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| 1 | The RppC-AvrRppC NLR-effector interaction mediates the resistance to southern corn rust in maize显示文摘Southern corn rust(SCR),caused by the fungal pathogen Puccinia polysora,is a major threat to maize pro-duction worldwide.Efficient breeding and deployment of resistant hybrids are key to achieving durable control of SCR.Here,we report the molecular cloning and characterization of RppC,which encodes an NLR-type immune receptor and is responsible for a major SCR resistance quantitative trait locus.Further-more,we identified the corresponding avirulence effector,AvrRppC,which is secreted by P.polysora and triggers RppC-mediated resistance.Allelic variation of AvrRppC directly determines the effectiveness of RppC-mediated resistance,indicating that monitoring of AvrRppC variants in the field can guide the rational deployment of RppC-containing hybrids in maize production.Currently,RppC is the most frequently deployed SCR resistance gene in China,and a better understanding of its mode of action is crit-ical for extending its durability. | Ce Deng April Leonard James Cahill Meng Lv Yurong Li Shawn Thatcher Xueying Li Xiaodi Zhao Wenjie Du Zheng Li Huimin Li Victor Llaca Kevin Fengler Lisa Marshall Charlotte Harris Girma Tabor Zhimin Li Zhiqiang Tian Qinghua Yang Yanhui Chen Jihua Tang Xintao Wang Junjie Hao Jianbing Yan Zhibing Lai Xiaohong Fei Weibin Song Jinsheng Lai Xuecai Zhang Guoping Shu Yibo Wang Yuxiao Chang Weiling Zhu Wei Xiong Juan Sun Bailin Li Junqiang Ding | 2022 | Molecular Plant2022，15，5： | 6 |
| 2 | Subtyping of type A influenza by sequencing the variable regions of HA gene specifically amplified with RT-PCR显示文摘The outbreak of a novel influenza A(H1N1) virus across the globe poses a threat to human health.It is of paramount importance to develop a rapid,reliable and inexpensive diagnostic procedure.Based on the bioinformatic information from public database,primers specific for influenza A virus surface protein haemagglutinin(HA) of several subtypes(including H1,H2,H3,H5,H7 and H9) were designed.Primer-specific PCR products were subjected to sequencing for accurately distinguishing H1 and H3 subtypes from others.This sequencing-based detection method will not only be applied to rapid detection and simultaneous subtype identification of new influenza A virus H1N1,but also provide the strategies to monitor other new types ofinfluenza virus with explosive potential. | YAN An DING GuoHui ZHOU ZhenFeng DONG Hui ZHANG YaKun ZHU Lei HE YunGang ZHANG GuoQing LI YiXue SUN Bing HUANG Zhong LAN Ke JIN Li WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang DAI JianXin GUO YaJun WANG Hao CHE XiaoYan WU Fan YUAN ZhenGan ZHANG Xi CAO ZhiWei ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi ZHAO GuoPing JIN WeiRong XIONG Hui | 2009 | Chinese Science Bulletin2009，54，13： | 3 |
| 3 | The mutation network for the hemagglutinin gene from the novel influenza A (H1N1) virus显示文摘A mutation network for the hemagglutinin gene(HA) of the novel type A(H1N1) influenza virus was constructed.Sequence homology analysis indicated that one HA sequence type from the viruses mainly isolated from Mexico was likely the original type in this epidemic.Based on the 658A and 1408T mutations in HA,the viruses evolving into this epidemic were divided into three categories,the Mexico,the transitional and the New York type.The three groups of viruses presented distinctive clustering features in their geographic distributions. | HE YunGang DING GuoHui BIAN Chao HUANG Zhong LAN Ke SUN Bing WANG XueCai LI YiXue WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang JIN WeiRong XIONG Hui DAI JianXin GUO YaJun WANG Hao CHE XiaoYan WU Fan YUAN ZhenAn ZHANG Xi CAO ZhiWei ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi ZHAO GuoPing JIN Li | 2009 | Chinese Science Bulletin2009，54，13： | 3 |
| 4 | Review of Rapid Transformation of Floodplain Wetlands in Northeast China: Roles of Human Development and Global Environmental Change显示文摘Northeast China is the region with the largest area of wetlands in China. The Sanjiang Plain and the Songnen Plain are large freshwater marsh distribution regions that are affected by climate warming and by the increasing frequency and density of extreme weather and are the regions most subject to disturbances by human activities in Northeast China. The wetlands of the Sanjiang Plain and the Songnen Plain have shrunk severely in the past 60 years, and wetland functions have been reduced substantially because of climate change, unreasonable land use, fire episodes, engineering and construction works and urbanization. Large-scale agricultural development started in the 1950 s has been the most important driving factor for wetland loss and degradation in the Sanjiang Plain. Water shortage has been the most important factor for degradation and fragmentation of wetlands in the Songnen Plain. To mitigate wetland degradation and better protect wetlands, special regulations, long-term mechanisms and technical support of wetland protection should be established. A wetland compensation program should be implemented, and technologies for increasing the adaptive capacity of wetlands should be developed. Moreover, it is most important to find the balanced threshold between agricultural development and wetland protection. | YU Xiaofei DING Shanshan ZOU Yuanchun XUE Zhenshan LYU Xianguo WANG Guoping | 2018 | Chinese Geographical Science2018，28，4： | 2 |
| 5 | Inhibition of ASCT2 induces hepatic stellate cell senescence with modified proinflammatory secretome through an IL-1α/NF-κB feedback pathway to inhibit liver fibrosis显示文摘Senescence of activated hepatic stellate cells(aHSCs) is a stable growth arrest that is implicated in liver fibrosis regression.Senescent cells often accompanied by a multi-faceted senescence-associated secretory phenotype(SASP).But little is known about how alanine-serine-cysteine transporter type-2(ASCT2),a high affinity glutamine transporter,affects HSC senescence and SASP during liver fibrosis.Here,we identified ASCT2 is mainly elevated in aHSCs and positively correlated with liver fibrosis in human and mouse fibrotic livers.We first discovered ASCT2 inhibition induced HSCs to senescence in vitro and in vivo.The proinflammatory SASP were restricted by ASCT2 inhibition at senescence initiation to prevent paracrine migration.Mechanically,ASCT2 was a direct target of glutaminolysisdependent proinflammatory SASP,interfering IL-1α/NF-κB feedback loop via interacting with precursor IL-1α at Lys82.From a translational perspective,atractylenolide Ⅲ is identified as ASCT2 inhibitor through directly bound to Asn230 of ASCT2.The presence of -OH group in atractylenolide Ⅲ is suggested to be favorable for the inhibition of ASCT2.Importantly,atractylenolide Ⅲ could be utilized to treat liver fibrosis mice.Taken together,ASCT2 controlled HSC senescence while modifying the proinflammatory SASP.Targeting ASCT2 by atractylenolide Ⅲ could be a therapeutic candidate for liver fibrosis. | Feixia Wang Zhanghao Li Li Chen Ting Yang Baoyu Liang Zili Zhang Jiangjuan Shao Xuefen Xu Guoping Yin Shijun Wang Hai Ding Feng Zhang Shizhong Zheng | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 2 |
| 6 | Structure modeling and spatial epitope analysis for HA protein of the novel H1N1 influenza virus显示文摘In recent months,a novel influenza virus H1N1 broke out around the world.With bioinformatics technology,the 3D structure of HA protein was obtained,and the epitope residues were predicted with the method developed in our group for this novel flu virus.58 amino acids were identified as potential epitope residues,the majority of which clustered at the surface of the globular head of HA protein.Although it is located at the similar position,the epitope of HA protein for the novel H1N1 flu virus has obvious differences in the electrostatic potential compared to that of HA proteins from previous flu viruses. | WU Di XU TianLei SUN Jing DAI JianXin DING GuoHui HE YunGang ZHOU ZhengFeng XIONG Hui DONG Hui JIN WeiRong BIAN Chao JIN Li WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang WANG Hao CHE XiaoYan HUANG Zhong LAN Ke SUN Bing WU Fan YUAN ZhenAn ZHANG Xi ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi GUO YaJun ZHAO GuoPing LI YiXue CAO ZhiWei | 2009 | Chinese Science Bulletin2009，54，13： | 2 |
| 7 | Al-Mn coating electrodeposited from ionic liquid on NdFeB magnet with high hardness and corrosion resistance显示文摘 | Jingjing Ding Bajin Xu Guoping Ling | 2014 | Applied Surface Science2014，，： | 2 |
| 8 | Efficient circular gene knockout system for Burkholderiales strain DSM 7029 and Mycobacterium smegmatis mc^2 155显示文摘Multiple gene knockouts are often employed in studies of microbial physiology and genetics. However, the selective markers that confer antibiotic resistance are generally limited, so it is necessary to remove these resistance genes before the next round of using, which is time consuming and labor intensive. Here, we created a universal circular gene knockout system for both the gram-negative bacterial Burkholderiales strain DSM 7029 and the gram-positive bacterial Mycobacterium smegmatis mc^2 155, by combining the homologous recombination with multiple serine integrase-meditated site-specific recombination systems. In this system, a resistance gene and an integrase gene were constructed within the two attachment sites corresponding to a second, different integrase to form a cassette for gene disruption, which could be easily removed by the second integrase during the subsequent round of gene knockout. The sacB gene was also employed for negative selection. As the integrase-mediated deletion of the resistance/integrase gene cassette was highly efficient and concurrent with the following knockout round, the cyclic use of three cassettes could achieve multiple gene knockout in a sequential manner. Following the modularity concept in synthetic biology, common components of the knockout plasmids were retained as BioBricks, accelerating the knockout plasmids construction process. The circular gene knockout system can also be used for multiple gene insertions and applied to other microorganisms. | Xiaolai Lei Qiuxia Fan Tian Huang Haiyun Liu Guoping Zhao Xiaoming Ding | 2019 | Acta Biochimica et Biophysica Sinica2019，51，7： | 2 |
| 9 | SarA influences the sporulation and secondary metabolism in Streptomyces coelicolor M145显示文摘细丝状的细菌 Streptomyces 展览包含词法区别和第二等的新陈代谢的一个复杂生命周期。通常认为的膜蛋白质基因 sarA (sco4069 ) ,孢子形成和抗菌素生产联系了基因 A,部分在 Streptomyces coelicolor M145 被描绘。基因产品不描绘了功能的领域并且高度在 Streptomyces 被保存。与野类型的 M145 相比, sarA 异种加速了孢子形成并且戏剧性地减少了 actinorhodin 和 undecylprodigiosin 的生产。反向的抄写聚合酶链反应分析证明 SarA 由控制许多 actII-orf4 和红 Z 送信人 RNA 影响了抗菌素生产。 | Xijun Ou Bo Zhang Lin Zhang Kai Dong Chun Liu Guoping Zhao Xiaoming Ding | 2008 | Acta Biochimica et Biophysica Sinica2008，40，10： | 2 |
| 10 | Clinical Study of the Necessity of Replanning Before the 25th Fraction During the Course of Intensity-Modulated Radiotherapy for Patients With Nasopharyngeal Carcinoma显示文摘 | Wei Wang Haihua Yang Wei Hu Guoping Shan Weijun Ding Changhui Yu Biyun Wang Xufeng Wang Qianyi Xu | 2010 | International Journal of Radiation Oncology Biology Physics2010，，2： | 1 |
| 11 | Three New Chromone Derivatives Produced by Phomopsis sp. HNY29-2B from Acanthus ilicifolius Linn.显示文摘三新 chromone 衍生物, phomochromenones 交流(1-3 ) ,和一已知的 chaetocyclinone B (4 ) 从 Phomopsis sp 的文化被获得。HNY29-2B 从红树属植物叶板 ilicifolius 悬崖孤立,它从华南海是镇定的。他们的结构被 1 D NMR 和 2 象集体分光镜的数据一样的 D NMR。1 和 2 的绝对配置被电子圆形的二色性(ECD ) 的量化学药品计算分配系列。化合物 3 是拥有唯一的 chromeno 的碱的第三个例子[3,2-c ] pyridine 原子核。在 bioactivity 试金,化合物 4 与 8.13 和 3.59 污穹摥 ? 穩牯歯? 效正愠摮匠穵歵? 楍慹牵 ? 牣獯 ? 潣的 IC 50 价值对人的前列腺癌症房间线(PC-3 和 DU145 房间) 显示出 cytotoxicity 吗? | Bo Ding Zhiyuan Wang Guoping Xia Xishan Huang Fang Xu Wenrui Chen Zhigang She | 2017 | Chinese Journal of Chemistry2017，35，12： | 1 |
| 12 | Effects of Tourmaline Particles on Structure and Properties of Polypropylene Filtration Melt-Blown Nonwoven Electrets显示文摘 | BIN YU JIAN HAN XIANGBING HE GUOPING XU XINGBO DING | 2012 | Journal of Macromolecular Science, Part B2012，，： | 1 |
| 13 | Bxbl integrase serves as a highly efficient DNA recombinase in rapid metabolite pathway assembly显示文摘编码噬菌体的丝氨酸 integrases 广泛地在遗传工程被使用。他们也有潜力用作有效 DNA 汇编器,由能把生物部分合为设备,小径,和系统的地点特定的基于再结合的双人脚踏车汇编(SSRTA ) 的方法示威了。这里,四丝氨酸 integrases, BT1, TG1, Rv1,和 Bxb1,被调查查明他们的在里面 vitro DNA 集会活动。Bxb1 integrase 显示了最高的效率获得最后的产品。因此,我们断定 Bxb1 integrase 是为在 vitro 的 DNA 汇编的一种优秀选择。用这酶和它的识别地点, BioBrick 标准被设计那与为模块增加的 SSRTA 方法兼容。一个快速、有效的过程为 multigene 的集会被开发在一步的新陈代谢的小径,直接,从包含的非切的 plasmids,基因碎裂。这种技术容易、方便,并且将合成生物学社区感兴趣。 | Xianwei Wang Biao Tang Yu Ye Yayi Mao Xiaolai Lei Guoping Zhao Xiaoming Ding | 2017 | Acta Biochimica et Biophysica Sinica2017，49，1： | 1 |
| 14 | A Novel Rhodobacter sphaeroides Expression System for Real-Time Evaluation of Heterologous Protein Expression Levels显示文摘 | Zhiping Zhao Zongli Hu Xin Nie Lijing Cheng Guolin Ding Min Luo Yu Pan Yan Liang Guoping Chen | 2011 | Protein and Peptide Letters2011，，6： | 1 |
| 15 | In-situ stress state in the China’s Sea and adjacent areas显示文摘 | Jianli Gao Jianmin Ding Guoping Liang Dahuang Xia Qiliang Guo | 1992 | Acta Seismologica Sinica1992，，3： | 1 |
| 16 | Ion exchanged YVO 4 :Eu 3+ nanocrystals and their strong luminescence enhanced by energy transfer of thenoyltrifluoroacetone ligands显示文摘 | Lu Tang Weijun Gui Kanjunjie Ding Nan Chen Guoping Du | 2013 | Journal of Alloys and Compounds2013，，： | 1 |
| 17 | In-situ stress state in the China’s Sea and adjacent areas显示文摘 | Jianli Gao Jianmin Ding Guoping Liang Dahuang Xia Qiliang Guo | 1992 | Acta Seismologica Sinica1992，，3： | 1 |
| 18 | A1 -Mn coating electrodeposited from ionic liquid on NdFeB mag- net with high hardness and corrosion resistance 显示文摘 | DING Jing-jing XU Bajin LING Guoping | 2014 | Ap- plied Surface Science2014，305，： | 1 |
| 19 | Utility of the Surgical Apgar Score in pancreatic cancer and modification显示文摘Objectives:The Surgical Apgar Score(SAS)can predict the incidence of complications in different surgical fields.However,it is rarely studied in pancreatic cancer.The aim of the present study was to assess the predictive value of the SAS in pancreatic ductal adenocarcinoma(PDAC),and then propose a modified SAS which was more suitable for pancreatic cancer patients.Materials and methods:A prospective cohort study of 160 PDAC patients was concluded.The primary endpoint was 30-day major complications.The SAS was calculated as described.The overall discriminatory power of the score was analyzed using receiver operating characteristic curves and the area under the curve(AUC)with respect to major complications or death.Results:It showed a significant predictive value of SAS in major complications or death in PDAC(p=0.020,AUC=0.606),especially in complication of pneumonia(p=0.022)and pleural effusion(p=0.023).In addition,the SAS exert significant predictive value in distal pancreatectomy group,but it has a weak predictive value for pancreaticoduodenectomy group.On multivariable analyses,occurrence of major postoperative complications was associated with lowest mean arterial pressure,estimated blood loss and operative time.Interestingly,as a characteristic of SAS,lowest heart rate was not involved.The modified SAS we proposed including lowest mean arterial pressure,estimated blood loss and operative time increased AUC from 0.606 to 0.743.Conclusions:The SAS can be a simple,rapid scoring system that effectively predicts major postoperative complications.Besides,the modified SAS we proposed in this study,which included lowest mean arterial pressure,estimated blood loss and operative time,exert a better predictive value in PDAC patients. | Guoping Ding Liangjing Zhou Wenchao Chen Zhengrong Wu Tao Shen Liping Cao | 2019 | Laparoscopic, Endoscopic and Robotic Surgery2019，2，4： | 0 |
| 20 | A review on ultra-small undoped MoS2 as advanced catalysts for renewable fuel production显示文摘Molybdenum disulfide(MoS2)has garnered significant attention in the field of catalysis due to the high density of active sites in its unique two-dimensional(2D)structure,which could be developed into numerous high-performance catalysts.The synthesis of ultra-small MoS2 particles(<10 nm)is highly desired in various experimental studies.The ultra-small structure could often lead to a distinct S-Mo coordination state and nonstoichiometric composition in MoSx,minimizing in-plane active sites of the 2D structure and making it probable to regulate the atomic and electronic structure of its intrinsic active sites on a large extent,especially in MoSx clusters.This article summarizes the recent progress of catalysis over ultra-small undoped MoS2 particles for renewable fuel production.Through a systematic review of their synthesis,structural,and spectral characteristics,as well as the relationship between their catalytic performance and inherent defects,we aim to provide insights into catalysis over this matrix that may potentially enable advancement in the development of high-performance MoS2-based catalysts for sustainable energy generation in the future. | Guoping Liu Lingling Ding Yuxuan Meng Ahmad Ali Guifu Zuo Xianguang Meng Kun Chang Oi Lun Li Jinhua Ye | 2024 | Carbon Energy2024，6，2： | 0 |
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