations.Overall,the maternal genetic history of Tibetans can be characterized as a long-term matrilineal continuity with frequent internal and external population interactions that are dynamically shaped by geography,climate changes,as well as historical events.Ganyu Zhang Can Cui Shargan Wangdue Hongliang Lu Honghai Chen Lin Xi Wei He Haibing Yuan Tinley Tsring Zujun Chen Feng Yang Tashi Tsering Shuai Li Norbu Tashi Tsho Yang Yan Tong Xiaohong Wu Linhui Li Yuanhong He Peng Cao Qingyan Dai Feng Liu Xiaotian Feng Tianyi Wang Ruowei Yang Wanjing Ping Ming Zhang Xing Gao Yichen Liu Wenjun Wang Qiaomei Fu 2023Journal of Genetics and Genomics2023,50,10:1
8A numerical study on Rayleigh-Taylor instability of aluminum plates driven by detonation显示文摘The authors,using elastic-plastic hydrodynamic code,present the Rayleigh-Taylor (RT) instability of Al plates driven by high-explosive detonation. Our numerical study assumes the material is fluid,or it is an elastic-plastic solid,and we compare the results of these simulations with the experimental data. For the numerical simulation of Rayleigh-Taylor instability of the metal driven by high-explosive detonation,the elastic-plastic effect must be assumed. The result of the simulation is different from the experiment,using only equation of state. However,the growth of perturbation agrees well with the measured growth under the second assumption. There is a cutoff wavelength for RT instability of the metal. The growth of perturbation is stable for short wavelength. The growth increases rapidly as the wavelength increases.HE ChangJiang,ZHOU HaiBing & HANG YiHong Institute of Applied Physics and Computational Mathematics,Laboratory of Computational Physics,Beijing 100088,China 2010Science China(Physics,Mechanics & Astronomy)2010,53,2:1
9Intermediate myasthenia syndrome following acute Organophosphosphates Posissoning an analysis of 21显示文摘Fengsheng He Haibing Xu FuKuang Qin 1998Human Exp Toxicol1998,17,:1
10An intravenous clarithromycin lipid emulsion with a high drug loading, H-bonding and a hydrogen-bonded ion pair complex exhibiting excellent antibacterial activity显示文摘The aim of this study was to develop an intravenous clarithromycin lipid emulsion(CLE)with good stability and excellent antibacterial activity. The CLE was prepared by the thinfilm dispersed homogenization method. The interaction between clarithromycin(CLA) and cholesteryl hemisuccinate(CHEMS) was confirmed by DSC, FT-IR and^1H NMR analysis. The interfacial drug loading, thermal sterilization, freeze–thaw stability, and in vitro and in vivo antibacterial activity were investigated systematically. DSC, FT-IR and^1H NMR spectra showed that CHEMS(CLA: CHEMS, M ratio 1:2) could interact with CLA through H-bonding and a hydrogen-bonded ion pair. The CHEMS was found necessary to maintain the stability of CLE.Ultracentrifugation showed that almost 88% CLA could be loaded into the interfacial layer.The optimized CLE formulation could withstand autoclaving at 121 °C for 10 min and remain stable after three freeze–thaw cycles. The in vitro susceptibility test revealed that the CLA–CHEMS ion-pair and CLE have similar activity to the parent drug against many different bacterial strains. The in vivo antibacterial activity showed that the ED50 of intravenous CLE was markedly lower than that of CLA solution administrated orally. CLE exhibited pronounced antibacterial activity and might be a candidate for a new nanocarrier for CLA with potential advantages over the current commercial formulation.Haoyu Gong Sicong Geng Qi Zheng Puxiu Wang Lifeng Luo Xiuzhi Wang Yan Zhang Yu Zhang Haibing He Xing Tang 2016Asian Journal of Pharmaceutical Sciences2016,11,5:1
11Intermediate myasthenia syndrome following acute organophosphates poisoning analysis of 21 cases显示文摘Fengsheng He Haibing Xu Fukuang Qin 0,,:1
12CO 2 laser scan- ning repair fused silica surface defects显示文摘Jiang Yong He Shaobo Yuan Xiaodong Wang Haijun Li- ao Wei Lv Haibing Liu Chunming Xiang Xia Qiu Rong Yang Yongjia Zheng Wanguo the experimental researches and numerical simulations of Zu Xiaotao 2014Journal of phys- ics2014,,06:1
13Total Synthesis of Three Families of Natural Antibiotics:Anthrabenzoxocinones,Fasamycins/Naphthacemycins,and Benastatins显示文摘Due to the critical bacterial resistance and antibiotic crisis,the discovery of new antibiotics is an urgent need in the clinic than ever.Naturally occurring antibiotics have proven to be an indispensable source of the development of new antibacterial agents.Herein,we report the total synthesis of three families of biogenetically related natural antibiotics,including anthrabenzoxocinones(ABXs),fasamycins/naphthacemycins,and benastatins.The synthesis featured divergent and convergent approaches,which enabled efficient construction of the basic polycyclic skeletons in 6–10 steps on a large-scale,followed by a collective synthesis of 14 natural products and their corresponding analogs.The core scaffold of gemdimethyl-anthracenone,a naturally occurring type II fatty acid-specific condensation enzyme(FabFspecific)antibiotic pharmacophore,was forged via a Ti(Oi-Pr)4-mediated photoenolization/Diels–Alder(PEDA)reaction between 2-isopropyl benzaldehyde and a variety of enones.A scale-up of the PEDA reaction was facilitated in an assembled continuous-flow reactor,which allowed us to overcome the issues associated with batch photochemistry.Subsequently,the synthetic natural antibiotics and their analogs would be utilized in structure–activity relationships(SAR)and mechanism studies,which should enable the discovery of new and leading antibiotic compounds.Delu Jiang Kunyun Xin Baochao Yang Yanyu Chen Quan Zhang Haibing He Shuanhu Gao 2020CCS Chemistry2020,2,6:1
14Clarithromycin-loaded liposomes offering high drug loading and less irritation显示文摘Xiaona Liu Wei Sun Bo Zhang Bin Tian Xing Tang Na Qi Haibing He Huifang Li Xiangqun Jin 2013International Journal of Pharmaceutics . 2013 (1-2)2013,,:1
15Thinking on the Theory of 'China's Century'显示文摘As China's economy and global influence increase,its international relations are quickly changing.As more credence is given to predictions of a'China Century'to follow the'American Century,'interest is also increasing in the adjustments China is making to its strategic diplomacy as it prepares to take the first chair from the United States.The conceptual innovation in China's diplomacy in 2014 is a significant harbinger in the eyes of many as to how this China Century will shape up.While China's new diplomacy is praised,opinion differs on its future intentions.After a series of proposals were put forward at summit meetings of CICA(Conference on Interaction and Confidence-Building MeasuresHe Lan Xing Haibing 2015Contemporary International Relations2015,25,2:0
16Rapid and sensitive detection of Epstein-Barr virus antibodies in nasopharyngeal carcinoma by chemiluminescence strips based on iron-porphyrin single atom nanozyme显示文摘The correlation between Epstein-Barr virus(EBV)infection and nasopharyngeal carcinoma(NPC)risk has been extensively researched.The continual monitoring of EBV-IgAs provides a promising approach of NPC screening in its early stage.In this study,we successfully synthesized a single-atom nanozyme(SANzyme)through the application of iron-porphyrin based metal organic framework(MOF-FeP).The MOF-FeP possesses precisely-defined electronic and geometric structures that accurately mimic highly-evolved catalytic site of natural peroxidase.The peroxidase-like activity of MOF-FeP enables it to catalyze the chemiluminescence of luminol substrate.By integrating MOF-FeP into a traditional strip,we created a rapid and highly-sensitive evaluation tool for detecting EBV-IgAs.Importantly,the MOF-FeP strip enables the simultaneous detection of three EBV-IgAs,greatly improving the accuracy of EBV-associated NPC screening.The sensitivities of the MOF-FeP strip(75.56%–93.30%)surpass those of current enzyme-linked immunosorbent assay(ELISA)methods(64.44%–82.22%).This test takes only 16 min to perform as opposed to the customary 1–2 h required for standard ELISA.Additionally,the MOF-FeP strip is suitable for whole blood samples,thereby significantly simplifying the sample preparation and detection process.In conclusion,the MOF-FeP strip combines the simplicity of traditional strip with the high catalytic activity of SANzyme.Our innovative MOF-FeP strip offers a new point-of-care strategy for EBV-IgAs detection,which is expected to markedly facilitate early screening for EBV-associated diseases.Daji Wang Jie Wang Dan Liu Jiuyang He Meiying Wang Haibing Huang Guohui Nie Hui Ding Xiyun Yan 2024Nano Research2024,17,3:0
17Characteristics of S-wave Envelope Broadening in the Changbaishan Tianchi Volcano显示文摘High-frequency S-wave seismogram envelopes of microearthquakes broaden with increasing travel distance,a phenomenon known as S-wave envelope broadening. Multiple forward scattering and diffraction for the random inhomogeneities along the seismic ray path are the main causes of S-wave envelope broadening,so the phenomenon of S-wave envelope broadening is used to study the inhomogeneity of the medium. The peak delay time of an S-wave,which is defined as the time lag from the direct S-wave onset to the maximum amplitude arrival of its envelope,is accepted to quantify S-wave envelope broadening. 204 small earthquake records in Changbaishan Tianchi volcano were analyzed by the S-wave envelope broadening algorithm. The results show that S-wave envelope broadening in the Changbaishan Tianchi volcano is obvious,and that the peak delay time of S-wave has a positive correlation with the hypocenter distance and frequency of the S-wave. The relationships between the S-wave peak delay time and the hypocenter distance for different frequency bands were obtained using the statistics method. The results are beneficial to the understanding of the S-wave envelope broadening phenomena and the quantitative research on the inhomogeneities of the crust medium in the Changbaishan Tianchi volcano region.Fan Xiaoping Li Qinghe He Haibing Yang Congjie Jin Shumei 2010Earthquake Research in China2010,24,3:0
18Hot-melt sub-and outercoating combined with enteric aqueous coating to improve the stability of aspirin tablets显示文摘Aspirin is apt to hydrolyze. In order to improve its stability, a new method has been developed involving the application of hot-melt sub-and outercoating combined with enteric aqueous coating. The main aim was to investigate the influence of these factors on the stability of ASA and understand how they work. Satisfactory storage stability were obtained when the aspirin tablet core coated with Eudragit L30D55 film was combined with glycerin monostearate(GMS) as an outercoat. Hygroscopicity testing indicated that the moisture penetrating into the tablet may result in a significant change in the physical properties of the coating film observed by scanning electron microscopy. Investigation of the compatibility between the drug and film excipients shows that the talc and methacrylic acid had a significant catalytic effect on ASA. A hypothesis was proposed that the hydrolysis of ASA enteric coated tablets(ASA-ECT) was mostly concentrated in the internal film and the interfaces between the film and tablet core. In conclusion, hot-melt coating technology is an alternative to subcoating or outercoating. Also, GMS sub-coating was a better choice for forming a stable barrier between the tablet core and the polymer coating layer, and increases the structure and chemical stability.Xiuzhi Wang Puxiu Wang Chenglong Huang Xiaoyang Lin Haoyu Gong Haibing He Cuifang Cai 2017Asian Journal of Pharmaceutical Sciences2017,12,3:0
19Titanium-promoted Intramolecular Photoenolization/Diels-Alder Reaction to Construct Polycyclic Terpenoids: Formal Synthesis of Mycoleptodiscin A显示文摘Summary of main observation and conclusion A titanium-promoted intramolecular photoenolization/Diels-Alder (PEDA) reaction was developed to construct the core skeleton of aromatic polycyclic terpenoids bearing an all-carbon quaternary center on the benzylic position. Titanium(Ⅳ) isopropoxide [Ti(Oi-Pr)4] plays a key role during the photo cycloaddition, which may help to accelerate the in teraction between dienophile and the stereo-hi ndered diene species as well as control the diastereoselectivity. This photolysis provides a new solution for the stereospecific formation core structures of aromatic abietane diterpenoids and sesquiterpenoids, which have multiple functional groups for the further transformations. As a synthetic application, it was successfully used in the synthesis of indolosesquiterpenoid mycoleptodiscin A.Dongsheng Xue Mengmeng Xu Chaoying Zheng Baochao Yang Min Hou Haibing He Shuanhu Gao 2019Chinese Journal of Chemistry2019,37,2:0
20Effects of mixed fertilizers formed by the compounding of two targeted controlled-release nitrogen fertilizers on yield,nitrogen use efficiency,and ammonia volatilization in double-cropping rice显示文摘One-time application of mixed fertilizer formed by the compounding of two controlled-release nitrogen fertilizers(CRUs)with targeted N supply during the periods from transplantation(TS)to panicle initiation(PI)and from PI to heading(HS)is expected to synchronize the double-peak N demand of rice.However,its effects on the yield and N use efficiency(NUE)of labor-intensive double-cropping rice were unknown.Two targeted CRU(CRU_(A)and CRU_(B))were compounded in five ratios(CRU_(A):CRU_(B)=10:0,7:3,5:5,3:7,and 0:10)to form five mixed fertilizers(BBFs):BBF1-5.A field experiment was performed to investigate the characteristics of N supply in early and late seasons under different BBFs and their effects on N uptake,yield,and ammonia volatilization(AV)loss from paddy fields of double-cropping rice.Conventional high-yield fertilization(CK,three split applications of urea)and zero-N treatments were established as controls.The N supply dropped significantly with the increased compound ratio of CRU_(B)during the period from TS to PI,but increased during the period from PI to HS.With the exception of the period from TS to PI in the late rice season,the N uptake of early and late rice maintained close synchronicity with the N supply of BBFs during the double-peak periods.Excessive N supply(BBF1 and BBF2)in the late rice season during the period from TS to PI increased N loss by AV.The effect of BBF on grain yield increase varied widely between seasons,irrespective of year.Among the BBFs,the BBF2 treatment of early rice not only stabilized the spikelets per panicle but also ensured a high number of effective panicles by promoting N uptake during the period from TS to PI and a high grain-filling percentage by appropriately reducing the N supply at the later PI stage,resulting in the highest rice yield.While stabilizing the effective panicle number,the BBF4 treatment of late rice increased the number of spikelets per panicle by promoting N uptake during the period from PI to HS,resulting in the highest rice yield.The two-year average yield and apparent N recovery efficiency of the BBF2 treatment during the early rice season were 9.6 t ha 1 and 45.3%,while those of late rice in BBF4 were 9.6 t ha 1 and 43.0%,respectively.The yield and NUE indexes of BBF2 in early rice and BBF4 in late rice showed no significant difference from those of CK.The AVs of BBF2 during the early rice season and of BBF4 during the late rice season were 50.0%and 76.8%lower,respectively,than those of CK.BBF2 and BBF4 could effectively replace conventional urea split fertilization in early and late rice seasons,ensuring rice yield and NUE and reducing AV loss in paddy fields.Jian Ke Jie Sun Tingting Chen Shibao Tao Tiezhong Zhu Chuanjun Yin Haibing He Cuicui You Liquan Wu Shuangshuang Guo 2023The Crop Journal2023,11,2:0
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