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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the develop- ment of autoimmunity in mice显示文摘 | Biswas PS Gupta S Chang E | 2010 | J Clin Invest2010，120，9： | 1 |
| 3 | Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice 显示文摘 | Biswas PS Gupta S Chang E | 2010 | J Clin Invest2010，120，9： | 1 |
| 4 | Administration of fasudi!, a ROCK inhibitor, attenuates disease in lupus-prone NZB/WF1 female mice 显示文摘 | Stirzaker RA Biswas PS Gupta S | 2012 | Lupus2012，21，6： | 1 |
| 5 | Apoptosis in the retina显示文摘 | Rosenbaum PS Gupta H Savitz SI | 1997 | Clin Neurosci1997，4，5： | 1 |
| 6 | Radiofrequency ablation and plication--a new technique for prolapsing hemorrhoidal disease显示文摘 | Gupta PJ Heda PS Kalaskar S | 2006 | Curr Surg2006，63，1： | 1 |
| 7 | Preconditioning provides complete protection against retinal ischemic injury in rats 显示文摘 | Roth S Li B Rosenbaum PS Gupta H Goldstein IM Maxwell KM | 1998 | Invest Ophthalmol Vis Sci1998，，： | 1 |
| 8 | Phosphorylation of IRF4 by ROCK2 regulates IL -17 and IL- 21 production and the development of autoimmunity in mice 显示文摘 | Biswas PS Gupta S Chang E | 2010 | Journal of Biological Chemistry2010，120，9： | 1 |
| 9 | Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice显示文摘 | Biswas PS Gupta S Chang E | 2010 | J Clin Invest2010，120，9： | 1 |
| 10 | Administration of fasudil, a ROCK inhibitor, attenuates disease in lupus-prone NZB/W FI female mice显示文摘 | Stirzaker RA Biswas PS Gupta S | 2012 | Lupus2012，21，6： | 1 |
| 11 | Retinal ischemia leads to apoptosis which is ameliorated by aurintricarboxylic acid显示文摘 | Rosenbaum DM Rosenbaum PS Gupta A Michaelson MD Hall DH Kessler JA | 1997 | Vision Res1997，37，24： | 1 |
| 12 | Long-term adverse effects of atypical anfipsychotics显示文摘 | MASAND PS GUPTA S | 2000 | Psychiatr Prakt2000，6，： | 1 |
| 13 | Topical sucralfate decreases pain after hemorrhoidectomy and improves healing:a randomized,blinded,controlled study显示文摘 | Gupta PJ Heda PS Kalaskar S | 2008 | Dis Colon Rectum2008，51，2： | 1 |
| 14 | Malignant granular cell tumor of the breast ; literature review 显示文摘 | Gupta N Sanchety N Verma PS | 2015 | Indian J Pathol Microbiol2015，58，2： | 1 |
| 15 | Preconditioning provides complete protection against retinal ischemic injury in rats 显示文摘 | Roth S Li B Rosenbaum PS Gupta H Goldstein IM Maxwell KM Gidday JM | 1998 | Invest Ophthalmol Vis Sci1998，39，5： | 1 |
| 16 | Olanzapine:reciew of its pharmacology and indications in clinical practice显示文摘 | Gupta S Masand PS | 1997 | Prim Psychiatry1997，53，： | 1 |
| 17 | Differential expression of genes during banana fi-uit development, ripening and 1-MCP treatment: Presence of distinct fruit specific, ethylene induced and ethylene repressed expression 显示文摘 | Gupta SM Srivastava S Aniruddha PS | 2006 | Postharvest Biology and Technology2006，42，1： | 1 |
| 18 | Effect of tau- rine and melatonin in the culture medium on buffalo in vitro embryo development显示文摘 | Manjunatha BM Devaraj M Gupta PS | 2009 | Reproduction in domestic animals2009，44，1： | 1 |
| 19 | Cress-section-al nodal atlas:a tool for the definition of clinical target volumes in three-dimenional radiation therapy planning显示文摘 | Fernandes PS Gupta N | 1999 | Radiology1999，211，3： | 1 |
| 20 | Selective serotonin-reputake inhibitors:an update显示文摘 | Masand PS Gupta S | 1999 | Harv Rev Psychiatry1999，7，4： | 1 |
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