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| 1 | Similarities and differences between biliary sludge and microlithiasis: Their clinical and pathophysiological significances显示文摘The terms biliary sludge and cholesterol microlithiasis(hereafter referred to as microlithiasis)were originated from different diagnostic techniques and may represent different stages of cholesterol gall-stone disease.Although the pathogenesis of biliary sludge and microlithiasis may be similar,micro-lithiasis could be preceded by biliary sludge,followed by persistent precipitation and aggregation of solid cholesterol crystals,and eventually,gallstone formation.Many clinical conditions are clearly associated with the formation of biliary sludge and microlithiasis,including total parenteral nutrition,rapid weight loss,pregnancy,organ transplantation,administration of certain medications,and a variety of acute and chronic illnesses.Numerous studies have demonstrated complete resolution of biliary sludge in approximately 40%of patients,a cyclic pattern of disappearing and reappearing in about 40%,and progression to gallstones in nearly 20%.Although only a minority of patients with ultrasonographic demonstration of biliary sludge develop gallstones,it is still a matter of controversy whether micro-lithiasis could eventually evolve to cholesterol gallstones.Biliary sludge and microlithiasis are asymp-tomatic in the vast majority of patients;however,they can cause biliary colic,acute cholecystitis,and acute pancreatitis.Biliary sludge and microlithiasis are most often diagnosed ultrasonographically and bile microscopy is considered the gold standard for their diagnosis.Specific measures to prevent the development of biliary sludge are not practical or cost-effective in the general population.Laparoscopic cholecystectomy offers the most definitive therapy on biliary sludge.Endoscopic sphincterotomy or surgical intervention is effective for microlithiasis-induced pancreatitis.Ursodeoxycholic acid can effectively prevent the recurrence of solid cholesterol crystals and significantly reduce the risk of recurrent pancreatitis. | Helen H.Wang Piero Portincasa Min Liu Patrick Tso David Q.-H.Wang | 2018 | Liver Research2018，2，4： | 3 |
| 2 | Effect of gallbladder hypomotility on cholesterol crystallization and growth in CCK-deficient mice显示文摘 | Helen H. Wang Piero Portincasa Min Liu Patrick Tso Linda C. Samuelson David Q.-H. Wang | 2009 | BBA - Molecular and Cell Biology of Lipids2009，，2： | 2 |
| 3 | Relationship between Myopia and Optical Components - A Study among Chinese Hong Kong Student Population显示文摘Purpose: To establish the prevalence and severity of myopia among the Chinese Hong Kong students and to study the relationship between myopia and optical components.Methods;One thousand and seventy-five freshmen of the 1993-1994 academic year in the Chinese University of Hong Kong underwent the eye examination including evaluation of refractive error, keratometry, and A-scan ultrasonic biometry. The data were analyzed with the SPSS/PC+4. 01 statistical package. Results: The prevalence of myopia was 91. 7% with the mean refraction being -4. 00 ± 2. 64D in this young adult population. The statistical analyses demonstrated a significant correlation between refractive value and axial length of the globe (r=-0. 78), vitreous length (r=-0. 76), anterior chamber depth (r=-0. 33), lens thickness (r = 0. 13) and corneal curvature (r = 0. 19). Conclusion: The refractive status is mainly dependent on the axial length. In general, the higher the myopia was, the longer the eyeball, the deeper the anterior chamber, | Peng Iob Lo Patrick CP Ho Joseph TF Lau Albert YK Cheung Ernst Goldschmidt Mark OM Tso | 1996 | Eye Science1996，16，3： | 2 |
| 4 | Consumption of a high-fat diet induces central insulin resistance independent of adiposity显示文摘 | Deborah J. Clegg Koro Gotoh Christopher Kemp Matthew D. Wortman Stephen C. Benoit Lynda M. Brown David D’Alessio Patrick Tso Randy J. Seeley Stephen C. Woods | 2011 | Physiology & Behavior2011，，1： | 1 |
| 5 | 载脂蛋白A-Ⅳ的研究进展显示文摘 | 李辉 徐贵发 Patrick Tso | 2004 | 预防医学文献信息2004，10，2： | 1 |
| 6 | Duodenal-Jejunal Exclusion Improves Glucose Tolerance in the Diabetic, Goto-Kakizaki Rat by a GLP-1 Receptor-Mediated Mechanism显示文摘 | Tammy L. Kindel Stephanie M. Yoder Randy J. Seeley David A. D’Alessio Patrick Tso | 2009 | Journal of Gastrointestinal Surgery2009，，10： | 1 |
| 7 | The mechanism of the formation and secretion of chylomicrons显示文摘 | Tammy Kindel Dana M. Lee Patrick Tso | 2010 | Atherosclerosis (Supplements) (Component)2010，，1： | 1 |
| 8 | Omega-3 fatty acid deficiency increases stearoyl-CoA desaturase expression and activity indices in rat liver: Positive association with non-fasting plasma triglyceride levels显示文摘 | Rylon Hofacer I. Jack Magrisso Ronald Jandacek Therese Rider Patrick Tso Stephen C. Benoit Robert K. McNamara | 2011 | Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)2011，，1： | 1 |
| 9 | Regulation of Intestinal and Hypothalamic Apolipoprotein A-Ⅳ显示文摘 | Min Liu Takashi Doi and Patrick Tso | 2003 | experimental Biology and Medicine2003，228，： | 1 |
| 10 | Enterohepatic circulation of organochlorine compounds: a site for nutritional intervention显示文摘 | Ronald J. Jandacek Patrick Tso | 2007 | The Journal of Nutritional Biochemistry2007，，3： | 1 |
| 11 | New insights into the role of Lith genes in the formation of cholesterol-supersaturated bile显示文摘Cholesterol gallstone formation represents a failure of biliary cholesterol homeostasis in which the physical-chemical balance of cholesterol solubility in bile is disturbed.Lithogenic bile is mainly caused by persistent hepatic hypersecretion of biliary cholesterol and sustained cholesterol-supersaturated bile is an essential prerequisite for the precipitation of solid cholesterol monohydrate crystals and the formation of cholesterol gallstones.The metabolic determinants of the supply of hepatic cholesterol molecules that are recruited for biliary secretion are dependent upon the input-output balance of cholesterol and its catabolism in the liver.The sources of cholesterol for hepatic secretion into bile have been extensively investigated;however,to what extent each cholesterol source contributes to hepatic secretion is still unclear both under normal physiological conditions and in the lithogenic state.Although it has been long known that biliary lithogenicity is initiated by hepatic cholesterol hypersecretion,the genetic mechanisms that cause supersaturated bile have not been defined yet.Identification of the Lith genes that determine hepatic cholesterol hypersecretion should provide novel insights into the primary genetic and pathophysiological defects for gallstone formation.In this review article,we focus mainly on the pathogenesis of the formation of supersaturated bile and gallstones from the viewpoint of genetics and pathophysiology.A better understanding of the molecular genetics and pathophysiology of the formation of cholesterol-supersaturated bile will undoubtedly facilitate the development of novel,effective,and noninvasive therapies for patients with gallstones,which would reduce the morbidity,mortality,and costs of health care associated with gallstones,a very prevalent liver disease worldwide. | Helen H.Wang Tiangang Li Piero Portincasa David A.Ford Brent A.Neuschwander-Tetri Patrick Tso David Q-H.Wang | 2017 | Liver Research2017，1，1： | 0 |
| 12 | 载脂蛋白A-Ⅳ对摄食的调节作用显示文摘尽管载脂蛋白A Ⅳ (apo AⅣ )表现出许多重要的生理功能 ,但本文重点综述其对摄食的短期与长期调节作用 ,其中包括作者领导的实验室所进行的大量研究工作。apo AⅣ是由人体肠道合成的一种糖蛋白。啮齿类动物的小肠和肝脏均可分泌apo AⅣ ,但循环中的apo AⅣ主要来自于小肠 ,脂肪的吸收可明显刺激apo AⅣ的合成。值得一提的是作者的实验室最近发现在大鼠的下丘脑可以合成apo AⅣ。乳糜微粒的形成是肠道apo AⅣ形成的诱导信号。来自回肠的一种可能是酪氨酸 酪氨酸肽 (PPY)的因子同样也可增加肠道apo AⅣ的合成。apo AⅣ对食物摄入的抑制作用是通过神经中枢而介导的。脂肪的吸收可在短时间内刺激肠道apo AⅣ合成与分泌。因此apo AⅣ可能对食物摄入的短期调节发挥作用。另有研究表明apo AⅣ也涉及到对摄食和体重的长期调节作用。长期摄入高脂肪膳食可使肠道apo AⅣ对脂肪的摄入反应迟钝 。 | Patrick Tso 徐贵发 | 2003 | 卫生研究2003，32，1： | 0 |
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