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| 1 | TNF-αTNFR1 Signaling is Required for the Full Expression of Acute and Chronic Itch in Mice via Peripheral and Central Mechanisms显示文摘Increasing evidence suggests that cytokines and chemokines play crucial roles in chronic itch. In the present study, we evaluated the roles of tumor necrosis factor-alpha(TNF-a) and its receptors TNF receptor subtype-1(TNFR1) and TNFR2 in acute and chronic itch in mice.Compared to wild-type(WT) mice, TNFR1-knockout(TNFR1-KO) and TNFR1/R2 double-KO(DKO), but not TNFR2-KO mice, exhibited reduced acute itch induced by compound 48/80 and chloroquine(CQ). Application of the TNF-synthesis inhibitor thalidomide and the TNF-αantagonist etanercept dose-dependently suppressed acute itch. Intradermal injection of TNF-α was not sufficient to evoke scratching, but potentiated itch induced by compound 48/80, but not CQ. In addition, compound 48/80 induced TNF-α mRNA expression in the skin, while CQ induced its expression in the dorsal root ganglia(DRG) and spinal cord. Furthermore, chronic itch induced by dry skin was reduced by administration of thalidomide and etanercept and in TNFR1/R2 DKO mice. Dry skin induced TNF-α expression in the skin, DRG, and spinal cord and TNFR1 expression only in the spinal cord. Thus, our findings suggest that TNF-α/TNFR1 signaling is required for the full expression of acute and chronic itch via peripheral and central mechanisms, and targeting TNFR1 may be beneficial for chronic itch treatment. | Xiuhua Miao Ya Huang Teng-Teng Liu Ran Guo Bing Wang Xue-Long Wang Li-Hua Chen Yan Zhou Ru-Rong Ji Tong Liu | 2018 | Neuroscience Bulletin2018，34，1： | 8 |
| 2 | Loss of Lkb1 impairs Treg function and stability to aggravate graft-versus-host disease after bone marrow transplantation显示文摘Accumulating evidence suggests that a reduction in the number of Foxp3^(+) regulatory T cells(Tregs)contributes to the pathogenesis of acute graft-versus-host disease(aGVHD),which is a major adverse complication that can occur after allogeneic hematopoietic stem cell transplantation(allo-HSCT).However,the precise features and mechanism underlying the defects in Tregs remain largely unknown.In this study,we demonstrated that Tregs were more dramatically decreased in bone marrow compared with those in peripheral blood from aGVHD patients and that bone marrow Treg defects were negatively associated with hematopoietic reconstitution.Tregs from aGVHD patients exhibited multiple defects,including the instability of Foxp3 expression,especially in response to IL-12,impaired suppressor function,decreased migratory capacity,and increased apoptosis.Transcriptional profiling revealed the downregulation of Lkb1,a previously identified critical regulator of murine Treg identity and metabolism,and murine Lkb1-regulated genes in Tregs from aGVHD patients.Foxp3 expression in human Tregs could be decreased and increased by the knockdown and overexpression of the Lkb1 gene,respectively.Furthermore,a loss-of-function assay in an aGVHD murine model confirmed that Lkb1 deficiency could impair Tregs and aggravate disease severity.These findings reveal that Lkb1 downregulation contributes to multiple defects in Tregs in human aGVHD and highlight the Lkb1-related pathways that could serve as therapeutic targets that may potentially be manipulated to mitigate aGVHD. | Xiuhua Su Qianqian Wang Wei Guo Xiaolei Pei Qing Niu Maolan Liu Yuanyuan Liu Song Chen Sizhou Feng Yi He Donglin Yang Rongli Zhang Qiaoling Ma Weihua Zhai Aiming Pang Jialin Wei Yong Huang Yuechen Luo Mingzhe Han Xiaoming Feng Erlie Jiang | 2020 | Cellular & Molecular Immunology2020，17，5： | 3 |
| 3 | Effects of dry dietary protein on digestibility, nitrogen-balance and growth performance of young male mink显示文摘The experiment was to study the nutrient digestibility and metabolism performance of male minks,which were fed different protein level diets during growth period. Effects of protein quantity on growth and development of minks and feed conversion ratio(FCR) were also investigated. Sixty healthy male minks of 45 d were randomly allocated into six groups with ten replicates, which was one sable for each replicate. The minks in six groups were fed diets in which protein levels were 28, 30,32, 34, 36 and 38%,respectively. The six groups were denoted as P28, P30, P32, P34, P36 and P38. After 2 wk, all minks were weighed, average daily gains(ADG) were calculated, and the digestibility values of nutrients were determined. The results indicated that digestibility of calcium, nitrogen of fence, nitrogen deposition, net protein utilization(NPU), and biological value of protein(BV) were similar(P > 0.05), however, nitrogen intake greatly varied among groups(P < 0.01). Compared with group P28, groups of P34, P36 and P38 showed significant difference(P < 0.01) in ADG and FCR. In conclusion, it was recommended that adding34% protein to mink diet would optimize production parameters including ADG, digestibility of nutrition,and FCR, and negative result was observed when diet protein was lower than 28%. | Tietao Zhang Haihua Zhang Xuezhuang Wu Qiang Guo Zhi Liu Wang Qian Xiuhua Gao Fuhe Yang Guangyu Li | 2015 | Animal Nutrition2015，，2： | 2 |
| 4 | STUDY ON THE SIGNATURE OF GROUND MOVING TARGET FOR AIRBORNE SQUINT SAR IMAGING显示文摘Compared with the side-looking Synthetic Aperture Radar (SAR), the flexible beampointing of squint SAR makes great application value. This paper derives the image signature of the ground moving target after the processing of Range-Doppler (RD) algorithm, the SAR signatures of ground moving targets are analyzed, including the geometry correction, the offsets and defocusing in both range and azimuth direction. Finally, computer simulation results validate its effectiveness. The research results are especially significant for moving targets detection and parameters estimation in squint mode SAR. | Shi Hongyin Guo Xiuhua Hou Zhitao Zhou Yinqing | 2012 | Journal of Electronics(China)2012，29，6： | 2 |
| 5 | Thermal expansion behavior of MgO/Cu composite with lower MgO volume fraction显示文摘 | Xiuhua Guo Kexing Song Shuhua Liang Cuihua Zheng | 2012 | Materials Research Bulletin2012，，11： | 1 |
| 6 | Effects of dietary methionine supplementation on growth performance of cubs,nutrient digestibility, nitrogen metabolism and serum biochemical indicators of female blue foxes(Alopex lagopus)显示文摘The objective of the present study was to investigate the effects of methionine(Met) supplementation on growth performance of cubs, nutrient digestibility, nitrogen metabolism and serum biochemical parameters of female blue foxes. One hundred primiparous female blue foxes that were similar in breeding date, pedigree, age, and weight were selected for the trial. The foxes were randomly assigned to four groups(n = 25 each group) and fed diets supplemented with Met at 2(Met2), 4(Met4), 6(Met6)and 8 g/kg(Met8), respectively, for 40 days. Our data showed that body weights at 20 and 40 d were significantly higher in the Met4 group than in the Met2 group(P < 0.05). The Met4 group also had the highest apparent digestibility of dry matter and crude protein compared with either the Met2, Met6, or Met8 group(P< 0.05). The serum Met and isoleucine(Ile) concentrations were significantly higher in the Met4 group than in the Met6 or Met8 group(P < 0.05). In summary, these data indicate that supplementary Met improves growth performance of cubs likely due to increased crude protein and dry matter and increased nitrogen retention of female blue foxes. The optimal amount of Met supplementation is10 g/kg basal diet. | Jungang Guo Xuezhuang Wu Tietao Zhang Zhi Liu Hu Cui Fuhe Yang Xiuhua Gao | 2015 | Animal Nutrition2015，，4： | 1 |
| 7 | A novel fusion protein- based indirect enzyme-linked immunosorbent assay for the detection of bovine tuberculosis显示文摘 | Siguo Liu Sheping Guo Chunlai Wang Meili Shao Xiuhua Zhang Yang Guo and Qiang Gong | 2006 | Tuberculosis2006，3，： | 1 |
| 8 | Formation and Relative Stabilities of Core-Shelled L12-Phase Nano-structures in Dilute Al–Sc–Er Alloys显示文摘First-principles thermodynamic calculations were carried out at the interface level for understanding the precipitation of coherent L12-phase nano-structures in dilute Al–Sc–Er alloys.All energetics,relevant to bulk substitution,interface formation,interfacial coherent strain and segregation,were calculated and used to evaluate the nucleation and relative stabilities of various possible L12 nano-structures.Only matrix-dissolved solute Er(or Sc)can substitute Sc(or Er)in L12-Al3Sc(or Al3Er).The inter-substitution between L12-Al3Sc and Al3Er is not energy feasible.Ternary L12-Al3(Er x Sc 1.x)precipitates tend to form the Al3Er-core and Al3Sc-shell structure with a sharp core/shell interface.Three possible formation mechanisms were proposed and examined.The eff ects of Er/Sc ratio and aging temperature on the relative stabilities of L12-phase nanostructures in Al were also discussed. | Chaomin Zhangi Yong Jiang Xiuhua Guo Kexing Song | 2020 | Acta Metallurgica Sinica(English Letters)2020，33，12： | 1 |
| 9 | The short isoform of the long‐type PML ‐ RARA fusion gene in acute promyelocytic leukaemia lacks sensitivity to all‐trans‐retinoic acid显示文摘 | Yanhong Tan Sicheng Bian Zhifang Xu Xiuhua Chen Xiling Qi Fanggang Ren Li Li Haixiu Guo Aining Xu Linlin Zhang Hongwei Wang | 2013 | Br J Haematol2013，，1： | 1 |
| 10 | The effect of Mo on the glass forming ability, mechanical and magnetic properties of FePC ternary bulk metallic glasses显示文摘 | Xiaohui Yang Xiuhua Ma Qiang Li Shengfeng Guo | 2012 | Journal of Alloys and Compounds2012，，： | 1 |
| 11 | Maternal health and its affecting factors in Nepal显示文摘Maternal health is still a public health problem in developing countries,especially in low-resource settings rural and poor communities.The main aim of this article is to critically evaluate and explore the situation of maternal health in Nepal based on published or unpublished governmental or nongovernmental organization’s scientific reports regarding maternal health.We found that there were several direct or indirect causes and affecting factors of maternal death in Nepal,which are preventable.Women have been facing different consequences during pregnancy and delivery,attributed to lack of proper knowledge or less available and affordable health facilities in rural communities.Therefore,there is needed an essential maternal health knowledge to women and also establish health facilities with a quality health care service on affordable and accessible to prevent maternal death and minimize complications. | Gehendra Mahara Jill Barr Janeeta Thomas Wei Wang Xiuhua Guo | 2016 | Family Medicine and Community Health2016，4，3： | 1 |
| 12 | Effects of degenerative autologous nucleus pulposus on the lumbar sympathetic trunk: Sympathetic inflammation in rats显示文摘Objective: We have reported the presence of discogenic visceral pain secondary to anterior herniation of the lumbar disc. The aim of this study was to observe the inflammatory response of the sympathetic trunk to an autologous degenerative nucleus pulposus(NP) injection under fluoroscopy. Methods: A total of 72 rats were used. In 24 rats,the autologous NP suspension was injected into the right sympathetic trunk. Next,food intake and body weight of each rat were monitored for 14 days. Fourteen days after the injection,the right lumbar sympathetic trunk was harvested for histological assessment,and protein levels of IL-1 β,IL-6,and TNF-α were quantified via ELISA. Results: In the NP-treated group,endoneural hyperemia and intensive infiltration of inflammatory cells could be identified in sections of the sympathetic trunk by the hematoxylin and eosin(H&E) stain. Meanwhile,elevated concentrations of IL-1 β,IL-6,and TNF-α were determined in the sympathetic trunk of the NP group as compared to that of the na?ve and control groups,which indicated the development of an inflammatory response. Furthermore,food intake and body weight of rats in the NP group decreased significantly. Conclusions: The results indicated that an inflammatory response in the sympathetic trunk can be caused by anterior herniation of the lumbar disc,which can generate a sympathetic inflammatory pain response. | Yuanzhang Tang Jingjing Bian Yuna Guo Chenli Sun Yawei Xiuhua Li Jiaxiang Ni | 2017 | Translational Neuroscience and Clinics2017，3，4： | 0 |
| 13 | Arc Erosion Behavior of Cu–0.23Be–0.84Co Alloy after Heat Treatment: An Experimental Study显示文摘The arc erosion behavior of Cu–0.23Be–0.84 Co alloy after heat treatment was investigated experimentally by a JF04 C electric contact test system. The arc duration, arc energy, contact resistance and contact pressure of Cu–0.23Be–0.84 Co alloy after solution treatment and aging treatment were analyzed. The arc erosion morphologies were contrastively observed by a three-dimensional measuring system and scanning electron microscopy. For the Cu–0.23Be–0.84 Co alloy in solution state and aging state, the maximum values of arc duration are 90 and 110 ms, and the arc energies are 15,000 and18,000 m J, respectively. The maximum value of the contact resistance of Cu–0.23Be–0.84 Co alloy in different states is about 33 m X. The contact pressure of Cu–0.23Be–0.84 Co alloy in solution state generally changes between 50 and 60 c N during whole make-and-break contacts, while in aging state, it has a larger fluctuation range. Moreover, the quality of moving contact(anode) decreases, while static contact(cathode) increases. The materials transfer from anode to cathode during make-and-break contacts. The total mass losses of Cu–0.23Be–0.84 Co alloy in solution state and aging state are 3and 1.2 mg, respectively. In addition, a number of discrete corrosion pits, molten droplet, porosity and cavity distribute on the surface of moving contact and static contact. The arc erosion model of Cu–0.23Be–0.84 Co alloy in make-and-break contact was built. The arc erosion resistance of Cu–0.23Be–0.84 Co alloy after heat treatment is closely related to the microstructure and the properties of contact materials. This experimental study is important to evaluate the anode or cathode electrocorrosion fatigue life. | Yanjun Zhou Kexing Song Jiandong Xing Zhou Li Xiuhua Guo | 2016 | Acta Metallurgica Sinica(English Letters)2016，29，4： | 0 |
| 14 | Long-term exposure to air pollution and cerebrovascular disease:findings from Beijing Health Management Cohort study显示文摘The relationship between air pollution and cerebrovascular disease has become a popular topic,yet research findings are highly heterogeneous.This study aims to investigate this association based on detailed individual health data and a precise evaluation of their exposure levels.The integrated models of generalized additive model,land use regression model and back propagation neural network were used to evaluate the exposure concentrations.And doubly robust additive model was conducted to explore the association between cerebrovascular disease and air pollution after adjusted for demographic characteristics,physical examination,disease information,geographic and socioeconomic status.A total of 25097 subjects were included in the Beijing Health Management Cohort from 2013 to 2018.With a 1µg/m^(3)increase in the concentrations of PM_(2.5),SO_(2)and NO_(2),the incidence risk of cerebrovascular disease increased by 1.02(95%CI:1.008–1.034),1.06(95%CI:1.034–1.095)and 1.02(95%CI:1.010–1.029)respectively.Whereas CO exposure could decrease the risk,with an odds ratio of 0.38(95%CI:0.212–0.626).In the subgroup analysis,individuals under the age of 50 with normal BMI were at higher risk caused by PM2.5,and So2 was considered more hazardous to women.Meanwhile,the protective effect of CO on women and those with normal BMI was stronger.Successful reduction of long-term exposure to PM2.5,SO_(2)and NO_(2)would lead to substantial benefits for decrease the risk of cerebrovascular disease especially for the health of the susceptible individuals. | Yuhan Zhao Xiaoping Kang Xue Tian Lulu Liu Zemeng Zhao Lili Luo Lixin Tao Xiangtong Liu Xiaonan Wang Xiuhua Guo Juan Xia Yanxia Luo | 2023 | Frontiers of Environmental Science & Engineering2023，17，7： | 0 |
| 15 | The Malaysian health care system:Ecology,plans,and reforms显示文摘Malaysia is on its way to achieving developed nation status in the next 4 years.Currently,Malaysia is on track for three Millennium Development Goals(MDG1,MDG4,and MDG7).The maternal mortality rate,infant mortality rate,and mortality rate of children younger than 5 years improved from 25.6%(2012)to 6.6%(2013),and 7.7%(2012)per 100,000 live births,respectively whereas immunization coverage for infants increased to an average of 90%.As of 2013 the ratio of physicians to patients improved to 1:633 while the ratio of health facilities to the population was 1:10,272.The current government administration has proposed a reform in the form of the 10th Malaysian Plan coining the term“One Care for One Malaysia”as the newly improved and reorganized health care plan,where efficiency,effectiveness,and equity are the main focus.This review illustrates Malaysia’s transition from pre-independence to the current state,and its health and socioeconomic achievement as a country.It aims to contribute knowledge through identifying the plans and reforms by the Malaysian government while highlighting the challenges faced as a nation. | Andrea Sebastian Mohamed Ali Alzain Collins Otieno Asweto Gehendra Mahara Xiuhua Guo Manshu Song Youxin Wang Wei Wang | 2016 | Family Medicine and Community Health2016，4，3： | 0 |
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