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| 1 | Deep Learning in Medical Ultrasound Analysis: A Review显示文摘Ultrasound (US) has become one of the most commonly performed imaging modalities in clinical practice. It is a rapidly evolving technology with certain advantages and with unique challenges that include low imaging quality and high variability. From the perspective of image analysis, it is essential to develop advanced automatic US image analysis methods to assist in US diagnosis and/or to make such assessment more objective and accurate. Deep learning has recently emerged as the leading machine learning tool in various research fields, and especially in general imaging analysis and computer vision. Deep learning also shows huge potential for various automatic US image analysis tasks. This review first briefly introduces several popular deep learning architectures, and then summarizes and thoroughly discusses their applications in various specific tasks in US image analysis, such as classification, detection, and segmentation. Finally, the open challenges and potential trends of the future application of deep learning in medical US image analysis are discussed. | Shengfeng Liu Yi Wang Xin Yang Baiying Lei Li Liu Shawn Xiang Li Dong Ni Tianfu Wang | 2019 | Engineering2019，5，2： | 24 |
| 2 | Climate and environment reconstruction during the Medieval Warm Period in Lop Nur of Xinjiang, China显示文摘We made multi-proxy analysis of 14C, grain size, microfossils, plant seeds, and geochemical elements on samples from a profile in the central West Lake of Lop Nur. The grain size suggests relatively stable sedimentary environment around the Medieval Warm Period (MWP) with weak storm effect, which is followed by frequent strong storm events. Abundant microfossils and plant seeds in this stage indicate a warm and humid fresh to brackish lake environment. C, N, and stable elements are high in content in the sediments while Rb/Sr, Ba/Sr, and Ti/Sr are in a steady low level. In addition, plenty of red willows lived here prior to about 700 a B.P., indicating a favorable environmental condition. The results indicate that the environment in Lop Nur and its west bank turned to be favorable at about 2200 a B.P., where the Loulan Culture began to thrive. Then the climate and environment came to be in the good condition in the Tang and Song Dynasties, when the storm effect became weaker, rainfall increased and the salty lake water turned to be brackish to fresh lake water. Hence, limnic biomass increased with higher species diversity. | MA ChunMei WANG FuBao CAO QiongYing XIA XunCheng LI ShengFeng Li XuSheng | 2008 | Chinese Science Bulletin2008，53，19： | 13 |
| 3 | Enhanced mechanical properties and degradation rate of Mg-Ni-Y alloy by introducing LPSO phase for degradable fracturing ball applications显示文摘In this work,as-cast Mg-Ni-Y alloys were proposed to develop a feasible material for fracturing balls,and their mechanical performance and corrosion behavior were systematically investigated.Long period stacking order(LPSO)phase was firstly introduced to improve both the mechanical properties and degradation rate of magnesium alloys.With the increase of LPSO phase,the compressive strength was improved significantly,while the elongation of the alloys decreased owing to the relatively brittle nature of LPSO phase.Due to the higher corrosion potential of LPSO phase,the LPSO phase can accelerate the corrosion process by providing more micro-couples.However,the LPSO phase would serve as the corrosion barrier between the corrosion medium and the matrix when the contents of LPSO phase are too high in Mg92.5Ni3Y4.5 and Mg87.5Ni5Y7.5 alloys.As-cast Mg97.5Ni1Y1.5 alloy with satisfactory mechanical properties and rapid degradation rate was successfully developed,exhibiting a high degradation rate of 6675 mm/a(93℃)in 3 wt.%KCl solution and a favorable ultimate compressive strength of 410 MPa.The degradation rate of Mg97.5Ni1Y1.5 alloy is 2-5 times of the current commercial magnesium alloy fracturing materials. | Jingfeng Wang Shiqing Gao Xiuying Liu Xing Peng Kui Wang Shijie Liu Weiyan Jiang Shengfeng Guo Fusheng Pan | 2020 | Journal of Magnesium and Alloys2020，8，1： | 13 |
| 4 | Tolerance to low phosphorus in rice varieties is conferred by regulation of root growth显示文摘Phosphorus use efficiency(PUE)can be improved through cultivation techniques and breeding.However,little is known about rice(Oryza sativa L.)agronomic and physiological traits associated with high PUE.We characterized the agronomic and physiological traits of rice varieties with different tolerances to low phosphorus in nutrient solution.Two varieties with strong tolerance to low phosphorus(STVs)and two with weak tolerance(WTVs)were grown at normal(NP,control)and low phosphorus(LP,1/20 of NP)concentrations.Plants grown at LP produced significantly lower grain yield than those grown at NP.WTVs yields were lower than STVs yields.Compared to NP,LP significantly increased phosphorus translocation efficiency(PTE),internal phosphorus efficiency(IPE)and phosphorus harvest index(PHI).Under the LP condition,PTE and IPE were higher for STVs than for WTVs.LP also reduced tiller number,shoot biomass,leaf area index(LAI),leaf photosynthetic rate,and mean root diameter of both kinds of varieties at the main growth stages,but to a lower extent in STVs.LP significantly increased the number of productive tillers,root biomass,root-shoot ratio,root bleeding rate,and root acid phosphatase(RAP)activity.Total root length,root oxidation activity(ROA),and root total and active absorbing surface areas for STVs were significantly increased under LP,whereas the opposite responses were observed for WTVs.Total root length,ROA,root bleeding rate,root active absorbing surface area,and RAP activity were positively and significantly correlated with grain yield,PTE,and IPE.These results suggest that the tolerance of rice varieties to a low-phosphorus growth condition is closely associated with root growth with higher biomass and activity. | Yaping Deng Chuanbao Men Shengfeng Qiao Wenjie Wang Junfei Gu Lijun Liu Zujian Zhang Hao Zhang Zhiqin Wang Jianchang Yang | 2020 | The Crop Journal2020，8，4： | 8 |
| 5 | Texture control by {10-12} twinning to improve the formability of Mg alloys: A review显示文摘Texture control of wrought Mg alloys, particularly in rolled Mg alloy sheets, has been an important research topic for the past several decades because it has significant influence on stretch formability at room temperature. For Mg alloys, {10-12} twinning can be easily activated and causes a 86.3° lattice rotation. Thus, pre-twinning deformation is considered as an effective and low-cost method for texture control in wrought Mg and its alloys. Furthermore, it has been verified that texture control via pre-twinning deformation can remarkably improve stretch formability of rolled Mg alloy sheets. In this review, recent researches on texture control via twinning deformation and its influence on stretch formability will be critically reviewed. The main contents include the micro-mechanism and impact factors of control in twin-orientation, plastic processing techniques of pre-inducing twins and the application of pre-induced twins in improvement of stretch formability. Finally, further research directions on this field were proposed. | Bo Song Qingshan Yang Tao Zhou Linjiang Chai Ning Guo Tingting Liu Shengfeng Guo Renlong Xin | 2019 | Journal of Materials Science & Technology2019，35，10： | 8 |
| 6 | Experimental Study on Formation Conditions of Ammoniojarosite and Its Environmental Significance显示文摘在 systemFe_2 (SO_4 ) 的 ammoniojarosite 的形成条件 _3-(NH_4 )_2SO_4-H_2O 在这篇论文被调查。结果证明 ammoniojarositecan 被控制合适的 pH andFe_2 (SO_4 ) 在标准温度和压力下面很快形成 _3 并且(NH_4 )_2SO_4 集中。pH,温度和集中 ofFe_2 (SO_4 )_3 媒介是影响 ammoniojarosite 的形成的关键因素。在标准温度下面, ammoniojarosite 的降水能在在 2.6 -3.1, 之间的 pH 在 24 个小时以内被看见, ammoniojarosite 的大数量在 48 个小时以内被形成。在大约 90 deg C,形成 ammoniojarosite 的 pHvalue 范围延长到 1.2 - 3.1,并且在这个范围以内, pH 的上升对 ammoniojarosite 的形成有益,高 Fe_2 (SO_4 )_3 集中也是有益的。相对纯 ammoniojarosite 在高 Fe_2 (SO_4 )_3 集中(>=0.05 M ) 和包含非结晶的氢氧化物讽刺 IronIs 在低 Fe_2 (SO_4 )_3 集中形成了的 melanterite 和胶体的 ammoniojarosite 下面被综合。ammoniojarosite 的免职过程能被用来从矿和另外的工业利用废水并且移开 S, Fe 和另外的有毒、有害的元素,例如作为, Cr, Hg,水里的 Pb。在标准温度和压力下面的 ammoniojarosite 和另外的 jarositeanalogs 的快速的形成为借助于黄钾铁矾和它的类似物的降水利用酸废水有好潜在的前景。 | WANG Changqiu MA Shengfeng LU Anhuai ZHOU Jiangong | 2006 | Acta Geologica Sinica(English Edition)2006，80，2： | 7 |
| 7 | Effect of Sn addition on the mechanical properties and bio-corrosion behavior of cytocompatible Mg-4Zn based alloys显示文摘The mechanical properties and bio-corrosion behaviors of as-extruded Mg-4Zn alloys after Sn addition were investigated,systemati-cally.A small amount of Sn addition to Mg-4Zn alloy slightly improved the mechanical properties for solid solution strengthening,and significantly controlled the bio-corrosion rates.Sn participating in the outer layer film formation as SnO/SnO_(2)resisted the bio-corrosion proceeding.Especially,Mg-4Zn-1.5Sn alloy,with a weight loss rate of 0.45 mm/y and hydrogen evolution rate of 0.099 mL/cm^(2)/day,showed cytotoxicity grade of 0 to MC3T3-E1 cells.The perfect alliance of cytocompatibility,suitable mechanical properties and low bio-corrosion rate demonstrates that this Mg-4Zn-1.5Sn alloy is a promising biodegradable magnesium alloy for orthopedic implants. | Weiyan Jiang Jingfeng Wang Weikang Zhao Qingshan Liu Dianming Jiang Shengfeng Guo | 2019 | Journal of Magnesium and Alloys2019，7，1： | 6 |
| 8 | Investigation on Multiple Cylindrical Holes Casing Treatment for Transonic Axial Compressor Stability Enhancement显示文摘Casing treatment is one possible way of regaining axial compressor operating range. However, most of casing treatments extend the operating range with the cost of efficiency penalty. A new form of multiple cylindrical holes casing treatment(MHCT) with pre-swirl blowing for the NASA Rotor-37 has been designed based on profound understanding of the stall inception. Unsteady numerical simulations have been performed for Rotor-37 with and without MHCT. Parametric studies of the total extraction holes area and their axial locations show that the compressor performance deteriorates as the area ratio increases but the stall margin is extended and there is an optimum extraction holes axial location for stall margin extending. The better configuration of MHCT could extend the stall margin by 6.2% with only 0.23% peak efficiency reduction. Detailed analysis of the physical mechanism behind the stall margin improvement shows that the casing treatment could eliminate the passage blockage by suppressing breakup of tip leakage vortex and decrease the blade load in tip region, which both contribute to improve stall margin of transonic axial compressors. | YANG Chengwu ZHAO Shengfeng LU Xingen HAN Ge ZHU Junqiang | 2014 | Journal of Thermal Science2014，23，4： | 6 |
| 9 | Special Issue on Future Digital Design and Manufacturing:Embracing Industry 4.0 and Beyond显示文摘Industry 4.0 as referred to the fourth industrial revolution has endorsed in several national manufacturing initiatives or development plans such as in Germany,the UK,USA and China.A set of important pervasive and secondary technologies for future manufacturing activities have been identified such as additive manufacturing,sensor technology,big | QIN Shengfeng CHENG Kai | 2016 | Chinese Journal of Mechanical Engineering2016，29，6： | 6 |
| 10 | Characterization of bbtTICAM from amphioxus suggests the emergence of a MyD88-independent pathway in basal chordates显示文摘MyD88 独立的小径,发信号的二关键 TLR 之一发送,被认为是脊椎动物革新。然而,一个新奇 Toll/interleukin-1 受体(TIR ) 适配器,指明的 bbtTICAM,在基础脊索动物文昌鱼被识别,连接这条小径到无脊椎动物。bbtTICAM 的蛋白质建筑学类似于脊椎动物 TICAM1 的(包含 TIR 适配器 molecule-1,也作为 TRIF 知道) 当种系发生的分析基于 TIR 领域显示了那时, bbtTICAM 是脊椎动物 TICAM1 和 TICAM2 的最旧的 ortholog (包含 TIR 适配器 molecule-2,是也知道电车) 。类似于人的 TICAM1, bbtTICAM 激活 NF-κ以由与受体交往蛋白质交往的一种 MyD88 独立的方式的 B (裂开) 经由它的 RHIM 主题。如此的激活要求 bbtTICAM 形成 homodimers 在里面内涵体,和它可以被文昌鱼 SARM 否定地调整(无菌的 α并且犰狳包含主题的蛋白质) 并且 TRAF2。然而, bbtTICAM 没导致类型的生产我干扰素。因此,我们的学习不仅介绍脊椎动物 TICAM1 和 TICAM2 的祖先的特征,而且从基础脊索动物揭示 MyD88 独立的小径的进化起源,它将帮助理解脊椎动物 TLR 网络的开发。 | Manyi Yang Shaochun Yuan Shengfeng Huang Jun Li Liqun Xu Huiqing Huang Xin Tao Jian Peng Anlong Xu | 2011 | Cell Research2011，21，10： | 5 |
| 11 | Power-efficient RWA in dynamic WDM optical networks considering different connection holding times显示文摘The challenges imposed by environmental issues,such as global warming and the energy crisis,are demanding more responsible energy usage,including in the optical networking field.In optical transmission networks,most of the electrical power is consumed by the optical-electrical-optical conversion in optical repeaters.Modern optical network control plane technologies allow idle optical repeaters to be put into a low-power sleep mode.Inspired by this,we propose a novel power-efficient routing and wavelength assignment(RWA) algorithm,called HTAPE.The HTAPE algorithm exploits the knowledge of the connection holding times to minimize the number of optical repeaters in the active mode,and hence reduce the total electricity consumption of the optical network.We test the new algorithm on the typical CERNET and USNET networks.Compared with traditional RWA algorithms without holding-time-awareness,it is observed that the HTAPE algorithm yields significant reductions in power consumption. | DU Shu ZHANG ShengFeng PENG YunFeng LONG KePing | 2013 | Science China(Information Sciences)2013，56，4： | 4 |
| 12 | Preparation, structure and properties of Mg/Al laminated metal composites fabricated by roll-bonding, a review显示文摘Laminated metal composites(LMCs) are a unique composite material and have great application prospects in automobiles, ships, aircraft,and other manufacturing industries. As lightweight materials, the Mg/Al LMCs are expected to combine the advantages of both Mg and Al alloys to broaden their application prospects. Roll-bonding is the most popular process for the fabrication of Mg/Al LMCs due to high production efficiency and good product quality stability. The roll-bonding process involves the deformation of the substrates and the formation of the interfacial diffusion layer. The latter will directly determine the interface bonding strength of Mg/Al LMCs. Bonding strength is very sensitive to the thickness of the reaction layer in the diffusion layer. When the thickness of the reaction layer exceeds 5 μm, the bonding strength decreases sharply. Therefore, controlling the thickness of the reaction layer is very important for the design of rolling parameters.The latest research also showed that the addition of intermediate layer metal and the construction of three-dimensional interfaces can further improve the interface bonding strength. How to apply these methods to roll-bonding is the focus of future research. Recently, a new rolling technique, corrugated roll/plat roll rolling+flat roll/flat roll rolling has been developed to fabricate Mg/Al LMCs. It can effectively promote the deformation of the hard layer and generate a wavy interface, resulting in the enhancement of the bonding quality and rolling quality.In the current review, the effects of rolling parameters and subsequent annealing on the interface structure of Mg/Al LMCs were elaborated in detail. The application of some special rolling techniques in the preparation of Mg/Al LMCs was also summarized. The latest research results on the relationship between interface structure and mechanical properties of Mg/Al LMCs were reviewed. Finally, further research directions in this field were proposed. | Tingting Liu Bo Song Guangsheng Huang Xianquan Jiang Shengfeng Guo Kaihong Zheng Fusheng Pan | 2022 | Journal of Magnesium and Alloys2022，10，8： | 4 |
| 13 | Learning General Gaussian Kernels by Optimizing Kernel Polarization显示文摘 | WANG Tinghua HUANG Houkuan TIAN Shengfeng DENG Dayong | 2009 | Chinese Journal of Electronics2009，18，2： | 4 |
| 14 | A review of real-time multi-GNSS precise orbit determination based on the filter method显示文摘Stable and reliable high-precision satellite orbit products are the prerequisites for the positioning services with high performance.In general,the positioning accuracy depends strongly on the quality of satellite orbit and clock products,especially for absolute positioning modes,such as Precise Point Positioning(PPP).With the development of real-time services,real-time Precise Orbit Determination(POD)is indispensable and mainly includes two methods:the ultra-rapid orbit prediction and the real-time filtering orbit determination.The real-time filtering method has a great potential to obtain more stable and reliable products than the ultra-rapid orbit prediction method and thus has attracted increasing attention in commercial companies and research institutes.However,several key issues should be resolved,including the refinement of satellite dynamic stochastic models,adaptive filtering for irregular satellite motions,rapid convergence,and real-time Ambiguity Resolution(AR).This paper reviews and summarizes the current research progress in real-time filtering POD with a focus on the aforementioned issues.In addition,the real-time filtering orbit determination software developed by our group is introduced,and some of the latest results are evaluated.The Three-Dimensional(3D)real-time orbit accuracy of GPS and Galileo satellites is better than 5 cm with AR.In terms of the convergence time and accuracy of kinematic PPP AR,the better performance of the filter orbit products is validated compared to the ultra-rapid orbit products. | Yidong Lou Xiaolei Dai Xiaopeng Gong Chenglong Li Yun Qing Yang Liu Yaquan Peng Shengfeng Gu | 2022 | Satellite Navigation2022，3，3： | 4 |
| 15 | Incidence and prevalence of moyamoya disease in urban China: a nationwide retrospective cohort study显示文摘Background and objective Moyamoya disease(MMD)is an increasingly recognised cause of stroke,mainly described in East Asia.China is the largest nation in Asia,but few studies reported the epidemiology of MMD,especially at a national level.We aimed to estimate the incidence and prevalence of MMD in China.Methods We performed a population-based study using data from the national databases of Urban Basic Medical Insurance between 2013 and 2016,covering approximately 0.50 billion individuals.MMD cases were identified by diagnostic code(International Classification of Diseases,10th Revision I67.5)or related diagnostic text.Results A total of 1987 MMD patients(mean age 44.45±14.30 years,female-to male ratio 1.12)were identified,representing a national crude incidence of 0.59(95%CI:0.49 to 0.68)and a prevalence of 1.01(95%CI:0.81 to 1.21)per 100000 person-years in 2016.Rates were higher in females than in males for the incidence(0.66 vs 0.52)and prevalence(1.05 vs 0.90).And the age-specific rates showed a bimodal distribution,with the highest peak in middle-aged group and the second peak in child group.Conclusions Our results confirm that MMD is relatively common in East Asians,but the rates in China were lower than those in other East Asian countries such as Japan and Korea.The unique epidemiological features,including a relatively weak female predominance and a shift in the highest peak of incidence from children to adults,revealed new sight into MMD.Further research is expected to explore the potential pathogenesis of MMD. | Yixin Sun Guoyu Zhou Jingnan Feng Lu Chen Guozhen Liu Jinxi Wang Qingliang Wang Junyou Yu Xiwang Yang Zheng Yang Pei Gao Shengfeng Wang Siyan Zhan | 2021 | Stroke & Vascular Neurology2021，6，4： | 4 |
| 16 | Diatom-based reconstruction of Holocene environmental changes in Angren Lake,Southern Tibet显示文摘Based on the diatom analysis the climatic sequence between 11 000 and 6 000 aBP in Angren, southern Tibet is established, i.e. cold period (11 095-9 970 aBP)→temperate period (9 970-9 870 aBP)→Anathermal (9 870-9 770 aBP)→cool-dry period (9 770-8 740 aBP) →super-megathermal (8 740-8 590 aBP)→Megathermal (8 590-5 970 aBP). And the opinion that the reaction of diatom to temperature change is more sensitive than to other ecological factors has been pointed out and certified. | Shengfeng Li Fubao Wang Jie Zhang Xuhui Shen Zhaoqi Zeng | 1999 | Chinese Science Bulletin1999，44，12： | 3 |
| 17 | Effects of “Bioactive” amino acids leucine, glutamate, arginine and tryptophan on feed intake and mRNA expression of relative neuropeptides in broiler chicks显示文摘Feed intake control is vital to ensuring optimal nutrition and achieving full potential for growth and development in poultry. The aim of the present study was to investigate the effects of L-leucine, L-glutamate, L-tryptophan and L-arginine on feed intake and the mRNA expression levels of hypothalamic Neuropeptide involved in feed intake regulation in broiler chicks. Leucine, glutamate, tryptophan or arginine was intra-cerebroventricularly (ICV) administrated to 4d-old broiler chicks respectively and the feed intake were recorded at various time points. Quantitative PCR was performed to determine the hypothalamic mRNA expression levels of Neuropeptide Y (NPY), agouti related protein (AgRP), pro-opiomelanocortin (POMC), melanocortin receptor 4 (MC4R) and corticotrophin releasing factor (CRF). Our results showed that ICV administration of L-leucine (0.15 or 1.5 μmol) significantly (P<0.05) increased feed intake up to 2 h post-administration period and elevated both hypothalamic NPY and AgRP mRNA expression levels. In contrast, ICV administration of L-glutamate (1.6μmol) significantly (P<0.05) decreased feed intake 0.25, 0.5 and 2 h post-injection, and increased hypothalamic CRF and MC4R mRNA expression levels. Meanwhile, both L-tryptophan (10 or 100μg) and L-arginine (20 or 200μg) had no significant effect on feed intake. These findings suggested that L-leucine and L-glutamate could act within the hypothalamus to influence food intake, and that both orexigenic and anorexigenic Neuropeptide genes might contribute directly to these effects. | Songbo Wang Paul Khondowe Shengfeng Chen Jianjian Yu Gang Shu Xiaotong Zhu Lina Wang Ping Gao Qianyun Xi Yongliang Zhang Qingyan Jiang | 2012 | Journal of Animal Science and Biotechnology2012，3，4： | 3 |
| 18 | Experimental Study on Treatment of High-concentrated Sulfur Wastewater by Process of Depositing Natrojarosite and Its Environmental Significance显示文摘摘要:有直到从一家化学工厂的 26000 mg/L 的钠和货到付款(化学的氧需求) 的集中高度的硫废水,中国的江苏省被 natrojarosite 的免职在实验室对待。结果显示废水的 COD 从 26000 mg/L 严厉地被减少到 1001 mg/L,与直到 96% 的货到付款由的移动率两次 natrojarosite 并且两次的猛冲 H2O2 的氧化。对待的硫废水到达了随后的生物化学的处理的要求浇质量。最佳的运作的参数应该在在固体每公升废水加在一起的 2.50 和 3.20 和 50 g FeCl36H2O 之间的 pH 价值上被控制。学习为集中高度的硫废水的预告的处理提供了一个试验性的基础并且在另外的废水的处理上建议了一个新矿物学的方法。扔 jarosite 和它的类似物的过程应该能被用来从我的和另外的工业对待废水移开 S, Fe 和有毒的其它和有害元素,例如作为, Cr, Hg, Pb,水里的等等。 | MA Shengfeng WANG Changqiu LU Anhuai GUO Yanjun HE Hongliao | 2007 | Acta Geologica Sinica(English Edition)2007，81，2： | 3 |
| 19 | Selective laser melting of bulk immiscible alloy with enhanced strength:Heterogeneous microstructure and deformation mechanisms显示文摘To overcome the dimension limits of immiscible alloys produced by traditional techniques and enhance their mechanical properties,bulk Cu-Fe-based immiscible alloy with abundant nanotwins and stacking faults was successfully produced by selective laser melting(SLM).The SLM-produced bulk immiscible alloy displays a heterogeneous microstructure characterized by micro-scaledγ-Fe particles dispersed in fineε-Cu matrix with a high fraction(~92%)of high-angle grain boundaries.Interestingly,abundant nanotwins and stacking faults are generated in the interior of nano-scaledγ-Fe particles embedded withinε-Cu matrix.The heterogeneous interface of soft domains(ε-Cu)and hard domains(γ-Fe)not only induces the geometrically necessary dislocations(GNDs)but also affects the dislocation propagation during plastic deformation.Therefore,the bimodal heterogeneous interface,and the resistance of nanotwins and stacking faults to the propagation of partial dislocation make the bulk immiscible alloy exhibit an enhanced strength of~590 MPa and a good ductility of~8.9%. | Shengfeng Zhou Min Xie Changyi Wu Yanliang Yi Dongchu Chen Lai-Chang Zhang | 2022 | Journal of Materials Science & Technology2022，，9： | 3 |
| 20 | Safety,tolerability,and pharmacokinetics of BAT8001 in patients with HER2-positive breast cancer:An open-label,dose-escalation,phase I study显示文摘Background:The introductions of anti-human epidermal growth factor receptor-2(HER2)agents have significantly improved the treatment outcome of patients with HER2-positive breast cancer.BAT8001 is a novel antibodydrug conjugate targeting human epidermal growth factor receptor-2(HER2)-expressing cells composed of a trastuzumab biosimilar linked to the drug-linker Batansine.This dose-escalation,phase I study was designed to assess the safety,tolerability,pharmacokinetics,and preliminary anti-tumor activity of BAT8001 in patients with HER2-positive locally advanced or metastatic breast cancer.Methods:This trial was conducted in subjects with histologically confirmed HER2-positive breast cancer(having evaluable lesions and an Eastern Cooperative Oncology Group performance status of 0 or 1)using a 3+3 design of escalating BAT8001 doses.Patients received BAT8001 intravenously in a 21-day cycle,with dose escalation in 5 cohorts:1.2,2.4,3.6,4.8,and 6.0 mg/kg.The primary objective was to evaluate the safety and tolerability of BAT8001.Preliminary activity of BAT8001 was also assessed as a secondary objective.Results:Between March 2017 to May 2018,29 HER2-positive breast cancer patients were enrolled.The observed dose-limiting toxicities were grade 4 thrombocytopenia and grade 3 elevated transaminase.The maximum tolerated dose was determined to be 3.6 mg/kg.Grade 3 or greater adverse events(AEs)occurred in 14(48.3%)of 29 patients,including thrombocytopenia in 12(41.4%)patients,aspartate aminotransferase increased in 4(13.8%)patients,γ-glutamyl transferase increased in 2(6.9%)patients,alanine aminotransferase increased in 2(6.9%)patients,diarrhea in 2(6.9%)patients.Objective response was observed in 12(41.4%,95%confidence interval[CI]=23.5%-61.1%)and disease control(including patients achieving objective response and stable disease)was observed in 24(82.8%,95%CI=64.2%-94.2%)patients.Conclusions:BAT8001 demonstrated favorable safety profiles,with promising anti-tumor activity in patients with HER2-positive locally advanced or metastatic breast cancer.BAT8001 has the potential to provide a new therapeutic option in patients with metastatic HER2-positive breast cancer. | Ruoxi Hong Wen Xia Liye Wang Kaping Lee Qianyi Lu Kuikui Jiang Shengfeng Li Jinquan Yu Jin Wei Weijia Tang Danyang Zhou Xin An Jiajia Huang Cong Xue Xiwen Bi Yanxia Shi Zhongyu Yuan Fei Xu Shusen Wang | 2021 | Cancer Communications2021，41，2： | 2 |
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