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| 1 | Rescue associating liver partition and portal vein ligation for staged hepatectomy after portal embolization: Our experience and literature review显示文摘AIM To report a single-center experience in rescue associating liver partition and portal vein ligation for staged hepatectomy(ALPPS), after failure of previous portal embolization. We also performed a literature review.METHODS Between January 2014 and December 2015, every patient who underwent a rescue ALPPS procedure in Toulouse Rangueil University Hospital, France, was included. Every patient included had a project of major hepatectomy and a previous portal vein embolization(PVE) with insufficient future liver remnant to body weight ratio after the procedure. The ALPPS procedure was performed in two steps(ALPPS-1 and ALPPS-2), separated by an interval phase. ALPPS-2 was done within 7 to 9 d after ALPPS-1. To estimate the FLR, a computed tomography scan examination was performed 3 to 6 wk after the PVE procedure and 6 to 8 d after ALPPS-1. A transcystic stent was placed during ALPPS-1 and remained opened duringthe interval phase, in order to avoid biliary complications. Postoperative liver failure was defined using the 50-50 criteria. Postoperative complications were assessed according to the Dindo-Clavien Classification.RESULTS From January 2014 to December 2015, 7 patients underwent a rescue ALPPS procedure. Median FLR before PVE, ALPPS-1 and ALPPS-2 were respectively 263 cc(221-380), 450 cc(372-506), and 660 cc(575-776). Median FLR/BWR before PVE, ALPPS-1 and ALPPS-2 were respectively 0.4%(0.3-0.5), 0.6%(0.5-0.8), and 1%(0.8-1.2). Median volume growth of FLR was 69%(18-92) after PVE, and 45%(36-82) after ALPPS-1. The combination of PVE and ALPPS induced a growth of median initial FLR of +408 cc(254-513), leading to an increase of +149%(68-199). After ALPPS-2, 4 patients had stage Ⅰ-Ⅱ complications. Three patients had more severe complications(one stage Ⅲ, one stage Ⅳ and one death due to bowel perforation). Two patients suffered from postoperative liver failure according to the 50/50 criteria. None of our patients developed any biliary complication during the ALPPS procedure.CONCLUSION Rescue ALPPS may be an alternative after unsuccessful PVE and could allow previously unresectable patients to reach surgery. Biliary drainage seems to reduce biliary complications. | Charlotte Maulat Antoine Philis Bérénice Charriere Fatima-Zohra Mokrane Rosine Guimbaud Philippe Otal Bertrand Suc Fabrice Muscari | 2017 | World Journal of Clinical Oncology2017，8，4： | 7 |
| 2 | Dihydropyrimidine dehydrogenase activity in normal,inflammatory and tumour tissues of colon and liver in humans 显示文摘 | Guimbaud R Guichard S Dusseau C | 2000 | Cancer Chemother Pharmacol2000，45，： | 1 |
| 3 | Network of inflammatory cytokines and correlation with disease activity in ulcerative colitis显示文摘 | GUIMBAUD R BERTRAND V Chauvelot-Moachon L | 1998 | Am J Gastroenterol1998，93，12： | 1 |
| 4 | Annexin 1 is secreted in situ during ulcerative colitis in humans显示文摘 | Vergnolle N Pages P Guimbaud R | 2004 | Inflamm Bowel Dis2004，10，5： | 1 |
| 5 | Network of inflammatory cytokines and correlation with disease activity in ulcerative colitis显示文摘 | Guimbaud R Bertrand V Chauvelot-Moachon L | 1998 | Am J Gastroenterol1998，93，12： | 1 |
| 6 | Population pharmacokinetics of oxaliplatin 显示文摘 | Delord JP Umlil A Guimbaud R | 2003 | Cancer Chemother Pharmacol2003，51，2： | 1 |
| 7 | Dihydropyrimidine dehydrogenase activity innormal, inflammatory and tumour tissues ofcolon and liver in humans显示文摘 | GUIMBAUD R GUICHARD S DUSSEAU C | 2000 | Cancer ChemotherPharmacol2000，45，6： | 1 |
| 8 | Prospective, randomized, muhicenter, phase m study of fluorouraeil, leueovorin, and iri- notecan versus epirubicin, eisplatin, and capeeitabine in ad- vanced gastric adenoeareinoma: a French intergroup (Federation Franeophone de Cancerologie Digestive, Federation Nationale des Centres de Lutte Contre le Cancer, and Groupe Cooperateur Multidiseiplinaire en Oncologie) study显示文摘 | Guimbaud R Louvet C Ries P | 2014 | J Clin Oncol2014，32，31： | 1 |
| 9 | Net work of inflammatory cytokines and correlation with disease activity in ulcerative colitis 显示文摘 | GUIMBAUD R BERTRAND V CHAUVELOT MOACHON L | 1998 | Am J Gastroenterol1998，93，12： | 1 |
| 10 | Inducible nitric oxide synthase activity in colon biopsies from inflammatory areas:correlation with inflammation intensity in patients with ulcerative colitis but not with Crohn's disease显示文摘 | Guimbaud R Bertrand V | 2000 | Amino Acids2000，18，3： | 1 |
| 11 | Prospective,randomized,multicenter,phaseⅢstudy of fluorouracil,leucovorin,and irinotecan versus epirubicin,cisplatin,and capecitabine in advanced gastric adenocarcinoma:a French intergroup(Federation Francophone de Cancerologie Digestive,Federation Nationale des Centres de Lutte Contre le Cancer,and Groupe Cooperateur Multidisciplinaire en Oncologie)Study显示文摘 | Guimbaud R Louvet C Ries P | 2014 | J Clin Oncol2014，32，31： | 1 |
| 12 | Prospective, randomized, multi- center, phase m study of fluorouracil, leucovorin, and irinotecan versus epirubicin, cisplatin, and capecitabine in advanced gastric adenocarcinoma: a French intergroup (Federation Francophone de Cancerologie Digestive, Federation Nationale des Centres de Lutte Contre le Cancer, and Groupe Cooperateur Multidisciplinaire en Oncologie) study显示文摘 | Guimbaud R Louvet C Ries P | | J Clin Oncol0，32，31： | 1 |
| 13 | Network of inflammatory cytokinesand correlation with disease activity in ulcerative colitis 显示文摘 | Guimbaud R Bertrand V Chauvelot-MoachonL | 1998 | Am J Gastroenterol1998，93，12： | 1 |
| 14 | FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer显示文摘 | Conroy T Desseigne F Ychou M BouchéO Guimbaud R Bécouarn Y | 2011 | N Engl J Med2011，364，： | 1 |
| 15 | Network of inflammatory cytokines and correlation with disease activity in ulcerative colitis显示文摘 | Guimbaud R Bertrand V Chauvelot-Moachon L | 1998 | Am J Gastroenterol1998，93，12： | 1 |
| 16 | Dihy-dropyrimidine dehydrogenase activity in normal, inflammatory and tumour tissues of colon and liver in humans 显示文摘 | GUIMBAUD R GUICHARD S DUSSEAU C | 2000 | Cancer Chemother Pharmacol2000，45，： | 1 |
| 17 | Dihydropyrimidine dehydrogenase activity in normal, inflammatory and turnout tissues of colon and liver in humans 显示文摘 | Guimbaud R Guichard S Dusseau C | 2000 | Cancer Chemother Pharmacaol2000，45，6： | 1 |
| 18 | Dihydropyrimidine de- hydrogertase activity in normal, inflammatmw and tumour tissues of colon and liver in humans 显示文摘 | Guimbaud R Guiehard S Dusseau C | 2000 | Cancer Chemother Pharmeol2000，45，： | 1 |
| 19 | Dihydropyrimidine dehydrogenase activity in normal, inflammatory and tumor tissues of colon and liver in humans 显示文摘 | Guichard S Dusseau C | 2000 | Cancer Chemother Pharmacol2000，45，6： | 1 |
| 20 | Dihydropyrimidine dehydrogenase activity in normal, inflammatory and tumour tissues of colon and liver in humans显示文摘 | Guimbaud R Guichard S Dusseau C | 2000 | Cancer Chemother Pharmacol2000，45，6： | 1 |
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