| 1 | Measurements of dihadron correlations relative to the event plane in Au+Au collisions at√^(S)NN=200 GeV显示文摘Dihadron azimuthal correlations containing a high transverse momentum(pr)trigger particle are sensit-ive to the properties of the nuclear medium created at RHIC through the strong interactions occurring between the traversing parton and the medium,ie.jet-quenching.Previous measurements revealed a strong modification to di-hadron azimuthal correlations in Au+Au collisions with respect to ptp and d+Au collisions.The modification in-creases with the collision centrality,suggesting a path-length or energy density dependence to the je-quenching ef-fect.This paper reports STAR measurements of dihadron azimuthal correlations in mid-central(20%-60%)Au+Au collisions at√^(S)NN=200 GeV as a function of the trigger particle's azimuthal angle relative to the event plane,Ф_(s)=|Ф_(t)-ψ_(Ep)|.The azimuthal correlation is studied as a function of both the trigger and associated particle pr.The subtractions of the combinatorial background and anisotropic flow,assuming Zero Yield At Minimum(ZYAM),are described.The correlation results are first discussed with subtraction of the even harmonic(elliptic and quadrangu-lar)flow backgrounds.The away-side correlation is strongly modifed,and the modification varies withФ_(s),with a double-peak structure for out-of-plane trigger particles.The near-side ridge(long range pseudo-rapidity△_(η)correla-tion)appears to drop with increasingФ_(s)while the jet-like component remains approximately constant.The correla-tion functions are further studied with the subtraction of odd harmonic triangular flow background arising from fluc-tuations.It is found that the triangular flow,while responsible for the majority of the amplitudes,is not sufficient to explain theφs-dependence of the ridge or the away-side double-peak structure.The dropping ridge withФ_(s)could be attributed to aФ_(s)-dependent lliptie anisotropy;however,the physics mechanism of the ridge remains an open ques-tion.Even with aФ_(s)-dependent elliptic flow,the away-side correlation structure is robust.These results,with extens-ive systematic studies of the dihadron correlations as a function ofФ_(s),trigger and associated particle pT,and the pseudo-rapidity range△_(η),should provide stringent inputs to help understand the underlying physics mechanisms of jet-medium interactions in high energy nuclear collisions. | H.Agakishiev M.M.Aggarwal Z.Ahammed A.V.Alakhverdyants I.Alekseev J.Alford B.D.Anderson C.D.Anson D.Arkhipkin G.S.Averichev J.Balewski D.R.Beavis N.K.Behera R.Bellwied M.J.Betancourt R.R.Betts A.Bhasin A.K.Bhat H.Bichsel J.Bieleik J.Bielcikova B.Biritz L.C.Bland W.Borowski J.Bouchet E.Braidot A.V.Brandin A.Bridgeman S.G.Brovko E.Bruna S.Bueltmann I.Bunzarov T.P.Burton X.Z.Cai H.Caines M.Calderon de la Barca Sanchez D.Cebra R.Cendejas M.C.Cervantes Z.Chajecki P.Chaloupka S.Chattopadhyay H.F.Chen J.H.Chen J.Y.Chen L.Chen J.Cheng M.Cherney A.Chikanian K.E.Choi W.Christie P.Chung M.J.M.Codrington R.Corliss J.G.Cramer H.J.Crawford S.Dash A.Davila Leyva L.C.De Silvat R.R.Debbe T.G.Dedovich A.A.Derevschikov R.Derradi de Souza L.Didenko P.Djawotho S.M.Dogra X.Dong J.L.Drachenberg J.E.Draper J.C.Dunlop L.G Efimov M.Elnim J.Engelage G Eppley M.Estienne L.Eun O.Evdokimov R.Fatemi J.Fedorisin A.Feng R.G.Fersch P.Filip E.Finch V.Fine Y.Fisyak C.A.Gagliardi D.R.Gangadharan A.Geromitsos F.Geurts P.Ghosh Y.N.Gorbunov A.Gordon O.Grebenyuk D.Grosnick S.M.Guertin A.Gupta W.Guryn B.Haag O.Hajkova A.Hamed L-X.Han J.W.Harris J.P.Hays-Wehle M.Heinz S.Heppelmann A.Hirsch E.Hjort G.W.Hoffmann D.J.Hofiman B.Huang H.Z.Huang T.J.Humanic L.Huo G.Igo P.Jacobs W.W.Jacobs C.Jena F.Jin J.Joseph E.G.Judd S.Kabana K.Kang J.Kapitan K.Kauder H.Ke D.Keane A.Kechechyan D.Kettler D.P.Kikola J.Kiryluk A.Kisiel V.Kizka A.G.Knospe D.D.Koetke T.Kollegger J.Konzer I.Koralt L.Koroleva W.Korsch L.Kotchenda V.Kouchpil P.Kravtsov K.Krueger M.Krus L.Kumar P.Kurnadi M.A.C.Lamont J.M.Landgraf S.LaPointe J.Lauret A.Lebedev R.Lednicky J.H.Lee W.Leight M.J.LeVine C.Lil L.Li N.Li W.Li X.Li X.Li Y.Li Z.M.Li M.A.Lisa F.Liu H.Liu J.Liu T.Ljubicic W.J.Llope R.S.Longacre W.A.Love Y.Lu E.V.Lukashov X.Luo G.L.Ma Y.G.Mai D.P.Mahapatra R.Majka O.I.Mall L.K.Mangotra R.Manweiler S.Margetis C.Markert H.Masui H.S.Matis Yu.A.Matulenko D.MeDonald T.S.McShane A.Meschanin R.Milner N.G.Minaev S.Mioduszewski A.Mischke M.K.Mitrovski B.Mohanty M.M.Mondal B.Morozov D.A.Morozov M.G.Munhoz M.Naglis B.K.Nandi T.K.Nayak P.K.Netrakanti L.V.Nogach S.B.Nurushev G.Odyniec A.Ogawa Oh Ohlson V.Okorokov E.W.Oldag D.Olsont M.Pachr B.S.Page S.K.Pal Y.Pandit Y.Panebratsev T.Pawlak H.Pei T.Peitzmann C.Perkins W.Peryt S.C.Phatak P.Pile M.Planinic M.A.Ploskon J.Pluta D.Plyku N.Poljak A.M.Poskanzer B.V.K.S.Potukuchi C.B.Powell D.Prindle N.K.Pruthi A.M.Poskanzer B.V.K.S.Potukuchi B.Powell D.Prindle N.K.Pruthi P.R.Pujahar J.Putschke H.Qiu R.Raniwala S.Raniwala R.L.Ray R.Redwine R.Reed H.G.Riter J.B.Roberts O.V.Rogachevskiy J.L.Romero A.Rose L.Ruan J.Rusnak N.R.Sahoo S.Sakai I.Sakrejda T.Sakuma S.Salur J.Sandweiss E.Sangaline A.Sarkar J.Schambach R.P.Scharenberg A.M.Schmah N.Schmitz T.R.Schuster J.Seele J.Seger I.Selyuzhenkov P.Seyboth E.Shahaliev M.Shao M.Sharma S.S.Shi Q.Y.Shou E.P.Sichtermann F.Simon R.N.Singaraju M.J.Skoby N.Smirnov H.M.Spinka B.Srivastava T.D.S.Stanislaus D.Staszak S.G.Steadman J.R.Stevens R.Stock M.Strikhanov B.Stringfellow A.A.P.Suaide M.C.Suarez N.L.Subba M.Sumbera X.M.Sun Y.Sun Z.Sun B.Surrow D.N.Svirida T.J.M.Symons A.Szanto de Toledo J.Takahashi A.H.Tang Z.Tang L.H.Tarini T.Tarnowsky D.Thein J.H.Thomas J.Tian A.R.Timmins D.Tlusty M.Tokarev V.N.Tram S.Trentalange R.E.Tribble Tribedy O.D.Tsai T.Ullrich D.G.Underwood G.Van Buren G.van Nieuwenhuizen J.A.Vanfossen R.Varma G.M.S.Vasconcelos A.N.Vasiliev F.Videbaek Y.P.Viyogi S.Vokal M.Wadat M.Walker F.Wang G.Wang H.Wang J.S.Wang Q.Wang X.L.Wang Y.Wang G.Webb J.C.Webb G.D.Westfall C.Whitten H.Wieman S.W.Wissink R.Witt W.Witzke Y.F.Wu Xiao W.Xie H.Xu N.Xu Q.H.Xu W.Xu Y.Xu Z.Xu L.Xue Y.Yang P.Yepes K.Yip I-K.Yoo M.Zawisza H.Zbroszczyk W.Zhan J.B.Zhang S.Zhang W.M.Zhang X.P.Zhang Y.Zhang Z.P.Zhang J.Zhao C.Zhong W.Zhou X.Zhu Y.H.Zhu R.Zoulkarneev Y.Zoulkarneeva | 2021 | Chinese Physics C2021，45，4： | 351 |
| 3 | PLGA nanodepots co-encapsulating prostratin and anti-CD25 enhance primary natural killer cell antiviral and antitumor function显示文摘Natural killer(NK)cells are attractive effector cells of the innate immune system against human immunodeficiency virus(HIV)and cancer.However,NK cell therapies are limited by the fact that target cells evade NK cells,for example,in latent reservoirs(in HIV)or through upregulation of inhibitory signals(in cancer).To address this limitation,we describe a biodegradable nanoparticlebased“priming”approach to enhance the cytotoxic efficacy of peripheral blood mononuclear cell-derived NK cells.We present poly(lactic-co-glycolic acid)(PLGA)nanodepots(NDs)that co-encapsulate prostratin,a latency-reversing agent,and anti-CD25(aCD25),a cell surface binding antibody,to enhance primary NK cell function against HIV and cancer.We utilize a nanoemulsion synthesis scheme to encapsulate both prostratin and aCD25 within the PLGA NDs(termed Pro-aCD25-NDs).Physicochemical characterization studies of the NDs demonstrated that our synthesis scheme resulted in stable and monodisperse Pro-aCD25-NDs.The NDs successfully released both active prostratin and anti-CD25,and with controllable release kinetics.When Pro-aCD25-NDs were administered in an in vitro model of latent HIV and acute T cell leukemia using J-Lat 10.6 cells,the NDs were observed to prime J-Lat cells resulting in significantly increased NK cell-mediated cytotoxicity compared to free prostratin plus anti-CD25,and other controls.These findings demonstrate the feasibility of using our Pro-aCD25-NDs to prime target cells for enhancing the cytotoxicity of NK cells as antiviral or antitumor agents. | Elizabeth E.Sweeney Preethi B.Balakrishnan Allison B.Powell Allan Bowen Indra Sarabia Rachel A.Burga R.Brad Jones Alberto Bosque C.Russell Y.Cruz Rohan Fernandes | 2020 | Nano Research2020，13，3： | 0 |
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