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| 1 | TNF-αTNFR1 Signaling is Required for the Full Expression of Acute and Chronic Itch in Mice via Peripheral and Central Mechanisms显示文摘Increasing evidence suggests that cytokines and chemokines play crucial roles in chronic itch. In the present study, we evaluated the roles of tumor necrosis factor-alpha(TNF-a) and its receptors TNF receptor subtype-1(TNFR1) and TNFR2 in acute and chronic itch in mice.Compared to wild-type(WT) mice, TNFR1-knockout(TNFR1-KO) and TNFR1/R2 double-KO(DKO), but not TNFR2-KO mice, exhibited reduced acute itch induced by compound 48/80 and chloroquine(CQ). Application of the TNF-synthesis inhibitor thalidomide and the TNF-αantagonist etanercept dose-dependently suppressed acute itch. Intradermal injection of TNF-α was not sufficient to evoke scratching, but potentiated itch induced by compound 48/80, but not CQ. In addition, compound 48/80 induced TNF-α mRNA expression in the skin, while CQ induced its expression in the dorsal root ganglia(DRG) and spinal cord. Furthermore, chronic itch induced by dry skin was reduced by administration of thalidomide and etanercept and in TNFR1/R2 DKO mice. Dry skin induced TNF-α expression in the skin, DRG, and spinal cord and TNFR1 expression only in the spinal cord. Thus, our findings suggest that TNF-α/TNFR1 signaling is required for the full expression of acute and chronic itch via peripheral and central mechanisms, and targeting TNFR1 may be beneficial for chronic itch treatment. | Xiuhua Miao Ya Huang Teng-Teng Liu Ran Guo Bing Wang Xue-Long Wang Li-Hua Chen Yan Zhou Ru-Rong Ji Tong Liu | 2018 | Neuroscience Bulletin2018，34，1： | 8 |
| 2 | Bionic Design and Finite Element Analysis of Elbow in Ice Transportation Cooling System显示文摘With the increase in mining depth, mine heat harm has appeared to be more prominent. The mine heat harm could be resolvedor reduced by ice refrigeration. Thus, ice transportation through pipeline becomes a critical problem; typically flowresistance occurs in the elbow. In the present study, according to the analysis of the surface morphology of fish scale, abiomimetic functional surface structure for the interior wall of elbow is designed. Based on the theory of liquid-solid two phaseflow, a CFD numerical simulation of ice-water mixture flowing through the elbow is carried out using finite element method.Conventional experiments of pressure drop and flow resistance for both bionic and common elbows are conducted to test theeffect of the bionic elbow on flow resistance reduction. It is found that with the increase in the ice mass fraction in the ice-watermixture, the effect of bionic elbow on resistance reduction becomes more obvious. | Dejun Miao~(1,2), Xiuhua Sui~3, Linjing Xiao~3 1. Key Laboratory of Mine Hazard Prevention and Control (Ministry of Education, China), Shandong University of Science and Technology, Qingdao 266510, P. R. China 2. School of Architecture, Tsinghua University, Beijing 100084, P. R. China 3. College of Mechanical and Electronic Engineering, Shandong University of Science and Technology, Qingdao 266510, P. R. China | 2010 | Journal of Bionic Engineering2010，7，3： | 3 |
| 3 | Electromigration profiles of Cynomorium songaricum based on capillary electrophoresis with amperometric detection显示文摘 | CHU Qingcui TIAN Xiuhua LIN Miao | 2006 | J Agrie Food Chem2006，54，21： | 1 |
| 4 | Sensitization of sodium channels by cystathionine β-synthetase activation in colon sensory neurons in adult rats with neonatal maternal deprivation显示文摘 | Shufen Hu Weiyuan Xu Xiuhua Miao Yanping Gao Liyan Zhu Youlang Zhou Ying Xiao Guang-Yin Xu | 2013 | Experimental Neurology2013，，： | 1 |
| 5 | Occurrence Dynamics and Countermeasure of Wheat Crown Rot in Weifang City显示文摘Wheat crown rot was first found in Weifang City in 2015,and now has become a major disease of wheat,showing an aggravating trend year by year.The author investigated the occurrence area and characteristics of wheat crown rot in Weifang City over the past 5 years,and analyzed the causes of the disease.The disease was mainly related to variety resistance and farming system.According to the occurrence regularity of the disease,a set of comprehensive control measures were put forward. | Hongping TIAN Guocai LU Xiuhua WEI Hongxia TIAN Miao ZHANG Fujun LI | 2022 | Plant Diseases and Pests2022，13，5： | 0 |
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