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| 1 | Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors显示文摘Multipotent 神经干细胞为房间治疗保持大诺言。到导致的 pluripotent 干细胞以及成熟神经原的成纤维细胞的 reprogramming 建议可能性没有首先建立 pluripotency,把一个严重地区分的体的房间变换成一个 multipotent 状态。这里,我们证明房间从中层导出的那 Sertoli 能直接被变换成拥有神经干细胞性质的一个 multipotent 状态。导致的神经干细胞(iNSCs ) 表示多重 NSC 特定的标记,展出类似于正常 NSC 的全球基因表示侧面,并且能够自强并且区分功能的神经原进神经胶质并且 electrophysiologically。为酷氨酸 hydroxylase (TH ) 积极的导出 iNSC 的神经原污点, γ -aminobutyric 酸,和胆碱 acetyltransferase。另外, iNSCs 能熬过并且产生跟随移植进有牙齿的回转的触处。iNSCs 的产生可以为疾病建模和再生药有重要含意。 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Libin Wang Wei Li Haijiang Zhang Xiao-Yang Zhao Lei Liu Ziwei Wang Changlong Guo Hua-Jun Wu Zhonghua Liu Liu Wang Shigang He Xiu-Jie Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，1： | 31 |
| 2 | Palaeogeothermal response and record of the effusing of Emeishan basalts in the Sichuan basin显示文摘Thermal history of the Sichuan basin is reconstructed based on vitrinite reflectance from boreholes in the basin using a paleo-heat flow method.The results show that the Sichuan basin experienced a relatively low heat flow period in the Early Paleozoic,and an elevated paleo-heat flow,ranging 60-80 mW/m2 with a maximum as high as 100 mW/m2 around 259 Ma,from the beginning of the Late Paleozoic to the end of the early Permian,and a decreased paleo-heat flow from the late Permian to the late Triassic,and then maintained nearly stable to the present.The Late Paleozoic paleo-heat flow was quite high where there were extensive Emeishan flood basalts or concealed basalts which erupted between the early and the late Permian,such as the southwestern and northeastern areas of the Sichuan basin.According to the distribution of paleo-heat flow,it can be inferred that,the northeastern Sichuan basin was also influenced by the Emeishan magmatic activity during the Dongwu movement though there was lack of Emeishan flood basalts.In addition,the results of thermal history reconstruction of the Sichuan basin provide paleogeothermal evidence for the existence and onset of the Emaishan mantle plume. | ZHU ChuanQing XU Ming YUAN YuSon ZHAO YongQing SHAN JingNan HE ZhiGuo TIAN YunTao HU ShengBiao | 2010 | Chinese Science Bulletin2010，55，10： | 30 |
| 3 | Testing method and distribution characteristics of spatial pesticide spraying deposition quality balance for unmanned aerial vehicle显示文摘In order to explore the spatial pesticide spraying deposition distribution,the downwash flow field characteristics for unmanned aerial vehicle(UAV)pesticide application with accurate flight height and velocity and the relationship of these two aspects,a novel measurement method was proposed in this paper.A model‘3WQF80-10’single-rotor diesel UAV was tested using this method in wheat field and the effects of flight direction,flight parameters and crosswind on the distribution of spatial spraying deposition quality balance(SSDQB)and the downwash flow field distribution were researched.A cuboid aluminum sampling frame of spatial spraying deposition quality balance(SFSSDQB)with monofilament wires was made for collecting the droplets in four directions,and a set of multi-channel micro-meteorology measurement system(MMMS)was applied for measuring the downwash wind speed in three directions.Besides,BeiDou Navigation Satellite System(BNSS)was used for controlling and recording the working height,velocity and track of this model of single-rotor UAV.The results showed the distribution of the spatial spray deposition and the downwash flow field of UAV could be measured effectively at exact flight height and velocity via this method.When the average wind speed was 0.9 m/s,the average temperature was 31.5℃ and the average relative humidity was 34.1%,and the average distribution ratios of spraying deposition for model‘3WQF80-10’UAV on the upwind part,the top part,the downwind part and the bottom part were 4.4%,2.3%,50.4%and 43.7%,respectively.The flight directions of forward and backward had an impact on droplet deposition distribution and the working effect of flying backwards,with 60%of deposition ratio of the bottom part of the SFSSDQB,was better than flying forward.There was a linear negative correlation between the coefficient of variation(CV)of the bottom part and the flight height and the coefficient of determination was 0.9178,which means that the deposition distribution becomes more uniform with the increase of height.Additionally,there was a linear positive correlation between weighted mean deposition rate and crosswind speed and the coefficient of determination was 0.9684,which shows the deposition distribution gets more concentrated towards the downwind part with the rise of crosswind speed.Therefore,according to the results of tests of downwash airflow speed,it is shown that regardless of the flight direction and height and the crosswind,all these factors influence the droplet deposition distribution via weakening the intensity of the downwash airflow field in the direction perpendicular to the ground.The results can provide valuable information for the research of UAV pesticide application techniques and the establishment of the standard of spraying deposition and drift tests of UAV in crop field. | Changling Wang Xiongkui He Xiaonan Wang Zhichong Wang Shilin Wang Longlong Li Jane Bonds Andreas Herbst Zhiguo Wang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，2： | 14 |
| 4 | Effects of vegetation on flow conveyance and sediment transport capacity显示文摘In-stream and riparian vegetation may significantly affect flow and sediment transport in vegetated channels. A hydraulic model has been developed in this paper to compute the flow discharge in channels with rigid and flexible vegetation under emergent and submerged conditions. An empirical formula has also been presented to determine the bed-load discharge in vegetated channels. The model has been tested against experimental and field data available in the literature. The computed flow discharge and bed-load transport rate agree well with the measured data. | Weiming WU Zhiguo HE | 2009 | International Journal of Sediment Research2009，24，3： | 13 |
| 5 | Surface pollen assemblages of human-disturbed vegetation and their relationship with vegetation and climate in Northeast China显示文摘Pollen assemblages of 53 surface pollen samples from farmlands and wastelands in Northeast China were analyzed. Tree pollen percentages were usually higher than 30%, with Pinus (26.9%), Quercus (0.9%), Betula (0.9%) and Populus (0.7%) as the major types, and herb pollen percentages were usually higher than 50%, with weedy Poaceae (8.7%), Chenopodiaceae (7.1%), Artemisia (1.9%) and Compositae (3.5%) as the major taxa. Thus, the pollen assemblages were consistent with the regional vegetation compositions. However, there were differences in pollen assemblages among regions, especially among different geomorphological units. For example, in the mountains, there were more types of tree pollen and higher total percentages (average 42%) than in other areas, while cereal pollen percentages were lowest (11.2%). In the hills and high plains, herbs made up more than 60% of the pollens, with cereals (average 53.6%) the dominant type. In the low plains, pollen types were similar to those in the hills and high plains, but total pollen concentrations and the proportion of Concentricystes were much higher, while cereal pollen percentages were slightly lower (average 41.6%). Pollen assemblages in different land use types also differed. For example, in farmland, cereal pollen percentages were more than 40% and Chenopodiaceae was usually less than 2.5%, while in wasteland, weedy Poaceae was usually less than 10% and Chenopodiaceae was usually higher than 25%. Total pollen concentrations in farmland (average 3909 grains/g) were much lower than in wasteland (average 15074 grains/g). Redundancy analysis revealed that pollen assemblages were significantly negatively correlated with mean annual temperature (-0.73) and July mean temperature (-0.81) and significantly positively correlated with mean annual precipitation (0.48), indicating that pollen assemblages in the artificial or human-disturbed vegetation reflect regional climate well. Comparison of pollen assemblages in different areas of northern China showed that pollen concentrations reflect the intensities of human impact to some degree. For example, pollen concentrations decrease as human impacts increase in intensity. The cereal pollen proportions in farmland differed by area. In Northeast China, cereal pollen proportions were distinctly higher than in most other areas of northern China, suggesting differences in planting habits and climate. | LI ManYue LI YueCong XU QingHai PANG RuiMing DING Wei ZHANG ShengRui HE ZhiGuo | 2012 | Chinese Science Bulletin2012，57，5： | 10 |
| 6 | Rehabilitation and Sustainable Use Pattern of Rocky-desertified Land in Southwest China’s Poverty-stricken Karst Mountainous Areas——A Case Study in Benggu Township, Xichou County, Yunnan, China显示文摘The rocky desert in a karst area directly causes the lack of soil, water and forest, hence leading to the poverty there. In 1990, the villagers from the Muzhe Village in Benggu Township, Xichou County, Yunnan declared a war against rocky desert in an attempt to ask the fields for more yields. They invented a distinctive land rehabilitation and sustainable use pattern called “transforming heavenand earth” that had been practiced in Southwest China’s karst areas. The key mechanism of the pattern was to develop terraced fields with well conserved soil, water and fertility by exploding rocks in the fields, building stone walls, gathering more soil, and improving soil quality and productivity for the fields in combination with building of irrigation facilities and roads, as well as with forestation and agriculture structure adjustment. The purpose of the pattern was to alleviate poverty in the karst areas by improving soil productivity and promoting agriculturaldevelopment. A typical area was studied with the help of Participatory Rural Appraisal (PRA) and the pattern was carried out there for fifteen years, have produced excellent ecological benefits and good economic benefits. Its application in the area approved that it was a sustainable land use pattern for rocky desert areas. | YANG Zisheng LIU Yansui BAO Guangjing LI Zhiguo HE Yimei | 2006 | Journal of Mountain Science2006，3，3： | 10 |
| 7 | Construction of China Osmanthus City and Intellectual Property Right Protection in Xianning City in the Context of Three New Developments显示文摘Xianning City of Hubei Province is one of the five major traditional osmanthus producing areas in the world and the hometown of osmanthus in China. Xianning is constructing China Osmanthus City in the whole city. This paper first introduces the main characteristics of the osmanthus industry in Xianning City, and analyzes the characteristics of traditional knowledge, biological genetic resources, new plant varieties, patents, geographical indications, and trademarks. Then, it studies the intellectual property resources of the osmanthus industry, and analyzes the main problems existing in the construction of China Osmanthus City and intellectual property right protection. Finally, it comes up with constructive recommendations including applying for China and Globally Important Agricultural Heritage Systems, developing colored-leaf osmanthus varieties, creating a regional public brand of osmanthus specialty products, and building a new development pattern of osmanthus industry. | Li GAO Zhiguo SUN Yueqiu HE Jiandong LAI Hongguo CHEN | 2022 | Asian Agricultural Research2022，14，9： | 9 |
| 8 | Preliminary analysis of spatiotemporal pattern of global land surface water显示文摘Land surface water(LSW) is one of the most important resources for human survival and development, and it is also a main component of global water recycling. A full understanding of the spatial distribution of land surface water and a continuous measuring of its dynamics can support to diagnose the global ecosystem and environment. Based on the Global Land 30-water 2000 and Global Land 30-water 2010 products, this research analyzed the spatial distribution pattern and temporal fluctuation of land surface water under scale-levels of global, latitude and longitude, continents, and climate zones. The Global Land 30-water products were corrected the temporal inconsistency of original remotely sensed data using MODIS time-series data, and then calculated the indices such as water area, water ration and coefficient of spatial variation for further analysis. Results show that total water area of land surface is about 3.68 million km2(2010), and occupies 2.73% of land area. The spatial distribution of land surface water is extremely uneven and is gathered mainly in mid- to high-latitude area of the Northern Hemisphere and tropic area. The comparison of water ratio between 2000 and 2010 indicates the overall fluctuation is small but spatially differentiated. The Global Land 30-water products and the statistics provided the fundamental information for analyzing the spatial distribution pattern and temporal fluctuation of land surface water and diagnosing the global ecosystem and environment. | CAO Xin CHEN Jun CHEN LiJun LIAO AnPing SUN FangDi LI Yang LI Lei LIN ZhongHui PANG ZhiGuo CHEN Jin HE ChaoYing PENG Shu | 2014 | Science China Earth Sciences2014，57，10： | 8 |
| 9 | In vitro effect of iASPP on cell growth of oral tongue squamous cell carcinoma显示文摘iASPP is an inhibitory member of the apoptosis-stimulating proteins of P53(ASPP) family. iASPP is over expressed in several malignant tumors and potentially affects cancer progression. However, the expression and potential role of iASPP in oral tongue squamous cell carcinoma(OTSCC) have not been addressed. In our study, we detected iASPP expression in OTSCC by immunohistochemistry. iASPP expression is up-regulated in OTSCC tissues. Moreover, in clinical pathology specimens, we found that increased iASPP expression correlates with poor differentiation and lymph node metastasis. Using multicellular tumor spheroids(MTS) and flow cytometry, we demonstrated that iASPP down-regulation arrests OTSCC cells at the G0/G1 phase, induces OTSCC cell apoptosis and inhibits OTSCC cell proliferation. These results indicate that iASPP plays a significant role in the progression of OTSCC and may serve as a biomarker or therapeutic target for OTSCC patients. | Yu Chen Wangxiang Yan Shuqi He Jiechun Chen Dan Chen Zhaoqiang Zhang Zhiguo Liu Xueqiang Ding Anxun Wang | 2014 | Chinese Journal of Cancer Research2014，26，4： | 7 |
| 10 | A formal model for access control with supporting spatial context显示文摘There is an emerging recognition of the importance of utilizing contextual informa tion in authorization decisions. Controlling access to resources in the field of wireless and mobile networking require the definition of a formal model for access control with supporting spatial context. However, traditional RBAC model does not specify these spatial requirements. In this paper, we extend the existing RBAC model and propose the SC-RBAC model that utilizes spatial and location-based information in security policy definitions. The concept of spatial role is presented, and the role is assigned a logical location domain to specify the spatial boundary. Roles are activated based on the current physical position of the user which obtained from a specific mobile terminal. We then extend SC-RBAC to deal with hierarchies, modeling permission, user and activation inheritance, and prove that the hierarchical spatial roles are capable of constructing a lattice which is a means for articulate multi-level security policy and more suitable to control the information flow security for safety-critical location-aware information systems. Next, constrained SC-RBAC allows express various spatial separations of duty constraints, location-based cardinality and temporal constraints for specify fine-grained spatial semantics that are typical in location-aware systems. Finally, we introduce 9 invariants for the constrained SC-RBAC and its basic security theorem is proven. The constrained SC-RBAC provides the foundation for applications in need of the constrained spatial context aware access control. | ZHANG Hong HE YePing SHI ZhiGuo | 2007 | Science in China(Series F)2007，50，3： | 7 |
| 11 | Intellectual Property Protection and High-quality Development of Cotton Industry in Xinjiang显示文摘This paper firstly introduces the general situation of cotton planting areas in China and cotton industry in Xinjiang,and the current situation of intellectual property protection of Xinjiang's cotton industry.Then,it analyzes the main problems in its intellectual property protection and high-quality development.On this basis,it comes up with the recommendations for high-quality development of cotton industry in Xinjiang under the strategy of strengthening the country with intellectual property.The recommendations include improving the level of creation of creative intellectual property rights,building an intellectual property rule system in the entire cotton industry chain in Xinjiang,building protected zones for production of major high quality agricultural product cotton,establishing a demonstration zone to undertake the transfer of the domestic cotton textile and garment industry,undertaking education on the sense of community for the Chinese nation in response to the Xinjiang cotton incident,and developing the'Belt and Road'blue market for Xinjiang cotton and its products. | Miaomiao XU Yueqiu HE Wanzhen XIONG Chengshun SONG Zhiguo SUN | 2022 | Asian Agricultural Research2022，14，6： | 7 |
| 12 | Cotton Breeding in Xinjiang and Its Intellectual Property Protection显示文摘In 2021,Xinjiang's cotton output was 5.129 million t,accounting for 89.50%of China's total.The autonomous region produces high-quality long-staple cotton,natural colored cotton,fine-staple cotton(upland cotton),organic cotton,etc.The southern Xinjiang cotton area is one of the three major long-staple cotton(island cotton)producing regions in the world.This paper introduced the history of cotton planting and breeding in Xinjiang from the aspects of cultural relics records,history of entering Xinjiang,historical achievements of breeding and breeding leaders.We studied the intellectual property protection of cotton breeding in the autonomous region from the aspects of biological genetic resources,invention patents,utility model patents and new plant varieties,analyzed the six main problems existing in cotton breeding and its intellectual property protection,and discussed the tactics for cotton breeding and its intellectual property protection in Xinjiang under the strategy of strengthening the country with intellectual property.Eight suggestions in response to the Xinjiang cotton incident were also put forward,including establishing a Xinjiang national cotton germplasm nursery,protecting biological genetic resources,and strengthening the protection of creative intellectual property rights in the field of breeding to escort technological innovation in the cotton seed industry. | Miaomiao XU Wanzhen XIONG Yueqiu HE Chengshun SONG Zhiguo SUN | 2022 | Agricultural Biotechnology2022，11，4： | 7 |
| 13 | Comparative genomic and transcriptomic analyses uncover the molecular basis of high nitrogen-use efficiency in the wheat cultivar Kenong 9204显示文摘Studying the regulatory mechanisms that drive nitrogen-use efficiency(NUE)in crops is important for sustainable agriculture and environmental protection.In this study,we generated a high-quality genome assembly for the high-NUE wheat cultivar Kenong 9204 and systematically analyzed genes related to nitrogen uptake and metabolism.By comparative analyses,we found that the high-affinity nitrate transporter gene family had expanded in Triticeae.Further studies showed that subsequent functional differentiation endowed the expanded family members with saline inducibility,providing a genetic basis for improving the adaptability of wheat to nitrogen deficiency in various habitats.To explore the genetic and molecular mechanisms of high NUE,we compared genomic and transcriptomic data from the high-NUE cultivar Kenong 9204(KN9204)and the low-NUE cultivar Jing 411 and quantified their nitrogen accumulation under high-and low-nitrogen conditions.Compared with Jing 411,KN9204 absorbed significantly more nitrogen at the reproductive stage after shooting and accumulated it in the shoots and seeds.Transcriptome data analysis revealed that nitrogen deficiency clearly suppressed the expression of genes related to cell division in the young spike of Jing 411,whereas this suppression of gene expression was much lower in KN9204.In addition,KN9204 maintained relatively high expression of NPF genes for a longer time than Jing 411 during seed maturity.Physiological and transcriptome data revealed that KN9204 was more tolerant of nitrogen deficiency than Jing 411,especially at the reproductive stage.The high NUE of KN9204 is an integrated effect controlled at different levels.Taken together,our data provide new insights into the molecular mechanisms of NUE and important gene resources for improving wheat cultivars with a higher NUE trait. | Xiaoli Shi Fa Cui Xinyin Han Yilin He Long Zhao Na Zhang Hao Zhang Haidong Zhu Zhexin Liu Bin Ma Shusong Zheng Wei Zhang Jiajia Liu Xiaoli Fan Yaoqi Si Shuiquan Tian Jianqing Niu Huilan Wu Xuemei Liu Zhuo Chen Deyuan Meng Xiaoyan Wang Liqiang Song Lijing Sun Jie Han Hui Zhao Jun Ji Zhiguo Wang Xiaoyu He Ruilin Li Xuebin Chi Chengzhi Liang Beifang Niu Jun Xiao Junming Li Hong-Qing Ling | 2022 | Molecular Plant2022，15，9： | 6 |
| 14 | Implementation of an efficient segregated algorithm-IDEAL on 3D collocated grid system显示文摘The segregated algorithm-IDEAL (inner doubly-iterative efficient algorithm for linked-equations) is an efficient and stable algorithm. In this algorithm, there exist inner doubly-iterative processes for pres-sure equation, which almost completely overcome two approximations in SIMPLE algorithm. Thus the coupling between velocity and pressure is fully guaranteed, greatly enhancing the convergence rate and stability of iteration process. In this paper, implementation of the IDEAL algorithm on a 3D collo-cated grid system is conducted. The interface velocity is calculated by the modified momentum inter-polation method (MMIM), by which the converged result is independent of the under-relaxation factor. Finally, five three-dimensional incompressible fluid flow and heat transfer problems are provided to compare the convergence rate and robustness between the IDEAL and three other most widely-used algorithms (SIMPLER, SIMPLEC and PISO). By the comparison it can be concluded that the IDEAL al-gorithm is more robust and efficient than the three other algorithms. | SUN DongLiang QU ZhiGuo HE YaLing Tao WenQuan | 2009 | Chinese Science Bulletin2009，54，6： | 5 |
| 15 | Numerical simulation of dam-break flow and bed change considering the vegetation effects显示文摘Existing numerical investigations of dam-break flows rarely consider the effects of vegetation.This paper presents a depth-averaged two-dimensional model for dam-break flows over mobile and vegetated beds.In the model,both the consequences of reducing space for storing mass and momentum by the existence of vegetation and dragging the flow are considered:the former is considered by introducing a factor(1-c) to the flow depth,where c is the vegetation density;the later is considered by including an additional sink term in the momentum equations.The new governing equations are discretized by the finite volume method;and an existing second-order central-upwind scheme embedded with the hydrostatic reconstruction method for water depth,is used to estimate the fluxes;the source terms are estimated by either explicit or semi-explicit methods fulfilling the stability requirement.Laboratory experiments of dam-break flows or quasi-steady flows with/without vegetation effects/sediment transport are simulated.The good agreements between the measurements and the numerical simulations demonstrate a satisfactory performance of the model in reproducing the flow depth,velocity and bed deformation depth.Numerical case studies of six scenarios of dam-break flows over a mobile and vegetated bed are conducted.It is shown that when the area of the vegetation zone,the vegetation density,and the pattern of the vegetation distribution are varied,the resulted bed morphological change differs greatly,suggesting a great influence of vegetation on the dam-break flow evolution.Specifically,the vegetation may divert the direction of the main flow,hindering the flow and thus result in increased deposition upstream of the vegetation. | Zhiguo He Ting Wu Haoxuan Weng Peng Hu Gangfeng Wu | 2017 | International Journal of Sediment Research2017，32，1： | 5 |
| 16 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 17 | A Study on Intellectual Property Right Protection of Geographical Indications and Regional Public Brand Building in Xinjiang显示文摘This paper studies the geographical indication resources of Xinjiang and their distribution in administrative regions,national grain production functional zones,protected zones for production of major agricultural products,advantageous areas of Chinese characteristic agricultural products,and national advantageous characteristic industrial clusters.It analyzes the main problems existing in the protection of intellectual property rights of geographical indications.Besides,it discusses the strategies for the protection of intellectual property rights of geographical indications in the autonomous region and the building of regional public brands in the contest of the strategy of strengthening the country with intellectual property and rural revitalization strategy.Finally,it comes up with recommendations,including collecting and sorting out the human factors and natural factors of geographical indications of famous,excellent and special products,strengthening the protection of geographical indications of Xinjiang cotton and its products,enhancing the protection of geographical indications of grain and oil crops and sugar beet,implementing the protection of geographical indications for products with special needs for ethnic minorities,building national geographical indication product protection demonstration areas,formulating national and international standards for geographical indication products,and take full advantage of the EU-China Agreement on Cooperation on and Protection of Geographical Indications to actively participate in the EU protection of geographical indications. | Miaomiao XU Chengshun SONG Yueqiu HE Wanzhen XIONG Zhiguo SUN | 2022 | Asian Agricultural Research2022，14，7： | 5 |
| 18 | Inheritance,Innovation and High-quality Development of Tea Industry in Xianning City,Hubei Province显示文摘Xianning City is a main tea producing area in Hubei Province,the capital of'border-selling tea'in China,and an important starting point for the Ten-Thousand-Mile Tea Road across the Eurasian continent.This paper studies the tea industry in Xianning from the aspects of top 100 counties of tea industry,important agricultural cultural heritage,famous Chinese historical and cultural villages,China’s time-honored brands,major brands,and designated production enterprises of border-selling tea.Besides,it introduces intellectual property resources of the tea industry from traditional knowledge,biological genetic resources,new plant varieties,patents,geographical indications,trademarks,etc.Then,it analyzes major problems in the inheritance,innovation and high-quality development of Xianning tea,especially the border-selling tea.Finally,it comes up with constructive recommendations of starting the cultural inheritance and development project and upgrade project of the tea industry to build the capital of China’s border-selling tea. | Li GAO Zhiguo SUN Yueqiu HE Deying ZHANG Jiandong LAI Zhen CHEN | 2022 | Asian Agricultural Research2022，14，8： | 4 |
| 19 | Multi-dimensional overall regulatory modes and threshold values for water cycle of the Haihe River Basin显示文摘In this study, a multi-dimensional critical regulatory criteria and decision-making mechanism based on the scientific cognition of multi-dimensional attributes and characteristics of the water cycle was proposed. This system was functioned by deeply discriminating the nature-society binary characteristics of the five-dimensional characteristics of the water cycle system of the Haihe River Basin (water resources, economy, society, ecology, and environment) under the influence of high-intensity human activities and hydrological changes and by analyzing the organic interactive relationships between the five dimensions and their overall effect on the water cycle. A GDP calculation model was constructed in this study by adjusting the water environment for water resources, after which five-dimensional normalization objective functions were established for multi-objective analysis to carry out trade-off analysis of multi-dimensional regulatory indexes. In addition, synergetic theory, entropy theory and dissipation structure theory were introduced to construct an evaluation model for multi-dimensional regulatory schemes. A water cycle multi-dimensional critical overall regulatory model system was also established. This system consisted of a multi-objective macroeconomic model (DAMOS), water resource allocation model based on rules (ROWAS), evaluation model for WEDP (EMW) and multi-dimensional regulatory scheme evaluation model (SEAMUR) as the main body. To address the national demands faced by the Haihe River Basin as a result of combinatorial schemes for different hydrological series and water amounts diverted by the south-to-north water diversion project, this study adopted a hierarchy progression method to set up the technologies, investigated multi-dimensional overall regulatory methods, proposed an overall regulation threshold value for the water cycle of the Haihe River Basin, and recommended corresponding five-dimensional regulatory schemes. | GAN Hong WANG Lin CAO YinBai YOU JinJun GAN ZhiGuo QIN ChangHai HE Shan XU Kai | 2013 | Chinese Science Bulletin2013，58，27： | 4 |
| 20 | Elastic Scattering of 7Be on Pb Target显示文摘 | Yang Yanyun Wang Jiansong Wang Qi Huang Meirong Ma Junbing Ma Peng Cao Xiguang Han Jianlong Bai Zhen Jin Shilong Hu Qiang Jin Lei Chen Jiangbo Zhang Xueying Chen Ruofu Hu Zhengguo Xu Shiwei Zhen Chuan Xu Zhiguo Xu Hushan Duan Liming Sun Zhiyu Chen Zhiqiang He Jianjun Li Songlin Lei Xiangguo Fu Fen Zhang Xueheng Yuan Xiaohua Du Chengming Yan Xinshuang Hu Jun Tang Shuwen Ye Ruiping Yang Kun Shi Fudong Zhang Wei Chen Ze Li Long Xu Xing Liu Longxiang Zhang Liyong Lin Qingyun Gou Boxing Xu Ge Zhou Xionghong Zhang Yuhu Xiao Guoqing | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
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