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| 1 | The burden of liver disease in Europe: A review of available epidemiological data显示文摘 | Martin Blachier Henri Leleu Markus Peck-Radosavljevic Dominique-Charles Valla Fran?oise Roudot-Thoraval | 2013 | Journal of Hepatology2013，，3： | 16 |
| 2 | Mucosal healing progression after acute colitis in mice显示文摘BACKGROUND Mucosal healing has become a therapeutic goal to achieve stable remission in patients with inflammatory bowel diseases. To achieve this objective, overlapping actions of complex cellular processes, such as migration, proliferation, and differentiation, are required. These events are longitudinally and tightly controlled by numerous factors including a wide range of distinct regulatory proteins. However, the sequence of events associated with colon mucosal repair after colitis and the evolution of the luminal content characteristics during this process have been little studied.AIM To document the evolution of colon mucosal characteristics during mucosal healing using a mouse model with chemically-induced colitis.METHODS C57 BL/6 male mice were given 3.5% dextran sodium sulfate(DSS) in drinking water for 5 d. They were euthanized 2(day 7), 5(day 10), 8(day 13), and 23(day28) d after DSS removal. The colonic luminal environment and epithelial repair processes during the inflammatory flare and colitis resolution were analyzed with reference to a non-DSS treated control group, euthanized at day 0. Epithelial repair events were assessed histo-morphologically in combination with functional permeability tests, expression of key inflammatory and repairing factors, and evaluation of colon mucosa-adherent microbiota composition by 16 S rRNA sequencing.RESULTS The maximal intensity of colitis was concomitant with maximal alterations of intestinal barrier function and histological damage associated with goblet cell depletion in colon mucosa. It was recorded 2 d after termination of the DSStreatment, followed by a progressive return to values similar to those of control mice. Although signs of colitis were severe(inflammatory cell infiltrate, crypt disarray, increased permeability) and associated with colonic luminal alterations(hyperosmolarity, dysbiosis, decrease in short-chain fatty acid content), epithelial healing processes were launched early during the inflammatory flare with increased gene expression of certain key epithelial repair modulators, including transforming growth factor-β, interleukin(Il)-15, Il-22, Il-33, and serum amyloid A. Whereas signs of inflammation progressively diminished, luminal colonic environment alterations and microscopic abnormalities of colon mucosa persisted long after colitis induction.CONCLUSION This study shows that colon repair can be initiated in the context of inflamed mucosa associated with alterations of the luminal environment and highlights the longitudinal involvement of key modulators. | Sandra Vidal-Lletjós Mireille Andriamihaja Anne Blais Marta Grauso Patricia Lepage Anne-Marie Davila Claire Gaudichon Marion Leclerc Francois Blachier Annaig Lan | 2019 | World Journal of Gastroenterology2019，25，27： | 5 |
| 3 | Intrauterine growth restriction alters growth performance, plasma hormones,and small intestinal microbial communities in growing-finishing pigs显示文摘Background: The interaction of the gut microbiota with key metabolic and physiological processes may be associated with poor growth outcomes in animals born with intrauterine growth restriction(IUGR).Results: Growth performance, plasma hormone concentrations, and intestinal microbiota composition were analyzed in IUGR pigs and in normal birth weight(NBW) pigs when the NBW pigs reached 25, 50, and 100 kg of body weight(BW). Compared to NBW pigs, IUGR pigs had lower initial, weaned, and final BW, and lower average daily gain and average daily feed intake in all the considered time points. In the 25 kg BW group, IUGR pigs had higher concentrations of plasma ghrelin and pancreatic polypeptide(PP), but lower insulin concentration than NBW pigs, while the situation was reversed in the 50 kg BW group. As compared to NBW pigs, IUGR pigs had higher microbial alpha diversity in the jejunum and ileum;in the 50 and 100 kg BW groups, IUGR pigs had higher Firmicutes abundance but lower Proteobacteria abundance in the jejunum, and lower Lactobacillus abundance in the jejunum and ileum;in the 25 kg BW group, IUGR pigs showed higher unclassified Ruminococcaceae abundance in the ileum;and in 25 and 50 kg BW groups, IUGR pigs showed lower Ochrobactrum abundance in the jejunum.Spearman's correlation revealed that Lactobacillus was negatively correlated with growth performance, while unclassified Ruminococcaceae was positively correlated. Predictive metagenomic analysis detected significantly different expression of genes in the intestinal microbiota between IUGR and NBW pigs, suggesting different metabolic capabilities between the two groups.Conclusions: Growing-finishing IUGR pigs showed lower growth performance, higher microbial alpha diversity, and differences in plasma hormone concentrations compared to NBW pigs. Alterations in the abundance of Firmicutes,Proteobacteria, Ruminococcaceae, Lactobacillus, and Ochrobactrum in the small intestine may be associated with IUGR, and may therefore serve as a future target for gut microbiota intervention in growing-finishing IUGR pigs. | Liang Xiong Jinming You Wanghong Zhang Qian Zhu Francois Blachier Yulong Yin Xiangfeng Kong | 2021 | Journal of Animal Science and Biotechnology2021，12，1： | 5 |
| 4 | Dietary proline supplementation alters colonic luminal microbiota and bacterial metabolite composition between days 45 and 70 of pregnancy in Huanjiang mini-pigs显示文摘Background: Pregnancy is associated with important changes in gut microbiota composition. Dietary factors may affect the diversity, composition, and metabolic activity of the intestinal microbiota. Among amino acids, proline is known to play important roles in protein metabolism and structure, cell differentiation, conceptus growth and development, and gut microbiota re-equilibration in case of dysbiosis.Results: Dietary supplementation with 1% proline decreased(P < 0.05) the amounts of Klebsiella pneumoniae,Peptostreptococcus productus, Pseudomonas, and Veillonella spp. in distal colonic contents than that in the control group. The colonic contents of Butyrivibrio fibrisolvens, Bifidobacterium sp., Clostridium coccoides, Clostridium coccoides-Eubacterium rectale, Clostridium leptum subgroup, Escherichia coli, Faecalibacterium prausnitzii,Fusobacterium prausnitzii, and Prevotella increased(P < 0.05) on d 70 of pregnancy as compared with those on d 45 of pregnancy. The colonic concentrations of acetate, total straight-chain fatty acid, and total short-chain fatty acids(SCFA) in the proline-supplemented group were lower(P < 0.05), and butyrate level(P = 0.06) decreased as compared with the control group. Almost all of the SCFA displayed higher(P < 0.05) concentrations in proximal colonic contents on d 70 of pregnancy than those on d 45 of pregnancy. The concentrations of 1,7-heptyl diamine(P = 0.09) and phenylethylamine(P < 0.05) in proximal colonic contents were higher, while those of spermidine(P = 0.05) and total bioamine(P = 0.06) tended to be lower in the proline-supplemented group than those in the control group. The concentrations of spermidine, spermine, and total bioamine in colonic contents were higher(P < 0.05) on d 70 of pregnancy than those measured on d 45 of pregnancy. In contrast, the concentration of phenylethylamine was lower(P < 0.05) on d 70 than on d 45 of pregnancy.(Continued on next page)(Continued from previous page)Conclusion: These findings indicate that L-proline supplementation modifies both the colonic microbiota composition and the luminal concentrations of several bacterial metabolites. Furthermore, our data show that both the microbiota composition and the concentrations of bacterial metabolites are evolving in the course of pregnancy. These results are discussed in terms of possible implication in terms of luminal environment and consequences for gut physiology and health. | Yujiao Ji Qiuping Guo Yulong Yin Francois Blachier Xiangfeng Kong | 2018 | Journal of Animal Science and Biotechnology2018，9，2： | 5 |
| 5 | The burden of liver disease in Europe : a review of available epidemiological data显示文摘 | Blachier M Leleu H Peck-Radosavljevic M | 2013 | Hepatol2013，58，3： | 1 |
| 6 | Intestinal microbiota : Development,metabolism and functions 显示文摘 | Wang S P Blachier F Zhao F | 2011 | JoumaJ of Food Agriculture 8c Environment2011，9，2： | 1 |
| 7 | Effects of amino acidderived luminal metabolites on the colonic epithelium and physiopathological consequences显示文摘 | Blachier F Mariotti F Huneau J F | 2007 | Amino Acids2007，33，： | 1 |
| 8 | Adsorption of poly- amine on clay minerals 显示文摘 | Blachier C Michot L Bihannic I | 2009 | Journal of Colloid and Inter- face Science2009，336，2： | 1 |
| 9 | Effects of amino acid - derived luminal metabolites on the colonic epitheliumand physiopathological con- sequences 显示文摘 | Blachier F Mariotti F Huneau JF | 2007 | AminoAcids2007，33，4： | 1 |
| 10 | Effects of amino acid-derived luminal metabolites on the colonic epithelium and physiopathological consequences显示文摘 | BLACHIER F MARIOTTI F HUNEAU J F | 2007 | Amino Acids2007，33，： | 1 |
| 11 | Does the site of magnetic resonance imaging abnormalities match the site ofrecentonset inflammatory back pain: the DESIR cohort显示文摘 | Blachier M Coutanceau B Dougados M | 2013 | Ann Rheum Dis2013，76，2： | 1 |
| 12 | Effects of amino acid-derived luminal metabolites on the colonic epitheliumand physiopathological consequences显示文摘 | Blachier F Mariotti F Huneau JF | 2007 | Amino Acids2007，33，4： | 1 |
| 13 | Stimulus-secretion coupling of arginine-induced insulin release: comparison with lysine-induced insulin secretion 显示文摘 | Sener A Blachier F Rasschaert J | 1989 | Endocrinology1989，124，5： | 1 |
| 14 | Blood pressure variability and risk of dementia in an elderly cohort, the Three- City Study显示文摘 | AlpSrovitch A Blachier M Soumar$ A | 2014 | Alzheimers Dement2014，10，5： | 1 |
| 15 | Alimentary proteins, amino acids and cholesterolemia 显示文摘 | Blachier F Jr Lancha A H Boutry C | 2010 | Amino Acids2010，38，1： | 1 |
| 16 | Intestinal luminal nitrogen metabolism:role of the gut microbiota and consequences for the host显示文摘 | Davila A-M Blachier F Gotteland M | 2013 | Pharmacological Research2013，68，1： | 1 |
| 17 | Stimulus-secretion coupling of arginine-indueed insulin release: uptake of metabolized and nonmetabolized cationic amino acids by pancreatic islets 显示文摘 | Blachier F Mourtada A Sener A | 1989 | Endocrinology1989，124，1： | 1 |
| 18 | Mitochondria and sulfide: a very old story of poisoning, feeding,and signaling? 显示文摘 | Bouillaud F Blachier F | 2011 | Antioxid Red- ox Signal2011，15，2： | 1 |
| 19 | The burden of liver disease in Europe: a review of available epidemiological data显示文摘 | Blachier M Leleu H Peck-Radosavljevic M | 2013 | J Hepatol2013，58，59： | 1 |
| 20 | Alimentary proteins, amino acids and cholesterol 显示文摘 | BLACHIER F LANCHA A H Jr BOUTRY C | 2010 | Amino Acids2010，38，1： | 1 |
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