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| 1 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 2 | Comparative cardiopulmonary effects of xylazine and detomidine in goats显示文摘 | Dilipkumar D Sharma A K Gupta O P | 1998 | Indian Veterinary Journal1998，75，10： | 1 |
| 3 | Electrolytic plasma technology: Science and engineering-An overview 显示文摘 | Gupta P Tenhundfeld G Daiglf E O | 2007 | Surface and Coatings Technology2007，201，21： | 1 |
| 4 | Fuzzy logic controlled shunt active power filter for power quality improvement显示文摘 | Jain S K Agrawal P Gupta H O | 2002 | IEE Proceedings of Electric Power Applications2002，149，5： | 1 |
| 5 | Primary endocardial fibroelastosis presenting in a young child as incessant ventricular tachycardia and dilated cardiomyopathy显示文摘 | ARYA S O KARPAWICH P P GUPTA P J | 2012 | Tex Heart Inst J2012，39，5： | 1 |
| 6 | Multi- objective demand side management solutions for utilities with peak demand deficit 显示文摘 | Kinhekar N Padhy N P Gupta H O | 2014 | International Journal of Electrical Power & Energy Systems2014，55，： | 1 |
| 7 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 8 | Responese of rainfed wheat to Zn at varglog levels of N and P on an acidic soil of Nepal显示文摘 | Gupta O P Misrn N K | 1992 | Indian J Agron1992，27，1： | 1 |
| 9 | Effect of radial gap between impeller and diffuser on vibration and noise in a centrifugal pump 显示文摘 | Srivastav O P Pandu K R Gupta K | 2003 | Journal of the Institution of Engineers (India) Part MC Mechanical Engineering Division2003，84，1： | 1 |
| 10 | A new amlde from Piper offtcinarum显示文摘 | Gupta O P Gupta S C Dhar K L | 1977 | Phytochemistry1977，16，9： | 1 |
| 11 | Toward Improved Calibration of Hydrological Models:Multiple and Noncommensurable Measures of Information显示文摘 | Gupta H V Sorooshian S Yapo P O | 1998 | Water Resources Research1998，34，4： | 1 |
| 12 | Multi-objective Global Optimization for Hydrologic Models 显示文摘 | Yapo P O Gupta H V Sorooshian S | 1998 | Journal of Hydrology1998，204，： | 1 |
| 13 | Multi-objective global optimization for hydrologic models显示文摘 | Yapo P O Gupta H V Sorooshian S | 1998 | Journal of Hydrology1998，204，14： | 1 |
| 14 | Desulfurization of hot syngas containing hydrogen chloride vapors using zinc titanate sorbents显示文摘 | Gupta R P O'Brien W S | | 0，，03： | 1 |
| 15 | Toward improved calibration of hydrological models:multiple and noncommensurable measures of information显示文摘 | Gupta H V Sorooshian S Yapo P O | 1998 | Water Resources Research1998，34，4： | 1 |
| 16 | Design of random vibration controller using adaptive filtering显示文摘 | Groud D R Gupta H O Agarwal P | 2009 | International Journal of Recent Trends in Engineering2009，2，5： | 1 |
| 17 | Design of random vibration controller using adaptive filtering显示文摘 | Groud D R Gupta H O Agarwal P | 2009 | Interna- tional Journal of Recent Trends in Engineering2009，2，5： | 1 |
| 18 | Status of auto- matic calibration for hydrologic models: Comparison with multilevel expert calibration 显示文摘 | Gupta H V Sorooshian S Yapo P O | 1999 | Journal of Hydrologic Engineering1999，4，2： | 1 |
| 19 | Performance investigation of neural-network-based unified power-quality conditioner显示文摘 | Kinhal V G Agarwal P Gupta H O | 2011 | IEEETrans on Power Delivery2011，26，1： | 1 |
| 20 | Fuzzy logic controlled shunt active power filter for power quality improvement 显示文摘 | JAIN S K AGRAWAL P GUPTA H O | 2002 | IEEE Transactions on Power Electronics2002，149，5： | 1 |
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