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    题名 作者 年代 出处 被引量
1Developmental engineering: design of clinically efficacious bioartificial tissues through developmental and systems biology显示文摘THE CREATION OF A NEW RESEARCH FIELD:FUNG’S IDEA ON ENGINEERING TISSUES Tissue engineering emerged three decades ago as a distinct research field with the goal to radically change the clinical practice by fabricating in vitro cell-biomaterial assemblies,bioartificial tissues,that could be used as biological tissue substitutes to restore,maintain or improve the functions of diseased or damaged tissues and to eventually solve the problem of organ shortage for transplantations.It was proposed as a new discipline in 1985 by Yuan-Cheng Fung。Petros Lenas Laertis Ikonomou 2018Science China(Life Sciences)2018,61,8:1
2Transitions between mesenchymal and epithelial states and the concomitant gene expression changes显示文摘Epithelial-mesenchymal transition(EMT),mesenchymal-epithelial transition(MET),and even the sequential EMT-MET can be observed during multiple cell fate conversions including cancer progression and embryonic development.In the current review,we first focused on the existence and beneficial roles of the sequential EMT-MET during three typical cell fate conversions,differentiation from pluripotent stem cells(PSCs)to neurons,de-differentiation from mouse embryonic fibroblasts(MEFs)to PSCs,and trans-differentiation from MEFs to neurons.We tried to provide some preliminary hypotheses to connect EMT-MET and cell fate conversions,like the possible contributions of the intermediate mesenchymal state to iPSCs generation and neurontrans-differentiation.The intermediate mesenchymal state during sequential EMT-MET was further discussed by exploring the conserved signatures on gene expression during a variety of EMT.Discussion on the interaction among vitamin C,DNA methylation,and EMT/MET was also provided.LIANG LiNing SUN Hao LI LingYu ZHENG Hui 2016Science Foundation in China2016,24,1:0
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