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| 1 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 2 | Ginger-indirect moxibustion plus acupuncture versus acupuncture alone for chronic fatigue syndrome:a randomized controlled trial显示文摘OBJECTIVE:To assess the efficacy and safety of gingerindirect moxibustion for chronic fatigue syndrome(CFS).METHODS:In this central randomized,controlled trial,290 CFS participants were recruited and randomly allocated to group A(ginger-indirect moxibustion plus acupuncture)or group B(acupuncture alone).The study consisted of a treatment period of 8 weeks with a total of 24 treatments(3 sessions per week,every other day),and a follow-up period of 12 weeks.The outcome was measured by Fatigue Severity Scale(FSS),Psychological Health Report(SPHERE),the Self-rating depression scale(SDS)and the Hamilton anxiety scale(HAMA)at baseline,2,4,6,8,12 and 20 weeks.RESULTS:With the treatment undergoing,the changes of FSS,SPHERE,SDS and HAMA scores in both groups increased gradually,and the effect maintained at the 12th week.Between groups,significantly higher score changes were seen in group A in FSS after 4 weeks treatment(11.94 vs 9.12,95%CI:0.94,4.7)and in SPHERE after 2 weeks treatment(3.7 vs 2.27,95%CI:0.56,2.31).But for SDS and HAMA,the improvement did not differ significantly between groups.No severe adverse events were reported.CONCLUSION:Ginger-indirect moxibustion is a safe and effective intervention to relieve fatigue and accompanying physical symptoms of CFS. | MA Tingting WU Jie YANG Lijie FENG Fen YANG Huilin ZHANG Jinhua ZHONG Yanjin NING Qing HUANG Lirong LIN Youbing YAN Jue CHEN Guiquan HOU Tianshu WANG Li REN Yuanfang TAN Jing | 2022 | Journal of Traditional Chinese Medicine2022，42，2： | 2 |
| 3 | Clinical significance of assessing Her2/neu expression in gastric cancer with dual tumor tissue paraffin blocks显示文摘 | Xiaowen Ge Haixing Wang Haiying Zeng Xuejuan Jin Akesu Sujie Chen Xu Yalan Liu Jie Huang Yuan Ji Yunshan Tan Tianshu Liu Yingyong Hou Jing Qin Yihong Sun Xinyu Qin | 2015 | Human Pathology2015，，6： | 1 |
| 4 | Natural co-infection of fowl adenovirus type E-8b and avian hepatitis E virus in parental layer breeders in Hebei,China显示文摘Dear Editor,Fowl adenovirus(FAdV)and avian hepatitis E virus(aHEV)are the most important causative agents of hepatic injury,representing one of the greatest health concerns in layer chicken flocks(LCFs)in China and causes substantial economic losses.FAdVs are non-enveloped,double-stranded DNA viruses containing a genome of 43–45 kb in size and belong to the genus Aviadenovirus in the family of Adenoviridae(Hess,2000).Based on restriction enzyme digestion patterns and serum cross-neutralization tests,FAdV is currently clustered into five species(FAdV-A–FAdV-E)with 12 serotypes(FAdV-1 to-7,FAdV-8a,FAdV-8b,and FAdV-9 to-11).Different serotypes of FAdVs cause different clinical symptoms in poultry flocks.FAdV-1 can induce gizzard erosion in chickens,whereas inclusion body hepatitis(IBH)in chickens is often associated with FAdV-2,-8a,-8b,and-11.FAdV-4 causes hydropericardium hepatitis syndrome and IBH in chickens,and its infections have caused severe economic losses in the global poultry industry(Ye et al.,2016).Avian hepatitis E virus(aHEV)is a major causative agent of big liver and spleen disease(BLS),hepatitis splenomegaly syndrome,and hepatic rupture hemorrhage syndrome(HRHS)in chickens(Sun et al.,2019). | Lidan Hou Zengna Chi Yawen Zhang Qi Xue Tianshu Zhai Shuang Chang Jia Wang Peng Zhao | 2023 | Virologica Sinica2023，38，2： | 0 |
| 5 | Electronic properties and tunability in graphene/3D-InP mixed-dimensional van der Waals heterostructure显示文摘InP solar cell is promising for space application due to its strong space radiation resistance and high power conversion efficient(PCE).Graphene/InP heterostructure solar cell is expected to have a higher PCE because strong near-infrared light can also be absorbed and converted additionally by graphene in this heterostructure.However,a low PCE was reported experimentally for Graphene/InP heterostructures.In this paper,electronic properties of graphene/InP heterostructures are calculated using density functional theory to understand the origin of the low PCE and propose possible improving ways.Our calculation results reveal that graphene contact with InP form a p-type Schottky heterostructure with a low Schottky barrier height(SBH).It is the low SBH that leads to the low PCE of graphene/InP heterostructure solar cells.A new heterostructure,graphene/insulating layer/InP solar cells,is proposed to raise SBH and PCE.Moreover,we also find that the opened bandgap of graphene and SBH in graphene/InP heterostructures can be tuned by exerting an electric field,which is useful for photodetector of graphene/InP heterostructures. | Qingyun Zhou Yusheng Hou Tianshu Lai | 2023 | Frontiers of physics2023，18，2： | 0 |
| 6 | The Truth,Good,and Beauty of the Craftsman Spirit in the New Era显示文摘The construction and development of the craftsman spirit in the new era needs to be based on the essence of the Craftsman spirit in the new era.The thinking on the essence of the craftsman spirit in the new era is carried out from three dimensions:from the perspective of epistemology,the craftsman spirit in the new era is the intention of human beings to master the unknown.The embodiment of the original desire;from the perspective of ethics,the craftsman spirit of the new era is the extension of good;from the perspective of aesthetics,the craftsman spirit of the new era is the pursuit of beauty.Thinking about the essence of craftsman spirit in the new era provides goals,content,carriers,and means for the construction and development of craftsman spirit in the new era. | HOU Tianshu CHEN Hongbing | 2022 | Journal of Philosophy Study2022，12，9： | 0 |
| 7 | Association of branched-chain amino acid intake trajectory in adulthood with the risk of type 2 diabetes and its related risk factors显示文摘To the Editor:Type 2 diabetes(T2D)showed increasing prevalence worldwide and put a huge burden on healthcare systems.[1]Branched-chain amino acids(BCAAs,including Leucine,Isoleucine,and Valine),a prominent group of essential amino acids,are important nutrition signals that have important effects on protein synthesis,glucose homeostasis,and nutrient-sensitive signaling pathways.Plasma BCAA can predict the development of T2D,whereas the studies of dietary BCAA on T2D risk showed conflicting results.[2]Most of the researches about dietary BCAAs used a single or limited number of measurements,ignoring the dynamic changes of dietary BCAA levels throughout life and their relevance to the development of diabetes.A life-course approach using multiple dietary BCAA measurements over time may shed new light on dietary BCAA trajectories and their relation to T2D risk.Therefore,in the current study,we first use latent class mixed model(LCMM)to characterize BCAA intake trajectories over 18 years in longitudinal data from China and investigate the association of BCAA intake trajectories with the risk of T2D and its biomarkers after adjusting for potential confounding factors. | Weiqi Wang Tianshu Han Wanying Hou Xiyun Ren Wei Duan Zhipeng Liu Changhao Sun | 2022 | Chinese Medical Journal2022，，1： | 0 |
| 8 | Generation of mode‑locked states of conventional solitons and bright‑dark solitons in graphene mode‑locked fber laser显示文摘This paper proposes a mode-locked fber laser based on graphene-coated microfber.The total length of the fber laser resonant cavity is 31.34 m.Under the condition of stable output of bright-dark soliton pairs from the fber laser,dual-wavelength tuning is realized by adjusting the polarization controller(PC),and the wavelength tuning range is 11 nm.Furthermore,the efects of polarization states on bright-dark solitons are studied.It is demonstrated that the mode-locking state can be switched between conventional solitons and bright-dark solitons in the graphene mode-locked fber laser.Bright-dark soliton pairs with diferent shapes and nanosecond pulse width can be obtained by adjusting the PC and pump power. | Zixiong Li Mingyu Li Xinyi Hou Lei Du Lin Xiao Tianshu Wang Wanzhuo Ma | 2023 | Frontiers of Optoelectronics2023，16，2： | 0 |
| 9 | Negative correlation between acetyl-CoA acyltransferase 2 and cetuximab resistance in colorectal cancer显示文摘The emergence of anti-EGFR therapy has revolutionized the treatment of colorectal cancer(CRC).However,not all patients respond consistently well.Therefore,it is imperative to conduct further research to identify the molecular mechanisms underlying the development of cetuximab resistance in CRC.In this study,we find that the expressions of many metabolism-related genes are downregulated in cetuximab-resistant CRC cells compared to their sensitive counterparts.Specifically,acetyl-CoA acyltransferase 2(ACAA2),a key enzyme in fatty acid metabolism,is downregulated during the development of cetuximab resistance.Silencing of ACAA2 promotes proliferation and increases cetuximab tolerance in CRC cells,while overexpression of ACAA2 exerts the opposite effect.RTK-Kras signaling might contribute to the downregulation of ACAA2 expression in CRC,and ACAA2 predicts CRC prognosis in patients with Kras mutations.Collectively,our data suggest that modulating ACAA2 expression contributes to secondary cetuximab resistance in Kras wild-type CRC patients.ACAA2 expression is related to Kras mutation and demonstrates a prognostic role in CRC patients with Kras mutation.Thus,ACAA2 is a potential target in CRC with Kras mutation. | Yitao Yuan Xun Sun Mengling Liu Suyao Li Yu Dong Keshu Hu Jiayu Zhang Bei Xu Sining Ma Hesheng Jiang Pengcong Hou Yufu Lin Lu Gan Tianshu Liu | 2023 | Acta Biochimica et Biophysica Sinica2023，55，9： | 0 |
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