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| 1 | A life support-based comprehensive treatment regimen dramatically lowers the in-hospital mortality of patients with fulminant myocarditis: a multiple center study显示文摘Fulminant myocarditis(FM) has unacceptable high mortality. This study aimed to evaluate the therapeutic efficacy of a life support-based comprehensive treatment regimen(LSBCTR), a completely novel treatment regimen, for FM. A total of 169 FM patients recruited from January 2008 to December 2018 were divided into two groups: patients receiving LSBCTR(81 cases),which includes(i) mechanical life support(positive pressure respiration, intra-aortic balloon pump with or without extracorporeal membrane oxygenation),(ii) immunomodulation therapy using sufficient doses of glucocorticoids and immunoglobulins, and(iii) application of neuraminidase inhibitors, and those receiving conventional treatment(88 cases). The endpoints were in-hospital death and heart-transplantation. Of all the population, 44 patients(26.0%) died in hospitals. Inhospital mortality was 3.7%(3/81) for LSBCTR group and 46.6%(41/88) for traditional treatment(P<0.001). Early application of LSBCTR, mechanical life support, neuraminidase inhibitors, and immunomodulation therapy significantly contributed to reduction in in-hospital mortality. This study describes a novel treatment regimen for FM patients that dramatically reduces inhospital mortality. Its generalization and clinical application will efficiently save lives although further optimization is needed.This study offers an insight that virus infection induced inflammatory waterfall results in cardiac injury and cardiogenic shock and is the therapeutic target. | Sheng Li Shengyong Xu Chenze Li Xiao Ran Guanglin Cui Mengying He Kun Miao Chunxia Zhao Jiangtao Yan Rutai Hui Ning Zhou Yan Wang Jiangang Jiang Jing Zhang Daowen Wang | 2019 | Science China(Life Sciences)2019，62，3： | 43 |
| 2 | China's treatment regimen for fulminant myocarditis is bringing wonderful achievement to the world显示文摘Fulminant myocarditis is characterized by acute and severe inflammation with injury of myocardium globally. It has a fulminant course and high in-hospital mortality rate of up to50%-70%. It onsets rapidly after viral infection and progresses to hypotension. | Jing Zhang Weijian Hang Rutai Hui Qiong Zhao Shashank S.Desai | 2019 | Science China(Life Sciences)2019，62，2： | 8 |
| 3 | Telomeres,cardiovascular aging,and potential intervention for cellular senescence显示文摘A consistent association has been observed between leukocyte telomere length(LTL)and atherosclerosis,but the mechanisms underlying these associations are still not well understood.Premature biology aging was evident in atherosclerotic plaques,characterized by reduced cell proliferation,irreversible growth arrest and apoptosis,and telomere attrition.As atherosclerosis is a state of chronic low-grade inflammation and increased oxidative stress,shortened LTL in patients with atherosclerosis might stem from the two sources,one is an accelerated rate in hematopoietic stem cells(HSCs)replication to replace leukocytes consumed in the inflammatory process,and another is the increase in the loss of telomere repeats per replication.Thus,diminished HSC reserves at birth and age-dependent telomere attrition afterward are mirrored in shortened LTL during the adulthood.In addition,the inter-individual variation of LTL in the general population can be partly explained by genetic factors regulating telomere maintenance and the rate of HSCs replication.Atherosclerosis is an aging-related disease,and practically all humans develop atherosclerosis if they live long enough.Here we overview the potential roles of LTL dynamics in the imbalance between injurious oxidative stress/inflammation and endothelial repair during the pathogenesis of age-related atherosclerosis,and discuss the possibility that preventing accelerated cellular senescence is a potential target in prevention of atherosclerosis. | ZHANG WeiLi HUI RuTai YANG ShuJun | 2014 | Science China(Life Sciences)2014，57，8： | 5 |
| 4 | Cyclooxygenase-2 (COX-2) G-765C is a protective factor for coronary artery disease but not for ischemic stroke: A meta-analysis显示文摘 | Wenlong Li Jing Xu Xiaojian Wang Jingzhou Chen Channa Zhang Kai Sun Rutai Hui | 2009 | Atherosclerosis2009，，2： | 1 |
| 5 | MiR‐451 is decreased in hypertrophic cardiomyopathy and regulates autophagy by targeting TSC 1显示文摘 | Lei Song Ming Su Shuiyun Wang Yubao Zou Xiaojian Wang Yilu Wang Hongli Cui Peng Zhao Rutai Hui Jizheng Wang | 2014 | J. Cell. Mol. Med2014，，： | 1 |
| 6 | Factor V gene G1691A mutation, prothrombin gene G20210A mutation, and MTHFR gene C677T mutation are not risk factors for pulmonary thromboembolism in Chinese population显示文摘 | Yanhui Lu Yanfen Zhao Guozhang Liu Xiaoling Wang Zhihong Liu Baiping Chen Rutai Hui | 2002 | Thrombosis Research2002，，1： | 1 |
| 7 | Elevated Plasma Homocysteine Was Associated With Hemorrhagic and Ischemic Stroke, but Methylenetetrahydrofolate Reductase Gene C677T Polymorphism Was a Risk Factor for Thrombotic Stroke: A Multicenter Case-Control Study in China显示文摘 | Zhaohui Li Li Sun Hongye Zhang Yuhua Liao Daowen Wang Bingrang Zhao Zhiming Zhu Jizong Zhao Aiqun Ma Yu Han Yibo Wang Yi Shi Jue Ye Rutai Hui | 2003 | Stroke: Journal of the American Heart Association2003，，9： | 1 |
| 8 | Lack of association between the G protein β3 subunit gene and essential hypertension in Chinese: a case-control and a family-based study显示文摘 | Xiaohong Huang Zhenyu Ju Yan Song Hongye Zhang Kai Sun Hongyan Lu Zhiwei Yang Pedro A. Jose Gang Zhou Meng Wang Weifeng Wang Shixian Feng Rutai Hui | 2003 | Journal of Molecular Medicine2003，，11： | 1 |
| 9 | Factors Influencing Prognosis in Patients With Marfan Syndrome After Aortic Surgery显示文摘 | Linggen Gao Xianliang Zhou Lin Zhang Dan Wen Qian Chang Yongbo Wu Lizhong Sun Rutai Hui | 2011 | Journal of Cardiothoracic and Vascular Anesthesia2011，，4： | 1 |
| 10 | A retrospective clinical study of transaortic extended septal myectomy for obstructive hypertrophic cardiomyopathy in China显示文摘 | Shuiyun Wang Mingyao Luo Hongtao Sun Yunhu Song Chaohua Yin Liqing Wang Rutai Hui Shengshou Hu | 2013 | European Journal of Cardio-Thoracic Surgery2013，，3： | 1 |
| 11 | Factor V gene G1691A mutation, prothrombin gene G20210A mutation, and MTHFR gene C677T mutation are not risk factors for pulmonary thromboembolism in Chinese population显示文摘 | Yanhui Lu Yanfen Zhao Guozhang Liu Xiaoling Wang Zhihong Liu Baiping Chen Rutai Hui | 2002 | Thrombosis Research2002，，1： | 1 |
| 12 | Elevated Plasma Homocysteine Was Associated With Hemorrhagic and Ischemic Stroke, but Methylenetetrahydrofolate Reductase Gene C677T Polymorphism Was a Risk Factor for Thrombotic Stroke: A Multicenter Case-Control Study in China显示文摘 | Zhaohui Li Li Sun Hongye Zhang Yuhua Liao Daowen Wang Bingrang Zhao Zhiming Zhu Jizong Zhao Aiqun Ma Yu Han Yibo Wang Yi Shi Jue Ye Rutai Hui | 2003 | Stroke: Journal of the American Heart Association2003，，9： | 1 |
| 13 | Cystatin C, Associated With Hemorrhagic and Ischemic Stroke, Is a Strong Predictor of the Risk of Cardiovascular Events and Death in Chinese显示文摘 | Li Ni Jiagao Lü Ling Bo Hou Jiang Tao Yan Qiao Fan Rutai Hui Katherine Cianflone Wei Wang Dao Wen Wang | 2007 | Stroke2007，，： | 1 |
| 14 | Depression increases the risk of hypertension incidence: a meta-analysis of prospective cohort studies显示文摘 | Lin Meng Dongmei Chen Yang Yang Yang Zheng Rutai Hui | 2012 | Journal of Hypertension2012，，5： | 1 |
| 15 | Cystatin C, Associated With Hemorrhagic and Ischemic Stroke, Is a Strong Predictor of the Risk of Cardiovascular Events and Death in Chinese显示文摘 | Li Ni Jiagao Lü Ling Bo Hou Jiang Tao Yan Qiao Fan Rutai Hui Katherine Cianflone Wei Wang Dao Wen Wang | 2007 | Stroke2007，，12： | 1 |
| 16 | Plasma Uric Acid and Hypertension in a Chinese Community: Prospective Study and Metaanalysis显示文摘 | Zhang Weili Sun Kai Yang Ying Zhang Hongye Hu Frank B Hui Rutai | 2009 | Clinical Chemistry2009，，： | 1 |
| 17 | Elevated C-reactive protein levels predict worsening prognosis in Chinese patients with first-onset stroke显示文摘The role of high sensitivity C-reactive protein(hsCRP)in predicting prognosis after stroke in the Asian population has not been investigated.We hypothesized that elevated levels of hsCRP were associated with worsening prognosis after stroke in Chinese patients.Two hundred and ninety consecutive patients withfirst-onset stroke and 290 age-and gender-matched control subjects without any cerebrovascular disease were enrolled for study.Plasma hsCRP level was detected and subsequent vascular events and death were recorded in both groups over a 5-year period.Compared to control group,patients presenting with stroke had higher plasma hsCRP level(3.3±3.8 vs 1.3±2.2 mg/L,P<0.01).Furthermore,in the group of patients with stroke,the mean plasma hsCRP level was higher in patients who developed subsequent vascular diseases or died as compared with the patients without further complications(4.4±4.3 vs 2.7±3.3 mg/L,P<0.01).Compared to the lowest tertile of hsCRP level,the relative risk for vascular events or death in stroke patients was 2.91 in the highest tertile of hsCRP(95%CI,1.54–5.50,P=0.001).This increase in relative risk for vascular events or death in stroke patients continued after adjustment for age,sex and other cardiovascular risk factors such as hypertension and diabetes(OR:2.771,95%CI:1.367–5.617,P=0.005).Thesefindings indicate that increased hsCRP level is associated with worsening prognosis after stroke in Chinese patients and suggests that inflammation is correlated with stroke outcome. | Jiangtao YAN Rutai HUI Daowen WANG | 2009 | Frontiers of Medicine2009，3，1： | 0 |
| 18 | Predication of increased plasma homocysteine level on the prognosis of Chinese patients with first-onset ischemic stroke显示文摘Epidemiological studies show that increased plasma total homocysteine(tHcy)level was an independ-ent risk factor of cardiovascular diseases.This study was aimed to investigate the relationship between tHcy level and prognosis of first-onset stroke in Chinese people.One hundred ninety six patients with first-onset ischemic stroke and ninety-five patients with first-onset hemorrha-gic stroke were enrolled in this study.The patients were divided into two groups in terms of tHcy level(,18 mmol/L and>18 mmol/L).The plasma tHcy level was detected by a high performance liquid chromatography method with fluorescence detection.All the patients underwent a 5-year follow-up.Survival analysis shows that the probability of death or new vascular events in the ischemic stroke patients with high tHcy level(>18 mmol/L)was significantly higher than that in the counter-parts with lower tHcy level(,18 mmol/L)(50.9%and 28.7%,respectively,P 50.004).The relative risk of death or new vascular events was 2.363(95%CI,1.209 to 4.617,P 50.012)in ischemic stroke patients with high tHcy levels(>18 mmol/L)compared to those with a lower tHcy level(,18 mmol/L).The increased tHcy level was significantly associated with the risk of death or new vascular events(OR,2.492,95%CI,1.148 to 5.407,P 50.021)in patients with ischemic stroke in the exclusion of the influence of other risk factors such as gender,age,body mass index,plasma cholesterol level,the history of hypertension,diabetes or smoking.However,in the patients with hemorrhagic stroke,there was no significant difference in the probability of death or new vascular events between patients with a high tHcy level and those with a lower tHcy level(33.3%and 28.2%,respectively,P 50.546).Increased tHcy level was an independent risk factor for a worse outcome in patients with first-onset ischemic stroke,but not in hemorrhagic stroke patients. | Jiangtao YAN Zhengliang YUE Jiaomei SHAO Rutai HUI Daowen WANG | 2008 | Frontiers of Medicine2008，2，4： | 0 |
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