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| 1 | The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters显示文摘最近的研究在众多的生物过程增加了我们长 noncoding RNA (lncRNAs ) 的理解,但是很少在体的房间 reprogramming 检验了他们的角色。通过表示介绍并且功能的屏蔽,我们鉴别了大 intergenic noncoding RNA p21 (lincRNA-p21 ) 损害 reprogramming。尤其是, lincRNA-p21 被 p53 导致,但是不在 reprogramming 支持 apoptosis 或房间老朽。相反, lincRNA-p21 与 H3K9 methyltransferase SETDB1 和维护 DNA methyltransferase DNMT1 联系,它被 RNA 有约束力的蛋白质 HNRNPK 便于。因而, lincRNA-p21 由在 pluripotency 基因倡导者支撑 H3K9me3 或 CpG methylation 阻止 reprogramming。我们的结果在 reprogramming 提供卓见进 lncRNAs 的角色并且建立在 p53 和 heterochromatin 规定之间的一个新奇连接。 | Xichen Bao Haitao Wu Xihua Zhu Xiangpeng Guo Andrew P Hutchins Zhiwei Luo Hong Song Yongqiang Chen Keyu Lai Menghui Yin Lingxiao Xu Liang Zhou Jiekai Chen Dongye Wang Baoming Qin Jon Frampton Hung-Fat Tse Duanqing Pei Huating Wang Biliang Zhang Miguel A Esteban | 2015 | Cell Research2015，25，1： | 21 |
| 2 | Joint Motion Control of a Powered Lower Limb Orthosis for Rehabilitation显示文摘许多病人与针伤害被限制到轮椅,在 carer 上与第二等的病理和增加的依赖导致一种坐着的生活方式。增加的证据证明了运动训练减少这些第二等的病理的发生,但是物理努力在这涉及训练是以便有差的依从。这篇论文在一个新鈥渉u 人的设计和控制上报导友好鈥 ? orthosis (皮骨骼) ,以高力量灵魂肌肉致动器(pMAs ) 为动力。一个高度顺从的使活动系统的联合与臀部,膝,和脚关节放感觉的聪明的嵌入的控制机制,速度,加速和力量,生产强大还为半身不遂者病人的内在地安全的操作。这份报纸在零装载下面分析脚关节,膝,和新潮的关节的运动,并且装载哪个模仿人的手足质量,证明鈥渟o 英尺鈥 ? 致动器的使用能提供一个光滑的用户友好运动。这种技术的申请将极大地为半身不遂者病人改进使复权协议。关键词皮骨骼 - 集中人的机器人学 - 人的适应 Mechatronics - 灵魂肌肉致动器(pMAs )- 康复尼尔森肋前缘在计算机并且在 1999 的在机器的系统和自动化的在 1995 的电子设计和他的 M.Sc 收到了他的 B.Sc 度,在 Coimbra 的大学,葡萄牙。他当前在 Salford 的大学在先进机器人学正在追求博士,更大的英国曼彻斯特。他的研究兴趣包括传感器,致动器,电源来源,力量扩大皮骨骼,康复机器人学和触觉的反馈系统。米兰 Bezdicek 在 2003 在捷克的共和国从 Brno 工业大学在 Mechatronics 收到了他的 M.Sc。他当前在 Salford 的大学是机器人学和 haptics 的博士学生,英国。他的研究兴趣包括 biomechanics,电子学,计算机控制了分析的用机器制造的、人工的神经网络, haptics, DSP,聪明的传感器和结构。约翰· O ·格雷在控制工程从大学曼彻斯特获得了他的博士和 D.Sc 学位,他的早工作在非线性的控制系统, C.A.D 过程和精确的方面上集中了电磁的乐器学。在 1988,与学术、工业的同事一起,他建立了英国国家先进机器人学研究中心。在 1990 年代,他最近在先进机器人学和更多上组织了一系列 EC.sponsored 会议(2001 鈥 ? 005 ) 先进机器人学上的主持 EPSRC 和 IEE 网络。Darwin G. 考德威尔分别地在 1986 和 1990 从赫尔的大学在机器人学收到了他的 B.Sc 和博士。在 1994 在里面在管理收到了 M.Sc。自从 1999,他在 Salford 的大学是在机器人学和自动化的中心的先进机器人学的主席。他是超过 150 篇学术论文的作者或合作者并且有 4 项专利。他的研究兴趣包括为食物工业的创新致动器和传感器,触觉的反馈,力量扩大皮骨骼,灵巧的操纵者,类人动物机器人学, biomimetic 系统,康复机器人学和机器的系统。考德威尔教授当前是 IEEE (机器人学和自动化社会) 的 UKRI 区域的主席。史蒂芬·胡钦斯与 HPC 在 1978 作为 orthotist 毕业了是在在 Salford 和登记 orthotist 的大学的 Orthotics 的高级讲师。他为在预防的膝 bracing 要过去常的原型 orthotic 膝关节的设计在 1997 由研究在 Orthotics 获得了 M.Sc。他当前在断断续续的跛的处理在摇椅脚底开发的题目上正在追求博士。他在 orthotic 膝关节设计上有很多项英国专利。他的研究兴趣包括更低的手足 orthotics 和鞋类设计的所有方面。 | Nelson Costa Milan Bezdicek Michael Brown John O.Gray Darwin G.Caldwell Stephen Hutchins | 2006 | International Journal of Automation and computing2006，3，3： | 7 |
| 3 | Transposable elements at the center of the crossroads between embryogenesis, embryonic stem cells, reprogramming,and long non-coding RNAs显示文摘Transposable elements(TEs) are mobile genomic sequences of DNA capable of autonomous and nonautonomous duplication. TEs have been highly successful,and nearly half of the human genome now consists of various families of TEs. Originally thought to be non-functional,these elements have been co-opted by animal genomes to perform a variety of physiological functions ranging from TE-derived proteins acting directly in normal biological functions, to innovations in transcription factor logic and influence on epigenetic control of gene expression. During embryonic development, when the genome is epigenetically reprogrammed and DNA-demethylated, TEs are released from repression and show embryonic stage-specific expression, and in human and mouse embryos, intact TEderived endogenous viral particles can even be detected. Asimilar process occurs during the reprogramming of somatic cells to pluripotent cells: When the somatic DNA is demethylated, TEs are released from repression. In embryonic stem cells(ESCs), where DNA is hypomethylated, an elaborate system of epigenetic control is employed to suppress TEs, a system that often overlaps with normal epigenetic control of ESC gene expression. Finally, many long non-coding RNAs(lnc RNAs) involved in normal ESC function and those assisting or impairing reprogramming contain multiple TEs in their RNA. These TEs may act as regulatory units to recruit RNA-binding proteins and epigenetic modifiers. This review covers how TEs are interlinked with the epigenetic machinery and lnc RNAs, and how these links influence each other to modulate aspects of ESCs,embryogenesis, and somatic cell reprogramming. | Andrew Paul Hutchins Duanqing Pei | 2015 | Science Bulletin2015，60，20： | 5 |
| 4 | 反应溅射氧化镍电变色薄膜显示文摘本文研究高频反应溅射工艺制备氧化镍电变色薄膜及其光学性能.电变色性能良好的氧化镍薄膜具有“grey”的变色特性,并且具有较高的红外透过特性,当沉积在镀有 SnO_2∶F 导电薄膜的窗玻璃上,其漂白态的太阳透过率为70%,着色态为30%.同时,本文还提出了新的氧化镍薄膜电变色机理,即碱金属离子与电子的共注入和共抽出导致薄膜变色. | 胡行方 陈晓峰 田静芬 Hutchins Michael G. | 1992 | 无机材料学报1992，7，3： | 3 |
| 5 | Spontaneous intramural duodenal hematoma in type 2B von Willebrand disease显示文摘Intramural duodenal hematoma is a rare cause of a proximal gastrointestinal tract obstruction.Presentation of intramural duodenal hematoma most often occurs following blunt abdominal trauma in children,but spontaneous non-traumatic cases have been linked to anticoagulant therapy,pancreatitis,malignancy,vasculitis and endoscopy.We report an unusual case of spontaneous intramural duodenal hematoma presenting as an intestinal obstruction associated with acute pancreatitis in a patient with established von Willebrand disease,type 2B.The patient presented with abrupt onset of abdominal pain,nausea,and vomiting.Computed tomography imaging identified an intramural duodenal mass consistent with blood measuring 4.7 cm×8.7 cm in the second portion of the duodenum abutting on the head of the pancreas.Serum lipase was 3828 units/L.Patient was managed conservatively with bowel rest,continuous nasogastric decompression,total parenteral nutrition,recombinant factorⅧ(humateP)and transfusion.Symptoms resolved over the course of the hospitalization.This case highlights an important complication of an inherited coagulopathy. | Derrick D Eichele Meredith Ross Patrick Tang Grant F Hutchins Mark Mailliard | 2013 | World Journal of Gastroenterology2013，19，41： | 3 |
| 6 | Where cell fate conversions meet Chinese philosophy显示文摘 | Hui Zheng Andrew Paul Hutchins Guangjin Pan Yinxiong Li Duanqing Pei Gang Pei | 2014 | Cell Research2014，24，10： | 2 |
| 7 | Pathogenesis of Persistent Left Superior Vena Cava with a Coronary Sinus Connection显示文摘 | Emmanuel N. Nsah G. William Moore Grover M. Hutchins | 1991 | Fetal & Pediatric Pathology1991，，2： | 2 |
| 8 | Cystic neoplasms of the pancreas: A diagnostic challenge显示文摘Cystic neoplasms of the pancreas are increasingly recognized due to the expanding use and improved sensitivity of cross-sectional abdominal imaging. Major advances in the last decade have led to an improved understanding of the various types of cystic lesions and their biologic behavior. Despite signifi cant improvements in imaging technology and the advent of endoscopic-ultrasound (EUS)-guided fineneedle aspiration, the diagnosis and management of pancreatic cystic lesions remains a significant clinical challenge. The fi rst diagnostic step is to differentiate between pancreatic pseudocyst and cystic neoplasm. If a pseudocyst has been effectively excluded, the cornerstone issue is then to determine the malignant potential of the pancreatic cystic neoplasm. In the majority of cases, the correct diagnosis and successful management is based not on a single test but on incorporating data from various sources including patient history, radiologic studies, endoscopic evaluation, and cyst fluid analysis. This review will focus on describing the various types of cystic neoplasms of the pancreas, their malignant potential, and will provide the clinician with a comprehensive diagnostic approach. | Grant F Hutchins Peter V Draganov | 2009 | World Journal of Gastroenterology2009，15，1： | 2 |
| 9 | 冠状动脉内皮功能障碍患者胆固醇流出异常,高密度脂蛋白颗粒物浓度降低显示文摘冠状动脉内皮功能障碍(endothelial dysfunction,ED)是动脉粥样硬化早期标志,增加心血管事件发生风险。该研究假设胆固醇流出容量和高密度脂蛋白颗粒浓度(high-density lipoprotein particle concentration,HDL-PIMA)较高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)更能预测ED。 | 刘莉 叶鹏 Monette JS Hutchins PM Ronsein GE Wimberger J Irwin AD Tang C Sara JD Shao B Vaisar T Lerman A Heinecke JW | 2016 | 中华高血压杂志2016，24，6： | 2 |
| 10 | Surgical site infection: Incidence and impact on hospital utilization and treatment costs显示文摘 | Gregory de Lissovoy Kathy Fraeman Valerie Hutchins Denise Murphy David Song Brian B. Vaughn | 2009 | AJIC: American Journal of Infection Control2009，，5： | 2 |
| 11 | Prevalence of mitochondrial DNA mutations in childhood/congenital onset non - syndromal sensorineural hearing impaiment 显示文摘 | Hutchin TP Thompson KR Parker M | 2001 | J Med Genet2001，38，： | 1 |
| 12 | Fibrovascu lar ingrowth at sclerotomy sites in vitreetomized diabetic eyes with recurrent vitreous hemorrhage: ultrasound biomicroscopy findings 显示文摘 | Hershberger VS Augsburger J J Hutchins RK | 2004 | Ophthalmology2004，111，6： | 1 |
| 13 | Ischemic heart disease secondary to amyloidosis of intramyocatdial arteries显示文摘 | Smith RR Hutchins GM | 1979 | Am J Cardiol1979，44，： | 1 |
| 14 | Effect of additives and refrigeration on reducing activity, metmyoglobiin and malonaldehyde of raw ground beef显示文摘 | Hutchins B K Liu T H P Watts B M | 1967 | J Food Sci1967，32，： | 1 |
| 15 | Sur-gical site infection : incidence and impact onhospital utilization and treatment costs 显示文摘 | Lissovoy G Fraeman S Hutchins V | 2009 | Am J Infect Control2009，37，9： | 1 |
| 16 | The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A显示文摘 | LUCIANI M G HUTCHINS J R ZhELEVA D | 2000 | J Mol Biol2000，300，3： | 1 |
| 17 | A model selection protocol to support the use of models for water management显示文摘 | Boorman D Williams R Hutchins M etal | 2007 | Hydrology and Earth System Scienses2007，11，1： | 1 |
| 18 | Volume of air in a lethal venous air embolism显示文摘 | Toung TJ Rossberg MI Hutchins GM | 2001 | Anesthesiology2001，94，2： | 1 |
| 19 | Uterine artery occlusion by em- bolization or surgery for the treatment of fibroids :A unif- ying hypothesis-transient utweine ischemia 显示文摘 | Burbank F Hutchins FL | 2000 | J Am As- soe Gynecol Laparosc2000，，： | 1 |
| 20 | Lymph Node Tumor Volumes in Patients Undergoing Sentinel Lymph Node Biopsy for Cutaneous Melanoma显示文摘 | Jeffrey D. Wagner MD Darrell Davidson MD PhD John J. Coleman MD Gary Hutchins PhD Donald Schauwecker MD PhD Hee-Myung Park MD Robert J. Havlik MD | 1999 | Annals of Surgical Oncology1999，，4： | 1 |
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