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| 1 | Functional exhaustion of antiviral lymphocytes in COVID-19 patients显示文摘In December 2019,a novel coronavirus was first reported in Wuhan,China.1 It was named by the World Health Organization as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and is responsible for coronavirus disease 2019(COVID-19).Up to 28 February 2020,79,394 cases have been confirmed according to China’s National Health Commission.Outside China,the virus has spread rapidly to over 36 countries and territories. | Yuanhong Xuand Zhigang Tian Meijuan Zheng Yong Gao Gang Wang Guobin Song Siyu Liu Dandan Sun Yuanhong Xu Zhigang Tian | 2020 | Cellular & Molecular Immunology2020，17，5： | 54 |
| 2 | γ-MnO2 nanorods/graphene composite as efficient cathode for advanced rechargeable aqueous zinc-ion battery显示文摘Aqueous Zn//MnO2 batteries are emerging as promising large-scale energy storage devices owing to their cost-effectiveness,high safety,high output voltage,and energy density.However,the MnO2 cathode suffers from intrinsically poor rate performance and rapid capacity deterioration.Here,we remove the roadblock by compositing MnO2 nanorods with highly conductive graphene,which remarkably enhances the electrochemical properties of the MnO2 cathode.Benefiting from the boosted electric conductivity and ion diffusion rate as well as the structural protection of graphene,the Zn//MnO2-graphene battery presents an admirable capacity of 301 mAh g^-1 at 0.5 A g^-1,corresponding to a high energy density of 411.6 Wh kg^-1.Even at a high current density of 10 A g^-1,a decent capacity of 95.8 mAh g^-1 is still obtained,manifesting its excellent rate property.Furthermore,an impressive power density of 15 kW kg^-1 is achieved by the Zn//MnO2-graphene battery. | Chao Wang Yinxiang Zeng Xiang Xiao Shijia Wu Guobin Zhong Kaiqi Xu Zengfu Wei Wei Su Xihong Lu | 2020 | Journal of Energy Chemistry2020，29，4： | 13 |
| 3 | Effect of Root Architecture on Structural Stability and Erodibility of Topsoils during Concentrated Flow in Hilly Loess Plateau显示文摘Traditional vegetation techniques for the control of concentrated flow erosion are widely recognized, whereas only a few studies have experimentally investigated the impacts of belowground roots on the erodibility of topsoils in semi-arid areas. To quantify the effects of root architectures on soil erodibility and its relevant structural properties, simulated flow experiments were conducted at six-week intervals from 18 July to 20 October in 2012 in the hilly Loess Plateau. Five treatments were: 1) bare(control), 2) purple alfalfa(Medicago sativa), representing tap roots(T), 3) switchgrass(Panicum virgatum), representing fibrous roots(F), 4) purple alfalfa and switchgrass, representing both tap and fibrous roots(T + F), and 5) natural recovery(N). For each treatment, soil structural properties and root characteristics were measured at an interval of six weeks. Soil anti-scouribility was calculated. Results showed that grass planting slightly reduced soil bulk density, but increased soil aggregate content by 19.1%, 10.6%, 28.5%, and 41.2% in the treatments T, F, T + F, and N, respectively. Soil shear strength(cohesion and angle of internal friction(φ)) significantly increased after the grass was planted. As roots grew, soil cohesion increased by 115.2%–135.5%, while soil disintegration rate decreased by 39.0%–58.1% in the 21 th week compared with the recorded value in the 9th week. Meanwhile, root density and root surface area density increased by 64.0%–104.7% and 75.9%–157.1%, respectively. No significant differences in soil anti-scouribility were observed between the treatments of T and F or of T + F and N, but the treatments of T + F and N performed more effectively than T or F treatment alone in retarding concentrated flow. Soil aggregation and root surface-area density explained the observed soil anti-scouribility during concentrated flow well for the different treatments. This result proved that the restoration of natural vegetation might be the most appropriate strategy in soil reinforcement in the hilly Loess Plateau. | LI Qiang LIU Guobin ZHANG Zheng TUO Dengfeng XU Mingxiang | 2015 | Chinese Geographical Science2015，25，6： | 13 |
| 4 | Distribution and drug resistance of pathogenic bacteria isolated from cancer hospital in 2013显示文摘Objective: To understand distribution and drug resistance of pathogenic bacteria from a specialized cancer hospital in 2013 in order to provide a basis for rational clinical antimicrobial agents. Methods: Pathogenic bacteria identification and drug sensitivity tests were performed with a VITEK 2 compact automatic identification system and data were analyzed using WHONET5.6 software.Results: Of the 1,378 strains tested, 980 were Gram-negative bacilli, accounting for 71.1%, in which Klebsiella pneumonia, Escherichia coli and Pseudomonas aeruginosa were the dominant strains. We found 328 Gram-positive coccus, accounting for 23.8%, in which the amount of Staphylococcus aureus was the highest. We identified 46 fungi, accounting for 4.1%. According to the departmental distribution within the hospital, the surgical departments isolated the major strains, accounting for 49.7%. According to disease types, lung cancer, intestinal cancer and esophagus cancer were the top three, accounting for 20.9%, 17.3% and 14.2%, respectively. No strains were resistant to imipenem, ertapenem or vancomycin.Conclusions: Pathogenic bacteria isolated from the specialized cancer hospital have different resistance rates compared to commonly used antimicrobial agents; therefore antimicrobial agents to reduce the morbidity and mortality of infections should be used. | Linjuan Liu Qi Li Qingyun Zhang Guohong Wang Guobin Xu Ji Zhang | 2014 | Chinese Journal of Cancer Research2014，26，6： | 10 |
| 5 | Nucleocytoplasmic Trafficking of the Arabidopsis WD40 Repeat Protein XIW1 Regulates ABI5 Stability and Abscisic Acid Responses显示文摘WD40 repeat-containing proteins(WD40 proteins)serve as versatile scaffolds for protein-protein interac-tions,modulating a variety of cellular processes such as plant stress and hormone responses.Here we report the identification of a WD40 protein,XIW1(for XPO1-interacting WD40 protein 1),which positively regulates the abscisic acid(ABA)response in Arabidopsis.XIW1 is located in the cytoplasm and nucleus.We found that it interacts with the nuclear transport receptor XPO1 and is exported by XPO1 from the nucleus.Mutation of XIW1 reduces the induction of ABA-responsive genes and the accumulation of ABA Insensitive 5(ABI5),causing mutant plants with ABA-insensitive phenotypes during seed germination and seedling growth,and decreased drought stress resistance.ABA treatment upregulates the expression of XIW1,and both ABA and abiotic stresses promote XIW1 accumulation in the nucleus,where it interacts with ABI5.Loss of XIW1 function results in rapid proteasomal degradation of ABI5.Taken together,these findings suggest that XIW1 is a nucleocytoplasmic shuttling protein and plays a positive role in ABA responses by interacting with and maintaining the stability of ABI5 in the nucleus. | Xuezhong XU Wang Wan Guobin Jiang Yue Xi Haijian Huang Jiajia Cai Yanan Chang Cheng-Guo Duan Satendra KMangrauthia Xinxiang Peng Jian-Kang Zhu Guohui Zhu | 2019 | Molecular Plant2019，12，12： | 8 |
| 6 | Analysis of Comprehensive Benefits of Transforming Slope Farmland to Terraces on the Loess Plateau:A Case Study of the Yangou Watershed in Northern Shaanxi Province,China显示文摘De-farming slope farmland has been an effective measure in recent years to improve environment and prevent soil and water loss on the Loess Plateau.There are different views about the defarming method,and also various de-farming patterns have been put into practice.This paper takes the Yangou Watershed in Shaanxi Province of China as a case for studying the comprehensive benefits of transforming slope farmland to terraces.Based on the day-by-day meteorological data of the Yan'an station in 2005 and the data of terrain features,soil and land use data of the Yangou Watershed,the impact of transforming slope farmland on terraces were simulated and analyzed in aspects of yield increase and water-soil conservation under different topographic conditions with the aid of software WIN-YIELD.Furthermore,an empirical analysis was applied to study the effects of transforming slope farmland to terraces in the Yangou Watershed.The results show that:(1) The bigger the topographic gradient is,the more remarkable benefits it has in yield increase and water-soil conservation.(2) Farmland with slope below 5° could be retained,but farmland with slope above 15° should be converted to forest or grassland as soon as possible.(3) Transforming slope farmland to terraces has the same remarkable effects as the current policy of 'Relieving and de-farming' in improving agricultural production conditions,safeguarding food security,raising permanent vegetation coverage rate,and preventing soil and water loss.Besides,it is more cost-effective than the policy of 'Relieving and de-farming'.It's strongly suggested that the policy of transforming slope farmland to terraces be carried out on the Loess Plateau without delay. | XU Yong YANG Bo TANG Qing LIU Guobin LIU Puling | 2011 | Journal of Mountain Science2011，8，3： | 8 |
| 7 | Mining the key regulatory genes of chicken inosine 5'-monophosphate metabolism based on time series microarray data显示文摘IMP(inosine 5'-monophosphate) is a compound that enhances the flavor of poultry meat.IMP has become a new breeding trait to improve poultry meat quality.We tried to identify several potential regulatory genes,and construct their predicted regulatory relationships.Time series gene expression profiles of thigh muscle tissues of Rugao chicken,a famous indigenous breed in China,were performed for analysis of genes that are co-expressed or correlated with the concentration of IMP.We found 15 crucial co-expression genes,which are Hspa2,Pten,Gabpa,Bpi,Mkl1,Srf,Cd34,Hspa4,Etv6,Bmpr2,Gde1,Igfbp5,Cd28,Pecam1 and Gja1,that may directly or indirectly regulate IMP metabolism.Eventually,we computed the correlation coefficient between 19 IMP Genes and 15 CGs(15co-expression genes),and we identified and constructed a predicted regulation network.In conclusion,variation of IMP concentration was primarily connected with the muscle development process.During this process,15 CGs were identified that may have significant influence on IMP metabolism.In particular,Bmpr2,Pten and co-expression genes correlated with Entpd8 might play important roles in regulating IMP de novo synthesis,decomposition and salvage synthesis. | Teng Ma Lu Xu Hongzhi Wang Jing Chen Lu Liu Guobin Chang Guohong Chen | 2015 | Journal of Animal Science and Biotechnology2015，6，3： | 6 |
| 8 | Fine Mapping of RppP25, a Southern Rust Resistance Gene in Maize显示文摘Southern rust (Puccinia polysora Underw.) is a major disease that can cause severe yield losses in maize (Zea mays L.). In our previous study, a major gene RppP25 that confers resistance to southern rust was identified in inbred line P25. Here, we report the fine mapping and candidate gene analysis of RppP25 from the near-isogenic line F939, which harbors RppP25 in the genetic background of the susceptible inbred line F349. The inheritance of resistance to southern rust was investigated in the BC1F1 and BC3F1 populations, which were derived from a cross between F939 and F349 (as the recurrent parent). The 1:1 segregation ratio of resistance to susceptible plants in these two populations indicated that the resistance is controlled by a single dominant gene. Ten markers, including three simple sequence repeat (SSR) markers and seven insertion/deletion (InDel) markers, were developed in the RppP25 region. RppP25 was delimited to an interval between P091 and M271, with an estimated length of 40 kb based on the physical map of B73. In this region, a candidate gene was identified that was predicted to encode a putative nucleotide-binding site leucine-rich repeat (NBS-LRR) protein. Two co-segregated markers will aid in pyramiding diverse southern rust resistance alleles into elite materials, and thereby improve southern rust resistance worldwide. | Panfeng Zhao Guobin Zhang Xiaojun Wu Na Li Dianyi Shi Dengfeng Zhang Chunfang Ji Mingliang Xu Shoucai Wang | 2013 | Journal of Integrative Plant Biology2013，55，5： | 5 |
| 9 | Diagnostic value of negative enrichment and immune fluorescence in situ hybridization for intraperitoneal free cancer cells of gastric cancer显示文摘Objective:To explore the intraperitoneal free cancer cell(IFCC)detection value of negative enrichment and immune fluorescence in situ hybridization(NEimFISH)on chromosomes(CEN)8/17.Methods:To verify the reliability of NEimFISH,29 gastric cancer tumors,their adjacent tissues and greater omental tissues were tested.Our study then included 105 gastric cancer patients for IFCC.We defined patients as IFCC-positive if a signal was detected,regardless of the detailed cancer cell numbers.A comparison of clinicopathological features was conducted among IFCC groups.We also compared the diagnosis value and peritoneal recurrence predictive value among different detection methods.The comparison of IFCC number was also conducted among different groups.Results:A cutoff of 2.5 positive cells could distinguish all benign tissue samples and 97%of malignant tissue samples in our study.Compared to intestinal gastric cancer,patients with diffuse gastric cancer tended to have more IFCCs(6 vs.4,P=0.002).The IFCC counts were often higher in the lymphovascular invasion positive group than negative group(3 vs.1,P=0.022).All IFCC samples that were considered positive using conventional cytology were also found to be positive using NEimFISH.When compared to conventional cytology and paraffin pathology,NEimFISH had a higher IFCC positive rate(68.9%)and higher one-year peritoneal recurrence predictive value with area under the curve(AUC)of 0.922.Conclusions:Gastric cancer could be effectively diagnosed by NEimFISH.The IFCC number found using NEimFISH on CEN8/17 is closely associated with Lauren type and vascular invasion of cancer.NEimFISH is a reliable detection modality with a higher positive detection rate,higher one-year peritoneal recurrence predictive value and quantitative features for IFCC of gastric cancer. | Anqiang Wang Zhongwu Li Qian Wang Yali Bai Xin Ji Tao Fu Ke Ji Yanwen Xue Tingxu Han Xiaojiang Wu Ji Zhang Yingjie Yang Guobin Xu Zhaode Bu Jiafu Ji | 2019 | Chinese Journal of Cancer Research2019，31，6： | 3 |
| 10 | Bone marrow and the control of immunity显示文摘Bone marrow is thought to be a primary hematopoietic organ. However, accumulated evidences demonstrate that active function and trafficking of immune cells, including regulatory T cells, conventional T cells, B cells, dendritic cells, natural killer T (NKT) cells, neutrophils, myeloid-derived suppressor cells and mesenchymal stem cells, are observed in the bone marrow. Furthermore, bone marrow is a predetermined metastatic location for multiple human tumors. In this review, we discuss the immune network in the bone marrow. We suggest that bone marrow is an immune regulatory organ capable of fine tuning immunity and may be a potential therapeutic target for immunotherapy and immune vaccination. | Ende Zhao Huanbin Xu Lin Wang Ilona Kryczek Ke Wu Yu Hu Guobin Wang Weiping Zou | 2012 | Cellular & Molecular Immunology2012，9，1： | 3 |
| 11 | Molecular cloning and expression patterns of the cholesterol side chain cleavage enzyme(CYP11A1) gene during the reproductive cycle in goose(Anas cygnoides)显示文摘Background: CYP11A1, a gene belonging to the family 11 of cytochrome P450, encodes a crucial steroidogenic enzyme that catalyzes the initial step in the production of all classes of steroids. Many studies show that CYP11A1 plays a role in ovary function. However, the role of CYP11A1 in goose reproductive cycle remains largely unknown.Results: In this study, full-length CYP11A1 c DNA of Zhedong goose was obtained using reverse transcription polymerase chain reaction(RT-PCR) and rapid amplification of c DNA ends(RACE). The c DNA consisted of a 96-base pair(bp) 5′untranslated region(UTR), a 179-bp 3′UTR and a 1509-bp open reading frame. The open reading frame encodes a putative 503 amino acid protein that shares high homology with CYP11A1 of other birds. The amino acid sequence possesses conserved domains of the P450 superfamily, which include the steroid-binding domain and the heme-binding region. Real-time quantitative polymerase chain reaction(q PCR) analysis revealed CYP11A1 mR NA was expressed ubiquitously in every Zhedong goose tissue analyzed, including the heart, liver, glandular stomach,lung, spleen, kidney, intestinum tenue, intestinum crassum, cerebrum, cerebellum, muscle, oviduct, pituitary,hypothalamus and ovary.. The relatively low levels of CYP11A1 m RNA were detected in pituitary, ovary and oviduct tissues at ovulation when compared with levels at oviposition. Interestingly, higher expression was observed in ovary and oviduct tissues during brooding. Lastly, higher m RNA expression of Yangzhou geese was detected during the ovulation period than that of Zhedong geese.Conclusions: Our findings reveal the sequence characterization and expression patterns of the CYP11A1 gene during the goose reproductive cycle, which may provides correlative evidence that CYP11A1 expression is important in reproduction activity. | Qi Xu Yadong Song Yang Chen Ran Liu Yang Zhang Yang Li Zhengyang Huang Wenming Zhao Guobin Chang Guohong Chen | 2016 | Journal of Animal Science and Biotechnology2016，7，2： | 2 |
| 12 | Derivation and verification of minimum energy dissipation rate principle of fluid based on minimum entropy production rate principle显示文摘基于非平衡热力学理论,最小的精力驱散率原则能从最小的熵被导出生产率原则。最小的熵生产率原则等价于最小的精力驱散率原则。为了验证液体运动追随者最小精力驱散率原则, RNG k 骚乱模型和 GMO,流动 3D 当模特儿被使用在笔直地矩形的斜槽模仿液体运动。结果证明那个液体运动满足最小的精力驱散率原则。冲积的河的最小的精力驱散率的有效性与地数据被测试了。当一个河系统以一个相对平衡状态时,它的精力驱散率的价值在最小。最小的值取决于用于河系统的限制。由于一条河的动态性质,然而,最小的价值可以变化与对时间和地点各自。统一溪流力量原则的最小的溪流力量和最小是更一般的最小的精力驱散率原则的特殊、简化的版本。 | Guobin Xu Lina Zhao Chih Ted Yang | 2016 | International Journal of Sediment Research2016，31，1： | 2 |
| 13 | Eff ect of Cementation on Calcium Carbonate Precipitation of Loose Sand Resulting from Microbial Treatment显示文摘Microbe-induced calcite precipitation is a sustainable improvement technique for sandy soil, which can alter the properties of sand via microbial activity. In this study, we investigated the loose-sand-consolidation eff ect by controlling the injection velocity, bacterial and cementingsolution concentrations, and hold times. The results demonstrate that, as the cyclic batch increases, the utilization rate of the bacterial fl uid increases and both the optical density(OD_(600)) of the bacteria and urease activity decrease. Moreover, it was determined that a 3-h hold time for a 0.5 mol/L cementing solution with a cementing fl uid velocity of 2 mL/min has the greatest bonding eff ect. The fi nal strength of the loose sand with an increase in calcium carbonate content was further discussed. | Yang Tang Jijian Lian Guobin Xu Yue Yan Hongyin Xu | 2017 | Transactions of Tianjin University2017，23，6： | 2 |
| 14 | The analysis of genetic diversity and differentiation of six Chinese cattle populations using microsatellite markers显示文摘A total of 321 individuals from six cattle populations of four species in a bovine subfamily in China were studied using 12 pairs of mi- crosatellite markers. The genetic diversities within and between populations were calculated. The phylogenetic trees were constructed by (δμ) 2 and DA distances, and the divergence times between populations were estimated by (δμ) 2. Altogether, 144 microsatellite alleles were detected including 24 private alleles and nine shared alleles. Chinese Holstein had the largest number of private alleles (10), whereas, Bohai black and Buffalo had the smallest number of private alleles (2). Chinese Holstein showed the highest genetic variability. Its ob- served number of alleles (Na), mean effective number of alleles (MNA), and mean heterozygosity (He) were 7.7500, 4.9722, and 0.7719, respectively, whereas, the Buffalo and Yak showed low genetic variability. In the phylogenetic trees, Luxi and Holstein grouped first, followed by Bohai and Minnan. Yak branched next and buffalo emerged as the most divergent population from other cattle populations. Luxi and Bohai were estimated to have diverged 0.039-0.105 million years ago (MYA), however, buffalo and Holstein diverged 0.501-1.337 MYA. The divergence time of Yak versus Minnan, Holstein and buffalo was 0.136-0.363, 0.273-0.729, and 0.326-0.600 MYA, respectively. | Yongjiang Mao Hong Chang Zhangping Yang Liu Zhang Ming Xu Guobin Chang Wei Sun Guangming Song Dejun Ji | 2008 | Journal of Genetics and Genomics2008，35，1： | 2 |
| 15 | Design and development of real-time query platform for big data based on hadoop显示文摘This paper designs and develops a framework on a distributed computing platform for massive multi-source spatial data using a column-oriented database(HBase).This platform consists of four layers including ETL(extraction transformation loading) tier,data processing tier,data storage tier and data display tier,achieving long-term store,real-time analysis and inquiry for massive data.Finally,a real dataset cluster is simulated,which are made up of 39 nodes including 2 master nodes and 37 data nodes,and performing function tests of data importing module and real-time query module,and performance tests of HDFS's I/O,the MapReduce cluster,batch-loading and real-time query of massive data.The test results indicate that this platform achieves high performance in terms of response time and linear scalability. | 刘小利 Xu Pandeng Liu Mingliang Zhu Guobin | 2015 | High Technology Letters2015，21，2： | 1 |
| 16 | 5 - 14 Application of Position Sensitive Detector on Gas-filled Separator显示文摘 | Zhang Zhiyuan Huang Minghui Huang Tianheng Ma Long Jia Guobin Gan Zaiguo Zhou Xiaohong Xu Hushan | 2010 | IMP & HIRFL Annual Report2010，，1： | 1 |
| 17 | Hippocampal long -term potentiation is reduced by chronic opiate treatment and can be restored by re -exposure to opiates显示文摘 | Pu Lu Bao Guobin Xu Nanjie | 2002 | J Neurosci2002，22，5： | 1 |
| 18 | Invasibility and recoverability of a plant community following invasion depend on its successional stages显示文摘Exotic species invasion represent important causes of harming the structure,function,and ecological environment in ecosystems.Yet,knowledge remains limited on the invasibility(invasion advantage of exotic species)and recoverability(recovery ability of native species)of a plant community following invasion depend on its successional stages.We selected three grasses of Setaria viridis,Artemisia gmelinii,and Bothriochloa ischemum representing early(E),middle(M),and late(L)successional species,respectively.Meanwhile,the grasses of Panicum virgatum was selected to represent exotic species(invasion species).Three types of soil were collected to treat the three E,M,and L successional species,and one type of soil was collected to treat the exotic species.We compared the performance of the three native plant species and one exotic species grown in their“own”and“other”soils in a 2-year greenhouse experiment.Our study showed that exotic species performed better in soils of E and M successional species than in the soil of L successional species.After exotic species removed,E and M successional species exhibited poor growth in the soil of exotic species,while that of L successional species performed poor in field exotic species soils,but performed better in soils disturbed by exotic species.Our study demonstrated that the invasibility and recoverability of native plant communities changed with vegetation succession. | Hongwei Xu Zemin Ai Qing Qu Minggang Wang Guobin Liu Sha Xue | 2022 | Soil Ecology Letters2022，4，2： | 1 |
| 19 | Trend of major hydroclimatic variables in the Tarim River basin during the past 50 years显示文摘 | XU Zongxue Liu Zhaofei Fu Guobin | 2010 | Journal of Arid Environments2010，74，2： | 1 |
| 20 | Selection of an Effective Small Interference RNA to Silence Myostatin Gene Expression in Sheep Fibroblast Cells显示文摘 | Jian Lu Dan Sun Lingyang Xu Guobin Lu Fuping Zhao Caihong Wei Li Zhang Jiatong Ding Bichun Li Lixin Du | 2012 | Biochemical Genetics2012，，11： | 1 |
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