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| 1 | Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism显示文摘Antibacterial activity of zinc oxide nanoparticles(Zn O-NPs) has received significant interest worldwide particularly by the implementation of nanotechnology to synthesize particles in the nanometer region. Many microorganisms exist in the range from hundreds of nanometers to tens of micrometers. Zn O-NPs exhibit attractive antibacterial properties due to increased specific surface area as the reduced particle size leading to enhanced particle surface reactivity. Zn O is a bio-safe material that possesses photo-oxidizing and photocatalysis impacts on chemical and biological species. This review covered Zn O-NPs antibacterial activity including testing methods, impact of UV illumination, Zn O particle properties(size, concentration, morphology, and defects), particle surface modification, and minimum inhibitory concentration. Particular emphasize was given to bactericidal and bacteriostatic mechanisms with focus on generation of reactive oxygen species(ROS) including hydrogen peroxide(H2O2), OH-(hydroxyl radicals), and O2-2(peroxide). ROS has been a major factor for several mechanisms including cell wall damage due to Zn O-localized interaction, enhanced membrane permeability, internalization of NPs due to loss of proton motive force and uptake of toxic dissolved zinc ions.These have led to mitochondria weakness, intracellular outflow, and release in gene expression of oxidative stress which caused eventual cell growth inhibition and cell death. In some cases, enhanced antibacterial activity can be attributed to surface defects on Zn O abrasive surface texture. One functional application of the Zn O antibacterial bioactivity was discussed in food packaging industry where Zn O-NPs are used as an antibacterial agent toward foodborne diseases. Proper incorporation of Zn O-NPs into packaging materials can cause interaction with foodborne pathogens, thereby releasing NPs onto food surface where they come in contact with bad bacteria and cause the bacterial death and/or inhibition. | Amna Sirelkhatim Shahrom Mahmud Azman Seeni Noor Haida Mohamad Kaus Ling Chuo Ann Siti Khadijah Mohd Bakhori Habsah Hasan Dasmawati Mohamad | 2015 | Nano-Micro Letters2015，7，3： | 76 |
| 2 | Anti-amoebic properties of a Malaysian marine sponge Aaptos sp . on Acanthamoeba castellanii显示文摘 | M. A. Nakisah M. Y. Ida Muryany H. Fatimah R. Nor Fadilah M. R. Zalilawati S. Khamsah M. Habsah | 2012 | World Journal of Microbiology and Biotechnology2012，，： | 1 |
| 3 | Bilirubin Clearance in Temporarily Hyperbilirubinemic Rats Treated with Aqueous Extract of Sida rhombifolia 显示文摘 | Faizah M F Habsah A K Saad T | 2012 | Life Science Journal2012，9，3： | 1 |
| 4 | Screening of Zingiberaceae extracts for antimicrobial and antioxidant activities显示文摘 | HABSAH M AMRAN M MACKEEN M M | 2000 | Journal of Ethnopharmacology2000，72，3： | 1 |
| 5 | Effects of asiatic acid on passive and active avoidance task in male spraque-dawley rats 显示文摘 | Nasir M N Habsah M Zamzuri I | 2011 | J Ethnopharmacol2011，134，3： | 1 |
| 6 | Screening of Zingiberaceae extracts for antimicrobial and antioxidant activities显示文摘 | M Habsah M Amran M.M Mackeen N.H Lajis H Kikuzaki N Nakatani A.A Rahman Ghafar A.M Ali | 2000 | Journal of Ethnopharmacology2000，，3： | 1 |
| 7 | Removal of chromium (VI) from aqueous solution using treated oil palm fibre显示文摘 | Mohamed Hasnain Isa Naimah Ibrahim Hamidi Abdul Aziz Mohd. Nordin Adlan Nor Habsah Md. Sabiani Ali Akbar Lorestani Zinatizadeh Shamsul Rahman Mohamed Kutty | 2007 | Journal of Hazardous Materials2007，，2： | 1 |
| 8 | Phenolics, fatty acids composition and biological activities of various extracts and fractions of Malaysian Aaptos aaptos显示文摘Objective: To investigate phenolics, fatty acids composition and biological activities of various extracts and fractions of Malaysian Aaptos aaptos. Methods: Fatty acid methyl ester was analyzed by gas chromatography-flame ionization detector. Antioxidant activity was determined using 2,2-diphenyl-picrylhydrazyl radical scavenging assay and total phenolics content by Folin-Ciocalteu procedure. Vero cells viability was evaluated using methyl thiazole tetrazolium and the inactivation of herpes simplex virus type 1 by neutral red uptake assay. p-Hydroxybenzamide isolated by column chromatography was characterized by utilizing nuclear magnetic resonance spectroscopy and electron impact mass spectrometry. Results: The chloroform, ethyl acetate and methanol extracts of Aaptos aaptos produced higher portions of straight-chain saturated fatty acid, while hexane extract mainly consisted of unsaturated fatty acid. The five majors of fatty acid methyl ester were identified as behenic acid, cis-10-heptadecenoic acid and cis-10-pentadecenoic acids, palmitic acid and tricosanoic acid. In addition, among all organic extracts, chloroform extract inactivated herpes simplex virus type 1 while exhibited weak cytotoxic activity against normal Vero cells and also exhibited strong cytotoxic activity on HL-60, MCF-7, K562, CEM-SS and WEHI-3 B cells. A phenolic compound, p-hydroxybenzamide was also isolated from the sponge. Conclusions: Aaptos aaptos could be a source to derive the potential antiviral and anticancer agents. However, further studies are needed to determine the mechanism involved in the process. | Zalilawati Mat Rashid Abdul M. Ali Philippe Douzenel Nathalie Bourgougnon Khozirah Shaari Yosie Andriani Tengku Sifzizul Tengku Muhammad Habsah Mohamad | 2018 | Asian Pacific Journal of Tropical Biomedicine2018，8，11： | 0 |
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